의료기기 QI 활동 개선방안에 대한 연구

강훈희,주라형,김종순,김서확,허수진 한국의료QA학회 1998 한국의료질향상학회지 Vol.5 No.2

Background : Medical equipments take a very important role in diagnosis and treatment of disease in modern medicine and effective maintenance of the equipments is a necessory to provide a good healthcare to the public. After developing a new QC program for effective maintenance of medical equipments and practicing it for a year, we report the results of the new program. Methods : The maintenance data of 9 equipments in 8 categories including a CT Scanner were analyzed with regard to the parts responsible for most frequent failure and cause of the failure. After learning the most frequent failure part and cause of the failure, we developed a new QC program that emphasizes preventive maintenance of the most frequent failure part. We compared the number of failure per year and active rate of each equipment before, and after the adoption of the new QC program. Results : The average number of failure per year per equipment was 20.7 before and it decreased by 43% to 11.9 after adoption of the new QC program. The average active rate of the equipments was 92.6% before and it increased by 3.2% to 95.8% after adoption of the new program. Conclusions : The practice of the new QC program appears very useful as it decreased the failure rate and increased the active rate of the equipments.

정신분열병 환자에서 얼굴 영상의 작동기억 장애 : 기능자기공명영상연구

이창욱,김태석,주라형,박주미,박여진,김종진,전신수,배치운,김정진,이수정,이철,백인호 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.2

Objectives : Impaired processing of facial information is one of the broad ranges of cognitive deficits seen in patients with Schi-zophrenia. We aimed to elucidate the differences in brain activities involved in the process of facial working memory between schizophrenic patients and healthy comparison subjects. Methods : Twelve patients with schizophrenia were recruited along with twelve demographically matched healthy volunteers as a comparison group. Functional magnetic resonance imaging (fMRI) was used to assess cortical activities during the Perfor-mance of a 2-back working memory paradigm using images of neutral faces as mnemonic content. Rcsults : The patient group performed the tasks with reduced accuracy. Group analysis revealed that the left fusiform gyrus, the right superior frontal gyrus, the bilateral middle frontal gyri/insula, the left middle temporal gyrus, the precuneus, the quadrangular lobules and the vermis of cerebellum showed decreased cortical activities in the patient group. On the other hand, an increased level of activation in the lateral prefrontal cortex and the pahetal lobule was observed from the patient group, all in the right hemisphere. Conulusion : A decreased level of activity in the left fusiform gyrus among the patient group implicates inefficient processing of facial information. An increased level of activation in prefrontal and parietal neural networks from the patient group confirms earlier findings on the impaired working memory of patients with schizophrenia.

일과성전기억상실증의 국소 뇌혈류 변화 : Statistical Parametric Mapping을 이용한 Tc-99m ECD SPECT분석 Statistical Parametric Mapping analysis of Tc-99m ECD SPECT

이승재,양동원,손영민,김범생,정용안,손형선,주라형 대한치매학회 2003 Dementia and Neurocognitive Disorders Vol.2 No.1

Background & Objectives:Transient global amnesia (TGA) is a clinical syndrome characterized by sudden memory loss of recent events, transient inability to retain new information, and retrograde amnesia in the absence of other neurological signs and symptoms, resolving within 24 hours. This study investigated alterations in regional cerebral blood flow (rCBF) in patients with TGA by using statistical parametric mapping 99 (SPM99). Methods:5 patients with TGA and 9 age-matched normal control subjects were evaluated. Tc-99m-ethyl cysteinate dimer (ECD) SPECT were performed within 1 to 4 days of the event to measure the regional CBF, and SPM99 were applied to the objective analysis of SPECT data between two groups. Follow-up ECD SPECT was done at 49 to 107 days (mean 76.8) after the previous SPECT to evaluate the long term changes of the regional CBF. Results:The SPM analysis of SPECT images revealed significantly decreased rCBF in the left superior temporal gyrus, the left parietal supramarginal gyrus and the left thalamus (corrected p=0.01) and increased CBF in the contralateral mirror regions in patients with TGA. Follow-up SPECT showed persistent rCBF changes in the same regions. Conclusions:We demonstrate decreased perfusion in the left cerebral hemisphere and increased perfusion in the right cerebral hemisphere in patients with TGA. This reciprocal change of rCBF might suggest that imbalanced neuronal activity between two hemispheres may be important in the pathogenesis of the TGA. Also, the abnormal rCBF changes appeared to last long after the complete recovery of clinical manifestation of TGA.

