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하시모토 갑상선염과 동반된 갑상선 유두암에서 BRAFV600E의 발현과 임상적 특징
남성진,최영식,박요한,김정훈 고신대학교 의과대학 2010 고신대학교 의과대학 학술지 Vol.25 No.2
Background: An association between Hashimoto's thyroiditis (HT) and papillary thyroid carcinoma (PTC) is still controversial. Studies to date established the coexistence of HT in 11% to 36% of PTC patients. BRAFV600E mutation was presented 90% with no HT, 64% with HT in PTC patients. Therefore, BRAFV600E mutation is associated with the pathogenesis of PTC arising in HT. The purpose of this study was to identify predictive factors for the coexistence of PTC and HT and to evaluate the association of the BRAFV600E mutation with the clinicopathological features of coexistence of PTC and HT. Methods: A total of 247 patients underwent surgery for thyroid disorders between January 2007 and April 2009. In all, 212 patients was diagnosed as thyroid papillary carcinoma only (PTC group), 33 had coexistence of PTC and HT (PTC+HT group), and 2 had been diagnosed with HT. DNA was extracted from paraffin embedded thyroid tumor specimens taken from 99 patients with PTC, 13 coexistence of PTC and HT, and 2 was HT. The presence of the BRAFV600E mutation was determined by polymerase chain reaction amplification of exon 15 followed by direct sequencing. Results: Among clinicopathological features sex, age, tumor size and capsule invasion was not significant between PTC group and PTC+HT group. Lymph node metastasis and stage was significantly lower in PTC+HT group than PTC group (p=0.044). BRAFV600E mutation was found in 34 of the 99 PTC group (34.3%), 1 of the 13 PTC+HT group and 2 HT show no BRAFV600E mutation. Conclusion: These data demonstrated that the coexistence of PTC and HT was less aggressive than PTC only.
전압비교기를 이용한 AB급 연산증폭기의 슬루율 개선에 관한 연구
김요섭,손상희 청주대학교 산업과학연구소 2016 産業科學硏究 Vol.33 No.2
In this paper, we introduce a circuit which has improved power consumption and slew rate by adding a voltage comparator on the structure of the class AB rail to rail folded cascode OP amplifier. Using a voltage comparator, bias voltage near to VDD is applied in charging and discharging time and so high voltage is transferred to the output load. Therefore, proposed class AB rail to rail folded cascode OP amplifier circuit has high slew rate and low power consumption. From the simulation results of slew rate, we know that slew rate of proposed circuit is improved from 2.5V/us to 12V/us comparing to the conventional circuit. That is the reason why voltage comparator transmits voltage near to the value of VDD to the load stage. From the simulation results of power consumption, we know that power consumption of proposed circuit is improved from 1.2mW to 0.5mW comparing to the conventional circuit. Proposed class AB rail to rail folded cascode OP amplifier is designed and simulated by using the TSMC 0.18um 1-Poly & 6-Metal CMOS process.
인터넷 WEB SITE구축을 통한 의료정보교육의 효과에 관한 연구
남상요 高神大學校保健科學硏究所 1998 보건과학연구소보 Vol.8 No.-
Yet many students do nat have any education about internet, the importance of internet in medical fields is emphasizing nowadays. The purpose of this study aims are to build web based medical facility information providing system and to compare the situation of students before and after having internet lecture. The results are as follows; 1. Student's attitude about internet are positively changed after they have internet lecture. Especially the change of knowledge about internet is statistically significant. 2. web based medical facility information providing system is made to provide medical facility information to those who need to access a proper medical facility for their disease and to educate the students who will be provider of medical information in the near future. The database was made through assembling newspaper articles which contain hospital facility information and data that was collected by the students who have work experience at various hospitals. This system is composed of 5 parts: 1. Search of the hospital by region 2. Treatment of information by disease 3. Consultation regarding hospital affairs 4. Current issues of various hospitals 5. Bulletin board system. It is possible not only to give the medical facility information to people but also to motivate and develope the information processing technical skills for the students y constructing this system.
