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      • KCI등재

        A Study on Grammatical Metaphor in Chinese News Headlines from the New Mass Media Platforms

        Ren, Yang(임양),Park, Ki seong(박기성) 동북아시아문화학회 2021 동북아 문화연구 Vol.1 No.68

        In this paper we specifically aim to investigate the occurrence and frequency of ideational grammatical metaphor(GM) expressions in Chinese new news platforms, and their preference for the types of GM. We have selected 3000 pieces of news headlines (1000 pieces per news platform) with various topics from three Chinese news online platforms to locate the types and subtypes of GM. It is found in this paper that there is an high frequency of the tokens in each platform. Considering that the tokens of GM are high without regard to the kinds of the platforms and headline topics, it may be claimed that GM is universal and diversified in Chinese. Among all the types of transformations, Adjectivization is highest in the frequency of use, which is followed by Nominalization. Adjectivization is likely to occur in nearly all styles, Nominalization in more formal styles, and Verbalization in more casual styles. It is also shown that actual tokens of GM are highest in more formal and integrated platform with some sentence complexity such as Peoples’ Daily Online(PDO). From the aspect of the headline topics, actual tokens are highest in the news headlines on politics. Hence it may be concluded that ideational GM concept can be applied equally to news headlines of Chinese online news platforms with some variations depending on the kinds of platforms and headline topics. It is also claimed that the tokens and types of GMs in new mass media flatforms are higher than those in traditional ones, and the new mass media flatforms show the features of diversity, flexibility, and compatibility due to the wide use of GMs. We hope that this study will make modest contributions for those who want to look into a further exploration of the grammatical metaphor in Chinese.

      • KCI등재

        A novel stricture prevention technique in blunt urethral injury: A multi-center retrospective observational study

        Yang Mi,Jingyu Wang,Jinfeng Wu,Xiaopeng Wang,Bin Yang,Ruimin Ren,Yangang Zhang,Xiaobin Yuan,Xuhui Zhang 대한비뇨의학회 2022 Investigative and Clinical Urology Vol.63 No.1

        Purpose: Bulbar injury is the most common type of urethral injury. This study investigated the efficacy and safety of a novel technique, local urethral flushing, in preventing stricture formation after blunt bulbar urethra injuries. Materials and Methods: This retrospective study included 205 males diagnosed with straddle injury-induced bulbar urethra injury at the Shanxi Bethune Hospital and First Hospital of Shanxi Medical University between January 2015 and January 2019. Patients were diagnosed by retrograde urethrography and classified as partial or complete urethral rupture according to the urethral integrity after injury. Complete urethral rupture patients received suprapubic cystostomy and received urethroplasty 3 months later. Patients with partial urethral rupture underwent endoscopic urethral realignment by cystoscopic guide-wire guided catheterization. Patients with both injury types were divided into 3 groups. The treatment groups received urethral flushing with 0.05% dexamethasone through a secondary ureteral catheter that locked at the urethral lesion. The blank control groups received normal saline. The negative control groups had only a single ureteral catheter placed. Patients were assessed for pain during catheterization, infection, and stenosis, and followed for at least 2 years. Results: Stenosis rates and length were significantly reduced in the normal saline groups, and even further reduced in the dexamethasone groups. The negative control groups had significantly higher infection rates than patients in the dexamethasone or saline groups. Conclusions: Local urethral flushing with dexamethasone could significantly decrease urethral stenosis rates and severity without increasing patients’ discomfort or infection risk.

      • KCI등재

        Positive Association of TEAD1 With Schizophrenia in a Northeast Chinese Han Population

        Yang Sun,Lin Wen,Yi-Yang Luo,Wen-Juan Hu,Hui-Wen Ren,Ye Lv,Cong Zhang,Ping Gao,Li-Na Xuan,Guan-Yu Wang,Cheng-Jie Li,Zhi-Xin Xiang,Zhi-Lin Luan 대한신경정신의학회 2023 PSYCHIATRY INVESTIGATION Vol.20 No.12

        Objective Schizophrenia is a complex and devastating psychiatric disorder with a strong genetic background. However, much uncertainty still exists about the role of genetic susceptibility in the pathophysiology of schizophrenia. TEA domain transcription factor 1 (TEAD1) is a transcription factor associated with neurodevelopment and has modulating effects on various nervous system diseases. In the current study, we performed a case–control association study in a Northeast Chinese Han population to explore the characteristics of pathogenic <i>TEAD1</i> polymorphisms and potential association with schizophrenia.Methods We recruited a total of 721 schizophrenia patients and 1,195 healthy controls in this study. The 9 single nucleotide polymorphisms (SNPs) in the gene region of <i>TEAD1</i> were selected and genotyped.Results The genetic association analyses showed that five SNPs (rs12289262, rs6485989, rs4415740, rs7113256, and rs1866709) were significantly different between schizophrenia patients and healthy controls in allele or/and genotype frequencies. After Bonferroni correction, the association of three SNPs (rs4415740, rs7113256, and rs1866709) with schizophrenia were still evident. Haplotype analysis revealed that two strong linkage disequilibrium blocks (rs6485989-rs4415740-rs7113256 and rs16911710-rs12364619-rs1866709) were globally associated with schizophrenia. Four haplotypes (C-C-C and T-T-T, rs6485989-rs4415740-rs7113256; G-T-A and G-T-G, rs16911710-rs12364619-rs1866709) were significantly different between schizophrenia patients and healthy controls.Conclusion The current findings indicated that the human <i>TEAD1</i> gene has a genetic association with schizophrenia in the Chinese Han population and may act as a susceptibility gene for schizophrenia.

