유산양 유즙으로부터 분리된 세균의 분포 및 항균제 감수성 검사

김혜라 ( Hye Ra Kim1 ),정지영 ( Ji Young Jung ),김선득 ( Seon Deuk Kim ),박준영 ( Jun Young Park ),조인영 ( In Young Cho ),신성식 ( Sung Shik Shin ),손창호 ( Chang Ho Son ),오기석 ( Ki Seok Ok ),허태영 ( Tai Young Hur ),정영훈 ( Y 한국동물위생학회 2012 韓國家畜衛生學會誌 Vol.35 No.4

The aim of this study was to isolate microorganisms from half milk samples of dairy goats by California mastitis test (CMT) during the lactation period and to further investigate the susceptibility of isolated organisms to antimicrobial drugs. From a total of 235 half milk samples with CMT scores of 2 or above from 366 dairy goats distributed throughout Jeonnam province, microorganisms were isolated from 198 (83.5%) samples either singly (99.0%) or in combination (1.0%). The most prevalent microorganism was the coagulase-negative Staphylococcus spp., (44.4%, n=88) followed by Staphylococcus aureus (24.2%, n=48), Escherichia coli (11.1%, n=22) and Streptococcus spp. (7.6%, n=15). Isolated bacteria also included Bacillus spp. (2.5%, n=5), Pseudomonas spp. (2.5%, n=5), Micrococcus spp. (1.5%, n=3), Corynebacterium spp. (1.5%, n=3), Enterococcus facium (1.0%, n=2), Morganella morganii (0.5%, n=1) and Streptococcus agalactiae (0.5%, n=1). During the summer season, a high prevalence of all micro-organisms were observed in which Staphylococcus spp. (30.8%), Escherichia coli (8.6%), and Streptococcus spp. (5.6%) were among the most prevalent bacteria isolated. Staphylococcus spp. was also shown to be high in the winter (21.7%). In most samples, the presence of bacterial pathogens in goat milk led to the increase in the total somatic cell count (SCC). Most of the half milk samples of dairy goats with bacterial contamination showed SCC of ≥1×10(6) cells/ml (90.4%). Minor pathogens (11.4%) were more detected from milk samples with SCC of <1×10(6) cells/ml than major pathogens (4.1%), while the major pathogens tended to be higher from samples with SCC of ≥3×10(6) cells/ml. Susceptibility of these bacteria to 12 antimicrobial agents was tested by the Kirby-Bauer disc diffusion method. Results indicated that more than 90% of bacteria isolated from CMT 2+ dairy goat half milk samples were susceptible to trimethoprim/sulfamethoxazole, amoxicillin/clavulanic, enrofloxacin and cephalothin while they were resistant to tetracycline (44.7%).

Clinical and Pathologic Features of Elderly Gastric Cancer

( Joo Hyun Lim ),( Dong Ho Lee ),( Cheol Min Shin ),( Na Yung Kim ),( Young Soo Park ),( Hyun Chae Jung ),( 1in Sung Song ) 대한내과학회 2011 대한내과학회 추계학술대회 Vol.2011 No.1

Background: Gastric cancer is one of the most common cancers in Korea and the incidence of which is great in elderly patients. However, not much is known about elderly gastric cancer. The aim of this study was to evaluate the specific features of gastric cancer in elderly patients. Methods: We reviewed medical records of 1107 patients who had undergone radical gastrectomy for gastric cancers between June 2005 and December 2009. All the patients were divided into two groups: Non-elderly group aged under 65 (n=676) and elderly group aged 65 and above (n=431). Results: There were more symptomatic patients among elderly group compared with non-elderly group (54.2% vs. 62.1%; p=0.009). Comorbidity was more prevalent in the elderly group (29.6% vs. 61.9%; p<0.001). The elderly group showed higher frequency of elevated tumor markers (CEA: 4.9% vs. 8.7%; p=0.041), CA19-9: 6.1% vs. 13.2%; p=0.001) and advanced diseases (42.5% vs. 49.4%, p=0.023).There were no significant differences in N stage (62.4% vs. 58.2%; p=0.164) or H. pylori status (63.6% vs. 57.5%; p=0.153) between the two groups. More cancers were located in lower third among the elderly group (45.1% vs 51.3%; p=0.045). The elderly group had more patients with Lauren intestinal type (40.7% vs. 58.2%; p<0.001) and well (8.0% vs. 13.7%; p=0.002) or moderately differentiated adenocarcinoma (29.6% vs. 44.1%; p<0.001). Rate of complication did not differ between the two groups (6.1% vs. 8.1%; p=0.187). Microsatellite instability (p<0.001) and p53 overexpression (p<0.001) were more frequent in the elderly group. Conclusion: Elderly gastric cancer showed a tendency of being diagnosed at more advanced stage with symptoms. However, it was related to pathologic features known for favorable prognosis except for p53 overexpression. Also surgery in elderly was as tolerable as in young patients. Thus we recommend to consider surgery more frequently for elderly patients with operable gastric cancers.

