허혈성 뇌졸중과 응고인자 XIII Val 34 Leu 다형성과의 무관성

방차옥,최종순,박형국,안무영,홍세용 순천향의학연구소 2000 Journal of Soonchunhyang Medical Science Vol.6 No.2

Background and purpose: Although a common G to T point mutation (FXIII Val34Leu) in exon 2 of the alpha-subunit of the FXIII is protective against myocardial infarction and venous thrombosis, there are few reported the association of FXIII Val34Leu and ischemic stroke. The aim of this study was to investigate the protective role of the FXIII Val34Leu against ischemic stroke and its suggested interaction with the plasminogen activator inhibitor-1 (PAI-1) 4G/5G polymorphism. Methods: We carried out genotype analyses for FXIII Val34Leu using single-stranded conformation polymorphism and 4G/5G polymorphism in the promoter region of the PAI-1 gene in 53 patients with ischemic stroke and in 82 race-matched control subjects. Results: Age, hypertension, diabetes, and low-density lipoprotein were significantly higher in ischemic stroke patients. However, genetic distributions of FXIII A subunit and promoter region of PAI-1 were not different on both groups. Even adjusting for age, sex, hypertension, diabetes, and total cholesterol, there were not significantly associated between FXIII Val34Leu or 4G/4G genotype of PAI-1 and ischemic stroke. Conclusion: FXIII Val34Leu and the 4G/4G genotype of the PAI-1 gene are not significantly associated with an increased or decreased risk of ischemic stroke.

低 사이클 反覆引張을 받는 構造用鋼의 疲勞强度와 疲勞크랙 傳播에 관한 硏究

吳世旭,玉致均,全泰玉,李圭用 동아대학교 공과대학 부설 한국자원개발연구소 1975 硏究報告 Vol.1 No.1

There has been many unexpected fractures of any steels used widely in many kinds of industries, which cause to a loss of lives and property. This is because the cause of fatigue demage which was not precisely considered In the conventional design. Recently it has been considered that most of fractures occurred in the design of various mechanical structures such as pressure vessels, piping, etc. are the cracks caused by low cycle fatigue. Especially it is very important in presuming the life of notched structural steel to clarify the characteristics of the low cycle fatigue crack propagation of notched structural steel. In this study, some experiments were carried out the domestic structural steel plates with "O"hole, "U" and "V" type notches under low cycle pulsating tension fatigue testing. And then the mechanism and behavior of low cycle fatigue were clarified through the consideration on the notch effect vs. fatigue strength of various notched specimens, the relations between crack propagation rate and stress intensity factor, and on the initiation of fatigue crack and its propagation, etc. The results obtained in this study are summarized as follows; (1) At the root radius R=0.25㎜ of "O" hole notch, it has higher fatigue strength and at R≥0.5㎜, almost the same in the S-N curve. But at the smaller "U" and "V" type notch root radius, it has the lower fatigue strength in the S-N curve. (2) The initiation of fatigue crack was occurred at 45~55%, 20~50% and 10~30% through each total fatigue life of the "O" hole, "U" and "V" type notch. The "O" hole notch specimen has almost the same initiation of fatigue crack without regard of notch size, but the "U" and "V" type notch specimens have the lower initiation at the larger notch root radius. (3) The "O" hole notch specimen has the lowest crack propagation rate and the incubation phenomenon of crack propagation rate occurred about 0.3㎜ of crack length. (4) Between the crack propagation rate and stress intensity factor, the value of exponent "m" was 1.11∼2.34. At the smaller root radius of "O" hole notch, the value of exponent "m" becomes the larger, but at the larger root radius of "U" and "V" type notch the value becames the smaller. (5) Propagating crack passes around or branches out on account of inclusions, with out passing through the inclusions. (6) At the smaller root radius of "U" and "V" type notch, the shape of crack propagation became more intricate, but in the case of "O" hole notch, the opposite phenomenon occurred. And at the higher stress level of each notch, the crack propagation tend to be more intricate.

Austenite Stainless鋼의 高溫强度및 破壞擧動에 관한 硏究(Ⅰ) : Creep 强度와 破壞擧動에 관하여 Creep Strength and Fracture Behavior

