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Lotte E. de Groot-de Laat,Jackie McGhie,Ben Ren,René Frowijn,Frans B. Oei,Marcel L. Geleijnse 한국심초음파학회 2019 Journal of Cardiovascular Imaging (J Cardiovasc Im Vol.27 No.3
In this report, we provide an overview of a new, updated echocardiographic classification of mitral regurgitation mechanisms to provide a more comprehensive and detailed assessment of mitral valve disorders. This is relevant to modern mitral valve repair techniques, with special attention to the added value of 3D-echocardiography.
Improving Interfacial Interactions of CF/PEEK Composites with Sulfonated Polyether Sulfone
Tianning Ren,Guangming Zhu,Xiaoming Ren,Renjie Tian,Ben Li 한국섬유공학회 2021 Fibers and polymers Vol.22 No.1
Due to the limitation of surface inertness and wettability of carbon fibers (CF), the adhesion between Poly(etherether-ketone) (PEEK) resin matrix and CF is poor, which reduces the mechanical properties of CF/PEEK composites. Inorder to improve the interfacial performance between PEEK matrix and carbon fiber fabric, sulfonated-polyether-sulfone (s-PSF) was coated as a sizing agent on the surface of the carbon fiber to construct CF/PEEK composite interface. On one hand,the formation of hydrogen bonds between s-PSF and activated CF increases the adhesion between s-PSF and fibers. On theother hand, Good compatibility between S-PSF and PEEK, which improves the interface performance between PEEK andCF. The results showed that the mechanical properties and interface properties of CF/PEEK composite prepared by modifiedCF were improved to some extent. The flexural strength, flexural modulus, impact strength and interlaminar shear strength ofthe materials were increased by 57.5 %, 16.7 %, 44.2 % and 39.7 %, respectively. By introducing s-PSF as sizing agent intoCF/PEEK composite interface, the comprehensive properties of the material were effectively improved.
Wang, Li,Ren, Yi,Gao, Yaozong,Tang, Zhen,Chen, Ken-Chung,Li, Jianfu,Shen, Steve G F,Yan, Jin,Lee, Philip K M,Chow, Ben,Xia, James J,Shen, Dinggang Published for the American Association of Physicis 2015 Medical physics Vol.42 No.10
<P>A significant number of patients suffer from craniomaxillofacial (CMF) deformity and require CMF surgery in the United States. The success of CMF surgery depends on not only the surgical techniques but also an accurate surgical planning. However, surgical planning for CMF surgery is challenging due to the absence of a patient-specific reference model. Currently, the outcome of the surgery is often subjective and highly dependent on surgeon's experience. In this paper, the authors present an automatic method to estimate an anatomically correct reference shape of jaws for orthognathic surgery, a common type of CMF surgery.</P>
Surgical management of inflammatory bowel disease in China: a systematic review of two decades
( Qiao Yu ),( Ren Mao ),( Lei Lian ),( Siew Chien Ng ),( Shenghong Zhang ),( Zhihui Chen ),( Yanyan Zhang ),( Yun Qiu ),( Baili Chen ),( Yao He ),( Zhirong Zeng ),( Shomron Ben-horin ),( Xinming Song 대한장연구학회 2016 Intestinal Research Vol.14 No.4
Background/Aims: The past decades have seen increasing incidence and prevalence of inflammatory bowel disease (IBD) in China. This article aimed to summarize the current status and characteristics of surgical management for IBD in China. Methods: We searched PubMed, Embase, and Chinese databases from January 1, 1990 to July 1, 2014 for all relevant studies on the surgical treatment IBD in China. Eligible studies with sufficient defined variables were further reviewed for primary and secondary outcome measures. Results: A total of 74 studies comprising 2,007 subjects with Crohn`s disease (CD) and 1,085 subjects with ulcerative colitis (UC) were included. The percentage of CD patients misdiagnosed before surgery, including misdiagnosis as appendicitis or UC, was 50.8%±30.9% (578/1,268). The overall postoperative complication rate was 22.3%±13.0% (267/1,501). For studies of UC, the overall postoperative complication rate was 22.2%±27.9% (176/725). In large research centers (n>50 surgical cases), the rates of emergency operations for CD (P =0.032) and in-hospital mortalities resulting from both CD and UC were much lower than those in smaller research centers (n≤50 surgical cases) (P =0.026 and P <0.001, respectively). Regarding the changes in CD and UC surgery over time, postoperative complications (P =0.045 for CD; P =0.020 for UC) and postoperative in-hospital mortality (P =0.0002 for CD; P =0.0160 for UC) both significantly improved after the year 2010. Conclusions: The surgical management of IBD in China has improved over time. However, the rates of misdiagnosis and postoperative complications over the past two decades have remained high. Large research centers were found to have relatively better capacity for surgical management than the smaller ones. Higher quality prospective studies are needed in China. (Intest Res 2016;14:322-332)
Dou, Xue,Wang, Ren-Ben,Meng, Xiang-Jiao,Yan, Hong-Jiang,Jiang, Shu-Mei,Zhu, Kun-Li,Xu, Xiao-Qing,Chen, Dong,Song, Xian-Rang,Mu, Dian-Bin Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.2
Objective: The purpose of this study was to examine the role of programmed cell death 4 (PDCD4) expression in predicting tumor response to neoadjuvant chemoradiotherapy and outcomes for patients with locally advanced rectal cancer. Methods: Clinicopathological factors and expression of PDCD4 were evaluated in 92 patients with LARC treated with nCRT. After the completion of therapy, 4 cases achieved clinical complete response (cCR), and thus the remaining 88 patients underwent a standardized total mesorectal excision procedure. There were 38 patients (41.3%) with a good response (TRG 3-4) and 54 (58.7%) with a poor one (TRG 0-2). Results: Immunohistochemical staining analyses showed that patients with high expression of PDCD4 were more sensitive to nCRT than those with low PDCD4 expression (P=0.02). High PDCD4 expression before nCRT and good response (TRG3-4) were significantly associated with improved 5-year disease-free survival and 5-year overall survival (P<0.05). Multivariate analysis demonstrated that the pretreatment PDCD4 expression was an independent prognostic factor. Conclusion: Our study demonstrated that high expression of PDCD4 protein is a useful predictive factor for good tumor response to nCRT and good outcomes in patients with LARC.
