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      • 米麥混食이 Cholesterol 및 無機質代射에 미치는 影響

        姜信英,孫延瑗,柳總根 고려대학교 의과대학 1986 고려대 의대 잡지 Vol.23 No.1

        This study was devised to investigate the effect of dietary fiber of barley on cholesterol metabolism and absorption of mineral on feeding either rice diets or barley mixed diets. Wistar albino rats were administered starch, rice, rice containing balrey by 10%, 30%, and 60% and barley diets for 2, 4, and 6 weeks. 1. Serum cholesterol level was higher in the rice diet group than in the barley diet group. In the meantime, fecal steroid content was highest in the barley diet group and decreased as the proportion of barley in diets became lower. 2. Correlation coefficient between the increase of fecal n-eight and the increase of fecal steroid content was 0. 988(p<0. 001). 3. Fecal Fe and Ca content was net affected by the extent of barley and rice in diets. But fecal Ka and K content was high in the barley diet group. 4. Fecal weight and fecal moisture content was highest in the barley diet group, and became lower in the diet group where barley was added in smaller proportion. The increase of fecal weight was significantly related with the increase of fecal water content(r=0.918, p<0.001). 5. Serum lipid level was lower in the diet group containing more barley than in the rice diet group. In contrast, focal lipid content was highest in the barley diet group, and decreased in proportion to the decrease of barley addition in diets. 6. Accumulation of adipose tissue was observed In the rice diet group, 2nd the more barley mixed in diets, the lower it was. 7. Length of small intestine was longer in the barley diet group than in the rice diet group.

      • 成熟赤血球의 Evans´blue 吸收에 미치는 二價金屬이온의 影響에 關한 硏究

        姜信英,曺龍鎬 慶熙大學校 1984 論文集 Vol.13 No.-

        Non-nucleated mature erythrocytes of human blood were stored at 4℃ in darkness for 4 hours. Upon the storage erythrocytes were separated by the fractional centrifugal method. The effect of divalent metallic ions on the percent of dye uptake rate of Evans' blue as a neutral salt of a organic dye in the presence of 580mM glucose was observed and the following results were obtained. 1. The dye uptake rate was found to be kinetically proportional in function of incubation period in the stored eryrocytes for 4 hours with the dye uptake of 42.2 percent for 120 minutes incubation. 2. The statistical analysis of this effect of the relationship between the incubation period and the percent dye uptake rate was found to be very highly significant (p<0.001). 3. The effect of magnesium ion (5 mM) on the percent dye uptake rate in function of incubation times was kinetically increased in human matured erythrocytes when compared to that of control group. At the end of 40 minutes of incubation the human matured erythrocytes treated with magnesium ion ( 5 mM) increased about 1.5 times more of 30.5 percent dye uptake than the control group of 20.3 percent dye uptake. 4. The effect of magnesium ion was slightly accelerated with the addition of 0.01 mM magnesium ion; between 0.05 mM and 10 mM of magnesium ions the influence of this divalent metallic ion was greatest. 5. The increase in the concentration of copper ion inhibited proportionally and remarkablly the percent dye uptake rate by human matured erythrocytes. Fifty percent inhibitory concentration (1_50) of copper ion on the percent dye uptake rate by human matured erythrocytes was found to be 10.07 micromoles. 6. Also, the effect of ferrous ion (5 micromoles) on the percent dye uptake rate is human matured erythrocytes for 40 minutes incubation was found to be 21.4 percent inhibition and it inhibited that the effect of hematin (5 micormoles) on the percent dye uptake rate o Evans' blue by 65.6 percent points for 40 minutes incubation. 7. No effect was exerted on the percent dye uptake rate in human matured erythrocytes during the incubation periods by the addition of calciumion (5 mM) and manganese ion (tmicromoles). 8. The addition of lithium ion at the concentration of 5 micormoles to reactant mixture was effectively increased on the percent dye uptake rate of Evans' blue for a incubation of 40 minutes when compared to that control group (20.3%) to 43.9 percent. In view of the above findings it is clear that the effect of magnesium ion and lithium ion, as divalent metallic ions, on the Evans' blue absorbed into non-nucleated erythrocytes is considered to accelerate this enhancing effect while it does not accelerate that of hematin and copper ion. However, the effects of calcium ion and manganese ion was ineffective on the percent dye uptake of Evans' blue by human matured erythrocytes.

      • 교육용 비디오 자료에서의 자막 특성을 이용한 대표화면추출 및 자막화면추출에 관한 연구

        유신(Sheen Lew),신희정(HeeJung Sheen),이완주(WanJoo Lee),이병래(Yongkyu Kim),김용규(ByeongRae Lee),강현철(Hyunchul Kang) 한국정보과학회 1999 한국정보과학회 학술발표논문집 Vol.26 No.1B

        본 연구에서는 자막특성을 이용하여 대표 프레임 추출과 문자 인식을 위한 문자 프레임 추출을 수행함과 동시에 장면전환을 검출할 수 있는 시스템을 구현하였다. 이는 기존의 방식인 장면전환 검출을 통해 비디오자료를 샷(shot)단위로 구조화하고 단순대표 프레임으로 각 샷의 내용을 요약하는 방식과는 달리, 비디오 스트림의 내용에 기반하여, 중요도가 상대적으로 높은 프레임을 대표 프레임으로 추출, 대표 프레임의 의미적(semantic)효용성을 보장한다. 이러한 기법은 교육용 비디오자료 특성에 기반하여 적용되었으며, 본 논문에서 제안한 시스템은 수행시간과 정확성면에서 뛰어난 특성을 보였다.

