http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Romics (검색결과 4 건)
- 무료
- 기관 내 무료
- 유료
-
Gene network and canonical pathway analysis in prostatecancer: a microarray study
Hakan Savli,Attila Szendrӧi,Imre Romics,Balint Nagy 생화학분자생물학회 2008 Experimental and molecular medicine Vol.40 No.2
The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets. The molecular mechanism playing a role in the development of prostate cancer (PCA) is not well defined. We decided to determine the changes in gene expression in PCA tissues and to compare them to those in noncancerous samples. Prostate tissue samples were collected by needle biopsy from 21 PCA and 10 benign prostate hyperplasic (BPH) patients. Total RNA was isolated, cDNA was synthesized, and gene expression levels were determined by microarray method. In the progression to PCA, 738 up-regulated and 515 downregulated genes were detected in samples. Analysis using Ingenuity Pathway Analysis (IPA) software revealed that 466 network and 423 functions-pathways eligible genes were up-regulated, and 363 network and 342 functions-pathways eligible genes were down-regulated. Up-regulated networks were identified around IL-1β and insulin-like growth factor-1 (IGF-1) genes. The NFKB gene was centered around two upand down-regulated networks. Up-regulated canonical pathways were assigned and four of them were evaluated in detail: acute phase response, hepatic fibrosis, actin cytoskeleton, and coagulation pathways. Axonal guidance signaling was the most significant down-regulated canonical pathway. Our data provide not only networks between the genes for understanding the biologic properties of PCA but also useful pathway maps for future understanding of disease and the construction of new therapeutic targets.
-
Goran Koricanac,Snezana Tepavcevic,Snjezana Romic,Manja Zec,Tijana Culafic,Mojca Stojiljkovic,Tamara Ivkovic,Marija Pantelic,Milan Kostic,Jelena Stanisic 한국식품영양과학회 2023 Journal of medicinal food Vol.26 No.11
The transport of cations in the cardiomyocytes, crucial for the functioning of the heart, can be affected bywalnut diet due to the high content of polyunsaturated fatty acids. Healthy and metabolically compromised rats (drinking 10%fructose solution) were subjected to a diet supplemented with 2.4 g of walnuts for 6 weeks to investigate the effect on proteinsinvolved in cation transport in the heart cells. Fructose increased the level of the a1 subunit of Na+/K+-ATPase and thephosphorylation of extracellular signal-regulated kinase 1/2 in the heart of control and walnut-eating rats, while elevatedL-type calcium channel a (LTCCa), sodium–calcium exchanger 1 (NCX1), and Maxi Ka level were observed only in rats thatdid not consume walnuts. However, walnuts significantly increased the cardiac content of LTCC, NCX1, and Maxi Ka, as wellas Kir6.1 and SUR2B subunits of KATP channel, but only in fructose-naive rats. In animals that drank fructose, a significantincreasing effect of walnuts was observed only in Akt kinase phosphorylation, which may be a part of the antiarrhythmicmechanism of decreasing cation currents in cardiomyocytes. The walnut diet-induced increase in LTCC and NCX1 expressionin healthy rats may indicate intense cardiac calcium turnover, whereas the effect on Kir6.1 and SUR2B subunits suggestsstimulation of KATP channel transport in the cardiac vasculature. The effects of walnuts on the cation-handling proteins in theheart, mostly limited to healthy animals, suggest the possible use of a walnut-supplemented diet in the prevention rather thanthe treatment of cardiological channelopathies.
-
-
Zoran Bonic´,Nebojsˇ a Davidovic´,Todor Vacev,Nikola Romic,Elefterija Zlatanovic´,Jelena Savicˇ 한국콘크리트학회 2017 International Journal of Concrete Structures and M Vol.11 No.4
Punching shear resistance of column footings and foundation slabs varies significantly in different standards. The reason for this is because standards define differently the position of the critical perimeter in which the punching shear resistance should be determined, and quantify the influences of the main parameters like effective depth, shear slenderness, compressive strength of concrete, longitudinal reinforcement ratio and tension yield stress of reinforcement in different ways. In order to quantify the level of safety in Eurocode 2 and in fib MC 2010, their design results are compared with the test results of the series of footings tested in completely realistic boundary conditions in terms of the subgrade soil. Besides the performed tests results, the analysis of the other investigations of the footing punching rested on the real soil is also included. Thus was obtained the answer to the question how individual characteristics of the footings and of the soil affect the punching bearing resistance and how accurately Eurocode 2 and fib MC 2010 predict the bearing capacity of the tested column footings. At the end, based on the test results and on the tests of others, and on and performed numerical analyses, a possible modification of Eurocode 2 in the field of reinforced concrete footing was proposed.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