Dou, Xue,Wang, Ren-Ben,Yan, Hong-Jiang,Jiang, Shu-Mei,Meng, Xiang-Jiao,Zhu, Kun-Li,Xu, Xiao-Qing,Mu, Dian-Bin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Objective: The objective of this study was to identify clinical predictive factors for tumor response after neoadjuvant chemoradiotherapy (nCRT) in locally advanced rectal cancer (LARC). Methods: All factors were evaluated in 88 patients with LARC treated with nCRT. After a long period of 4-8 weeks of chemoradiotherapy, 3 patients achieved clinical complete response (cCR) and thus aggressive surgery was avoided, and the remaining 85 patients underwent a curative-intent operation. The response to nCRT was evaluated by tumor regression grade (TRG) system. Results: There were 32 patients (36.4%) with good tumor regression (TRG 3-4) and 56 (63.6%) with poor tumor regression (TRG 0-2). Lymphocyte counts and ratios were higher in good response cases (P=0.01, 0.03, respectively) while neutrophil ratios and N/L ratios were higher in poor response cases (P=0.04, 0.02, respectively). High lymphocyte ratios before nCRT and good tumor regression (TRG3-4) were significantly associated with improved 5-year disease-free survival (P<0.05). Pretreatment nodal status was also significantly associated with 5-year disease-free survival and 5-year overall survival (P<0.05). Multivariate analysis confirmed that the pretreatment lymphocyte ratio and lymph nodal status were independent prognostic factors. Conclusion: Our study suggested that LARC patients with high lymphocyte ratios before nCRT would have good tumor response and high 5-year DFS and OS.
Zhang, Hai-Qin,Wang, Ren-Ben,Yan, Hong-Jiang,Zhao, Wei,Zhu, Kun-Li,Jiang, Shu-Mei,Hu, Xi-Gang,Yu, Jin-Ming Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.1
Purpose: To evaluate the prognostic value of serum CYFRA21-1, CEA and hemoglobin levels regarding long-term survival of patients with esophageal squamous cell carcinoma (ESCC) treated with concurrent chemoradiotherapy (CRT). Methods: Age, gender, Karnofsky Performance Status (KPS), tumor location, tumor length, T stage, N stage and serum hemoglobin, and CYFRA21-1 and CEA levels before concurrent CRT were retrospectively investigated and related to outcome in 113 patients receiving 5-fluorouracil and cisplatin combined with radiotherapy for ESCC. The Kaplan-Meier method was used to analyze prognosis, the log-rank to compare groups, the Cox proportional hazards model for multivariate analysis, and ROC curve analysis for assessment of predictive performance of biologic markers. Results: The median survival time was 20.1 months and the 1-, 2-, 3-, 5- year overall survival rates were 66.4%, 43.4%, 31.9% and 15.0%, respectively. Univariate analysis showed that factors associated with prognosis were KPS, tumor length, T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level. Multivariate analysis showed T-stage, N-stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis. By ROC curve, CYFRA21-1 and hemoglobin showed better predictive performance for OS than CEA (AUC= 0.791, 0.704, 0.545; P=0.000, 0.000, 0.409). Conclusions: Of all clinicopathological and molecular factors, T stage, N stage, hemoglobin, CYFRA21-1 and CEA level were independent predictors of prognosis for patients with ESCC treated with concurrent CRT. Among biomarkers, CYFRA21-1 and hemoglobin may have a better predictive potential than CEA for long-term outcomes.
Xiaoyun Yi,Yuwei Ren,Li Qi,Ben Niu,Yixian Fang 제어·로봇·시스템학회 2023 International Journal of Control, Automation, and Vol.21 No.4
In this paper, we investigate the problem of weight estimation and secure control for discrete stochastic distribution control (SDC) systems under sparse sensor attacks. Firstly, a Luenberger observer is designed for the linear SDC systems to perform the weight estimation under sparse sensor attacks. Then, a generalized proportionalintegral (PI) tracking control strategy is proposed for the linear B-spline model. Furthermore, the tracking problem for output probability density functions (PDFs) is implemented, and the designed controller ensures that the closedloop system is stable. Finally, the simulation results show the effectiveness of the proposed method.