김수성,조재훈,이학승,박현영,장혁,김요식,조광호 원광대학교 의과학연구소 2009 圓光醫科學 Vol.24 No.1
항응고제 치료의 주된 합병증은 출혈로서 주로 뇌실질과 복강 내에 발생하며 사지 근육에 발생하는 근육내 혈종은 매우 드문 것으로 알려져 있다. 이러한 항응고제 치료 후 발생하는 자발성 근육내 혈종은 발생빈도가 드물 뿐 아니라, 심부정맥혈전증과 그 증상이 유사하여 감별하기가 쉽지 않다. 저자들은 항응고제 치료 후 운동 마비가 발생한 사지 근육에서 자발성 근육내 혈종이 발생한 증례를 경험하여 이를 보고한다. Spontaneous intramuscular hematoma(SIH) is an uncommon but serious bleeding complication of anticoagulation therapy that has received little attention. We present a patient of spontaneous muscular hematoma during anticoagulation therapy for acute stroke management. A-74-year old man was admitted with sudden onset of dysarthria and left hemiparesis. Brain MRI and MRA showed acute cerebral infarction along right middle cerebral artery territory and severe stenosis of right proximal cervical internal carotid artery. During intravenous heparin treatment, he complained acute pain and swelling on left leg. Muscular CT showed enhancing focal soft tissue mass on left gastrocnemius muscle and ultrasonography demonstrated multiple hematomas on left gastrocnemius muscle. Treatment of heparin was stopped immediately. After conservative management for hematomas, symptoms were subsided.
김요숙,정애진,강경화,김상철 대한치과교정학회 2003 대한치과교정학회지 Vol.33 No.4
치열 공간 부조화에 영향을 미치는 골격 및 치성요소를 알아보기 위하여 하악 치열궁내 총생을 보이는 성인 45명과 공극을 보이는 성인 39명의 Ⅰ급 부정 교합 환자와 정상적인 배열을 갖는 성인 40명을 선정하여 측모 두부방사선사진과 모형을 분석하여 다음과 같은 결론을 얻었다. 1.공극군보다 총생군의 ANB각이 컸다. 2.공극군보다 총생군이 하악골 및 상악골의 전하방 경사가 커서 안모의 수직적 양상이 심했다. 3. 총생군보다 공극군이 전두개저와 하악체 길이가 컸다. 4. ANB 각, 전안면 고경과 하악지 길이가 공간 부조화 양의 예측에 기여하며, 다음과 같은 회귀방정식이 산출되었다. space discrepancy = 46.51 - 2.51ANB - 0.58AFH + 0.65RH (R² = 0.40) The purpose of this study was to investigate the relationship between the space discrepancy of the mandibular dentition and craniofacial morphology in adults with good Angle class I occlusion. Dental casts of normal group, crowded group and spaced group were selected on the basis of dental crowding and spacing. Subjects with excessive space to accomodate the lower teeth were classified as spaced group(39). Subjects with a space discrepancy of more than 4mm were classified as crowded group(45). Normal subjects had little or no dental crowding and spacing(40). Various skeletodental measurements in lateral cephalograms were evaluated and compared by ANOVA, Pearson correlation analysis and multiple stepwise regression analysis. The results were as follows : 1. ANB angle was larger in crowded group than in spaced group. 2. Maxilla and mandible in crowded group were inclined more downward and forward than in spaced group, so crowded group was found to have vertical tendency. 3. Anterior cranial base length and mandibular body length were longer in spaced group than in crowded group. 4. According to the multiple stepwise regression analysis with space discrepancy as dependent variable, 40% of variance of space discrepancy could be explained by ANB angle, anterior facial height and ramus height. Multiple regression equation was as follows Space discrepancy=46.51-2.51ANB-0.58AFH+0.65RH
세립형 고강도 구조용 강재를 이용한 보-기둥재의 실험적 평가
김요숙,임성우,장인화 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2(구조계)
As the structure becomes higher and longer-spanned nowadays, the need for strong and reliable structural material becomes greater. In order to apply high strength steel to the building structure, adaptability of the current design codes to the design with high strength steel has to be reviewed. Beam-column tests subjected to the simple and the combined bending and axial compressive load were performed with variable slenderness ratio. The ultimate strengths were satisfied with both of ASD and LHFD codes regardless of whether characteristic of yield phenomenon is continuous yielding or not.
