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      • KCI등재
      • 백혈병 세포주에 대한 (±)-ar-Turmerone, 자근 및 황금추출물에 의한 항암제의 세포독성 증강효과

        이윤영,유관희,김삼용,안병준 충남대학교부설 생명공학연구소 1992 생물공학연구지 Vol.2 No.-

        Using the colorimetric [3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide](MTT)assay, we evaluated the chemosensitivity of 8 anticancer drugs{vincristine(VCR), vinblastine(VBL), adriamycin(ADR), cisplatin(CPDD), etoposide(VP-16), cytosine arabinoside(ara-C), bleomycin(Bleo) and cyclophosphamide(CYC)} and the cytotoxicity-enhancing effects of (±)-ar-turmerone and the extracts of the crude drugs {Lithospermum erythrorhizon(LE) and Scutellaria baicalensis(SB)}on the above mentioned anticancer drugs against HL-60 and KG-1 cells among 8 anticancer drugs, VCR, VBL, ADR, and CPDD inhibited the growth of both cell lines by more than 50% while VP-16, ara-C, Bleo, and CYC were less effective. (±)-ar-Turmerone had significant inhibitory effects against both cell lines, showing the ID_50 values of 11.730 ㎍/㎖ and 0.292 ㎍/㎖ for HL-60 and KG-1 cells. respectively. But the extracts of LE and SB roots showed no significant cytotoxic effects. According to ID_50 values, the cytotoxicities of VCR, VBL and ADR against HL-60 were enhanced two, eight and three times by mixing (±)-ar-turmerone, five, seven and three times by adding the extract of LE root, and twenty, six and three times by mixing the extract of SB root, respectively. The cytotoxicities of the above mentioned drugs against KG-1 cell were enhanced two, seven and three times by mixing (±)-ar-turmerone, two, three and three times by conbining wilth the extract of LB root, and two, five and two times by adding the extract of SB root, respectively. The cytotoxicity-potentiating effects of (±)-ar-turmerone and the extracts of LE and SB roots against HL-60 cell were greater than KG-1 cell.

      • C.V.D. 방법에 의한 Cd_0.78Zn_0.22 S박막 성장과 광전기적 특성연구

        유상하,이상렬,홍광준,서상석,김혜숙,전승룡,윤은희,문종대 조선대학교 기초과학연구소 1993 自然科學硏究 Vol.16 No.1

        We had grown Cd_0.78Zn_0.22S polycrystal thin films on slide substrate using chemical vapour deposition(CVD) method. We measured X-ray diffraction patterns in order to study Cd_0.78Zn_0.22S polycrystal structure. We studied its band gap using transmission curves and photocurrent and also analyzed photoluminescence using configurational coordinate model. We measured Hall effect·on this sample by Van der Pauw method and studied on carrier density and mobility depending on temperature.

      • KCI등재후보

        만성 요통환자의 복부 심부근과 표재근을 중심으로 한 운동 효과 비교

        김진산,이창현,조미주,임연욱,정취산,김선엽 대한정형도수치료학회 2005 대한정형도수물리치료학회지 Vol.11 No.1

        Objectives: To compare the efficacy of two types specific exercise intervention (deep and superficial abdominal muscle exercises) in the treatment of patients with chronic low back pain (CLBP). Design: A randomized, comparative, repeated-measures. Subjects: Twenty-four patients with CLBP (at least for 3 months), mean age±SD=51.58±16.21 (yrs). Methods: Twenty-four patients with this condition were assigned randomly to two treatment groups. Both first and second group underwent 3 weeks specific exercise treatment program. The first group specific trained for the deep abdominal muscles. The second group specific trained for the superficial abdominal muscles. Results: After intervention, the first group showed a statistically significant reduction in pain intensity and functional disability levels (p<.05). The second group showed no significant change in these parameters after intervention (p>.05). Conclusions: According to results, a "deep abdominal muscle exercises" treatment approach appears more effective than a "superficial abdominal muscle exercises" treatment in patients with CLBP.

      • 여중생의 체지방율에 따른 보행 특성 분석

        노윤희,박종진,이계산 한국운동역학회 2001 한국운동역학회지 Vol.10 No.2

        This study is purpose to present the specification of gait such like step length, stride width, change of stride length, body-oriented static right-left ratio and average pressure & maximum pressure by the %fat when female middle school students are gait, subjects to female middle school students. To conduct this study, the change of step length, stride width, and stride length are comparative analyzed by using stick figures which collected through image analysis, and to be comparative analyzed body-oriented static right-left ratio and average pressure & maximum pressure by using DINATTO system Ver 2.5. The following results are shown like this. 1) The difference of step length, stride width, and stride length right-left ratio Among the step length, stride width, and stride length by the %fat has no significant difference in three groups. 2) The difference of body-oriented static right-left ratio by the %fat. Three groups have no significant difference in the body-oriented static right-left ratio by the %fat. 3) The difference of average pressure and maximum pressure by the %fat. Three groups have significant difference in the average pressure and maximum pressure by the %fat, the average pressure and maximum pressure are shown the highest in the above 30% groups.