다발성 골수종에서 혈청 Beta-2 Microglobulin에 관한 연구

정현철,한지숙,이선주,신용운,고윤웅 大韓血液學會 1986 大韓血液學會誌 Vol.21 No.2

Genetic Polymorphism of 1019C/G (rs6295) Promoter of Serotonin 1A Receptor and Catechol-O-Methyltransferase in Panic Disorder

Takashi Watanabe,Shin Ishiguro,Akiko Aoki,Mikito Ueda,Yuki Hayashi,Kazufumi Akiyama,Kazuko Kato,Kazutaka Shimoda1 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.1

Objective-Family and twin studies have suggested genetic liability for panic disorder (PD) and therefore we sought to determine the role of noradrenergic and serotonergic candidate genes for susceptibility for PD in a Japanese population. Methods-In this age-and gender-matched case-control study involving 119 PD patients and 119 healthy controls, we examined the genotype distributions and allele frequencies of the serotonin transporter gene linked polymorphic region (5-HTTLPR), -1019C/G (rs6295) promoter polymorphism of the serotonin receptor 1A (5-HT1A), and catechol-O-methyltransferase (COMT) gene polymorphism (rs4680) and their association with PD. Results-No significant differences were evident in the allele frequencies or genotype distributions of the COMT (rs4680), 5-HTTLPR polymorphisms or the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients and controls. Although there were no significant associations of these polymorphisms with in subgroups of PD patients differentiated by gender or in subgroup comorbid with agoraphobia (AP), significant difference was observed in genotype distributions of the -1019C/G (rs6295) promoter polymorphism of 5-HT1A between PD patients without AP and controls (p=0.047). Conclusion-In this association study, the 1019C/G (rs6295) promoter polymorphism of the 5-HT1A receptor G/G genotype was associated with PD without AP in a Japanese population.

Acriflavine-Guanosine 복합제 (AG60)의 조직내 분포에 대한 형광현미경적 연구

고정식,임수재,안의태,김진국,김상건,이경영,강종구,홍은경,정영신,유보림,한영복 대한해부학회 1999 Anatomy & Cell Biology Vol.32 No.1

<SUP>18</SUP>F-FDG PET-CT에서 진단된 갑상선 우연종의 악성종양 발견율 및 특징

이강영,고건<SUP>1<.SUP>,김선국<SUP>1<.SUP>,고진철<SUP>1<.SUP>,김행수,최상용,박신희,박용휘<SUP>2<.SUP>,Kang Young Rhee,Gun Koh,<SUP>1<.SUP>,Sun Kuk Kim,<SUP>1<.SUP>,Jin Chul Koh,<SUP>1<.SUP>,Haeng Soo Kim,Sang Yong Choi,Shin 대한갑상선-내분비외과학회 2008 The Koreran journal of Endocrine Surgery Vol.8 No.1

<B>Purpose: </B>PET-CT is often used to differentiate benign or malignant thyroid incidentalomas. In this retrospective study, we evaluated whether the <SUP>18</SUP>F-FDG uptake pattern and PET-CT findings improved accuracy over the standardized uptake value (SUV). <B>Methods:</B> <SUP>18</SUP>F-FDG PET-CT was performed on 2,178 subjects from August, 2004, to October, 2007, in Sung-ae Hospital. PET-CT was performed on 806 patients (37%) with suspected or known nonthyroidal cancer and 1,372 healthy subjects (63%) without a previous history of cancer. We investigated the clinical characteristics of patients, history, standardized uptake value (SUV), ultrasonography, and hormone levels in blood. Thyroidal cancer was confirmed by ultrasonography-guided fine needle aspiration and pathology after thyroid operation. <B>Results:</B> The prevalence of focal thyroid lesions on PET-CT was 8.8% (191/2178). Thyroid cancer confirmation was 7.9% (15/191). The maximum SUV of malignant thyroid lesions were significantly higher than that of benign lesions (7.00±3.08 vs. 4.49±1.84, P<0.001). <B>Conclusion:</B> PET-CT image interpretation that includes 18F-FDG uptake and SUV is better than PET-CT alone for differentiating benign and malignant lesions. Thyroid cancer risk increases as SUVmax levels increase. <B>(Ko</B><B></B><B>rean J Endocrine Surg 2008;8:38-42)</B>

