Correction to: Sustainability-Focused Multi-objective Optimization of a Turning process

Iván La Fé Perdomo,Ramón Quiza,Dries Haeseldonckx,Marcelino Rivas 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.1

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Assessment of buccal bone thickness of aesthetic maxillary region: a conebeam computed tomography study

Ramón Fuentes,Tania Flores,Pablo Navarro,Carlos Salamanca,Víctor Beltrán,Eduardo Borie 대한치주과학회 2015 Journal of Periodontal & Implant Science Vol.45 No.5

Purpose: The aim of this study was to analyze the anatomical dimensions of the buccal bone walls of the aesthetic maxillary region for immediate implant placement, based upon cone-beam computed tomography (CBCT) scans in a sample of adult patients. Methods: Two calibrated examiners analyzed a sample of 50 CBCT scans, performing mor¬phometric analyses of both incisors and canines on the left and right sides. Subsequently, in the sagittal view, a line was traced through the major axis of the selected tooth. Then, a second line (E) was traced from the buccal to the palatal wall at the level of the observed bone ridges. The heights of the buccal and palatal bone ridges were determined at the ma¬jor axis of the tooth. The buccal bone thickness was measured across five lines. The first was at the level of line E. The second was at the most apical point of the tooth, and the other three lines were equidistant between the apical and the cervical lines, and parallel to them. Statistical analysis was performed with a significance level of P≤0.05 for the bone thick¬ness means and standard deviations per tooth and patient for the five lines at varying depths. Results: The means of the buccal wall thicknesses in the central incisors, lateral incisors and canines were 1.14±0.65 mm, 0.95±0.67 mm and 1.15±0.68 mm, respectively. Additionally, only on the left side were significant differences in some measurements of buccal bone thickness observed according to age and gender. However, age and gender did not show significant differences in heights between the palatal and buccal plates. In a few cases, the buccal wall had a greater height than the palatal wall. Conclusions: Less than 10% of sites showed more than a 2-mm thickness of the buccal bone wall, with the exception of the central incisor region, wherein 14.4% of cases were ≥2 mm.

Subclinical versus advanced forms of alcohol-related liver disease: Need for early detection

Concepción Gómez-Medina,Luma Melo,David Martí-Aguado,Ramón Bataller 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.1

Alcohol-related liver disease (ALD) consists of a wide spectrum of clinical manifestations and pathological features, ranging from asymptomatic patients to decompensated cirrhosis and hepatocellular carcinoma. Patients with heavy alcohol intake and advanced fibrosis often develop a subacute form of liver failure called alcohol-induced hepatitis (AH). Globally, most patients with ALD are identified at late stages of the disease, limiting therapeutic interventions. Thus, there is a need for early detection of ALD patients, which is lacking in most countries. The identification of alcohol misuse is hampered by the existence of alcohol underreporting by many patients. There are useful biomarkers that can detect recent alcohol use. Moreover, there are several non-invasive techniques to assess the presence of advanced fibrosis among patients with alcohol misuse, which could identify patients at high risk of liver related events or early death. In this review, we discuss differences between early stages of ALD and AH as the cornerstone of advanced forms. A global overview of epidemiological, anthropometric, clinical, analytical, histological, and molecular differences is summarized in this article. We propose that campaigns aimed at identifying patients with subclinical forms can prevent the development of life-threatening forms.

Antimicrobial Activity of Northwestern Mexican Plants Against Helicobacter pylori

Ramón E. Robles-Zepeda,Carlos A. Velázquez-Contreras,Adriana Garibay-Escobar,Juan C. Gálvez-Ruiz,Eduardo Ruiz-Bustos 한국식품영양과학회 2011 Journal of medicinal food Vol.14 No.10

