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Obed Cortés-Aburto,José-Alfredo Hernández-Pérez,Rafael Rojas-Rodríguez 대한기계학회 2018 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.32 No.8
We performed a performance assessment of a recently developed method: Lévy flight particle swarm optimization. This method, which was developed for optimization problems, has shown good results. There is not an application to inverse problems. Now, it is applied for inverse heat transfer, and results are good enough. In particular, a parameter called “limit” is analyzed for different values (from 10 to 150). It shows that performance of the method for estimating parameters in inverse problems is affected by this parameter. When limit reaches a value of 80, ordinary least squares norm and consuming time begin to exhibit better results.
Aurelio Romero-Castro,Ismael León-Rivera,Laura Citlalli Ávila-Rojas,Gabriel Navarrete-Vázquez,Alejandro Nieto-Rodríguez 대한약학회 2011 Archives of Pharmacal Research Vol.34 No.2
In this study we report the synthesis and preliminary evaluation of a series of six 2-aryl-5(6)-nitro-1H-benzimidazole derivatives (1-6) as potential anticancer agents. Cytotoxicity was evaluated against seven human neoplastic cell lines using the MTT assay. Compound 6 [2-(4-chloro-3-nitrophenyl)-5(6)-nitro-1H-benzimidazole] was the most active of the series, showing an IC_50 of 28 nM against the A549 cell line. This compound displayed a selective in vitro cytotoxic activity index (>700) in non neoplastic HACAT cells (IC_50 = 22.2 μM). Compounds 3 and 6 induce arrest in the S phase of the cell cycle, and compounds 1-6 induce apoptosis in the K562 cell line. Compound 6 induces poly (ADP-ribose) polymerase (PARP) inhibition activity as a potential mechanism of action. These results suggest that compound 6 could be a potent anticancer agent. Compound 3 displayed the best inhibitory activity against PARP with an IC_50 value of 0.05 μM, compared to the activity shown by the positive control 3-aminobenzamide (IC_50 = 28.5 μM).
Recent introduction of Gracilaria parvispora (Gracilariales, Rhodophyta) in Baja California, Mexico
Garcí,a-Rodrí,guez, Luis Daniel,Riosmena-Rodrí,guez, Rafael,Kim, Su Yeon,Ló,pez-Meyer, Melina,Orduñ,a-Rojas, Javier,Ló,pez-Vivas, Juan Manuel,Boo, Sung Min Walter de Gruyter GmbH 2013 Botanica marina Vol.56 No.2