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WNT Signaling in Lung Repair and Regeneration
Raslan, Ahmed A.,Yoon, Jeong Kyo Korean Society for Molecular and Cellular Biology 2020 Molecules and cells Vol.43 No.9
The lung has a vital function in gas exchange between the blood and the external atmosphere. It also has a critical role in the immune defense against external pathogens and environmental factors. While the lung is classified as a relatively quiescent organ with little homeostatic turnover, it shows robust regenerative capacity in response to injury, mediated by the resident stem/progenitor cells. During regeneration, regionally distinct epithelial cell populations with specific functions are generated from several different types of stem/progenitor cells localized within four histologically distinguished regions: trachea, bronchi, bronchioles, and alveoli. WNT signaling is one of the key signaling pathways involved in regulating many types of stem/progenitor cells in various organs. In addition to its developmental role in the embryonic and fetal lung, WNT signaling is critical for lung homeostasis and regeneration. In this minireview, we summarize and discuss recent advances in the understanding of the role of WNT signaling in lung regeneration with an emphasis on stem/progenitor cells.
R-spondins: Multi-mode WNT signaling regulators in adult stem cells
Raslan, Ahmed A.,Yoon, Jeong Kyo Elsevier 2019 The international journal of biochemistry & cell b Vol.106 No.-
<P><B>Abstract</B></P> <P>R-spondins (RSPOs) are secreted cysteine-rich glycoproteins that belong to a superfamily of <U>t</U>hrombo<U>s</U>pondin type 1 <U>r</U>epeat-containing proteins. RSPOs together with WNT proteins potentiate canonical WNT/β-catenin signaling activity. Over the last several years, the understanding of the regulatory mechanisms and functional roles of RSPOs in many biological contexts has increased. Particularly, because a leucine-rich repeat containing G protein-coupled receptor 5 (LGR5), a stem cell marker originally identified as a marker for intestinal stem cells, and two closely related proteins, LGR4 and LGR6, were identified as cognate receptors for RSPOs, significant research progress has been made in understanding the functional roles of RSPO/LGR signaling in stem cell biology. Given the crucial roles of canonical WNT signaling in self-renewal and differentiation of various types of stem cells, examination of RSPO function and underlying mechanism in these stem cells has provided new insight into the regulatory roles of WNT signaling in stem cell behavior. In this review, we summarize and discuss recent advances in the understanding of the signaling mechanism and roles of RSPOs in different stem cell contexts.</P>
Some New Hilbert Type Inequalities
Salem, Shaban Raslan Department of Mathematics 2006 Kyungpook mathematical journal Vol.46 No.1
In this paper, we obtain some inequalities similar to Hilbert type. Some new inequalities are also given.
Some New Hilbert Type Inequalities
SALEM, SHABAN RASLAN 대한수학회 2006 Kyungpook mathematical journal Vol.46 No.1
In this paper, we obtain some inequalities similar to Hilbert type. Some new inequalities are also given.
Tackling neurodegenerative diseases: animal models of Alzheimer’s disease and Parkinson’s disease
Ahmed A. Raslan,기윤 한국유전학회 2013 Genes & Genomics Vol.35 No.4
Our ageing society is confronted with a dramatic increase in incidence of age-related neurodegenerative diseases; biomedical research leading to novel therapeutic strategies is crucial to address this problem. Animal models of neurodegenerative conditions are invaluable in improving our understanding of the molecular basis of pathology, potentially revealing novel targets for intervention. Here, we review transgenic animal models of Alzheimer’s and Parkinson’s disease reported in mice,zebrafish, Caenorhabditis elegans and Drosophila melanogaster. This information will enable researchers to compare different animal models targeting disease-associated molecules by genomic engineering and to facilitate the development of novel animal models for any particular study, depending on the ultimate research goals.
Consonant Clusters in a Northern Jordanian Arabic Dialect
Mohammed, El-Badarin,Raslan, Bani-Yasin 서울대학교 어학연구소 1993 語學硏究 Vol.29 No.2
In this research, we present a full description of the consonant clusters in a Northern Jordanian Arabic Dialect (NJA) by providing a list of the consonant clusters that are permissible and existing and a description of their phonological distribution. We also offer a description of the occurrence as well as the structure and composition of word-initial, word-medial, and word-final clusters.