Helicobacter pylori is the major etiologic agent of such gastric disorders as chronic active gastritis and gastric carcinoma. Over the past few years, the appearance of antibiotic-resistant bacteria has led to the development of better treatments, such as the use of natural products. This study evaluated the anti–H. pylori activity of 17 Mexican plants used mainly in the northwestern part of Mexico (Sonora) for the empirical treatment of gastrointestinal disorders. The anti–H. pylori activity of methanolic extracts of the plants was determined by using the broth microdilution method. The 50% minimum inhibitory concentrations ranged from less than 200 to 400 μg/mL for Castella tortuosa, Amphipterygium adstringens, Ibervillea sonorae, Pscalium decompositum, Krameria erecta, Selaginella lepidophylla, Pimpinella anisum, Marrubium vulgare, Ambrosia confertiflora, and Couterea latiflora and were greater than 800 μg/mL for Byophyllum pinnatum, Tecoma stans linnaeus, Kohleria deppena, Jatropha cuneata, Chenopodium ambrosoides, and Taxodium macronatum. Only Equisetum gigantum showed no activity against H. pylori. This study suggests the important role that these plants may have in the treatment of gastrointestinal disorders caused by H. pylori. The findings set the groundwork for further characterization and elucidation of the active compounds responsible for such activity.

Systematic Design of High-Resolution High-Frequency Cascade Continuous-Time Sigma-Delta Modulators

Ramón Tortosa,Rafael Castro-López,Elisenda Roca,Ángel Rodríguez-Vázquez,F.V. Fernández 한국전자통신연구원 2008 ETRI Journal Vol.30 No.4

This paper introduces a systematic top-down and bottom-up design methodology to assist the designer in the implementation of continuous-time (CT) cascade sigmadelta (ΣΔ) modulators. The salient features of this methodology are (a) flexible behavioral modeling for optimum accuracy-efficiency trade-offs at different stages of the top-down synthesis process, (b) direct synthesis in the continuous-time domain for minimum circuit complexity and sensitivity, (c) mixed knowledge-based and optimization-based architectural exploration and specification transmission for enhanced circuit performance, and (d) use of Pareto-optimal fronts of building blocks to reduce re-design iterations. The applicability of this methodology will be illustrated via the design of a 12-bit 20 MHz CT ΣΔ modulator in a 1.2 V 130 nm CMOS technology.

Parametric analysis based on energy and exergy balances of a condensing boiler

Rubén Arévalo-Ramírez,Javier Aros-Taglioni 대한기계학회 2023 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.37 No.3

Condensing boilers are highly efficient equipment increasingly used to heat water for heating or industrial use, characterized by taking advantage of the residual heat of the combustion gases, including the condensation latent heat of water vapor. The present work analyzes important aspects to optimize the design and operation of this type of equipment from the energy and exergy point of view, specifically, the effect that changes in fuel, water inlet temperature (20-70 °C), excess air used in combustion (5-100 %) and relative humidity of the air (10-100 %), have on their energy and exergy efficiencies. For this purpose, the energy and exergy balance equations for the reactive and heat exchange processes that occur within it were implemented and solved using the computational program engineering equation solver (EES). The model was validated by comparing its results with the efficiency curve of a commercial condensing boiler model. The results show an important effect of the fuel type on the operating ranges in condensing and non-condensing modes and on the energy efficiency values, finding that the technology is widely justified when used with natural gas, and not so much with the other fuels analyzed. Likewise, a favorable effect of the reduction of excess air for combustion on energy efficiency can be seen, which is why it is advisable to operate this equipment with the least possible amount of air that guarantees good combustion. On the other hand, exergy efficiency has the highest values using natural gas, and benefits from a higher water return temperature and lower excess air. The greatest irreversibilities are found in the main coil and the combustion chamber.

Sustainability-Focused Multi-Objective Optimization of a Turning process

Iván La Fé Perdomo,Ramón Quiza,Dries Haeseldonckx,Marcelino Rivas 한국정밀공학회 2020 International Journal of Precision Engineering and Vol.7 No.5

Using optimized cutting parameters can represent a key contribution for obtaining sustainable machining processes. This study presents the multi-objective optimization of the multi-passes cylindrical turning, where conflicting goals are simultaneously considered: economic, environmental and social sustainability. The first costs. The environmental impact was taking into account through the carbon dioxide emission. Finally, the key issue in the social sustainability was the operational safety. Also, the constraints resulting from the technical aspects of the turning process were also considered. From the decision-making point of view, an a posteriori approach was used, where the optimization process, which gives a Pareto front, is followed by the selection of the most convenient solution, depending on the specific workshop conditions. The nonsorting genetic algorithm (NSGA-II) was used as optimization heuristic. The main contribution of the paper is the use of a tridimensional Pareto front for selecting the best cutting conditions, by considering the three pillars of the sustainability.