Undoped 및 Co-doped ZnGa₂O₄형광체의 광학적 에너지 간격
최성휴,김요완 조선대학교 에너지.자원신기술연구소 2002 에너지·자원신기술연구소 논문지 Vol.24 No.2
Undoped 및 Co-doped ZnGa₂O₄형광체를 성장시켜 성장된 형광체의 결정구조와 광흡수 특성을 측정하였다. 성장된 형광체는 공간군이 Fd3m에 속한 입방체 구조로 결정화되었으며, 순순한 ZnGa₂O₄형광체의 경우 격자상수 a=8.3348Å이었고, 첨가한 cobalt 불순물의 mole% 비가 증가함에 따라서 약간씩 증가되었다. 기초 흡수단 영역에서 측정한 ZnGa₂O₄의 직접전이 에너지 간격 및 간접전이 에너지 간격은 297K에서 3.057eV, 2.535eV으로 주어졌고, cobalt 불순물 0.01 mole%를 첨가하였을 때 광학적 에너지 간격은 2.998eV, 2.517eV이었으며 cobalt 불순물 mole% 비가 증가함에 따라서 약간씩 감소하였다. Undoped ZnGa₂O₄phosphors crystallized in the cubic (space group Fd3m) with lattice constants a = 8.3348Å. The lattice constant of ZnGa₂O₄: Co^(2+) (0.01 mole %) was given as a = 8.3358Å. The lattice constant of these compound increased as increasing the mole% of cobalt dopant. The optical absorption measured near the fundamental band edge showed that the optical energy band structure of these compounds had a direct and indirect band gap, the direct and indirect energy gaps are found to be 3.057 and 2.535eV for ZnGa₂O₄, and 2.998 and 2.517 eV for ZnGa₂O₄: Co^(2+) (0.01 mole %) at 297 K. The optical energy gap of ZnGa₂O₄: Co^(2+) decreased as increasing the mole % of cobalt dopant.
서요성 한국독어독문학회 2003 獨逸文學 Vol.88 No.-
Der Roman Das Parfum ist dem literarischen Postmodernismus zuzuordnen. Er 1st wenige Monate nach dem Erscheinen zu einem Verkaufserfolg geworden und wird nicht nur ein Bestseller, sondern auch ein Longseller. Fu¨r den Erfolg des Romans ko¨nnen viele Gru¨nde besprochen werden. Die traditionelle Erza¨hltechnik und der auktorialer Erza¨hler herrschen die Handlung vor. Aber ein wichtigeres Element dieser Literatur ist das Erzeugen von Spannung beim Leser. Das gelingt durch Anleihen beim Kriminalroman, Reiseromen, erotischen Roman usw. Bewusst schreibt Su¨skind an der Grenze zwischen ernster und unterhaltender Literatur. Er spielt auch mit vorhandenen Formen und Genres. Die Aspekte von Pastiche und Parodie lassen sich zwar durchaus erkennen. Aber in der A¨sthetik des sinnlichen Erscheinens der Wahrheit ist die Leichtigkeit des Romans noch unu¨bersehbar.
하이너 뮐러의 희곡『필록테트』의 교훈 : 신화의 지양 Aufhebung des Mythos
서요성 한국독어독문학회 2002 獨逸文學 Vol.84 No.1
In dieser Abhandlung sollen die Stellungen von Mu¨ller und dessen Kritikern zum Mythos und zum antiken Erbe herausgearbeitet werden. Mu¨ller ist entta¨uscht u¨ber die totalita¨re Herrschaft der DDR. Er sieht von der laufenden Wirklichkeit ab, um nicht wieder an ihr zu scheitern. Aber er nimmt keinen Abschied von ihr zur Herausarbeitung der Dausalita¨ten hinter der Wirklichkeitsfassade und fa¨ngt mit der Selbstpru¨fung des Sozialismus an. Dieser soll nach der marxistischen Logik ein endpunkt sein, das der menschliche Geist die ganze Bahn rationalistischer Erkenntnis durchla¨uft und endlich erreicht. Die sozialistischen Utopisten vertrauen blind dem unend- lichen Fortschritt nach dem Zusammenbruch des Kapitalismus durch den Klassenkampf. Die DDR muss das historisch Neue sine. Aber bei Mu¨ller herrscht die Vorstellung, dass die sittliche Beschaffen- heit der Menschen nicht einfach durch die Herstellung der neuen Ordnung des Eigentums vera¨ndert werden kann. Die vorsozialistischen Beziehungen halten sich in allem Wechsel unvera¨ndert und bilden den Kern der Mentali- ta¨t nach. Mu¨ller gelangt zur Erkenntnis, dass sich die Geschichte nicht auf der abgemessen gerechneten Zeit, sondern auf der zyklischen Wiederholung befindet. Die DDR-Gesellschaft ist nicht von der Auswirkung des Mythos befeit und ist ein Posten auf dem Weg von der Antike zur Utopie.