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      • KCI등재

        Study and Design of High Strength and Low Heat Generation Polymer Composites by Molecular Dynamics Simulation

        Rui-Rui Zhang,Bin Wu,Peng Chen,Jia-Sheng Qian 한국고분자학회 2020 폴리머 Vol.44 No.6

        The molecular dynamics simulation was used to study and design a polymer composites system with excellent mechanical strength and less heat generation in a dynamic process. A series of system factors such as filler loading, surface modification onto filler, and network of cross-linking filler particles on mechanical and heat generation of polymer composites are systematically considered. It is found that the surface grafting onto fillers can restrain the heat generation of polymer composite in the dynamic process, while it shows less effect on the mechanical property. A network of cross-linking filler particles can be fabricated by a combination of grafting chains onto fillers. By filling such a network into the polymer, the mechanical and heat generation properties of polymer composites are significantly improved. Simulation results can help experimental fabrication of polymer composites with excellent mechanical and heat generation properties.

      • KCI등재

        Comparative Lipidomic Analysis of Cephalosporium acremonium Insights into Industrial and Pilot Fermentations

        Rui-Juan Xu,Bin Qiao,Bing-Zhi Li,Hua Lu,Yao Chen,Ying-Jin Yuan 한국생물공학회 2012 Biotechnology and Bioprocess Engineering Vol.17 No.2

        Cephalosporium acremonium has been widely applied in industrial cephalosporin C fermentation. However,little is known about the molecular basis of fermentation behavior of this strain. In this study, comparative lipidomic analysis using LC/ESI/MSn technology was employed to investigate responses of Cephalosporium acremonium to multiple environment variations in realistic industrial cephalosporin C fermentation process and provide molecular basis for the discrepancies between industrial and pilot fermentations. Totally 77 phospholipids species were detected and 65 species were further quantified. Score plot revealed that phospholipids metabolism differed in industrial and pilot process. Loading pilot indicated that the main variables responsible for the discrimination of industrial and pilot process were phosphatidylinositols (PIs), phosphatidylserines (PSs) and phosphatic acids (PAs). Higher PIs content in industrial process indicated that cells were more vigorous in industrial process than those in pilot process. Larger increases of PSs, PAs and ratio of oleic acid to linoleic acid coincided well with the earlier and more thorough cellular morphological differentiation in industrial process. The synergetic reaction between cellular behavior and cells living environment led to titer discrepancies between industrial and pilot process. These findings provided lipidomic insights into industrial cephalosporin C production. Cephalosporium acremonium has been widely applied in industrial cephalosporin C fermentation. However,little is known about the molecular basis of fermentation behavior of this strain. In this study, comparative lipidomic analysis using LC/ESI/MSn technology was employed to investigate responses of Cephalosporium acremonium to multiple environment variations in realistic industrial cephalosporin C fermentation process and provide molecular basis for the discrepancies between industrial and pilot fermentations. Totally 77 phospholipids species were detected and 65 species were further quantified. Score plot revealed that phospholipids metabolism differed in industrial and pilot process. Loading pilot indicated that the main variables responsible for the discrimination of industrial and pilot process were phosphatidylinositols (PIs), phosphatidylserines (PSs) and phosphatic acids (PAs). Higher PIs content in industrial process indicated that cells were more vigorous in industrial process than those in pilot process. Larger increases of PSs, PAs and ratio of oleic acid to linoleic acid coincided well with the earlier and more thorough cellular morphological differentiation in industrial process. The synergetic reaction between cellular behavior and cells living environment led to titer discrepancies between industrial and pilot process. These findings provided lipidomic insights into industrial cephalosporin C production.

      • An Efficient DHT Routing Protocol with Small-world Features for Structured P2P Network

        Bin Zeng,Rui Wang 보안공학연구지원센터 2016 International Journal of Grid and Distributed Comp Vol.9 No.7

        Distributed Hash Tables (DHT) provide a fault-tolerant and scalable means to store data blocks in P2P systems. In this thesis, we have proposed an improved version of CAN called “small-world DHT”. The key idea is to link each CAN node to a constant number of long-distance contacts, which are chosen according to the probability density function. This enables our scheme to achieve O(log2n) routing path length with O(1) routing table size per node. We have shown that the hybrid infrastructure of a structured overlay network (CAN) and a random graph (small-world model) not only preserve CAN’s simplicity, but also achieves a resilient and efficient DHT routing algorithm. We have also exploited the LookAhead-GREEDY routing algorithm, whereby each node obtains information about its neighbors’ neighbors by periodically exchanging the routing table entries with its neighbors. The routing algorithm improves the routing efficiency and enhances the network’s resilience to failure. Our scheme requires knowledge of the current network size in order to construct the long-distance links. To estimate the network size, the latter maintains a distributed binary partition tree and measures the size of the sample area by counting the number of leaves in the corresponding branch.

      • KCI등재

        Potent in Vitro Anticancer Activity of Metacycloprodigiosin and Undecylprodigiosin from a Sponge-Derived Actinomycete Saccharopolyspora sp. nov.

        Rui Liu,Cheng-Bin Cui,Lin Duan,Qian-Qun Gu,Wei-Ming Zhu 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.12

        Bioassay-guided fractionation of CHCl3 extract from the fermentation broth of a sponge Mycale plumose-derived actinomycete Saccharopolyspora sp. nov., led to the isolation of two known prodigiosin analogs - metacycloprodigiosin (1) and undecylprodigiosin (2). These compounds exhibited significant cytotoxic activities against five cancer cell lines: P388, HL60, A-549, BEL- 7402, and SPCA4. This is the first report on the significant cytotoxicity of metacycloprodigiosin (1) against human cancer cell lines.

