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Hologram Based QSAR Analysis of Caspase-3 Inhibitors
Sathya Babu 조선대학교 기초과학연구원 2018 조선자연과학논문집 Vol.11 No.2
Caspases, a family of cysteinyl aspartate–specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage because the activation of caspases-3 stimulates a signalling pathway that ultimately leads to the death of the cell. In this study, Hologram based Quantitative Structure Activity Relationship (HQSAR) models was generated on a series of Caspase-3 inhibitors named 3, 4-dihydropyrimidoindolones derivatives. The best HQSAR model was obtained using atoms, bonds, and hydrogen atoms (A/B/H) as fragment distinction parameter using hologram length 61 and 3 components with fragment size of minimum 5 and maximum 8. Significant cross-validated correlation coefficient (q2= 0.684) and non cross-validated correlation coefficients (r2= 0.754) were obtained. The model was then used to evaluate the eight external test compounds and its r2 pred was found to be 0.559. Contribution map show that presence of pyrrolidine sulfonamide ring and its bulkier substituent’s makes big contributions for improving the biological activities of the compounds.
Hologram Based QSAR Analysis of Caspase-3 Inhibitors
Sathya., B The Basic Science Institute Chosun University 2018 조선자연과학논문집 Vol.11 No.2
Caspases, a family of cysteinyl aspartate-specific proteases plays a central role in the regulation and the execution of apoptotic cell death. Caspase-3 has been proven to be an effective target for reducing the amount of cellular and tissue damage because the activation of caspases-3 stimulates a signalling pathway that ultimately leads to the death of the cell. In this study, Hologram based Quantitative Structure Activity Relationship (HQSAR) models was generated on a series of Caspase-3 inhibitors named 3, 4-dihydropyrimidoindolones derivatives. The best HQSAR model was obtained using atoms, bonds, and hydrogen atoms (A/B/H) as fragment distinction parameter using hologram length 61 and 3 components with fragment size of minimum 5 and maximum 8. Significant cross-validated correlation coefficient ($q^2=0.684$) and non cross-validated correlation coefficients ($r^2=0.754$) were obtained. The model was then used to evaluate the eight external test compounds and its $r^2_{pred}$ was found to be 0.559. Contribution map show that presence of pyrrolidine sulfonamide ring and its bulkier substituent's makes big contributions for improving the biological activities of the compounds.
Enhancement of Security and QoS in Wireless Medical Sensor Networks
Sathya Duraisamy,Pranavi Krishnasamy,Jeena Jacaob Israel,Jagadeesan Duraisamy 한국정보과학회 2020 Journal of Computing Science and Engineering Vol.14 No.2
Wireless medical sensor networks (WMSN) collect the data of a patient’s vital body parameters using wearable or nonwearable biosensors. Since WMSN is wireless in nature there occur numerous issues like a false alarm, lack of robustness, and low processor speed, which reduce the system’s effectiveness. One of the major issues is the security and privacy protection of the collected data and providing a greater Quality of Service (QoS) for the network in terms of energy efficiency, standardization, etc. Targeting these problems, we introduced a hybrid secure and fuzzy fusion system to achieve efficient secure transmission and data fusion in WMSN. The basic idea of the proposed method is to generate a private key from specific features of the digital color image; the generated key is encrypted by the Advanced Encryption Standards (AES) mechanism. The proposed system handles the vague and imprecise data to reduce energy consumption and increases the network lifetime. The inference results verify the efficiency of the proposed method in terms of security and energy consumption of the network.
Sathya, M. Arul,Usa, S. The Korean Institute of Electrical Engineers 2015 Journal of Electrical Engineering & Technology Vol.10 No.3
Power transformer is one of the major and key apparatus in electric power system. Monitoring and diagnosis of transformer fault is necessary for improving the life period of transformer. The failures caused by short circuits are one of the causes of transformer outages. The short circuit currents induce excessive forces in the transformer windings which result in winding deformation affecting the mechanical and electrical characteristics of the winding. In the present work, a transformer producing only the radial flux under short circuit is considered. The corresponding axial displacement profile of the windings is computed using Finite Element Method based transient structural analysis and thus obtained displacements are compared with the experimental result. The change in inter disc capacitance and mutual inductance of the deformed windings due to different short circuit currents are computed using Finite Element Method based field analyses and the corresponding Sweep Frequency Responses are computed using the modified electrical equivalent circuit. From the change in the first resonant frequency, the winding movement can be quantified which will be useful for estimating the mechanical withstand capability of the winding for different short circuit currents in the design stage itself.