Challenges managing COVID vaccine-induced immune thrombotic thrombocytopenia in low-middle income countries

Céleo Ramírez,Ramón Jeremías Soto Hernández,Reyna M. Durón 대한백신학회 2021 Clinical and Experimental Vaccine Research Vol.10 No.3

Vaccine-induced immune thrombotic thrombocytopenia (VITT) is an extremely rare complication associated with the adenovirus-vectored coronavirus disease 2019 (COVID-19) ChAdOx1 nCoV-19 (AZD1222) vaccine. It is characterized by venous thrombosis, mainly cerebral venous sinus thrombosis, moderate to severe thrombocytopenia, and rarely, thrombosis in cerebral arteries. This syndrome is similar to the heparin-induced thrombocytopenia and presents mostly among women aged 18–55 years, without previous exposure to heparin, usually 5 to 20 days after vaccination. However, cases have been reported in men and older adults [1-4]. Unlike COVID-19, this adverse effect might not represent a public health problem in itself, but it is already causing vaccine hesitancy in population groups susceptible to severe COVID-19, and poses a challenge in low resource settings [5]. The first case reports showed evidence that VITT has a mortality around 40% [1-3]. So far, cases have been reported and treated in hospitals of highly developed countries with first-rate health systems that facilitate early detection and treatment of this severe adverse event. VITT is confirmed by using PF4-dependent enzyme-linked immunosorbent assay (ELISA) assay, which allows the differential diagnosis from other causes of thrombosis in patients with a history of ChAdOx1 nCoV-19 vaccination in previous days. However, it is likely that a large number of hospitals in many low-middle income countries do not have approved PF4-dependent ELISA assays for accurate diagnosis, nor immunoglobulins, glucocorticoids, and non-heparin anticoagulants needed for the treatment of this condition [1-4]. In times of this COVID-19 pandemic and precision medicine, problems and solutions should be considered global. Policies related to COVID-19 need to be addressed considering varied public health and socioeconomic contexts. The ChAdOx1 nCoV-19 vaccine is one of the most used vaccines in low-middle income countries, where special testing to confirm VITT is not widely available. Therefore, real figures are unknown, and underreporting of this adverse effect should be considered. Patient information, government, and hospital preparedness in these countries are needed to diagnose and manage VITT adequately, and to reduce morbidity and mortality from this complication. These strategies will have a positive impact on public acceptance and adherence to COVID vaccination.

Metabolites in cultured cells of Ibervillea sonorae (S. Watson) Greene display increased hypoglycemic activity compared to that seen in plant roots

Ilse-Yazmín Arciniega-Carreón,María-Guadalupe Ramírez-Sotelo,Ana C. Ramos-Valdivia,Carlos Edmundo Salas,Arturo Ortega,Carmen Oliver-Salvador 한국원예학회 2020 Horticulture, Environment, and Biotechnology Vol.61 No.6

Ibervillea sonorae (S. Watson) Greene, (huereque) is an endemic shrub whose roots are used in traditional medicine to treatdiabetes. Here, we establish cell cultures of I. sonorae to evaluate the presence of antidiabetic metabolites. Stem and rootssections were incubated on media with diff erent concentrations of growth regulators to induce calli. Using B5 mediumcontaining 25 g L −1 sucrose, 150 mg L −1 ascorbic acid, 6 g L −1 agar–agar, supplemented with 0.5 mg L −1 α-naphthaleneaceticacid, 0.5 mg L −1 benzyladenine and 1 mg L −1 indole-3-acetic acid, 95% calli induction was attained. Flavonoids andphenols in I. sonorae cultured cell suspension were investigated. The methanol extracts exhibited antioxidant activity thatwas attributed to phenolic compounds. These extracts stimulated glucose uptake more effi caciously than I. sonorae plantroots. This study demonstrates that in vitro cultured cells stand as a good option for production of hypoglycemic metabolites.

Rescue intubation via i-gel® device in Pierre-Robin sequence

Rebollar Ramón Eizaga,Rodríguez Elena Borreiros,Fernández Ana Mercedes Martínez-Almendros,Hierro Paula Lozano,Morera Luis Miguel Torres 대한마취통증의학회 2021 Korean Journal of Anesthesiology Vol.74 No.3

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