한국인의 각막에 관한 연구

강현식,김대년,김상연,강인산,박은규,서용원 대구보건대학 1999 대구보건대학 論文集 Vol.19 No.-

As the results of measurement of the radius of corneal curvature by keratometry for the right eye of 100 subjects, the steep meridian radius is 7.21㎜ to 8.27㎜ and flat meridian is 7.45㎜ to 8.65㎜, for the left eye the steep meridian radius is 7.30㎜ to 8.35㎜, and flat meridian is 7.45㎜ to 8.72㎜. The mean value of radius of corneal curvature is 7.8㎜ for night eye, 7.8㎜ for left eye. The results of measurement of P-value by topography, it is ranged from 0.45 to 0.91 for the night eye, 0.55 to 0.90 for the left eye, mean value is 0.756 for right eye, 0.735 for left eye respectively. That means the corneal shape is ellipses. The corneal thickness is measured 0.69㎜ 10°degree to the nasal, 0.76㎜ 20°degree to the nasal, 0.66㎜ 10°degree to the temporal, 0.72㎜ 20° degree to the temporal from the visual axis and 0.60㎜ at the central position. The horizontal size of corneal is 11.34㎜ for the night eye, 11.373㎜ for left eye. Those data can be used for contact lens design and fitting.

미국의 식물유래약용물질(Plant-Made Pharmaceuticals, PMPs)의 안전성 규제

김태산,원소윤,이근표,류태훈,진용문,이길복,김현준 한국국제농업개발학회 2005 韓國國際農業開發學會誌 Vol.17 No.1

1. 식물유래 약용물질 (PMP)은 살아있는 식물에서 생산된 치료용 단백질로, 발효조에서 세포계통을 이용하는 것보다 적은 비용으로 높은 순도의 단백질을 생산할 수 있어 이에 대한 연구개발이 확대될 전망이다. 2. 식물유래 약용물질의 재배시험을 감독하는 주관부서는 미농무부(USDA)의 동식물 검역청(APHIS)이다. 3. PMP의 생산에는 알팔파. 옥수수, 벼 잇꽃과 담배 등이 이용되고 있다. 4. 현재 상업화된 PMP는 없으나 ProdiGene, Inc사 등 몇몇 생명공학 회사에서 이들의 연구개발이 진행되고 있다. 5. 2002년에 PMP 재배시험은 130에이커 규모로 34개 시험장에서 20건이 허가 되었으며 주별로는 애리조나, 네브라스카 등 14주에서 시험이 이루어 졌다. 6. 미국 USDA의 PMP 재배 지침에 의하면 PMP의 재배생산에는 안전성확보를 위한 별도의 전용장비를 필요로 하며 파종에서 생산까지 엄격하게 관리된다. 7. 미국 USDA의 APHIS는 2002년 PMP 옥수수를 생산하는 ProdiGene, Inc사에 대하여 2건의 포장시험허가 위반사항을 적발하여 벌금 조치를 한바있다. Plant-made pharmaceuticals(PMPs) are therapeutic agents(pharmaceutical proteins) produced in genetically engineered plants. To yield these valuable products plants offer several advantages that include large-scale production capacity at a reduced cost, equivalent purity/activity to other manufacturing systems, and freedom from contamination with animal pathogens, prions, or disease-causing germs. But there are risks of contamination of the food supply and unintended effects on ecosystems. In the U.S. PMPs are regulated under stringent requirement of the U.S. Department of Agriculture(USDA) and the Food and Drug Administration(FDA). In this article, contamination incident with PMP corn engineered by ProdiGene, Inc will be briefly introduced and regulations of PMPs will be discussed.

시각 인터페이스를 이용한 멀티미디어 저작 도구의 설계 및 구현

김은정,신현산,유관종 충남대학교 1996 忠南科學硏究誌 Vol.23 No.1

In this paper, we design and implement the multimedia authoring system which provides visual interface. Using this authoring system, users can make a multimedia document in the intuitive and natural way and be freed from making an inconsistent temporal relation. Our system provides visual interface to maintain an interactive relationship between users and the system, and it also provides Temporal Relation Formatter to maintain correct and consistent temporal relations.

