桓雄天皇의 無爲南向에 관한 經營哲學的 硏究

李勳燮(Lee, Hoon-sup) 한국전통상학회 2008 韓國傳統商學硏究 Vol.22 No.1

This article theme "MOOWINAMHYANG" is meaning "We make the work by force and do not do vain behavior." That is, Working to work simply better than serious working to effectiveness all for them. This article is purpose to consideration of a life managerial philosophy by Cheonboogyoung, Samilsingo, Chamjeongyegyoung.

An interface circuit designed for the load cell

Chung, Won Sup 청주대학교 산업과학연구소 2006 産業科學硏究 Vol.23 No.2

저항형 센서 브리지들을 위한 브리지 저항 편차-펄스폭 변환기를 제시한다. 이 변환기는 두 개의 전압-전류 변환기, 두 개의 전류-제어 슈미트 트리거, 하나의 램프 적분기, 그리고 두 개의 로직 게이트로 이루어져 있다. 개별 부품들을 사용하여 제작된 실험회로는 4.68 ms/Ω에 달하는 변환 감도와 ±0.03%보다 적은 선형 오차를 나타냈다. 브리지 저항 편차-펄스폭 변환기를 로드셀에 응용한 예도 제시하였다. A bridge resistance deviation-to-pulse width is presented for interfacing resistive sensor bridges. It consists of two voltage-to-current converters, two current-tunable Schmitt triggers, a ramp integrator, and two logic gates. A prototype circuit built using discrete components exhibits a conversion sensitivity amounting to 4.68 ms/Ω and a linearity error less than ±0.03 %. Its application to a load cell is also presented.

Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

토양처리용 천연물제초제 개발을 위한 생물검정법 개선

김재덕(Jae Deong Kim),황현진(Hyun Jin Hwang),서보람(Bo Ram Seo),최정섭(Jung Sup Choi),김진석(Jin Seog Kim) 韓國雜草學會 2011 Weed&Turfgrass Science Vol.31 No.3

본 연구는 토양처리용 천연물 제초제의 개발을 보다 신속하게 효율적으로 진행하기 위한 방안으로서 실용적인 입장에서 보다 개선된 검정법을 확립하기 위해 수행되었다. 검정하고자 하는 화합물의 량이 50㎎ 이상 충분할 경우, 잡초 4초종(피, 바랭이, 자귀풀, 어저귀)이 파종된 50㎠ 토양 표면적을 가진 폿트에서 온실검정을 함으로서 기존의 방법(토양 표면적이 350㎠인 폿트 이용)에 비해 약제 소요량을 78배 줄일 수 있었다. 이때 검정초기 처리농도는 10,000㎍ mL<;SUP>;-1<;/SUP>; 내외로 하는 것이 적당하였다. 한편 검정용 시료의 량이 10㎎ 이하로서 미량일 경우는 6 well plate를 이용하되 각 well에 밭토양을 담고 4가지 초종을 파종한 다음 실내에서 제초활성을 검정하는 방법이 추천될 수 있었다. 이는 기존의 방법(토양 표면적이 350㎠인 폿트 이용)에 비해 약제 소요량 및 처리용액 부피를 14배 가까이 줄일 수 있었고 실제에 가까운 데이터를 확보할 수 있어 보다 빠른 속도로 천연물 제초제를 개발하는데 도움이 될 것으로 판단되었다. This study was carried out to establish an improved bioassay system on the side of practicality, pre-emergence bioassay which is more effective in developing soil application natural herbicides. A miniaturized method which have a 50 cm² of soil surface area and was efficient by 7 times compared to the existing soil application assay (350 cm² of soil surface area) was established, in which four weed species (Echinochloa crus-galli, Digitaria sanguinalis, Aeschynomene indica, and Abutilon theophrasti) were planted and grown in greenhouse. This would be applicable when the amount of screening compound is much more than 50 mg. The initial application rate was desirable at 10,000 μg mL-1. On the other hand, the 6 well plate assay which has 4 weed species in each well containing upland soil and could be conducted in growth chamber, was established. This assay was resulted in minimizing in level of 1/14 test volume and 1/14 amounts of test compound to the conventional method that has been used for screening of synthetic compounds in KRICT, and applicable for the small amount of test compound (less than 10 mg). Therefore, the improved bioassays established in this study would be helpful for a rapid and efficient development of soil application natural herbicides.