全泰玉,周原植,金福仁,崔병국,吳世旭 東亞大學校 1980 東亞論叢 Vol.17 No.2

Austenite stainless steel 년 316 has heat treated to austenite structure by heating at 1100℃ for 1hr and suddenly cooling. These specimens has been dealed with aging treatment at 700℃ for 0hr, 2hr, 10hr, and 100hr separately, and then conducted by creep test on the uniaxial state of stress in atmosphere of 600℃. The experimental results are obtained as follows. 1) Creep rupture stain rate has increased by the increasing of aging time. 2) Creep rupture time have had large affect of aging time comparing with 0hr aging specimen and increased by 20%, 40%, and 60% separately for 2hr, 10hr, and 100hr aging specimen. The empirical formulas of creep rupture time "t" as follows. (aging time are in parenthesis) t?=2.297×10? t?=8.810×10? t?=2.951×10? t?=1.178×10? 3) Creep constant "n" has increased, "k" decreased and creep limit increased by increasing the aging time. Then creep strain rate has decreased and increased by increasing the aging time and stress. The empirical formulas as follows. ε?=3.326×10? ε?=1.905×10? ε?=1.347×10? ε?=3.465×10? 4) The creep strain rate multiplied by creep rupture time has constant value according to property of material and belongs to the range of parallel line at logarithmic graph paper. 5) Hardness has increased by the increasing of aging time and intergranular hardness is higher than transgranular hardness. 6) The micro cracks occur from wedge crack and cavitation crack at grain boundary and exist at the surface of specimen and the surface of longitudnal section. 7) High stress and aging specimens have mostly wedge crack. Low stress and nonaging specimens have mostly cavitation crack. 8) Rupture surface of higher stress has shearing fracture of about 45° inclination, and has tendency of fracture by directing perpendicular to the axis for decreasing creep stress and also has same phenomenon for occurrence and propagation of crack.

알루미나이징 表面處理한 構造用鋼의 彼勞强度 및 破壞擧動에 관한 硏究

吳世旭,朴春根,全泰玉,全哲昊,周原植,李圭用 東亞大學校 大學院 1978 大學院論文集 Vol.2 No.-

Aluminizing-treated structural steel is excellent in high temperature oxidation resistance, wear resistance and corrosion resistance. So, it has been widely used for the machine parts which have required such properties. However it is difficult to find out any study result of the notched influence on the aluminizing-treated materials and the second diffusion materials. In this investigation the low carbon steel plates with with V-notches were coated with aluminum and made into second diffusion. With these specimcns the bending fatigue strength and fatigue life were observed and also crack propagation of alloy layer was investigated. The results obtained are as follows: 1) On the smoothed specimens a fatigue limit of aluminizing material was lower than the one of raw material, but it was more increased than the one of heat treatment material, and the fatigue limit of second diffusion material was lowest. 2) On the V-notched specimens a fatigue limit of aluminizing material was higher with 44% increase ratio than the one of raw material and with 63% increase ratio than the one of heat treatment material, and the rate of increase became lower increase ratio in a fatigue limit comparing to aluminzing material, with no influence of notch radius. 3) According as the notch radius became smaller, the fatigue limit became. higher on the raw material, it was same on th aluminizing material and lowest on the second diffusion material. 4) Crack initiation period was 0.04% below of fatigue crack life and the full growth period of crack propagation at alloy layer was 0.1%. The crack propagation from alloy layer to matrix was 16% of the fatigue crack life. This means that the crack propagation rate at alloy layer was very fast but the crack delay at the boundary of both was so long. 5) Crack propagation grows through defects, inclusion, peeling and previous boundary.

金屬 Fiber의 效率에 關한 硏究

김흥준,박세만,박명균,차경옥 明知大學校 産業技術硏究所 1994 産業技術硏究所論文集 Vol.13 No.-

In review of he current technical difficulties and weaknesses in producing filters, this investigation presents a method to evaluate metallic fiber filters by utilizing the theory of fluid dynamics. A method for evaluations of the efficiency of filters in estabilished. Also the filter configuration is analyzed and the filter media is characterized. A trial product of pleated type filter is designd and produced. The product has optimal filtering surface area per unit flow rate. Also tests for filtration efficiency and characterizations of the products were conducted.

자동차용 축열시스템의 설계에 대한 연구

송영길,차경옥,박세만 明知大學校 産業技術硏究所 1994 産業技術硏究所論文集 Vol.13 No.-

A study was conducted to design automotive thermal energy storage for reduction in exhaust emission and enhancing the passenger's comfortability. Ba(OH)2 8H2O was chosen, based on its thermodynamic characteristics and a series of test, as a base material for the energy storage system. Sr(OH)2 8H2O and H2O were added to the base material to protect degradation that is appeared during the cycling test of the pure base material. Thermal storage were, then designed to provide 2,000 kJ of energy within a few minutes of engine ignition with the computer simulation results.

스펙트럼 해석법을 응용한 기관 배기계의 맥동압력 전달 특성에 관한 연구

이준서,박세만,차경옥 明知大學校 産業技術硏究所 1994 産業技術硏究所論文集 Vol.13 No.-

Pulsating pressure of exhaust system is generated by pulsating gas flow due to working of exhaust valve. The pulsating gas flow is closely concerned to engine power loss according to back pressure and exhaust noise. However, because of nonlinear effect due to large amplitude of pulsating pressure, it is difficult to exactly calculate pulsating pressure propagation in exhaust system of typical engine. Moreover, in case of estimating exhaust system performance, conventional prediction method which is based on linear theory, gives many restrictions and overestimate. As the first step for solving this problem, this paper contains experimental model to measure pulsating pressure propagation and shows power spectrum density,frequency response function, coherence in frequency domain for characterize pulsating pressure propagation in exhaust system of typical engine.

