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Overview of physics results from the conclusive operation of the National Spherical Torus Experiment
Sabbagh, S.A.,Ahn, J.-W.,Allain, J.,Andre, R.,Balbaky, A.,Bastasz, R.,Battaglia, D.,Bell, M.,Bell, R.,Beiersdorfer, P.,Belova, E.,Berkery, J.,Betti, R.,Bialek, J.,Bigelow, T.,Bitter, M.,Boedo, J.,Bono IOP Publishing 2013 Nuclear fusion. Fusion nucléaire. &n.Illiga Vol.53 No.10
El-Sabbagh, Osama I.,El-Nabtity, Sameh M. Korean Chemical Society 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
New benzotriazoles (5-8) or dibenzodiazepine derivatives (11-18) were synthesized starting from 3-[(2-amino- 4,5-disubstitutedphenyl)amino]-5,5-disubstitutedcyclohex-2-enones (1-4) through internal coupling of their diazonium salts or internal Mannich reaction in the presence of aromatic aldehydes. Pharmacological evaluation of benzotriazole and dibenzodiazepine derivatives for their clozapine-like properties revealed that dibenzodiazepine 11 bearing 4-bromophenyl group exhibited the same antipsychotic activity as the reference drug clozapine while the activity of benzotriazole 7 was 25% lesser than that of clozapine. Moreover, compounds 7 and 11 did not show significant CNS depressant activity as well as no or slight neurotoxicity on contrast to clozapine when tested in mice using forced swim, rotarod and horizontal screen tests.
El-Sabbagh, O.I.,El-Sadek, M.E.,Aboukull, M.E.,Shallal, H.M. Korean Chemical Society 2009 대한화학회지 Vol.53 No.1
새로운 종류의 히드라존 유도체는 4-(2-chloroethyl) semicarbazides로 부터 합성되었고, 인간 두 뇌(U251)와 간(Hepg2)의 암세포 에 대해 항증식성을 보였다. 히드라존 화합물은 벤즈알데히드, 아세토 페논, 3-formylindole 유도체이다. 아세토페논 유도체중에 3e (p-methoxy substituted)와 and 3f (p-nitro substituted)는 Hepg2 세포 (각각I$C_{50}$ = 6 ,8 $\mu$g/mL) 에 대해 가장 높은 세포독성활성을 보인다. 3-Formylindole 유도체중에 4a (hydrazone of 3-formylindole)은 U251 (I$C_{50}$ = 21 $\mu$g/mL)와 Hepg2 (I$C_{50}$ = 7 $\mu$g/mL)에 강한 세포독성활성을 보인다. A new series of hydrazone derivatives were synthesized from 4-(2-chloroethyl)semicarbazide and their antiproliferative activity against human brain (U251) and liver (Hepg2) carcinoma cell lines were evaluated. The hydrazone compounds are benzaldehyde (2a-2g), acetophenone (3a-3f), and 3-formylindole derivatives (4a-4d). Among the acetophenone derivatives, 3e (p-methoxy substituted) and 3f (p-nitro substituted) showed the highest cytotoxic activity against Hepg2 cell line (I$C_{50}$ = 6 and 8 $\mu$g/ml, respectively). Among the 3-formylindole derivatives, 4a (hydrazone of 3-formylindole itself) showed a pronounced cytotoxic activity against both U251 (I$C_{50}$ = 21 $\mu$g/ml) and Hepg2 (I$C_{50}$ = 7 $\mu$g/ml).
Ahmed El-Sabbagh,Heba Mansour,Magdy El-Hedeny 한국지질과학협의회 2015 Geosciences Journal Vol.19 No.4
This work is a taphonomic and paleoecologic study of Cenomanian oysters from the Musabaa Salama area, southwestern Sinai, Egypt. Disarticulation, fragmentation, encrustation and bioerosion are considered as the most predominant taphonomic features recorded in the studied oyster assemblages. Their distribution and frequency are greatly varied within the shells of the same species, as well as between shells of different species through the recorded oyster zones. Bioerosion structures include Tiers D, E, F, G and H. The multivariate statistical analyses document some characteristic ichnocoenoses. They include a sponge-dominated community (Entobia ichnocoenosis), a bivalve-dominated community (Gastrochaenolites ichnocoenosis), a serpulid-polychaete-dominated community (Maeandropolydora, Trypanites and/or Caulostrepsis ichnocoenosis), and an acrothoracican cirriped-dominated community (Rogerella ichnocoenosis). With rare exceptions, E. cretacea, G. torpedo and M. decipiens are common to abundant ichnospecies (>43%). E. ovula, E. retiformis and R. pattei are frequent to common ichnospecies (>5%). Other ichnospecies, including C. cretacea, G. orbicularis, T. solitarius, E. geometrica and C. taeniola are rare to frequent (<3%). Careful investigation of the host shells and the preserved encrusters and/or bioerosion sculptures provided data concerning the substrate characteristics, time of encrustation and bioerosion, rate of sedimentation, nutrients availability, and the general bathymetry and the rate of transgression.
