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Selenium and Vitamin E for Prostate Cancer - Justifications for the SELECT Study
Ramamoorthy, Venkataraghavan,Rubens, Muni,Saxena, Anshul,Shehadeh, Nancy Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.7
There are several studies that relate oxidative damage as possible mechanism for many cancers. Many studies have also shown that anti-oxidants like selenium and vitamin E decrease the risk for prostate cancer. The main objective of the Selenium and Vitamin E Cancer Prevention Trial (SELECT) study was to look for the benefits of selenium and vitamin E supplementation on prostate cancer. The study had a large sample size, stringent experimental conditions, very long duration, standardized laboratories for biochemical analyses and other factors that contribute to high external validity. The SELECT study failed to show any significant risk reduction for prostate cancers ascribable to selenium and vitamin E supplementations. Because of these conflicting results, many researchers argue about the methods used, supplementations administered (selenium and vitamin E) and indicators used for assessing levels of supplementations. We reviewed many epidemiological studies, clinical trials, and pre-clinical studies. With corroborative evidences we justify that SELECT study has a sound methodology and rationale. In lieu of the contrary results of the select study, researchers should focus on the probable mechanisms for these contrary findings and continue their search for newer and effective agents for prevention of prostate cancer.
Andre Luiz Ferreira Costa,Rubens Caliento,Glauber Bareia Liberato da Rocha,Joao Pedro Perez Gomes,Alison Jhisel Calle Mansmith,Claudio Froes de Freitas,Paulo Henrique Braz-Silva 대한영상치의학회 2017 Imaging Science in Dentistry Vol.47 No.4
Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Both clinical and histological features are described, underscoring the diagnostic role of magnetic resonance imaging findings.
Agarwal, Ankit,Saxena, Anshul,Rubens, Muni,Ahuja, Rinky,Tijare, Manisha Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.15
Background: In India smokeless tobacco users account for 25.9% of total tobacco use, Gutkha being the most common form. This study evaluated the association between serum lipid profile and Gutkha use as an early diagnostic and/or prognostic indicator for oral submucous fibrosis (OSMF) and oral cancer (Oral Ca) in non-smokers and non-alcohol consumers. Materials and Methods: A total of 163 participants were recruited from two sites in India. Participants were divided into four groups: individuals without any Gutkha chewing habit and without any oral lesions (control group), individuals with Gutkha chewing habit but without any oral lesions (GWL), patients with a confirmed clinical diagnosis of OSMF, and patients with a confirmed diagnosis of Oral Ca. Mixed linear modelling (MLM) was conducted to detect the change in mean serum lipid levels among four groups. Results: The sample consisted of 69% males and 31% females. Results of MLM show an inverse relationship between serum lipid levels in OSMF, and Oral Ca groups when compared to the control group. Conclusions: The results of our study demonstrated that GWL, OSMF and Oral Ca patients had lower serum lipid levels. Low serum lipid levels could be an indicator of initial neoplastic changes in oral cancer.
Visualizations of Relational Capital for Shared Vision
Russell, Martha G.,Still, Kaisa,Huhtamaki, Jukka,Rubens, Neil World Technopolis Association 2016 World Technopolis Review Vol.5 No.1
In today's digital non-linear global business environment, innovation initiatives are influenced by inter-organizational, political, economic, environmental, technological systems, as well as by decisions made individually by key actors in these systems. Network-based structures emerge from social linkages and collaborations among various actors, creating innovation ecosystems, complex adaptive systems in which entities co-create value. A shared vision of value co-creation allows people operating individually to arrive together at the same future. Yet, relationships are difficult to see, continually changing and challenging to manage. The Innovation Ecosystem Transformation Framework construct includes three core components to make innovation relationships visible and articulate networks of relational capital for the wellbeing, sustainability and business success of innovation ecosystems: data-driven visualizations, storytelling and shared vision. Access to data facilitates building evidence-based visualizations using relational data. This has dramatically altered the way leaders can use data-driven analysis to develop insights and provide ongoing feedback needed to orchestrate relational capital and build shared vision for high quality decisions about innovation. Enabled by a shared vision, relational capital can guide decisions that catalyze, support and sustain an ecosystemic milieu conducive to innovation for business growth.