99mTc - HMPAO 뇌 SPECT 에서 시각자극에 의한 국소 뇌 혈류변화의 정량적 검증

주라형(Ra Hyeong Juh),서태석(Tae Suk Suh),곽철은(Chul Eun Kwark),최보영(Bo Young Choe),이형구(Hyoung Koo Lee),정용안(Yong An Chung),김성훈(Sung Hoon Kim),정수교(Soo Kyo Chung) 대한핵의학회 2002 핵의학 분자영상 Vol.36 No.3

목적: 이 연구의 목적은 시각 활성 자극에 의한 뇌활성영역을 확인하고 국소 뇌 혈류량을 정량적으로 분석하는데 그 목적이 있다. ^8F-fluoro-2-deoxy glucose (FDG) PET과 ^15O-water PET에서 시각 자극을 가하는 동안 시각피질에서의 기전이 확인되었으며 PET에 비해 적은 비용으로 널리 사용되고 있는 ^99mTc-HMPAO Brain SPECT를 이용하여 시각자극을 주었을 때 대뇌 후두엽의 일차시각피질과 시각연합 피질에서의 국소 뇌 혈류 변화율을 정량적으로 분석하고자 하였다. 대상 및 방법: 오른손을 주로 사용하는 25세에서 33세의 나이 분포를 갖는 남자 3, 여자 3명(평균나이 26.7세)의 정상인을 대상으로 ^99mTc-HMPAO Brain SPECT (925 MBq)를 시행 하였고 8 Hz의 발광다이오드를 이용하여 4∼5분 동안 시각활성 자극을 주었을 때와 대조군으로 자극을 가하지 않은 비 활성상태에서의 경우로 나누어 스캔하고 해부학적 기준정보를 제공하기위해 MR영상과 융합하였으면 관심영역을 설정하여 혈류량을 정량적으로 분석하였다, 결과: 정량적인 분석을 위해 대뇌의 전체 용적과 계수율을 계산하고 관심영역을 설정하여 관심영역에 대한 복셀 당 평균 계수율을 측정하여 각 대상의 시각 활성자극을 가한 영상에서 정상 상태의 영상을 픽셀 당 픽셀로 감산 하여 통계적 파라미터를 이용한 뇌 지도를 구성하였으며 뇌 활성이 Brodmann 영역의 시각피질(Ba17)과 시각연합피질(Ba 18,19)에서 활성화되어있음을 Talairach 좌표를 통해 확인하였고 regional index를 계산하여 국소 뇌혈류 변화율을 측정하였다. 결론:^99mTc-HMPAO Brain SPECT에서 8 Hz의 발광다이오드로 시각 자극을 주었을 때 후두엽의 일차시각피질과 시각 연합 피질에서 뇌 활성화를 확인 하였고 통계적 파라미터를 이용한 SPM99에서 뇌지도를 작성하여 시각자극에 의한 활성영역을 Talairach 좌표와 Brodmann 분류에 의해 확인하여 Tl 강조 MR 영상에 융합하였다. 후두엽의 일차시각피질에서 시각 활성자극에 의해 국소 뇌 혈류량이 32.50±5.67% 증가하고 있음을 정량적으로 분석하였다. Purpose: The purpose of this study is to investigate the effects of visual activation and quantitative analysis of regional cerebral blood flow. Visual activation was known to increase regional cerebral blood flow in the visual cortex in occipital lobe. We evaluated that change in the distribution of ^99mTc-HMPAO (Hexamethyl propylene amine oxime) to reflect in regional cerebral blood flow. Materials and Merhods: The six volunteers were injected with 925 MBq (mean ages: 26.75 years, n=6, 3men, 3women) underwent MRl and ^99mTc-HMPAO SPECT during a rest state with closed eyes and visual stimulated with 8 Hz LED. We delineate the region of interest and calculated the mean count per voxel in each of the fifteen slices to quantitative analysis. The ROI to whole brain ratio and regional index was calculated pixel to pixel subtraction visual non-activation image from visual activation image and constructed brain map using a statistical parameter map (SPM99). Results: The mean regional cerevral blood flow was increased due to visual stimulation. The increase rate of the mean regional cerebral blood flow which of the activation region in primary visual cortex of occipotal lobe was 32.50±5.67%. The sifnificant activation sites using a statistical parameter of vrain constructed a rendering image and image fusion with SPECT and MRI. Conclusion: Visual activation was revealed sifnificant increase through quantitative anaysis in visual cortex. Activation refion was certified in Talairach coordinate and primary visual cortex (Ba17),visual association area(Ba18,19) of Brodmann. (Korean J Nucl Med 2002;36;166-76)