Osama I. El-Sabbagh,Sameh M. El-Nabtity 대한화학회 2009 Bulletin of the Korean Chemical Society Vol.30 No.7
New benzotriazoles (5-8) or dibenzodiazepine derivatives (11-18) were synthesized starting from 3-[(2-amino-4,5-disubstitutedphenyl)amino]-5,5-disubstitutedcyclohex-2-enones (1-4) through internal coupling of their diazonium salts or internal Mannich reaction in the presence of aromatic aldehydes. Pharmacological evaluation of benzotriazole and dibenzodiazepine derivatives for their clozapine-like properties revealed that dibenzodiazepine 11 bearing 4-bromophenyl group exhibited the same antipsychotic activity as the reference drug clozapine while the activity of benzotriazole 7 was 25% lesser than that of clozapine. Moreover, compounds 7 and 11 did not show significant CNS depressant activity as well as no or slight neurotoxicity on contrast to clozapine when tested in mice using forced swim, rotarod and horizontal screen tests.
Coupled arch dam-reservoir-massed foundation problem under different earthquake input mechanisms
Varmazyari, M.,Sabbagh-Yazdi, S.R.,Mirzabozorg, H. Techno-Press 2021 Coupled systems mechanics Vol.10 No.5
The aim of the present study is to investigate a coupled arch dam-reservoir-massed foundation problem under two earthquake input mechanisms. The problem nonlinearity originates from opening/slipping of the vertical contraction joints of the dam body. The reservoir-structure interaction is taken into account assuming compressible reservoir. Also, the meshing approach (structured mesh vs. unstructured one) in the foundation medium is investigated. The Karoun-I double curvature arch dam is selected as a case study. Three components of the 1994 Northridge earthquake are selected as the free-field ground motion. A deconvolution analysis in 3D space is conducted to adjust the amplitude and frequency contents of the earthquake ground motion applied to the bottom of the massed foundation to determine the desired acceleration response at various points on the dam-foundation interface taking into account the coupling between the foundation and the structure. It is found that in the deconvolved earthquake input models, the maximum tensile and the compressive stresses increase by 19% and 12%, respectively in comparison with those of the free-field input models. In addition, modeling foundation using the unstructured mesh decreases the maximum compressive stresses within the dam body by about 20% in comparison with that obtained using the structured mesh model. In the same way, the maximum crest displacements in the horizontal direction decreases by about 30%.
M. Taherian,A.A. Sabbagh Alvani,M. A. Shokrgozar,R. Salimi,S. Moosakhani,H. Sameie,F. Tabatabaee 대한금속·재료학회 2014 ELECTRONIC MATERIALS LETTERS Vol.10 No.2
In the present study, the ZnS semiconductor quantum dots were successfully synthesized via an aqueous method utilizing glutathione (GSH), thioglycolic acid (TGA) and polyvinyl pyrrolidone (PVP) as capping agents. The structural, morphological and photo-physical properties and biocompatibility were investigated using comprehensive characterization techniques such as x-ray diffraction (XRD), scanning and transmission electron microscopy (SEM and TEM), dynamic light scattering (DLS), Fourier transform infrared spectrometry (FT-IR), UVVis optical absorption, photoluminescence (PL) spectrometer and MTT assay. The XRD patterns showed a cubic zinc blende crystal structure and a crystallite size of about 2 - 3 nm using Scherrer’s equation confirmed by the electron micrographs and Effective Mass Approximation (EMA). The DLS and zeta-potential results revealed that GSH capped ZnS nanoparticles have the narrowest size distribution with an average size of 27 nm and relatively good colloidal stability. Also, the FT-IR spectrum confirmed the interaction of the capping agent groups with ZnS nanoparticles. According to the UV-Vis absorption results, optical bandgap of the spherical capped nanoparticles is higher compared to the uncapped sample and could be wider than 3.67 eV (corresponding to the bulk ZnS), which is due to the quantum confinement effect. From photoluminescence spectra, it was found that the emission becomes more intensive and shifts towards the shorter wavelengths in the presence of the capping agent. Moreover, the emission mechanism of uncapped and capped ZnS was discussed in detail. Finally, the MTT results revealed the satisfactory (>94%) biocompatibility of GSH capped ZnS quantum dots which would be a promising candidate applicable in fluorescent biological labels.
Nonlinear aerostatic analysis of long-span suspension bridge by Element free Galerkin method
Golriz Zamiria,Saeed-Reza Sabbagh-Yazdi 한국풍공학회 2020 Wind and Structures, An International Journal (WAS Vol.31 No.1
The aerostatic stability analysis of a long-span suspension bridge by the Element-free Galerkin (EFG) method is presented in this paper. Nonlinear effects due to wind structure interactions should be taken into account in determining the aerostatic behavior of long-span suspension bridges. The EFG method is applied to investigate torsional divergence of suspension bridges, based on both the three components of wind loads and nonlinearities of structural geometric. Since EFG methods, which are based on moving least-square (MLS) interpolation, require only nodal data, the description of the geometry of bridge structure and boundaries consist of defining a set of nodes. A numerical example involving the three-dimensional EFG model of a suspension bridge with a span length of 888m is presented to illustrate the performance and potential of this method. The results indicate that presented method can effectively be applied for modeling suspension bridge structure and the computed results obtained using present modeling strategy for nonlinear suspension bridge structure under wind flow are encouragingly acceptable.