한우비장(韓牛脾臟)에 있어서 비동맥비지(脾動脈脾肢)의 분기(分岐)에 관(關)해서

김종섭,김무강,원봉래,Kim, Chong Sup,Kim, Moo Kang,Woun, Bong Rae 대한수의학회 1968 大韓獸醫學會誌 Vol.8 No.2

This study was conducted to ramify of the Rami lienales at the hilus of the spleen in Korean cattle. The materials used were fifty spleens, 25 fresh samples, and 25 Cast specimens. The results obtained are summarized as follows. 1. The splenic arteries were divided into 2 Rami lienales (32 cases, 64%) and 3 Rami lienales(18 cases, 36%). and their branches were nominated as Aa, terminales superior et inferior and A. polares superior. 2. To ramify the A. terminalis superior and A. terminalis inferior, only one case diverged in the splenic parenchyma and 49 cases diverged in the outside of the spleen. 3. Immediately after dividing from the splenic artery to the Aa. terminales superior and inferior, the calibres of the A. terminalis inferior were larger than the A. terminalis superior (sup. 5.5 mm., inf. 8. 5mm.). 4. It was also observed, in all samples used. that Rami lienalis of the splenic artery were not anastomosis in the out side of the spleen.

서울 地域 一部 河川水의 重金屬 含量 調査 硏究

허윤행,노완섭 서울保健大學 1981 論文集 Vol.1 No.1

F⁰, Fe²⁺, Fe³⁺/H₂O₂ 시스템을 이용한 침출수의 Fenton 산화반응

박성호(Sung Ho Park),한인섭(Ihn Sup Han) 大韓環境工學會 2005 대한환경공학회지 Vol.27 No.4

Ca<SUP>2⁢</SUP> Sensitization Mechanism in Stretch-induced Myogenic Tone

Jung-Sup Kim,Sung-Kyung Ryu,Duck-Sun Ahn,Bok-Soon Kang,Young-Ho Lee 대한생리학회-대한약리학회 2002 The Korean Journal of Physiology & Pharmacology Vol.6 No.1

<P> It has been suggested that Ca<SUP>2⁢</SUP> sensitization mechanisms might contribute to myogenic tone, however, specific mechanisms have not yet been fully identified. Therefore, we investigated the role of protein kinase C (PKC)- or RhoA-induced Ca<SUP>2⁢</SUP> sensitization in myogenic tone of the rabbit basilar vessel. Myogenic tone was developed by stretch of rabbit basilar artery. Fura-2 Ca<SUP>2⁢</SUP> signals, contractile responses, PKC immunoblots, translocation of PKC and RhoA, and phosphorylation of myosin light chains were measured. Stretch of the resting vessel evoked a myogenic contraction and an increase in the intracellular Ca<SUP>2⁢</SUP> concentration ([Ca<SUP>2⁢</SUP>]<SUB>i</SUB>) only in the presence of extracellular Ca<SUP>2⁢</SUP>. Stretch evoked greater contraction than high K<SUP>⁢</SUP> at a given [Ca<SUP>2⁢</SUP>]<SUB>i</SUB>. The stretch-induced increase in [Ca<SUP>2⁢</SUP>]<SUB>i</SUB> and contractile force were inhibited by treatment of the tissue with nifedipine, a blocker of voltage-dependent Ca<SUP>2⁢</SUP> channel, but not with gadolinium, a blocker of stretch-activated cation channels. The PKC inhibitors, H-7 and calphostin C, and a RhoA-activated protein kinase (ROK) inhibitor, Y-27632, inhibited the stretch-induced myogenic tone without changing [Ca<SUP>2⁢</SUP>]<SUB>i</SUB>. Immunoblotting using isoform-specific antibodies showed the presence of PKCα and PKCε in the rabbit basilar artery. PKCα, but not PKCε, and RhoA were translocated from the cytosol to the cell membrane by stretch. Phosphorylation of the myosin light chains was increased by stretch and the increased phosphorylation was blocked by treatment of the tissue with H-7 and Y-27632, respectively. Our results are consistent with important roles for PKC and RhoA in the generation of myogenic tone. Furthermore, enhanced phosphorylation of the myosin light chains by activation of PKCα and/or RhoA may be key mechanisms for the Ca<SUP>2⁢</SUP> sensitization associated with myogenic tone in basilar vessels.

항-Xg^a항체 1예 보고

허미나,이규만,김종현,박경운,송은영,한규섭 大韓輸血學會 2001 大韓輸血學會誌 Vol.12 No.2

<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징

이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1

<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>