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Losartan과 Amlodipine의 병용투여에 의한 고혈압 및 혈관재협착 보호효과
한주희,정상혁,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
Abstract - To examine the protective effect of combination treatment of angiotensin II AT1-receptor blockers (ARBs) with Ca2+ channel blockers (CCBs) for high blood pressure and neointima hyperplasia, losartan and amlodipine were orally injected into telemetered-spontaneous hypertensive rats and vascular injury induced by cuff-inserted neointimal formation model in vivo. For the measurement of blood pressure, random orders of losartan 0, 4.79, 9.58 mg/kg/day, amlodipine 0, 0.48, 0.96 mg/kg/day, or higher/lower doses in combination were administered in spontaneous hypertensive rats (SHRs; n=10). For the measurement of neointimal hyperplasia, 9.58 mg/kg/day of losartan or 0.96 mg/kg/day of amlodipine in alone or combination were given for 2 weeks to cuffed C57BL/6 mice (n=6). Our results suggest that the combination therapy of high doses of losartan and amlodipine are effective in lowering systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of each drug, but not in combined therapy of low doses of two drugs. In protection for vascular remodeling, the combination therapy of losartan with amlodipine synergistically decreased BrdU-positive cells in neointima and DNA synthesis in [3H]-thymidine incorporation by reducing cell proliferation. Therefore, present study implies that combination of losartan with amlodipine may be effective for the treatment of hypertension and vascular remodeling such as restenosis.
혈압 및 혈관손상에 대한 Candesartan과 Cilnidipine의 병용투여 효능 평가
정상혁,한주희,명창선 충남대학교 약학대학 의약품개발연구소 2014 藥學論文集 Vol.29 No.-
This study was designed to evaluate the effect of candesartan combined with cilnidipine on high blood pressure in spontaneous hypertensive rats (SHRs) and vascular injury induced by cuff-placed neointimal hyperplasia model. To measure blood pressure, low and high doses of candesartan (0.765 and 1.53 mg/kg/day) and cilnidipine (0.96 and 1.92 mg/kg/day) alone or in combination were orally administered in telemetered-SHRs for 2 weeks. To examine the protective action of vascular injury, high doses of candesartan (1.53 mg/kg/day) and cilnidipine (1.92 mg/kg/day) alone or in combination was orally administered for 2 weeks in cuff-induced neointimal hyperplasia model of C56BL/6 mice. As a result, high doses of candesartan and cilnidipine in combination decreased in systolic blood pressure (SBP) and mean arterial pressure (MAP) as compared with monotherapy of high dose of each drug, but not statistically significant. In vascular injury model, candesartan and cilnidipine in combination decreased BrdU-positive cells in neointima and vascular smooth muscle cell proliferation as compared with monotheray of each drug. Thus, these results indicate that the combination of candesartan with cilnidipine is effective for the protection of vascular injury, suggesting this combination to be a valuable tool for the management of vascular remodelling such as restenosis.
위 MALT 림프종에서 다발성 림프절 전이로 오인된 동시성 림프절 결핵 1예
김성은,김규종,김도현,송준영,문대성,장리라,유찬희,문원,박무인,박선자,김영옥 고신대학교의과대학 2008 고신대학교 의과대학 학술지 Vol.23 No.2
28세 남자가 내시경적 점막절제술을 통해 저등급 위MALT 림프종으로 진단되었다. 병기설정을 위해 18F-FDG PET 검사를 시행하였고 우측 쇄골상부, 우측상/하부 기관주위, AP window 부위에 강한 섭취가 관찰되어 전이성 림프절로 판단하였다. 그러나, 우측 쇄골상부 림프절에서 시행한 절제생검에서 만성육아종성염증소견이 관찰되었고 조직의 결핵 중합효소연쇄반응에서도 양성 반응을 보였다. 2개월간 항결핵제의 사용 후 시행한 추적 컴퓨터단층촬영 검사에서 림프절 크기의 감소를 보여 최종적으로 위 MALT 림프종에서 광범위 림프절 전이로 오인된 동시성 림프절 결핵으로 진단되었다. A 28-year-old man was diagnosed as gastric MALT lymphoma in diagnostic EMR (endoscopic mucosal resection). He subsequently underwent an 18F-FDG PET. 18F-FDG PET showed intense multifocal uptake in right supraclavicular, right upper and lower paratracheal, and AP window areas that was considered radiologically to represent widespread metastatic lymphadenopathy. Excisional biopsy of a supraclavicular lymph node, however, revealed chronic granulomatous lymphadenitis with a positive reaction of Tb-nested PCR. After antituberculosis treatment for 2 months, a follow-up CT scan showed complete resolution of the lesions. Intense 18F-FDG uptake could be due to an infectious process such as synchronous tuberculous lymphadenitis. Therefore, this could mimic a malignant condition such as lymphoma with extensive lymph node metastasis due to a false-positive finding, which may lead to a misdiagnosis.