연구논문 : 당기손익 재분류 여부에 따른 기타포괄손익 항목의 구분 표시가 가치관련성에 미치는 영향

정수진(제1저자) ( Su Jin Jeong ),신현걸(교신저자) ( Hyun Geol Shin ) 한국회계학회 2015 회계저널 Vol.24 No.3

한국채택국제회계기준(K-IFRS) 제1001호 ``재무제표 표시``가 2012년에 일부 개정되어 2013년부터 기타포괄손익을 포괄손익계산서에 표시할 때 후속기간에 당기손익으로 재분류되는 기타포괄손익과 후속기간에 당기손익으로 재분류되지 않는 기타포괄손익으로 구분표시하도록 규정하였다. 이러한 개정은 기타포괄손익을 구분표시함으로써 기타포괄손익이 당기손익에 미치는 영향을 이해하고 예측하는데 도움을 줄 수 있을 것이라는 국제회계기준위원회(IASB)의 견해를 따른 것이다. 본 연구는 우리나라의 상장기업을 대상으로 2013년부터 개정된 K-IFRS 제1001호를 적용함으로써 기타포괄손익 항목을 후속기간의 당기손익 재분류 여부에 따라 구분표시하면 기타포괄손익의 가치관련성이 증가하는지 검증하였다. 또한 당기손익에 영향을 미치는 기타포괄손익은 후속기간에 당기손익으로 재분류되는 기타포괄손익이므로, 후속기간에 당기손익으로 재분류되는 기타포괄손익과 재분류되지 않는 기타포괄손익의 가치관련성 간에 차이가 존재하는지도 검증하였다. 연결재무제표에 기초한 996개 기업-연 표본기업을 대상으로 Ohlson(1995) 모형을 적용하여 회귀분석한 결과, 기타포괄손익을 후속기간에 당기손익으로 재분류되는 항목과 재분류되지 않는 항목으로 구분표시하면 구분표시하지 않은 경우에 비해 주가와의 관련성이 유의하게 더 높으며, 당기손익으로 재분류되는 기타포괄손익의 주가관련성이 당기손익으로 재분류되지 않는 기타포괄손익의 주가관련성보다 유의하게 더 높다는 증거를 발견하였다. 이러한 연구결과는 기타포괄손익의 구분표시로 인하여 기타포괄손익이 당기손익에 미치는 영향을 이해하고 예측하는데 도움을 줄 수 있을 것이라는 IASB의 개정 취지를 지지하는 결과이다. The Korean-International Financial Reporting Standards(K-IFRS) No. 1001 ``Presentation of Financial Statements`` revised in 2012 requires the items of other comprehensive income(OCI) to be classified into items that will be reclassified(recycled) to profit or loss(reclassified OCI) and items that will not be reclassified to profit or loss(non-reclassified OCI) in subsequent periods. This revision is led by the International Accounting Standards Board(IASB)``s opinion that the classified presentation of OCI on the comprehensive income statements could help the accounting information users to understand and predict the net income. While the prior foreign researches have not found the consistent results that the OCI has the positive relation with stock price, the Korean researches have found the consistent results that the OCI has the significantly positive relation with stock price. This study examines whether the revision of the K-IFRS No.1001 enhances the value relevance of OCI of the Korean listed companies and whether there is a significant difference of the value relevance between the reclassified OCI and non-reclassified OCI. Until 2012 the Korean listed companies adopting the K-IFRS have not made a classified presentation of the OCI based on the subsequent reclassification to profit or loss. However, the revised K-IFRS No.1001 requires the Korean listed companies to follow the classified presentation of the OCI on the comprehensive income statements from 2013. If the classified presentation is to help the users to understand and predict the net income, the value relevance of the OCI for the periods of the classified presentation would be significantly higher than that for the prior periods. Also since the only reclassified OCI may affect the net income, the value relevance of the reclassified OCI would be significantly higher than that of the non-reclassified OCI. If the classified presentation of the OCI does not enhance the value relevance or there is not a significant difference of the value relevance between the reclassified OCI and non-reclassified OCI, we would conclude that the revised presentation of the comprehensive income statements cannot provide the users with more useful information to predict the future effects of the net income. We address the above research questions using a sample of 996 OCIs from the consolidated financial statements of Korean listed companies. As many previous studies have applied, we also has used the Ohlson(1995)``s research model to verify the value relevance of the OCI. Based on the Ohlson``s research model we establish the regression model having the stock price as the dependent variable, and the interaction terms with the two types of OCI(reclassified and non-reclassified) and year dummy as the independent variables. The significant estimated coefficients of the interaction terms may indicate that the value relevance of the OCI increases after classified presentation and there is a value relevance difference between the two types of the OCI. Findings from the regression analyses indicate that the value relevance of the OCI is enhanced after the OCI is presented on the comprehensive i statements based on the subsequent reclassification. Also we find that the value relevance of the reclassified OCI is significantly higher than that of the non-reclassified OCI. These results support the IASB``s opinion that the revision of presentation of OCI can help th accounting information users to understand and predict the net income. As additional tests we analyse the value relevance of the individual OCI. Among reclassified OCIs the gains or losses on remeasuring available-for-sale financial assets have the most significantly positive correlation with stock price, while among non-reclassified OCIs the gains or losses on revaluation have the most significantly negative correlation with stock price. Also we test further the value relevance of the OCI by using the separate financial statements data. Taken as a whole the findings are consistent with those using the consolidated financial statements. However the findings on the individual OCI of the separate financial statements are slightly different from those on the consolidated financial statements. It indicates that the futureresearch in Korea should be based on the consolidated financial statement rather than on the separate financial statements since the main financial statements are the consolidated financial statements under the IFRS and almost all the foreign researches use the consolidated financial statements data. This study is the first research to examine the value relevance of the OCI reclassification and the difference in the value relevance between the reclassified OCI and non-reclassified OCI. Also, this study is differentiated from the previous ones as it has collected manually the individual items of OCI not served from the database since the IFRS adoption, and it focuses on the value relevance of the consolidated financial statements as well as the separate financial statements. However we cannot expand the test periods beyond 2013, so it has a limitation to generalize the results of this study. We expect resolve this limitation for the future research.