단풍취 분획물이 알콜대사효소에 미치는 영향

문형인,지옥표,문세훈,신말식 성균관대학교 약학연구소 1998 成均藥硏論文集 Vol.10 No.1

Spraque-Dawley계 수컷랫트에 계통분획한 단풍취의 각 분획물을 경구투여하고 혈청 ethanol농도와 간의 ADH활성에 미치는 효과를 검색 추적한 결과 알코올대사를 촉진시키는 성분은 주로 에탄올가용부에, 억제시키는 성분은 에탄올불용부에 주로 존재함을 추정할 수 있었고 현재 활성성분을 분리중에 있다.(1998년 9월 25일 접수, 1998년 10월 14일 수리) Effects of organic solvents fraction from Ainsliaea acerifolia ethanol extract on alcohol metabolism in rats were examined and the results were as follows: Ethanol souble fraction, after a single oral administration to rats, was found to cause a significant decrease in the serum ethanol concentration as well as enhancement of liver cytosolic alcohol dehydrogenase(ADH) activity, on the other hand, the fraction insouble in ethanol was found to cause an increase ethanol concentration in the blood and inhibit ADH activity.

대장수술 후에 발생한 급성신부전의 위험인자

이혜미,황창재,김재황,김흥대,박대팔,서일숙,송선옥,김세연,이덕희,지대림 영남대학교 의과대학 2007 Yeungnam University Journal of Medicine Vol.24 No.2

연구 배경 : 급성 신부전은 술 후 발생할 수 있는 합병증 중에서 사망률은 큰 영향을 줄 수 있으므로 이 연구를 통해 위험인자를 알아보려고 한다. 재료 및 방법 : 2004년 1월부터 2006년 12월까지 3년간 영남대학교 의과대학 부속병원에서 대장 수술을 받은 570명의 환자들을 대상으로 하였다. 환자들의 성별과 연령, 미국 마취과학회 신체등급, 동반질환, 수술의 종류, 응급수술의 여부, 수술 시간, 재수술의 여부, 술 중의 투약 상황, 술 후에 자가 통증 조절기에 사용한 약제, 술 중에 저혈압의 유무, 수혈 여부, 술 후 기계적 환기를 시행한 경우를 비교하였다. 결과 : 비교 결과에서 성별과 수술의 종류, 응급 수술의 여부, 개복여부 등에는 유의한 차이를 보이지 않았다. 반면 환자의 나이와 수술 시간, 재수술의 여부, 술중에 이뇨제 등을 사용한 경우, 술 중에 저혈압의 유무, 술 후에 기계적 환기를 시행한 경우 등에는 유의한 차이를 보였다. 결론 : 이상의 결과로 급성신부전의 원인은 어느 한 가지라고 하기 보다는 위험인자에 얼마나 노출되어 있는가가 결정하는 것 같고, 그 원인들이 모여서 상승효과를 내는 것 같다. 그러므로 수술 전부터 많은 위험에 노출된 환자는 술 중 더 적극적인 감시를 시행하여 수술 후의 합병증 발생을 줄이는 노력을 기울여야 하겠다. Background : Acute renal failure is one of the leading causes of postoperative morbidity and mortality. The purpose of this study was to determine the risk factors that are associated with acute renal failure after colorectal surgery. Materials and Methods : Five hundred seventy patients who operated colorectal surgery at the Yeungnam University Medical Center over three years from 2004 to 2006 were enrolled in this study. The effects of gender, age, ASA classification, concomitant disease, surgery type and duration, reoperation, urogenital manipulation, medication, hypotension, hypovolemia, transfusion, and postoperative ventilatory care on the occurrence of acute renal failure after colorectal surgery were studied. Results : The major risk factors of acute renal failure after colorectal surgery were age of patients (P=0.003), ASA classification (P<0.001), concomitant disease (P<0.001), duration of the time surgery (P=0.034), reoperation (P=0.001), use of intraoperative diuretics (P=0.005), use of postoperative diuretics (P<0.001), intraoperative hypotension (P=0.018), intraoperative transfusion (P<0.001), postoperative transfusion (P<0.001), and postoperative ventilatory care (P=0.001). Conclusion : Multiple factors cause synergistic effects on the development of acute renal failure after colorectal surgery. Therefore, efforts to reduce the risk factors associated with acute renal failure are needed. In addition, intensive postoperative care should be provided to all patients.

Effect of Extraction and Fermentation on Antioxidant Activities of Hemerocallis fulva L.

Sae-Rom Lee,Sungryul Yu,Youngseung Lee,Yoonhwa Jeong,Misook Kim,Geun Pyo Choi,Soo Jeong Lee,Na-Young Kim,Namji Cho,Seongjun Yoon,Ok Hyun Yoon 한국식품영양과학회 2016 한국식품영양과학회 학술대회발표집 Vol.2016 No.10