      • 山林鳥類의 繁殖經過와 育雛期의 食習性에 關한硏究 (Ⅰ)

        元炳徽,金閏山,李海浜 동국대학교 농림과학연구소 1967 農林科學 論文集 Vol.1 No.-

        1. This investigation has been made as a result of observation upon the breeding habits and feeding habits of nestling during nesting period with five species birds "Hypsipetes amaurotis hensoni, Garrulus glandarius brandtii, Oriolus chinensis diffusus, Accipiter soloe¨nsis, Cyanopica cyanus koreensis breeded at Kwang Nung, Kyung Kido, Expreimental forest from the begining of June to the end of July, 1965. 2. Above five Species birds are all Common forest bird and three species of this, Hypsipetes amaurotis hensoni, Garrulus glandarius brandtii, Cyanopica cyanus koreensis, are permanent resident, and the remaining two Species. Oriolus chinensis diffusus, Accipiter soloe¨nsis are common summer resident birds. 3. Hypsipetes amaurotis hensoni finish their breeding from the middle of may to the end of July and their nestling period is 15 days. The food consumed during the nesting period of nestlings, composed of : Insect adult 76.35% Insect larvae 2.7%, Araneina 1.35%, Mollusca 12.5% and the seeds of Prunus levrille and Kochee 5.12%, In view of forest protection, hexious inesct Occupied from 76.65% of all food. 4. Garrulus glandarius brandtii laid their 2∼7 eggs from the middle of may to the middle of July and the incubation would take place for 14 days. Nestling period is 16∼18days. The food during the nesting period of nestling composed of: Insect larvae 38.72%, Insect adult 32.65%, Insect pupae 2.3% Araneina 16.28%, Hyla alborea 10.12%, and Noxions insect occupied from 73.48% of all. 5. Oriolus chinensis diffusus arrive here from the middle of may and migrated to south ward from the beginining of September. Incubation period is 14 days and the number of eggs laid is 4∼6. The food during the nesting period of nestlings composed of: Iasect larvae 57.57%, Insect adult 15.15%, Aranina 13.64% and Noxions insect occupied from 72.72%, of all food. 6. Accipiter soloe¨nsis arrive here from the middle of may and migrate from the late part of september. The number of eggs laid is 3∼5. Inculation period is 21∼23 days and the nesting period of nestlings is 16∼19days. The food during the nesting period of nestling composed of: Rana n. nigromaculate 92.97% platyleura kaempferi 6.99% 7. Cyanopica cyanus koreensis laid their 4∼6 eggs from the middle of may to the late part of July and nesting period of nestling is 15∼18 days. The food during the nesting period of nestling composed of: Insect Adult 56.14%, Insect larvae 10.83%, Insect pupae 8.24%, Other animal items 23.69% and some of seeds of Oldhaml 8. Hypsipetes amaurotis hensoni "garrulus glandarius brandtii, Oriolus chinensis diffusus, "Cyanopica cyanus koreensis, feed on forest naxions insect as the principle food and we have to protect these useful birds for forest protection.

      • 各種 土壤 管理가 柑橘品質에 미치는 影響 : Influence of Artificial Mulch during Fruit Development Season 夏秋季의 土壤被覆 效果

        韓允三,韓海龍,文斗吉 제주대학교 1974 논문집 Vol.6 No.-

        With polyethylene film and straw, artificial mulch from early Aug. to harvest time was experimented in a Citrus orchard on volcanic soil growing nine years old Satsuma mandarin(Citrus unshiu Marcovitch) on trifoliate orange stock. No matter what material is used, mulch delayed loss of soil water. Low soil moisture level desirable for delicious fruit quality was not attained by preventing rain flow to soil with polyethylene film, except only when mulched on already dried soil. While polyethylene film mulch increased soil temperature by 3'C at 10cm depth, straw mulch lowered soil temp. in summer. Change in soil temp. showed no apparent effect on fruit maturity and quality. Dry soil condition accelerated fruit coloring a little, and increased Brix, but decreased fruit weight, and didn't increased Brix-acid ratio. It was concluded that polyethylene film mulch could hardly be practiced to improve Citrus fruit quality in Seogwipo area orchards on volcanic soil.

      • KCI등재
      • Identification of Homer1 as a Potential Prognostic Marker for Intrahepatic Cholangiocarcinoma

        Wu, San-Yun,Yu, Ming-Xia,Li, Xiao-Gai,Xu, Shu-Fang,Shen, Ji,Sun, Zhen,Zhou, Xin,Chen, Xing-Zhen,Tu, Jian-Cheng Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7

        Background: The aim of the present study was to analyze whether Homer1 is a potential prognostic marker for intrahepatic cholangiocarcinoma (ICC). Materials and Methods: The expression of Homer1 in ICC tissue was detected with immunohistochemistry and levels of protein in ICC and paratumor tissues were evaluated by Western blotting. Survival analysis by the Kaplan-Meier method was performed to assess prognostic significance. Results: Homer1 expression was high in 67.4% (58/86) of ICC samples, and there was significant difference between ICC and adjacent noncancerous tissues (p<0.001); high expression was associated with poor histologic differentiation (p=0.019), TNM stage (p=0.014), lymph node metastasis (p=0.040), and lymphatic invasion (p=0.025). On Kaplan-Meier analysis, a comparison of survival curves of low versus high expressors of Homer1 revealed a highly significant difference in OS (p=0.001) and DFS (p=0.006), indicating that high expression of Homer1 was linked with a worse prognosis. Multivariate analyses showed that Homer1 expression was an independent risk factor predicting overall survival[Hazard ratio(HR), 7.52; 95% confidence interval (CI), 2.63-21.47; p=0.002] and disease-free survival (HR, 11.56; 95%CI, 5.17-25.96; p<0.001) in ICC. Conclusions: Homer1 promotes lymphatic invasion and associates with lymph node metastasis and poor prognosis of ICC. The current study shows that Homer1 may be an independent prognostic factor for ICC patients after curative resection, and it provides an important basis for screening/treating high-risk patients.

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