      • KCI등재

        Simple Synthesis of Multi-Halogen Pyrazino[1,2-a]indole-1,8(2H,5aH)-diones

        Rui-Xia Yang,Yu-Cheng Zhao,Ling-Bin Kong,Sheng-jiao Yan,Jun Lin 대한화학회 2016 Bulletin of the Korean Chemical Society Vol.37 No.10

        A concise and efficient one-pot synthesis of multi-halogen pyrazino[1,2-a]indole-1,8(2H,5aH)-dione (MHPID) derivatives by the reaction of an enamino ester with multi-halogen benzoquinone derivatives is described. MHPIDs 3a–3d were obtained with good yields (78–83%) by refluxing enamino esters 1a and 1b and tetrahalogen-1,4-benzoquinones 2a and 2b for 24 h without the use of catalysts. Compounds 3e–3p were also obtained with excellent yields (69–92%) via the reaction of the phenyl-substituted enamino esters 1c–1h with tetrahalogen-1,4-benzoquinones 2a and 2b in CH3CN catalyzed by Cs2CO3. These two protocols are efficient and effective for the synthesis of MHPIDs.

      • KCI등재

        Trichodermamide A and Aspergillazine A, Two Cytotoxic Modified Dipeptides from a Marine-Derived Fungus Spicaria elegans

        Rui Liu,Qian-Qun Gu,Wei-Ming Zhu,Cheng-Bin Cui,Guo-Tao Fan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9

        Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.

      • KCI등재

        Ellipsometric Study of the Optical Properties of Silicon-Based Si:SiO2 Composite Thin Films under Different Annealing Temperatures

        Bin Sun,Yu-Xiang Zheng,Cong-Hui Xu,Liang-Yao Chen,Peng Zhou,Yue-Rui Chen,Yu-Fei Kong 한국물리학회 2006 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.49 No.5I

        In our work, silicon and silica composite .lms were prepared by using a magnetron sputtering method, and the samples were annealed in the temperature range between 200 ±C and 600 ±C. After annealing, the samples were investigated by spectroscopic ellipsometry (SE), and the SE spectra were measured in the range of 1.5 eV ≫ 4.5 eV with a dual-rotating-element ellipsometer. In order to investigate the microstructure information of the .lm by .tting the SE spectra using the eective- medium approximation (EMA), we modeled the whole .lm by using a multilayer optical model including a surface oxide layer, a composite layer, and substrate layer. We used dierent mixtures to describe the composite layer, and .nally we found that a mixture of amorphous silicon (a-Si), polycrystalline silicon (p-Si), and silicon dioxide had the best .t to the SE spectra. Whereafter, we studied the dependences of the surface roughness, the layer structure, and the composition on the dierent annealing temperatures and found that with increasing annealing temperature, the surface oxide layer grew in thickness, the silicon dioxide maintained its volume fraction, and a-Si transferred to p-Si.

      • A Mobility Aware and Low Latency Mac Protocol for Mobile Wireless Sensor Network with the Improvement of S_MAC

        Bin Zeng,Rui Wang 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.6

        There exist a lot of medium access control (MAC) protocols for wireless sensor networks. However, they consider mainly energy efficiency rather than latency which is important in delay sensitive mobile sensor networks. Therefore, a new MAC protocol called MS-MAC is proposed suitable to both stationary and mobile sensor networks. MS-MAC uses an adaptive frame structure improved for well known protocol S-MAC to overcome the performance problems caused by the packets latency in the mobile environment. The selection of monitor nodes and periodic scheduling of synchronization packets are used to predict the speed of mobile nodes, which can save the energy consumption and minimize latencies. Our studies show that under static scenarios, the MS-MAC behavior similar with MS-MAC. However, MS-MAC can increase the network throughput and reduce the latency significantly without more energy loss in comparison with S-MAC in mobile environment.

      • KCI등재

        Study on Enhancing Lightning Protection Scheme of Catenary in Subway Viaduct Section

        Rui-Fang Li,Kui Chen,Li-Sheng Chen,Xiao-Bin Cao,Guang-Ning Wu,Xue-Qin Zhang 대한전기학회 2017 Journal of Electrical Engineering & Technology Vol.12 No.2

        Viaduct increases the height of subway catenary, namely magnifies lightning attraction scope that lead to higher possibility of suffering lightning stroke. Therefore, it is necessary to analyze performance of lightning striking to catenary of subway in viaduct section and propose an improving lightning protection scheme. In this paper, using ATP-EMTP simulation software to establish an associated model to evaluate lightning withstand level of catenary with existing lightning protection schemes including arrester and grounding point, an improving lightning protection scheme is proposed — every pillar ground earth and arresters are installed with some installing spacing between 200m to 400m based on lightning damage degree and reliability requirements — according to analyzing results: while lightning withstand level is lowest for lightning striking to the neutral pillar, lightning withstand level is greatest for lightning striking to the both-ends pillar that arrester and grounding point are both installed; grounding point could obviously improve lightning withstand level for lightning striking to ground wire while arrester could obviously improve the lightning withstand level for lightning striking to catenary; every pillar ground earth could enhance the lowest lightning withstanding level up to 2.5 times than of that pillar ground earth across every 200m.

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