      • The impact of size on tissue distribution and elimination by single intravenous injection of silica nanoparticles

        Yhun Yhang, Sheen,Minjung, Cho,Wan-Seob, Cho,Mina, Choi,Sueng Jun, Kim,Beam Seak, Han,Sheen Hee, Kim,Hyoung Oak, Kim,Ja Young, Jeong 이화여자대학교 약학연구소 2010 藥學硏究論文集 Vol.- No.20

        Many approaches for the application of nano-sized particles to the human body as nanotechnology have been recently developed. The size of nanoparticles is related to their useful character and also plays a key role in toxicity. Since this surface area can interact with biological components of cells, nanoparticles can be more reactive in than larger particles. In the present study, a fluorescence dye-labeled 50, 100 and 200 nm-sized silica particle suspension was intravenously injected into mice to identify the toxicity, tissue distribution and excretion of silica nanoparticles in vivo. Incidence and severity of inflammatory response was transiently increased with injection of 200 and 100 nm silica nanoparticles within 12h. But there was no significant response related to injection of 50 nm particles. The silica particles of 50, 100 and 200 nm were cleared via urine and bile. The 50 nm silica anoparticles cleared to urine and bile than 100 nm and particles of 200 nm existed at lower concentration than other two smaller particles in urine and feces. Silica nanoparticles were trapped by macrophages in the spleen and liver and remained there until 4 weeks after the single injection.

      • KCI등재

        미용서비스 종사자의 직무스트레스와 직무소진의 관계에서 자아탄력성의 매개효과

        신영식(Young Seek Sheen),권도희(Do Hee Kwon),오경희(Kyung Hee Oh),신라미(La Mee Sheen) 한국인체미용예술학회 2017 한국인체미용예술학회지 Vol.18 No.4

        This study aimed to figure out correlations among job stress, ego resilience and job burn out in beauty salon workers. For this, a questionnaire survey was administered to 300 beauty salon workers in Busan and the capital region from May 2nd to 31st, 2014. Except for 44 poorly answered ones, 256 copies were used for a final analysis. For analysis of the data, the analysis was conducted to analyze the frequency analysis and the validity of the measurement of the measurement participants’ characteristics. In addition, a correlation analysis was conducted to verify the validity of the variables and the identification validity of the variables, and conducted a regression analysis to verify the suitability and validity of the research model. The study results found the following: while a positive correlation was found between job stress and job burn out, a negative correlation was observed between ego resilience and job burn out. In other words, job stress has a negative effect on beauty salon workers’ life as well as their working environment. In contrast, ego resilience reduces job burn out by helping staff build the ability to handle problems in a positive manner.

      • SCISCIESCOPUS
      • An updated review of case–control studies of lung cancer and indoor radon-Is indoor radon the risk factor for lung cancer?

        Sheen, Seungsoo,Lee, Keu Sung,Chung, Wou Young,Nam, Saeil,Kang, Dae Ryong BioMed Central 2016 Annals of occupational and environmental medicine Vol.28 No.1

        <P>Lung cancer is a leading cause of cancer-related death in the world. Smoking is definitely the most important risk factor for lung cancer. Radon (<SUP>222</SUP>Rn) is a natural gas produced from radium (<SUP>226</SUP>Ra) in the decay series of uranium (<SUP>238</SUP>U). Radon exposure is the second most common cause of lung cancer and the first risk factor for lung cancer in never-smokers.</P><P>Case–control studies have provided epidemiological evidence of the causative relationship between indoor radon exposure and lung cancer. Twenty-four case–control study papers were found by our search strategy from the PubMed database. Among them, seven studies showed that indoor radon has a statistically significant association with lung cancer. The studies performed in radon-prone areas showed a more positive association between radon and lung cancer. Reviewed papers had inconsistent results on the dose–response relationship between indoor radon and lung cancer risk.</P><P>Further refined case–control studies will be required to evaluate the relationship between radon and lung cancer. Sufficient study sample size, proper interview methods, valid and precise indoor radon measurement, wide range of indoor radon, and appropriate control of confounders such as smoking status should be considered in further case–control studies.</P>

      • SCISCIESCOPUS
      • SCIESCOPUSKCI등재

        Effect of 3-Methylcholanthrene on Rat Uterus: Uterine Growth and Mechanism of Action of 3-Methylcholanthrene

        Sheen, Yhun-Y.,Kim, Sun-S.,Yun, Hea-C. The Pharmaceutical Society of Korea 1993 Archives of Pharmacal Research Vol.16 No.4

        This study has been undertaken to examine the effect of 3-methylcholanthrene (3MC) on rat uterine growth and to understand the mechanism of action of 3MC in rat uterus. After diethylstilbesterol(DES) or tamoxifen(TAM) or 3MC or DES plus TAM or DES plus 3MC was administered into immature female rats, uterine weight over corn oil-treated uteri. 3MC treatment had no effect on uterine weight but, DES stimulated uterine weight was inhibited by 3MC concomitant tratment. While TAM alone treatment showed slight increase in uterine wieght, inhibited uterine growth simulated by DES when it was adiministrated with DES condirect binding assay with $[^3H]$ estradiol and the relative binding affinities of 3MC and TAM were estimated by competetion assy. Estradiol tumed out to have high affinity for rat uterine estrogen receptor (kd = 0.4 nM). The relative binding affinities of TAM and 3MC were 1% and 4.7% that of DES for rat uterine estrogen receptor, respectively. 3MC was shown to have similar affinity for eat uterine estrogen receptor to that of TAM. Effects of DES 3MC and TAM administration in vivo on rat uterine estrogen recptor level were examined. It was confirmed that the estrogen, DES and antiestrogen, TAM decreased estrogen receptor levels from rat ulterus and also 3MC decreased rat uterine estrogen receptor level when rats were treated with DES, TAM and 3MC in vivo. Data indicates that 3MC acts as an antiestrogen mediated through estrogen receptor system.

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