이진휘,장향동,최하영,서동호,이성미,김경하 서울産業大學校 1998 논문집 Vol.47 No.1
Glycyrrhiza uralensis계의 원감초 뿌리에서 추출도는 감초는 여러가지 질병의 약제로 널리 이용되어 왔다. 그 주성분인 gliycyrrhizin은 항염증 활성 및 anti-allergic activity를 갖고 있으며 이러한 생리활성은 aglycone β-gliycyrrhetinic acid 의 활성에 의한 것으로 알려져 있고, β-gliycyrrhetinic acid는 steroid 구조와 유사하며, 면역조절 특성을 갖는 것으로 인식되고 있다. 이러한 β-gliycyrrhetinic acid 의 면역조절 활성에 기여하는 인자와 그 경로에 대하여 조사된 바 있다 Glycyrrhizin은 감초뿌리의 주성분중 하나이며, 그외에도 surgars(14%), starches(30%), flavonoids, saponoids, amonoacids, gums 및 essential oil 등을 포함하고 있다. Licorice, the root extract of Glycyrrhiza uralensis, is used as a medicine for various diseases. Antiinflammatory as well as anti-allergic activities have been attributed to one of its main constituents, glycyrrhizin. These activities are mainly ascribed to the action of the aglycome β-glycyrrhetinic acid. βGlyeyrrhetinic acid has a steroid-like structure and is believed to have immunomodulatory properties, To determine whether interference with complement functions may contribute to the immunomdulatory activity of β-glycyrrbetinic acid. its effect on the classical and alternative activation pathways of human complement were investigated. The main constituent found in the root is glycyrrhizin. The plant also contains various sugars(14%), starches(30%), flavonoids, saponoids, aminoacids, gums, and essential oil etc.
9-11세 정상교합 어린이의 연조직 측모에 관한 두부방사선계측학적 연구
이창희,김정욱,김종철,이상훈 大韓小兒齒科學會 2005 大韓小兒齒科學會誌 Vol.32 No.3
본 연구의 목적은 정상교합인 건치 어린이에서 여러 가지 연조직 측모 분석법을 이용한 평균치를 제시하고 연령별, 성별에 따른 차이를 비교함으로써 이 시기에 행해지는 교정진단과 치료에 유용하게 이용하고자 하는 것이다. 2000년에서 2004년까지 서울시 치과의사회가 주관하는 건치 어린이 선발대회에서 선발된 정상교합인 9-11세 어린이 169명(남자 82명, 여자 87명, 9세 26명, 10세 118명, 11세 25명)을 촬영한 측모 두부규격 방사선사진으로 여러 가지 연조직 측모분석법을 이용하여 연조직 평균치를 구한 후 다음과 같은 결론을 얻었다. 1. 성별에 따른 연조직 평균치는 두 가지 항목을 제외하고는 유의성있는 차이를 보이지 않았다(p>0.05). 2. 여자가 남자보다 H line에 대해 하순이 더 돌출된 위치에 존재했으며, 중안모 길이에 비해 하안모 길이가 짧았다(p<0.05). 3. 연령에 따른 연조직 평균치는 유의성있는 차이를 보이지 않았다(p>0.05). The purpose of this study is to develop soft tissue cephalometric standards in children with normal occlusion and to determine the differences between males and females and the differences according to age ranges of 9, 10 and 11 years. The lateral cephalometric radiographs of 169 children(82 boys, 87 girls) among the contestants in 2000-2004 Healthy Dentition Contest in Seoul were studied with several soft tissue profile analyses and cephalometric means and following results were obtained. 1. The sex differences were not statistically significant between males and females soft tissue parameters except for two soft tissue parameters(p>0.05). 2. Females had relatively more protrusive lower lip relative to the H line than males and middle third face height to lower third face height of females was larger than males(p<0.05). 3. The age differences in soft tissue parameters were not statistically significant according to age ranges of 9, 10 and 11 years(p>0.05).
정희균,서상현 동아대학교 건설기술연구소 2003 硏究報告 Vol.27 No.1
At a turning point of new paradigm, each countries in the world are try to search solutions to a current problems of the times in maritime than land. To accomplish a powerful maritime power, it is necessary to construct MGII(Marine Geo-spatial Information Infrastructure) on the basis of Marine and Coastal GIS. In this paper, we establish concept, definition and framework about marine GIS in Korea through framework analysis of foreign GIS and so, in Korea, analyze the present status and application cases of marine GIS that have been developed and constructed until now.
김성휘,서정윤 7개 국립대학교 환경연구논문집 공동발행 위원회 2005 공업기술연구 Vol.5 No.-
It is said that though cleaning has implications for our lives, it ha been being only conducted by people's experiences and their insight to cleaning without certain methods. The teachings for effective cleaning include how students well conduct cleaning as well as how the teachers effectively teach the method for dffective cleaning. The concept of cleaning is related to the action which removes the foreign materials from our living environment, and they can be classified into three categories: waste, dust, and stain. Thus, conducting cleaning may mean the work for removing these from something. The results of this research suggested that preparation for cleaning is important, the tools should be sufficiently provided, and particularly the teacher should praise the students who did good job at cleaning. They also indicated that the conditions for cleaning allow for cleanig teaching as well as help to have better environment by the efficiency of the cleaning. And further studies should had focus on the method for cleaning and preparation for preferable cleaning conditions.
이광휘,정상국,안정희,김한경,이종근 國立 昌原大學校 精報通信硏究所 1998 精報通信論文集 Vol.2 No.-
In this paper, we are designed and implemented communication simulator, for two systems which communicates in peer-to-peer and simulating for protocol, to verify the interwork not yet designed system Peerl and now being operated Peer2. To begin with, after the investigation in Interworking Standard in Interface Control Document and check the satisfied requirements in each system, the environment of simulator is set up. We examine Interworking Standard in FSM representation. And in protocol design, partial steps follows necessary procedure of protocol engineering. Simulator is implemented in C++ and, to interwork two systems smoothly, the whole system will be merged. Finally, a design and implementation of simulator is completed by confirming simulation results of simulator and Interworking Standard coincide.