갑상선 수술 후 음성 변화

홍종철,이형신<SUP>1<.SUP>,김성원<SUP>2<.SUP>,이강대<SUP>2<.SUP>,Jong-Chul Hong,Hyoung-Shin Lee,M.D.<SUP>1<.SUP>,Sung- Won Kim,M.D.<SUP>2<.SUP> and Kang-Dae Lee,M.D.<SUP>2<.SUP> 대한갑상선-내분비외과학회 2011 The Koreran journal of Endocrine Surgery Vol.11 No.3

Purpose: Vocal symptoms have been reported after thyroidectomy and even in the absence of injury to the recurrent laryngeal nerve or the external branch of the superior laryngeal nerve. The aim of this prospective study was to evaluate the subjective and objective voice changes in patients without laryngeal nerve injury after thyroidectomy. Methods: The subjects had undergone total thyroidectomy for differentiated thyroid carcinoma from November 2007 to December 2008. Twenty-eight subjects (males: 8, females: 20) were selected for this study. Voice analysis was prospectively evaluated in the subjects at the time of preoperation and postoperation (10.8 months for the males and 11.7 months for the females). A subjective analysis was done using the visual analogue scale (VAS, 0: no symptom, 10: severe symptoms) and objective analyses were determined by several parameters such as the fundamental frequency (Fo), jitter, shimmer and the noise to harmonic ratio (NHR) using the multi-dimensional voice program. Maximum phonation time (MPT)was performed as an aerodynamic test. Results: 3 patients (37.5%) among the males and 14 patients (70%) among the females had subjective postoperative voice change. The VAS showed a significant difference for the females (0 to 1.25±0.97, P<0.001), whereas no changes were shown for the males (0 to 0.88±1.25, P>0.05). The vocal parameters (Fo, jitter, shimmer, NHR) and MPT showed no significant changes for both the males and females (P>0.05). Conclusion: Subjective voice changes may occur after thyroidectomy without laryngeal nerve injury. Surgeons should take possible voice changes into consideration when informing patients before thyroidectomy. (Korean J Endocrine Surg 2011;11:175-178)

