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Hénia Bouzidi Mousser,Aicha Hamoudi,Solenne Fleutot,Sébastien Fontana,Franck Cleymand,Abdelhamid Mousser 한국약제학회 2018 Journal of Pharmaceutical Investigation Vol.48 No.5
The newberyite MgHPO4 ·3H2O antacid activity has never been investigated before. Crystalline and heated Newberyite, at 200 °C, was tested as a neutralizing of hydrogen chloride acid (HCl 0.1 M to simulate gastric juice). Results show that the substrate has a basic behavior and may be used as an active ingredient in the antacid formulation. HCl Neutralization 0.1 M depends of newberyite concentration and pH1 was reached when 0.5 M was used. The crystalline and heated newberyite antacid power was compared with that of some commercial antacids. The newberyite heated pushed pH to 4 after 4 min when the crystalline product was brought it to 3 after 15 min. The antacid neutralizing capacity (ANC) was evaluated using direct and reverse titration methods. ANC values increased when particle sizes decreased. The heated product at 200 °C increased strongly the ANC and the maximum value reached was 13 meq/g. The kinetic study of neutralization reaction was carried out by pHmetry. The rate constants are depending of newberyite quantity and the optimal neutralization of HCl 0.1 M was obtained for 0.5 g. The resulting structural transformations have been investigated. XRD showed that the product became amorphous after heating at 200 °C. FT-IR and Raman spectroscopy agree on departure of the three crystallization water molecules, when MgHPO4 ·3H2O was heated. Surface area measurement was determined by Brunauer, Emmett and Teller and indicates that the product hasn’t an important porosity. Scanning electron microscopy coupled with energy dispersive spectrometry elementary analysis was also carried out and confirmed FT-IR and Raman spectroscopy results.
Carolina Palmela,Sónia Velho,Lisa Agostinho,Francisco Branco,Marta Santos,Maria Pia Costa Santos,Maria Helena Oliveira,João Strecht,Rui Maio,Marília Cravo,Vickie E. Baracos 대한위암학회 2017 Journal of gastric cancer Vol.17 No.1
Sarcopenia and sarcopenic obesity were associated with early termination of neoadjuvant chemotherapy in patients with gastric cancer; additionally, sarcopenic obesity was associated with poor survival.
Curcumin derivatives for Type 2 Diabetes management and prevention of complications
Sara Oliveira,Tamaeh Monteiro-Alfredo,Sónia Silva,Paulo Matafome 대한약학회 2020 Archives of Pharmacal Research Vol.43 No.6
Type 2 diabetes Mellitus (T2DM) is characterizedby chronically increased blood glucose levels, whichis associated with impairment of the infl ammatory and oxidativestate and dyslipidaemia. Although it is considered aworld heath concern and one of the most studied diseases,we are still pursuing an eff ective therapy for both the pathophysiologicalmechanisms and the complications. Curcumin,a natural compound found in the rhizome of Curcuma longa ,is well known for its numerous biological activities, as demonstratedby several studies supporting that curcumin possesseshypoglycaemic, hypolipidemic, anti-infl ammatoryand antioxidant properties, among others. These eff ects havebeen explored to the attenuation of hyperglycaemia and progressionof DM complications, being appointed as a potentialtherapeutic approach. Besides its strong intrinsic activity,the polyphenol has low bioavailability, compromisingits therapeutic effi cacy. In order to overcome this limitation,several chemical strategies have been applied to curcumin,such as drug delivery systems, chemical manipulation andthe use of adjuvant therapies. Given the promising results obtained with curcumin derivative, in this review we discussnot only the therapeutic targets of curcumin, but also itsmost recently developed analogues and their effi cacy in themanagement of T2DM pathophysiology and complications.
Study on Mechanical Properties and Fracture in Epoxy Composites Reinforced by Hybrid Twill Fabrics
Jorge Fernando de Sousa Oliveira,Mirtânia Antunes Leão,Ana Claudia Melo Caldas Batista,Sérgio Renan Lopes Tinô,Eve Maria Freire de Aquino 한국섬유공학회 2018 Fibers and polymers Vol.19 No.5
The aim of this study is to determine the influence of hybrid twill fabrics on the conception of polymer composites in terms of their mechanical properties and fracture mechanisms. Parameters associated with the type and/or process of hybridization, such as the presence or not of anisotropy, are influential factors in the final performance of these materials. For this, two composite laminates were manufactured, each containing four layers of reinforced hybrid twill fabrics made from Kevlar-49/AS4 carbon and Kevlar-49/E-glass fibers, with a high-performance epoxy vinyl ester as matrix. Mechanical properties were performed for uniaxial tensile, three-point bending and uniaxial compression tests. The type of hybrid twill fabric directly affected the mechanical properties and damage mechanism of the laminates studied for all loads applied. Highlight that specimens tested to carbon direction exhibited better mechanical behavior.