애도의 굴레 넘기: 사회적 재난으로 자녀를 잃은 어머니의 경험

라다형(Da Hyeong Ra),김연희(Yeun Hee Kim) 한국사회복지질적연구학회 2023 한국사회복지질적연구 Vol.17 No.3

생약추출물을 이용한 키크는 쌀 개발에 관한 연구

라정찬,김정호,이종은,박형근,김성훈,강경선 대한동의병리학회 2003 동의생리병리학회지 Vol.17 No.3

Various kinds of chinese herb have been known as to promote growth rate of animals. We investigated the growth promoting effect of the selected plants by using fish and rats as experimental animals. In a preliminary test by using fish, Eleutherococcus senticosus and Artemisia capillasis were found to be effective. Based on this result, we manufactured the mixture of plant extracts and applied this mixture to rice, named as Kiwoomi^TM. When we administered Kiwoomi^TM to rats, it was found to be effective in growth promotion. Kiwoomi^TM - administered group showed 49.3% (0.75g/㎏ B.W.) and 52.3% (1.5g/㎏ B.W.) growth promotion, respectively. On the other hand, Control group showed 46.2% growth promotion. This growth promotion was supported by increase of GH and IGF-1 level in the Kiwoomi^TM - administered group. From these results, we suggest that this functional rice could be helpful for growing children.

Initial Response of Osteoblast-Like Cells on Magnesium Ion Implanted Titanium Surface

( Hyeong Joo Shin ),( Dae Gon Kim ),( Chan Jin Park ),( Lee Ra Cho ),( Hee Su Lee ),( Eung Sun Byon ),( Yong Soo Jeong ) 한국조직공학과 재생의학회 2010 조직공학과 재생의학 Vol.7 No.3

The interactions between the implant surface and surrounding tissue are important for successful osteogenesis. Biomechanical interlocking and biochemical bonding are believed as to be the mechanism of osseointegration involving the initial osteoblast attachment, proliferation and differentiation. The purpose of this study is to evaluate the MC3T3-E1 cell responses to a magnesium (Mg) ion implanted titanium surface produced using a plasma source ion implantation method. Commercially pure titanium discs were prepared to produce four different surfaces; ground surface, Mg-implanted on ground surface, sandblasted surface, and Mg-implanted on sandblasted surface. Cell attachment, proliferation and differentiation of MC3T3-El cells were evaluated. Scanning electron microscopy and confocal laser microscopy revealed more cell proliferation on the Mg ion groups than on the non Mg ion groups. On the ground surface, cells showed some degree of contact guidance in alignment with the grooves. The MTT assay to determine the cellular viability and proliferation showed a higher optical density on the Mg ion groups than on the non Mg ion groups. This suggests that a Mg ion implanted titanium surface induces a better initial cellular response than the non Mg ion groups.

