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HYPERSURFACES IN 𝕊<sup>4</sup> THAT ARE OF L<sub>k</sub>-2-TYPE
Lucas, Pascual,Ramirez-Ospina, Hector-Fabian Korean Mathematical Society 2016 대한수학회보 Vol.53 No.3
In this paper we begin the study of $L_k$-2-type hypersurfaces of a hypersphere ${\mathbb{S}}^{n+1}{\subset}{\mathbb{R}}^{n+2}$ for $k{\geq}1$ Let ${\psi}:M^3{\rightarrow}{\mathbb{S}}^4$ be an orientable $H_k$-hypersurface, which is not an open portion of a hypersphere. Then $M^3$ is of $L_k$-2-type if and only if $M^3$ is a Clifford tori ${\mathbb{S}}^1(r_1){\times}{\mathbb{S}}^2(r_2)$, $r^2_1+r^2_2=1$, for appropriate radii, or a tube $T^r(V^2)$ of appropriate constant radius r around the Veronese embedding of the real projective plane ${\mathbb{R}}P^2({\sqrt{3}})$.
Silencing the cleavage factor CFIm25 as a new strategy to control Entamoeba histolytica parasite
Juan David Ospina-Villa,Nancy Guillén,Ce´sar Lo´pez-Camarillo,Jacqueline Soto-Sanchez,Esther Ramirez-Moreno,Raul Garcia-Vazquez,Carlos A. Castañon-Sanchez,Abigail Betanzos,Laurence A.Marchat 한국미생물학회 2017 The journal of microbiology Vol.55 No.10
The 25 kDa subunit of the Clevage Factor Im (CFIm25) is an essential factor for messenger RNA polyadenylation in human cells. Therefore, here we investigated whether the homologous protein of Entamoeba histolytica, the protozoan responsible for human amoebiasis, might be considered as a biochemical target for parasite control. Trophozoites were cultured with bacterial double-stranded RNA molecules targeting the EhCFIm25 gene, and inhibition of mRNA and protein expression was confirmed by RT-PCR and Western blot assays, respectively. EhCFIm25 silencing was associated with a significant acceleration of cell proliferation and cell death. Moreover, trophozoites appeared as larger and multinucleated cells. These morphological changes were accompanied by a reduced mobility, and erythrophagocytosis was significantly diminished. Lastly, the knockdown of EhCFIm25 affected the poly(A) site selection in two reporter genes and revealed that EhCFIm25 stimulates the utilization of downstream poly(A) sites in E. histolytica mRNA. Overall, our data confirm that targeting the polyadenylation process represents an interesting strategy for controlling parasites, including E. histolytica. To our best knowledge, the present study is the first to have revealed the relevance of the cleavage factor CFIm25 as a biochemical target in parasites.
Lopera Alex A.,Bezzon Vinicius D. N.,Ospina Victoria,Higuita-Castro Jorge L.,Ramirez Francisco J.,Ferraz Humberto G.,Orlando Marcos T. A.,Paucar Carlos G.,Robledo Sara M.,Garcia Claudia P. 한국세라믹학회 2023 한국세라믹학회지 Vol.60 No.1
Many efforts in the tissue engineering field have been devoted to producing biomedical devices with several physico-chemical properties that could promote an increase in the quality of therapeutic treatments. Thus, 3D printing is an efficient method which facilitates manufacturing high quality products to be used as medical devices. However, high-performance materials are required for obtaining products that are able to be 3D printed to attend the biomedical concerns. In this work, fused PLA-calcium phosphate-tobramycin-based filaments with antimicrobial properties were produced. X-ray powder diffraction, Fourier transform infrared spectroscopy and thermal analysis were performed to characterize the pure compounds as well as the composite filaments, revealing that the drug is preserved into the filaments by the implemented methodology, even after the hot extrusion procedure. The filaments and the printed pieces presented great antimicrobial effect and a controlled-release profile was also observed by the drug-release assays for the filaments produced, thereby indicating this material as a promising candidate to be used for implantable medical devices in the future.