Jean-Eric Pelet,Monia Massarini,Rubens Pauluzzo 한국마케팅과학회 2018 Journal of Global Fashion Marketing Vol.9 No.4
The globalization of trade and the increasingly mixed identities of consumers suggest that researchers on “country of origin” (COO) should go beyond nationality. Thus, we propose the “ethnicity of origin” (EOO) construct as an alternative to COO. We focus on a privileged area of investigation – fashion – and operationalize the construct through three variables: the designer’s birthplace, educational background and headquarters location. We conduct a cross-national experimental factorial analysis on a sample of 980 respondents from China, France and Italy. Results suggest that the three variables have an impact on brand evaluation. The indirect impact on willingness to buy (WBUY) and willingness to recommend (WREC) is also supported. However, correlations vary according to the ethnicity of the consumer. More specifically, our results stress that ethnicity cues have a strong influence on potential Chinese customers. Moreover, consumer ethnocentrism acts as an important moderator of the relationship between ethnicity cues and perceived brand image evaluation. EOO cues should be taken into account as strategic branding levers when defining marketing strategies in the fashion industry. Findings support our suggestion that studies on COO should address a situational focused approach to ethnicity.
Analysis of the fracture of brittle elastic materials using a continuum damage model
Costa Mattos, Heraldo S.,Sampaio, Rubens Techno-Press 1995 Structural Engineering and Mechanics, An Int'l Jou Vol.3 No.5
The most known continuum damage theories for brittle structures are suitable to model the degradation of the material due to the deformation process and the consequent initiation of a macro-crack. Nevertheless, they are not able to describe the propagation of the crack that leads, eventually, to the breakage of the structure into parts that undergo rigid body motion. This paper presents a theory, formulated from formal arguments of Continuum Mechanics, that may describe not only the degradation but also the fracture of elastic structures. The modeling of such a discontinuous phenomenon through a continuous theory is possible by taking a cohesion variable, related with the links between material points, as an additional degree of kinematical freedom. The possibilities of the proposed theory are discussed through examples.
Costa, Andre Luiz Ferreira,Caliento, Rubens,da Rocha, Glauber Bareia Liberato,Gomes, Joao Pedro Perez,Mansmith, Alison Jhisel Calle,de Freitas, Claudio Froes,Braz-Silva, Paulo Henrique Korean Academy of Oral and Maxillofacial Radiology 2017 Imaging Science in Dentistry Vol.47 No.4
Foreign body granulomas can develop after the injection of various cosmetic filling materials into the facial area to flatten wrinkles. Clinically, reactive lesions are easily mistaken for soft-tissue neoplasms or cysts. This report presents a case of foreign body granuloma in a 52-year-old female patient complaining of a painless swelling in the nasolabial region. Both clinical and histological features are described, underscoring the diagnostic role of magnetic resonance imaging findings.
Visualizations of Relational Capital for Shared Vision
Martha G. Russell,Kaisa Still,Jukka Huhtamäki,4) Neil Rubens 세계과학도시연합 2016 World Technopolis Review Vol.5 No.1
In today’s digital non-linear global business environment, innovation initiatives are influenced by inter-organizational, political, economic, environmental, technological systems, as well as by decisions made individually by key actors in these systems. Network-based structures emerge from social linkages and collaborations among various actors, creating innovation ecosystems, complex adaptive systems in which entities co-create value. A shared vision of value co-creation allows people operating individually to arrive together at the same future. Yet, relationships are difficult to see, continually changing and challenging to manage. The Innovation Ecosystem Transformation Framework construct includes three core components to make innovation relationships visible and articulate networks of relational capital for the wellbeing, sustainability and business success of innovation ecosystems: data-driven visualizations, storytelling and shared vision. Access to data facilitates building evidence-based visualizations using relational data. This has dramatically altered the way leaders can use data-driven analysis to develop insights and provide ongoing feedback needed to orchestrate relational capital and build shared vision for high quality decisions about innovation. Enabled by a shared vision, relational capital can guide decisions that catalyze, support and sustain an ecosystemic milieu conducive to innovation for business growth.