GG-19 : Treatment outcome with methotrexate for the interstitial pregnancy

( Hyeong In Ha ),( Hyeon Ha Seok ),( Mi Ra Kim ),( Mi Kyeong Kim ),( Seok Ju Sung ),( Woo Sik Lee ),( Tae Ki Yoon ),( Yong Wook Jung ) 대한산부인과학회 2014 대한산부인과학회 학술대회 Vol.100 No.-

목적: The purpose of this study is to evaluate the treatment outcome with methotrexate (MTX) for the interstitial pregnancy with respect to the success rate of MTX treatment and the result of subsequent pregnancy. 방법: This study is a retrospective study that performed in an urban university based hospital from Jan 2005 to July 2014. Total 101 cases of interstitial pregnancy were diagnosed and treated surgically or medically in the department of obstetrics and gynecology, CHA Gangnam Medical Center. Of those 38 cases were initially treated with MTX conservatively. The authors collected patient demographics, treatment regimen, number of doses administered, treatment results, and subsequent pregnancy outcomes by reviewing patients` medical records. 결과: Initially 7 patients were treated with combination of systemic MTX and direct MTX injection into gestational sac under the guidance of transvaginal sonography. 29 patients were treated with systemic MTX only. Of those, 6 (85.7 %) patients and 17 (58.6%) patients were successfully treated with combination MTX and systemic MTX, respectively. 12 patients tried to be pregnant. 10 (83.3%) patient were pregnant. There were several complication related to pregnancy including a case of uterine rupture from treatment failure , 3 cases of preterm deliveries. The median age of patients were 32 (range, 24-40). The b-hCG level at the diagnosis was 79312 (range, 374.8 - 159000). Fetal heart beat was noted in 5 cases (13.1%). A subject who tried to be pregnant experienced heterotopic pregnancy including tubal pregnancy. 결론: Methotrexate treatment for interstitial pregnancy may be an alternative for surgical approach. However, further study will be required to determine the factors that affect treatment results.

집중 시뮬레이션 모델을 활용한 건물의 실시간 냉방 예측 제어

라선중(Ra, Seon-Jung),김진홍(Kim, Jin-Hong),김영섭(Kim, Young-Sub),조형곤(Jo, Hyeong-Gon),신한솔(Shin, Han-Sol),박철수(Park, Cheol-Soo) 대한건축학회 2021 대한건축학회 학술발표대회 논문집 Vol.41 No.2

This paper presents a Model-Predictive Control (MPC) study applied to a cooling system in a large open-space building. The authors developed the MPC that uses minimal inputs based on a set of machine learning models for direct-expansion air handling unit (DX-AHU). For this study, the authors developed an DX-AHU supply air temperature prediction model and indoor temperature prediction models for 9 air conditioning zones. The prediction time horizon was set to 20-minute. The control objective is to minimize the energy consumption by DX-AHUs while keeping an average indoor temperature less than 27℃. It was found that the developed simulation models are accurate enough and the could save significant energy by 21.4% compared to the existing control.

위-위 장중첩증을 유발한 원발 위 림프종 1예

조형호 ( Hyeong Ho Jo ),강선미 ( Sun Mi Kang ),김시혜 ( Si Hye Kim ),라모니 ( Moni Ra ),박병규 ( Byeong Kyu Park ),권중구 ( Joong Goo Kwon ),김은영 ( Eun Young Kim ),정진태 ( Jin Tae Jung ),김호각 ( Ho Gak Kim ),류헌모 ( Hun Mo Ry 대한소화기학회 2016 대한소화기학회지 Vol.68 No.1

In adults, most intussusceptions develop from a lesion, usually a benign or malignant neoplasm, and can occur at any site in the gastrointestinal tract. Intussusception in the proximal gastrointestinal tract is uncommon, and gastro-gastric intussusception is extremely rare. We present a case of gastro-gastric intussusception secondary to a primary gastric lymphoma. An 82-year-old female patient presented with acute onset chest pain and vomiting. Abdominal CT revealed a gastro-gastric intussusception. We performed upper gastrointestinal endoscopy, revealing a large gastric mass invaginated into the gastric lumen and distorting the distal stomach. Uncomplicated gastric reposition was achieved with endoscopy of the distal stomach. Histological evaluation of the gastric mass revealed a diffuse large B cell lymphoma that was treated with chemotherapy. (Korean J Gastroenterol 2016;68:40-44)