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Trp-tRNA synthetase bridges DNA-PKcs to PARP-1 to link IFN-款 and p53 signaling
Sajish, Mathew,Zhou, Quansheng,Kishi, Shuji,Valdez Jr, Delgado M,Kapoor, Mili,Guo, Min,Lee, Sunhee,Kim, Sunghoon,Yang, Xiang-Lei,Schimmel, Paul Nature Publishing Group, a division of Macmillan P 2012 NATURE CHEMICAL BIOLOGY Vol.8 No.6
Interferon-款 (IFN-款) engenders strong antiproliferative responses, in part through activation of p53. However, the long-known IFN-款??dependent upregulation of human Trp-tRNA synthetase (TrpRS), a cytoplasmic enzyme that activates tryptophan to form Trp-AMP in the first step of protein synthesis, is unexplained. Here we report a nuclear complex of TrpRS with the catalytic subunit of DNA-dependent protein kinase (DNA-PKcs) and with poly(ADP-ribose) polymerase 1 (PARP-1), the major PARP in human cells. The IFN-款??dependent poly(ADP-ribosyl)ation of DNA-PKcs (which activates its kinase function) and concomitant activation of the tumor suppressor p53 were specifically prevented by Trp-SA, an analog of Trp-AMP that disrupted the TrpRS??DNA-PKcs??PARP-1 complex. The connection of TrpRS to p53 signaling in vivo was confirmed in a vertebrate system. These and further results suggest an unexpected evolutionary expansion of the protein synthesis apparatus to a nuclear role that links major signaling pathways.
Kumar, J.I. Nirmal,Sajish, P.R.,Kumar, Rita.N.,Bhoi, Rohit Kumar Institute of Forest Science 2010 Journal of Forest Science Vol.26 No.1
The present study was conducted to quantify wood and leaf litter decomposition and nutrient release of a dominant tree species, Tectona grandis Linn. F. in a tropical dry deciduous forest of Rajasthan, Western India. The mean relative decomposition rate was maximum in the wet summer and minimum during dry summer. Rainfall and its associated variables exhibited greater control over litter decomposition than temperature. The concentrations of N and P increased in decomposing litter with increasing retrieval days. Mass loss was negatively correlated with N and P concentrations. The monthly weight loss was significantly correlated (P < 0.05) with soil moisture and rainfall in both wood and leaf litter. Tectona grandis was found to be most suitable tree species for plantation programmes in dry tropical regions as it has high litter deposition and decomposition rates and thus it has advantages in degraded soil restoration and sustainable land management.
Bioprospecting in a Tropical Dry Deciduous Forest of Western Rajasthan, India
Kumar, J.I. Nirmal,Sajish, P.R.,Kumar, Rita.N.,Bhoi, Rohit Kumar Institute of Forest Science 2010 Journal of Forest Science Vol.26 No.1
Bioprospecting has been widely used to assess the economic potential of different plant species and their value-addition. Prospecting for biological material like plants with medicinal or other economically valuable properties like fibre or oil is becoming a dynamic activity. Our folklore with embedded cultural heritage has tremendous possibilities and potential for bioprospecting. This forest region of Western Rajasthan is enriched with diverse vegetational wealth, if subjected to bioprospecting may prove to be a boon for the society.
J. I. Nirmal Kumar,P. R. Sajish,Rita. N. Kumar,Rohit Kumar Bhoi 강원대학교 산림과학연구소 2010 Journal of Forest Science Vol.26 No.1
The present study was conducted to quantify wood and leaf litter decomposition and nutrient release of a dominant tree species, Tectona grandis Linn. F. in a tropical dry deciduous forest of Rajasthan, Western India. The mean relative decomposition rate was maximum in the wet summer and minimum during dry summer. Rainfall and its associated variables exhibited greater control over litter decomposition than temperature. The concentrations of N and P increased in decomposing litter with increasing retrieval days. Mass loss was negatively correlated with N and P concentrations. The monthly weight loss was significantly correlated (P < 0.05) with soil moisture and rainfall in both wood and leaf litter. Tectona grandis was found to be most suitable tree species for plantation programmes in dry tropical regions as it has high litter deposition and decomposition rates and thus it has advantages in degraded soil restoration and sustainable land management.
Bioprospecting in a Tropical Dry Deciduous Forest of Western Rajasthan, India
J. I. Nirmal Kumar,P. R. Sajish,Rita. N. Kumar,Rohit Kumar Bhoi 강원대학교 산림과학연구소 2010 Journal of Forest Science Vol.26 No.1
Bioprospecting has been widely used to assess the economic potential of different plant species and their value-addition. Prospecting for biological material like plants with medicinal or other economically valuable properties like fibre or oil is becoming a dynamic activity. Our folklore with embedded cultural heritage has tremendous possibilities and potential for bioprospecting. This forest region of Western Rajasthan is enriched with diverse vegetational wealth, if subjected to bioprospecting may prove to be a boon for the society.