선형파괴역학에 의한 Aluminum Foil과 종이의 파괴거동 해석

안득만,신용산,이현웅,옥영구 釜山大學校生産技術硏究所 1999 生産技術硏究所論文集 Vol.57 No.-

크랙이 내재된 시편을 크랙으로부터 멀리 떨어진 단면에 대해 균일한 크기의 응력과 변형량이 발생하도록 길이방향으로 당겨주는 장치를 이용하여, 선형 파괴 역학적 관점에서 알루미늄 호일과 종이의 파괴거동을 평가하였다. 상사형의 균열을 가진 파괴시편의 파괴하중을 차원해석으로 예측하였고, 실험을 통하여 예측된 하중과 실제하중을 비교, 검토하였다. The fracture behaviors of aluminum foils and sheet papers were analyzed on the basis of linear elastic fracture mechanics(LEFM). The fracture loads of the Al foil and paper were calculated by dimensional analysis. The actual fracture loads were measured using the simple tension equipment. The predicted fracture loads were compared with the experimental results, respectively.

人口豫測模型에 관한 硏究(1985)

崔鍾碩,申鉉山,姜正求 충남대학교 자연과학연구소 1986 忠南科學硏究誌 Vol.13 No.1

In this paper, the population projection is estimated by the method of extrapolation which is based on logistic curve. It is required that each time interval of input data is one year. But census is not usually done punctually. So we try to use the raw census data and corrected them by appropriate transformation. For the population projection, we use four kinds of data : Model Ⅰ annual report from 1955 to 1985, Model Ⅱ linear correction of inter census population from 1955 to 1985, Model Ⅲ Compound interest correction on inter census population from 1955 to 1985, Model Ⅳ five years moving average correction of all inter census population. Estimation by model Ⅰ is not good because of large error caused from wrong estimation of population between census. We get a low projection model Model Ⅱ P=5,314/(1+1.4904 EXP (-0.050756t)) × 10 exp((4) from the second try, a high projection model Model Ⅲ P=5,429/(1+1.5438 EXP (-0.04973t)) × 10 exp(4) from the third try and a medium projection model Model Ⅳ P=5,379/(1+1.5190 EXP (-0.050392t)) × 10 exp((4) from the fourth try. We can guess at a saturation population and at a demographic transition point by virtue of an estimation of this logistic curve. The saturation population of Korea is estimated as 5,314×10 exp (4) by model Ⅱ in this paper. We have found the fact that the domographic transition point of Korea has been rapidly advancing since 1963.

우수방사성의약품 생산시설 개발

신병철,정원명,박상현,이규일,박경배,박진호 한국약제학회 2003 Journal of Pharmaceutical Investigation Vol.33 No.2

Manufacturing facilities of the pharmaceuticals must meet certain level of the cleanness required so that foreign substances such as dust, moisture, heat, microorganism, or virus do not contaminate the product. In case of radiopharmaceuticals for medical treatment and diagnosis, not only should the operators and environment be protected from radiation but also need to be isolated from the foreign contaminant. Therefore, manufacturing facilities for radiopharmaceuticals must satisfy the design standards of both hot cell and clean room which are specified by GNP. However, standards of maintaining negative pressure for preventing spread of radioactive contaminant in isolated facilities conflict with the standards of maintaining positive pressure for keeping cleanness. To solve this problem, are pressure of hot cell was designed lower than in the adjacent area to meet standards of the radiation safety. To keep higher cleanness in certain part of the hot cell for filling, minimal relative positive pressure allows. In order to effectively maintain the cleanness that is required for production of Tc-99m generator, which takes 70% of whole demand of radiopharmaceuticals, the rooms placed in each side of production room are used as a buffer area and three lead hot cells are installed in production room. In this research, we established the appropriate engineered design concept for Tc-99m generator manufacturing facility, which satisfies both GMP cleanness standard for preventing particles, bacteria, other contaminants and the regulations of radiation safety for supervising and controlling the amount of radiation exposure and exhausted radioactivity. And the concept of multi-buffer zones is introduced to apply negative air pressure for hot cell with first priority and to continue relative positive air pressure for clean room.

