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Teaching Research Methods to Young Neurologists: The Erice International Courses
Walter A. Rocca 대한파킨슨병및이상운동질환학회 2022 Journal Of Movement Disorders Vol.15 No.3
Clinical and epidemiologic research in neurology, as in anyother field of medicine, relies on scientific thinking and rigorousresearch methods. Therefore, young neurologists seeking todevelop a career in clinical research are in need of appropriatetraining and mentoring.
Cacciaguerra Laura,Rocca Maria A.,Filippi Massimo 대한영상의학회 2023 Korean Journal of Radiology Vol.24 No.12
Magnetic resonance imaging (MRI) has been extensively applied in the study of multiple sclerosis (MS), substantially contributing to diagnosis, differential diagnosis, and disease monitoring. MRI studies have significantly contributed to the understanding of MS through the characterization of typical radiological features and their clinical or prognostic implications using conventional MRI pulse sequences and further with the application of advanced imaging techniques sensitive to microstructural damage. Interpretation of results has often been validated by MRI-pathology studies. However, the application of MRI techniques in the study of neuromyelitis optica spectrum disorders (NMOSD) remains an emerging field, and MRI studies have focused on radiological correlates of NMOSD and its pathophysiology to aid in diagnosis, improve monitoring, and identify relevant prognostic factors. In this review, we discuss the main contributions of MRI to the understanding of MS and NMOSD, focusing on the most novel discoveries to clarify differences in the pathophysiology of focal inflammation initiation and perpetuation, involvement of normal-appearing tissue, potential entry routes of pathogenic elements into the CNS, and existence of primary or secondary mechanisms of neurodegeneration.
Interventional Treatment for Stroke Prevention
Carola Gianni,Domenico G. Della Rocca,Andrea Natale,Rodney P. Horton 대한심장학회 2021 Korean Circulation Journal Vol.51 No.1
Closure of the left atrial appendage using percutaneous transcatheter occlusion devices is used for stroke prevention as an alternative for patients with a high risk or contraindications for long-term oral anticoagulation use. Herein, we will discuss the practical aspects of five among the available devices used for interventional left atrial appendage occlusion: Watchman, Amulet, WaveCrest, LAmbre, and Lariat.
Effects of Bauhinia forficata Link Tea on Lipid Profile in Diabetic Patients
Pia Cordova Mariangel,Marcia Avello Lorca,Felipe Morales Leon,Pola Ferna´ndez Rocca,Lorenzo Villa Zapata,Edgar Pastene Navarrete 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.3
Twenty-five type 2 diabetic volunteer patients (mean age 62 years) were recruited in a quasi-experimental study without a control group to evaluate the effects of Bauhinia forficata Link tea on lipid profiles. Participants drank the tea of 0.4% B. forficata in 200 mL of water twice a day for 3 months. The clinical parameters evaluated were cholesterol and triglycerides (mg/dL), total cholesterol (mg/dL), weight (kg), postprandial glycemia (mg/dL), and glycosylated hemoglobin (HbA1c). For the study period, statistically significant decreases in triglycerides and total cholesterol levels of 48 and 17 mg/dL, respectively, were observed. B. forficata tea as a complementary therapy in type 2 diabetic patients may help to reduce the levels of some lipid profile parameters. Further studies are suggested to evaluate the effect of the tea.
Complications and local relapse after intraoperative low-voltage X-ray radiotherapy in breast cancer
Ana Alicia Tejera Hernández,Víctor Manuel Vega Benítez,Juan Carlos Rocca Cardenas,Neith Ortega Pérez,Nieves Rodriguez Ibarria,Juan Carlos Díaz Chico,Juan José García-Granados Alayón,Pedro Pérez Correa 대한외과학회 2020 Annals of Surgical Treatment and Research(ASRT) Vol.98 No.6
Purpose: To study those factors that influence the occurrence of surgical complications and local relapse in patients intervened for breast cancer and receiving intraoperative radiotherapy. Methods: Observational study on patients intervened for breast cancer with conservative surgery and intraoperative radiotherapy with low-voltage X-ray energy source (INTRABEAM), from 2015 to 2017 with 24 months minimum followup. Variables possibly associated to the occurrence of postoperative complications were analyzed with the Student t-test and the Fisher exact test; P < 0.05 considered significant. Subsequently, the construction of multiple multivariate analysis models began, thus building a logistic regression analysis using the IBM SPSS Statistics ver. 23 software. Local relapse was described. Results: The study included 102 patients, mean age of 61.2 years; mean global size of tumor, 12.2 mm. Complications occurred in 29.4%. Fibrosis was the most frequently observed complication, followed by postoperative seroma. Using a 45 mm or larger applicator were significantly associated with the occurrence of complications. Tumor size 2 cm or larger and reintervention showed borderline significant association. Only one case of local relapse was observed. Conclusion: Certain factors may increase the risk of complication after the use of intraoperative radiotherapy. Using external complementary radiotherapy does not seem to increase the rate of complications. Select patients and the involvement of a multidisciplinary team are essential for achieving good results