유압 피스톤 펌프의 롤러 베어링에 대한 윤활 해석

정재연(Jaeyoun Jung),신현일(Hyuni1 Shin),백일현(Ilhyun Beak),조인성(Ihnsung Cho),송규근(Kyukeun Song),오석형(Seokhyung Oh),정용욱(YongWook Jung) 한국트라이볼로지학회 2008 한국트라이볼로지학회 학술대회 Vol.2008 No.6

Recently, noise and vibration by roller bearing brings trouble to pass in need to more speedy rotating and light weight, high durability in rotating system. For distinction clearly of appropriateness of roller bearing element, the effect of total system necessaries sure understanding under the motion condition. But, although roller bearing is used extensively, the related researches in this field are extremely limited. Therefore, attempts have been made to calculate film thickness, pressure distribution throughout the analysis of elastohydrodynamic lubrication, and contribute to high efficiency and performance improvement of bent-axis type piston pump throughout the close examination of lubrication characteristics between roller and inner race of roller bearing in this paper.

신명사도의 학습심리적 함의: 인간정보처리론적 관점을 중심으로

사재명(제1저자) ( Jae Myung Sa ),황영신 ( Young Shin Hwang ) 경상대학교 남명학연구소 2015 남명학연구 Vol.45 No.-

이 연구는 남명의 신명사도에 나타난 인간 마음의 특징과 그 작용에 대한 관점을 인간정보처리론적 학습심리 관점에서 학습심리적 함의를 고찰하는 것이 목적이다. 우선, 신명사도의 의미와 인간정보처리론과 정보처리모형을 살펴본 다음, 신명사도의 학습심리적 요소와 정보처리모형을 상호 비교해 볼 것이다. 그럼으로써 신명사도가 지니는 학습심리적 함의를 인간정보처리론에 기초하여 고찰하고자 한다. 신명사도는 외부의 자극에 대한 마음의 작용을 통해서 실천적으로 나타나는 행동을 표현하는 그림이다. 구조적으로는 원곽, 원곽내, 그리고 하단으로 구성되어 있다. 이는 신체적으로 눈·귀·입, 두뇌 및 마음, 몸으로 구성되어 있고, 기능적으로는 정보수집, 인지과정, 몸의 행동으로 작용한다. 또한 신명사도는 인간정보처리론적 학습심리의 관점을 내포하고 있으며, 이러한 관점을 밝혀냄으로써 본 연구는 서구의 학습심리 이론보다도 무려 400여년이나 앞서 교육에 활용되었다는 점을 구명했다는 측면에서 연구의 의의를 찾아볼 수 있다. 신명사도를 인간정보처리론적 관점에서 고찰해 볼 때, 드러낼 수 있는 학습심리적 함의는 다음과 같다. 첫째 학습자의 내적 인지과정을 이해할 수 있는 학습심리모델을 제시하였다는 점, 둘째 인간의 학습과정에 있어서 효과적인 학습방략을 제시해 주었다는 점, 그리고 셋째 학습자를 능동적인 정보처리자로 간주하였다는 점을 들 수 있다. As for this study, it is a purpose to derive a learning psychological connotation at the point of view of the human being information processing idea in ShinMyeongSaDo. ShinMyeongSaDo(神明舍圖)is a picture expressing the practical action of the body through the action of the heart for the outside stimulation. It is structural and is constituted in Fence out(垣郭外), Inside the fence(垣郭內), and Lower(下段). This is composed of eyes ear mouth, a brain and a heart, the body physically, and It is functional for information collection, cognitive process, acts by the action of the body. At the point called the learning psychology theory that ShinMyeongSaDo preceded it than a human being information processing theory of Europe as for about 400 rest of life, and inflected for education of the study is important. The learning psychological connotation of ShinMyeongSaDo is like the next. First, ShinMyeongSaDo shows the learning psychology model. Second, ShinMyeongSaDo show a clear concept for learning strategy. and Third, ShinMyeongSaDo consider a learner in people of active information processing.