http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Ali Pourjavadi,Zahra Mazaheri Tehrani,Safura Jokar 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.28 No.-
In the present work a novel multifunctional drug nanocarrier was prepared. Polyglycerol-gpolycaprolactonewas grafted on Mesoporous silica-coated magnetic graphene oxide. Doxorubicin, asanticancer drug, was loaded on this carrier. The in vitro drug release showed the controlled pHresponsive behavior. At the endosomal pH (pH 5.5) the amount of drug release enhanced. Thisnanocarrier would have potential application in the tumor therapy owing to its biodegradability,controlled release and pH responsive behavior
Clival Chordoma in an Adolescent: A Perspective from Primary Care
Hayatul Najaa Miptah,Siti Fatimah Badlishah-Sham,Hilwati Hashim,Anis Safura Ramli 대한가정의학회 2020 Korean Journal of Family Medicine Vol.41 No.6
Clival chordoma is a rare malignant tumor of the brain that typically occurs in older adults. It has a high local recurrence rate and is hence associated with poor prognosis. Here, we report a case of an adolescent who presented with a 1-month history of worsening headache and blurring of vision, as well as a 6-month history of left-sided facial and body numbness. Clinical findings were consistent with left upper motor neuron lesion of the seventh cranial nerve with involvement of the fifth cranial nerve. He was also found to have a sixth cranial nerve palsy demonstrated by diplopia upon lateral gaze with no evidence of papilledema. Magnetic resonance imaging of the brain suggested clival chordoma. He was subsequently referred to the neurosurgical team, and he successfully underwent an endoscopic trans-sphenoidal surgery to excise the lesion. He recovered well, continued his follow-ups with the neurosurgical team, and showed good progress. He also attended regular follow-ups with his primary care physician to ensure ongoing psychosocial support and monitoring of his overall health status. This case demonstrates the importance of prompt identification and treatment of clival chordoma in an adolescent. Long-term follow-ups and shared care between primary and secondary care physicians are essential to monitor recurrence of tumor and to provide psychosocial support.