Raquel Venâncio Fernandes Dantas,Hugo Ramalho Sarmento,Rosângela Marques Duarte,Sônia Saeger Meireles Monte Raso,Ana Karina Maciel de Andrade,Maria Luiza dos Anjos Pontual 대한영상치의학회 2013 Imaging Science in Dentistry Vol.43 No.3
Purpose: This study was performed to evaluate and compare the radiopacity of dentin, enamel, and 8 restorative composites on conventional radiograph and digital images with different resolutions. Materials and Methods: Specimens were fabricated from 8 materials and human molars were longitudinally sectioned 1.0 mm thick to include both enamel and dentin. The specimens and tooth sections were imaged by conventional radiograph using #4 sized intraoral film and digital images were taken in high speed and high resolution modes using a phosphor storage plate. Densitometric evaluation of the enamel, dentin, restorative materials, a lead sheet, and an aluminum step wedge was performed on the radiographic images. For the evaluation, the Al equivalent (mm) for each material was calculated. The data were analyzed using one-way ANOVA and Tukey’s test (p⁄0.05), considering the material factor and then the radiographic method factor, individually. Results: The high speed mode allowed the highest radiopacity, while the high resolution mode generated the lowest values. Furthermore, the high resolution mode was the most efficient method for radiographic differentiation between restorative composites and dentin. The conventional radiograph was the most effective in enabling differentiation between enamel and composites. The high speed mode was the least effective in enabling radiographic differentiation between the dental tissues and restorative composites. Conclusion: The high speed mode of digital imaging was not effective for differentiation between enamel and composites. This made it less effective than the high resolution mode and conventional radiographs. All of the composites evaluated showed radiopacity values that fit the ISO 4049 recommendations.
Paola Marques de Mattos,Vula Papalexiou,Vinícius Augusto Tramontina,Sung Hyun Kim,Sônia Mara Luczyszyn,Patrícia Vida Cassi Bettega,Aline Cristina Batista Rodrigues Johann 대한치주과학회 2020 Journal of Periodontal & Implant Science Vol.50 No.1
Purpose: Subepithelial connective tissue grafts (SCTGs) are commonly performed for the treatment of gingival recession due to their high predictability. This study evaluated and histologically compared connective tissue grafts in terms of the presence of epithelial remnants and composition of the tissue types that were present (epithelium, lamina propria, and submucosa). Methods: Ten patients underwent epithelium removal using 2 different techniques: the use of a blade (group B) and through abrasion (group A). Twenty samples were collected and each tissue type was analyzed histologically in terms of its area, thickness, and proportion of the total area of the graft. Results: In 4 samples (40%) from group B (n=10) and 2 samples (20%) from group A (n=10), the presence of an epithelial remnant was observed, but the difference between the groups was not statistically significant ( P >0.05). Likewise, no statistically significant differences were observed between the groups regarding the area, mean thickness, or proportion of the total area for any of the tissue types ( P >0.05). Conclusions: Histologically, SCTGs did not show statistically significant differences in terms of their tissue composition depending on whether they were separated from the epithelial tissue by abrasion or by using a blade.
M.da CT. Cavalcanti Liberato,Selene Maia de Morais,Sônia Maria Costa Siqueira,Jane Eire Silva Alencar de Menezes,Denise Nogueira Ramos,Lyeghyna Karla Andrade Machado,Islay Lima Magalha˜es 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.6
Twenty-three honey samples of Apis mellifera L. forged on plants from northeastern Brazil were analyzed to determine total phenolic content, flavonoid content, antioxidant activity, and antiacetylcholinesterase activity. The total phenol content was determined by using the Folin–Ciocalteu method, and the flavonoid content was analyzed using by the aluminum chloride method. The antioxidant activity was evaluated using the diphenyl-1-picrylhydrazyl–scavenging test. Honey samples from Lippia sidoides Cham. (mean [±standard deviation] 50% inhibitory concentration [IC_50], 4.20±1.07 mg/mL) and Myracrodruon urundeuva Fr. All. (IC_50, 28.27±1.41 mg/mL) showed better antioxidant activity and presented higher total phenol values (108.50±3.52 mg gallic acid equivalents/100 g for L. sidoides and 68.55±1.01 mg gallic acid equivalents/100 g for M. urundeuva). Several honey samples had relevant results on antiacetylcholinesterase assay. The biological activity of honeys is related to their floral origin, and medicinal plants constitute a useful resource for the generation of functional foods.
Nonlocal strain gradient effects on forced vibrations of porous FG cylindrical nanoshells
Mirjavadi, Seyed Sajad,Forsat, Masoud,Nia, Alireza Farrokhi,Badnava, Salman,Hamouda, A.M.S. Techno-Press 2020 Advances in nano research Vol.8 No.2
The present paper explores forced vibrational properties of porosity-dependent functionally graded (FG) cylindrical nanoshells exposed to linear-type or triangular-type impulse load via classical shell theory (CST) and nonlocal strain gradient theory (NSGT). Employing such scale-dependent theory, two scale factors accounting for stiffness softening and hardening effects are incorporated in modeling of the nanoshell. Two sorts of porosity distributions called even and uneven have been taken into account. Governing equations obtained for porous nanoshell have been solved through inverse Laplace transforms technique to derive dynamical deflections. It is shown that transient responses of a nanoshell are affected by the form and position of impulse loading, amount of porosities, porosities dispensation, nonlocal and strain gradient factors.
Diversity minimization through part combination – a Portuguese railway infrastructure case study
Diogo Rechena,Luís Sousa,Virgínia Infante,Elsa Henriques 한국CDE학회 2020 Journal of computational design and engineering Vol.7 No.1
With increasing market needs for product and service variety, companies struggle to provide diversity in cost-effective ways. Through standardization of components with a low perceived added value, companies can take advantage of economies of scale while maintaining product diversity. Railway infrastructure managers face similar challenges of providing economically sustainable services while dealing with the costs of maintaining the system diversity. Typically, unintended design diversity stems from design practices in which existing solutions are not reused for new problems and new solutions are rarely planned considering the dynamics of requirement changes. In this paper we provide a methodology to assess how to standardize different designs to minimize design diversity and to assess design divergence in a product family. The developed methodology is able to take into account any set of standardization compatibility constraints that the user can define. The methodology was applied in the context of a small-scale railway infrastructure manager using a dataset of 223 unique designs of functionally similar components from its electrification system. Depending on the activated compatibility constraints, results indicate that over 60% of components can be reduced to a set of 86 unique designs.