노화와 간경변이 인체의 적혈구, 혈장 및 위 점막의 Glutathione 농도와 Glutathione Peroxidase 활성도에 대해 미치는 영향

백광호,김종혁,백일현,한태호,박현주,박상훈,서중산,박충기,유재영 대한노인병학회 2001 대한노인병학회지 Vol.5 No.3

감염 조절용 차단막의 두께가 광중합기의 중합광에 미치는 영향

장훈상,이석련,홍성옥,류현욱,송창규,민경산 大韓齒科保存學會 2010 Restorative Dentistry & Endodontics Vol.35 No.5

연구목적: 본 연구는 감염 조절용 차단막을 여러 겹으로 사용했을 때 광중합기의 광강도와 파장, light diffusion 등에 미치는 영향에 대해 조사하였다. 연구 재료 및 방법: 감염 조절용 차단막은 투명 랩 (크린랩)을 사용하였고 광중합기는 할로겐 광중합기 (Optilux 360)와 LED 광중합기 (Elipar FreeLight 2)를 사용하였다. 차단막을 1겹, 2겹, 4겹, 8겹으로 광중합기의 광섬유말단을 감싸고 휴대용 광강도 측정기 (Cure Rite)로 광중합기의 광강도를 측정하였다. 광중합기를 주문제작한 optical breadboard에 고정시킨 후 휴대용 spectroradiometer (CS-1000)를 이용하여 광중합기의 파장을 측정하였고, DSLR (Nikon D70s)을 이용하여 광중합기의 light diffusion을 사진 촬영하였다. 결과: 광강도 측정 결과는 차단막의 두께가 증가할수록 광강도가 유의하게 감소하였으나 할로겐 광중합기에서 1겹과 2겹 사이에는 유의차가 없었으며, 4겹 이상의 차단막을 투과할 때 광강도가 더 많이 감소하였다. 여러 겹의 차단막을 투과한 광중합기의 전체적인 파장 형태와 peak wavelength의 변화는 관찰되지 않았다. Light diffusion 사진 촬영 시, LED 광중합기에서는 차단막의 두께가 미치는 영향이 없었으나 할로겐 광중합기에서는 차단막을 4겹 사용했을 때부터 중합광이 조사되는 각도가 감소하기 시작하여 8겹 사용했을 때 통계적으로 유의하게 감소하는 것을 볼 수 있었다 (p < 0.05). 결론: 광중합형 복합레진을 광중합할 경우 감염 조절용 차단막이 찢어지는 경우를 대비하여 1겹으로 사용하기 보다는 2겹으로 사용하는 것이 환자간의 교차감염을 예방하는데 유리할 것으로 사료된다. Objectives: This study investigated the effect of infection control barrier thickness on power density, wavelength, and light diffusion of light curing units. Materials and Methods: Infection control barrier (Cleanwrap) in one-fold, two-fold, four-fold, and eightfold, and a halogen light curing unit (Optilux 360) and a light emitting diode (LED) light curing unit (Elipar FreeLight 2) were used in this study. Power density of light curing units with infection control barriers covering the fiberoptic bundle was measured with a hand held dental radiometer (Cure Rite). Wavelength of light curing units fixed on a custom made optical breadboard was measured with a portable spectroradiometer (CS-1000). Light diffusion of light curing units was photographed with DSLR (Nikon D70s) as above. Results: Power density decreased significantly as the layer thickness of the infection control barrier increased, except the one-fold and two-fold in halogen light curing unit. Especially, when the barrier was four-fold and more in the halogen light curing unit, the decrease of power density was more prominent. The wavelength of light curing units was not affected by the barriers and almost no change was detected in the peak wavelength. Light diffusion of LED light curing unit was not affected by barriers, however, halogen light curing unit showed decrease in light diffusion angle when the barrier was four-fold and statistically different decrease when the barrier was eight-fold (p < 0.05). Conclusions: It could be assumed that the infection control barriers should be used as two-fold rather than one-fold to prevent tearing of the barriers and subsequent cross contamination between the patients.

비글개에서 분만 후 자궁수복의 연속적 초음파상

손형원, 김홍석, 김형진, 김일화, 이기창, 이청산, 강현구 충북대학교 동물의학연구소 2006 Journal of Biomedical and Translational Research Vol.7 No.2

본문참고

Occurrence of Tomato spotted wilt virus from commercial flamingo plant (Anthurium sp.) in Korea

San Yeong Kim,Sangmin Bak,Euncheol Seo,Hyun-Sook Lee,Seung Tae Kim,Se Hyun Seong 한국농약과학회 2018 한국농약과학회 학술발표대회 논문집 Vol.2018 No.10