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( Sabina Shrestha ),( Ji Hae Park ),( Jin Gyeong Cho ),( Dae Young Lee ),( Ji Hyun Kang ),( Hua Li ),( Tae Sook Jeong ),( Somi Kim Cho ),( Dong Sun Lee ),( Nam In Baek ) 한국응용생명화학회(구 한국농화학회) 2015 Journal of Applied Biological Chemistry (J. Appl. Vol.58 No.2
Fruits of Rhus parviflora were extracted with 80% aqueous methanol (MeOH), and the concentrated extract was partitioned using ethyl acetate (EtOAc), n-butanol (n-BuOH), and H2O, successively. Purification of EtOAc fraction led to isolation of fifteen polyphenols of which structures were identified by spectroscopic methods including 2D-NMR. Most compounds apart from compound 10 inhibited low density lipoproteinoxidation within IC50 value of 10 μM. Among compounds, taxifolin (2), quercetin 3-O-α-L-rhamnopyranoside (13), agathisflavone (5) sulfuretin (4), and aureusidin (3) showed IC50 values 0.9, 0.8, 5.8, 2.9, and 2.4 μM which were of highly significant in comparison positive control butylated hydroxytoluene with IC50 value of 2.1 μM. The results indicate fruits of R. parviflora as a source of antihypercholesterolemic compounds.
( Sabina Shrestha ),( Ji Hae Park ),( Dae Young Lee ),( Jin Gyeong Cho ),( Do Gyeong Lee ),( Moon Hee Cho ),( Tae Sook Jeong ),( Hee Cheol Kang ),( Nam In Baek ) 한국응용생명화학회(구 한국농화학회) 2011 Journal of Applied Biological Chemistry (J. Appl. Vol.54 No.1
The bark of Machilus thunbergii was extracted with 80% aqueous methanol (MeOH), and the concentrated extract was partitioned using ethyl acetate (EtOAc), butanol (n-BuOH), and H2O, successively. From the EtOAc fraction, five lignans were isolated through the repeated silica gel, octadecyl silica gel (ODS) and, Sephadex LH-20 column chromatography. Based on nuclear magnetic resonance (NMR), mass spectroscopy (MS), and infrared spectroscopy (IR) spectroscopic data, the chemical structures of the compounds were determined to be machilin A (1), machilin F (2), licarin A (3), nectandrin A (4), and nectandrin B, (5). This study presents comparative account of five lignans from M. thunbergii bark contributing inhibition of low density lipoprotein (LDL), ACAT-1, and ACAT-2. Compounds 2-5 showed varied degree of antioxidant activity on LDL with IC50 values of 2.1, 11.8, 15.3, and 4.1 μM. Compounds 1, 2, and 3 showed inhibition activity on ACAT-1 with values 63.4±6.9% (IC50=66.8 μM), 53.7±0.9% (IC50=109.2 μM), and 78.7±0.2% (IC50= 40.6 μM), respectively, at a concentration of 50 mg/mL, and on ACAT-2 with values 47.3±1.5% (IC50=149.7 μM), 39.2±0.2% (IC50=165.2 μM), and 52.1±1.0% (IC50=131.0 μM), respectively, at a concentration of 50 mg/mL.
Sabina Yeasmin,Il Jun Kwon,Dong Jun Kwon,Jungeon Lee,Jeong Hyun Yeum,Byung Chul Ji,Jae Min Park,Seong Baek Yang 한국섬유공학회 2022 Fibers and polymers Vol.23 No.3
In this study, pullulan (PULL) nanocomposite films containing tempo cellulose nanofibrils (TOCNs) and Agnanoparticles were successfully prepared using a solution casting technique in aqueous solutions. X-ray diffraction resultsand optical microscopy images revealed the coexistence of Ag and PULL/TOCNs blend matrix as well as the uniformdistribution of Ag nanoparticles. The Fourier-transform infrared data showed that a good interaction occurred betweenTOCNs, Ag, and PULL matrix; the prepared composite film showed improved characteristics including higher tensilestrength, thermal stability, water barrier properties and reduced moisture susceptibility compared to a neat PULL film. Inaddition, the prepared film is biodegradable and possesses antimicrobial characteristics. These excellent properties clearlyindicate that this type of ternary nanocomposite film may have prospective food packaging and medical application.
Sabina Shrestha,이대영,박지해,조진경,이동성,Bin Li,김윤철,전용진,연승우,백남인 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.4
Nepalese sumac (Rhus parviflora) is a wild edible fruit used for the treatment of various ailments including neurological complications and stomach disorders in the traditional medicinal system of south Asia (Ayurveda). Four flavonoids were isolated from ethyl acetate (EtOAc)fraction of Nepalese sumac fruits and their chemical structures were determined on the basis of NMR, fast atom bombardment mass spectrometry (FAB/MS), and IR. The efficiency of isolated compounds in attenuating glutamateinduced cell death in an immortalized mouse hippocampal cell line (HT-22) and inhibition of cycline dependent kinase 5 (Cdk5) were investigated. Among the compounds,flavanols, fustin (1) and taxifolin (2), an aurone, aureusidin (3), and a biflavonoid, agathisflavone (4) were found to have protective effect against glutamate induced oxidative injury in HT22 cells. Aureusidin (3), a Cdk5/p25 inhibitor (IC50 3.5 μM), was the most potent neuroprotector with an EC50 value of 11.90 μM.