      • Shear behavior of steel reinforced concrete shallow floor beam: Experimental and theoretical study

        Yang Chen,Chong Ren,Yuqing Yuan,Yong Yang 국제구조공학회 2022 Steel and Composite Structures, An International J Vol.44 No.5

        This paper reports experimental investigation on shear behavior of steel reinforced concrete (SRC) shallow floor beam, where the steel shape is embedded in concrete and the high strength bolts are used to transfer the shear force along the interface between the steel shape and concrete. Six specimens were conducted aiming to provide information on shear performance and explore the shear bearing capacity of SRC shallow floor beams. The effects of the height of concrete slab, the size and the type of the steel section on shear performance of beams were also analyzed in the test. Based on the strut-and-tie model, the shear strength of the SRC shallow floor beam was proposed. Experimental results showed that composite shallow floor beam exhibited satisfactory composite behavior and all of the specimen failed in shear failure. The shear bearing capacity increased with the increasing of height of concrete slab and the size of steel shape, and the bearing capacities of beam specimens with castellated steel shape was slightly lower than those of specimens with H-shaped steel section. Furthermore, the calculations for evaluating the shear bearing capacity of SRC shallow floor beam were verified to be reasonable.

      • P53 Arg72Pro and MDM2 SNP309 Polymorphisms Cooperate to Increase Lung Adenocarcinoma Risk in Chinese Female Non-smokers: A Case Control Study

        Ren, Yang-Wu,Yin, Zhi-Hua,Wan, Yan,Guan, Peng,Wu, Wei,Li, Xue-Lian,Zhou, Bao-Sen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

        Background: Cell cycle deregulation is a major component of carcinogenesis. The p53 tumor suppressor gene plays an important role in regulating cell cycle arrest, and mouse double minute 2 (MDM2) is a key regulator of p53 activity and degradation. Abnormal expression of p53 and MDM2 occurs in various cancers including lung cancer. Methods: We investigated the distribution of the p53 Arg72Pro (rs1042522) and MDM2 SNP309 (rs2279744) genotypes in patients and healthy control subjects to assess whether these single nucleotide polymorphisms (SNPs) are associated with an increased risk of lung adenocarcinomas in Chinese female non-smokers. Genotypes of 764 patients and 983 healthy controls were determined using the TaqMan SNP genotyping assay. Results: The p53 Pro/Pro genotype (adjusted OR = 1.55, 95% CI = 1.17-2.06) significantly correlated with an increased risk of lung adenocarcinoma, compared with the Arg/Arg genotype. An increased risk was also noted for MDM2 GG genotype (adjusted OR = 1.68, 95% CI = 1.27-2.21) compared with the TT genotype. Combined p53 Pro/Pro and MDM2 GG genotypes (adjusted OR = 2.66, 95% CI = 1.54-4.60) had a supermultiplicative interaction with respect to lung adenocarcinoma risk. We also found that cooking oil fumes, fuel smoke, and passive smoking may increase the risk of lung adenocarcinomas in Chinese female non-smokers who carry p53 or MDM2 mutant alleles. Conclusions: P53 Arg72Pro and MDM2 SNP309 polymorphisms, either alone or in combination, are associated with an increased lung adenocarcinoma risk in Chinese female non-smokers.

      • The role of peroxiredoxin V in (-)-epigallocatechin 3-gallate-induced multiple myeloma cell death.

        Ren, Lina,Yang, Hee-Young,Choi, Hoon-In,Chung, Kyoung-Jin,Yang, Ung,Lee, Il-Kwon,Kim, Hyeoung-Joon,Lee, Dong-Seok,Park, Byung-Ju,Lee, Tae-Hoon Pergamon Press 2011 Oncology Research Vol.19 No.8

        <P>(-)-Epigallocatechin 3-gallate (EGCG) is a potent antioxidant polyphenol in green tea that acts as an anticancer agent via both direct and indirect pathways. Although the relationship between EGCG's anticancer effects and its antioxidant activity is not fully understood, it is known that EGCG stimulates production of reactive oxygen species (ROS), which induce oxidative stress leading to cell death. In IM9 multiple myeloma cells, EGCG acted in a dose- and time-dependent manner to induce apoptotic cell death. Among the antioxidant enzymes expressed in IM9 cells, levels of peroxiredoxin V (PrdxV) were selectively and significantly reduced by EGCG. Moreover, the ROS scavenger NAC completely inhibited EGCG-induced apoptosis and PrdxV reduction, while overexpression of PrdxV, but not a Prdx(VC48S) mutant, protected IM9 cells from EGCG-induced apoptosis. EGCG-induced reductions in cell viability and PrdxV levels were also observed in primary CD138+ multiple myeloma cells from patients. These results suggest that PrdxV is a key target via which EGCG mediates its anticancer effects.</P>

      • KCI등재

        A Study on the Levels of Grammaticalization of the New Degree Adverbs in Chinese

        Ren Yang(임양),Park Kiseong(박기성) 동북아시아문화학회 2021 동북아 문화연구 Vol.1 No.66

        The Chinese degree adverbs comprise a closed set derived mainly from the content words and enrich the vocabularies. In this paper we specifically aim to investigate the levels of grammaticalization of four new degree adverbs “chāo” “zéi” “mán” “jù” in terms of their frequencies of use as adverbs and their variations in sentence structures. To answer the above questions, we have examined 1000 tokens for each new adverb from three Chinese corpus being commonly used. Considering the low percentage in the frequency of their uses as adverbs and their preferences for simple structures instead of compound ones, it is claimed that the grammaticalization level of the four new degree adverbs is still in the low stage. From the corpus data, it is shown that among the four words, three of them are nearly in the low stages of grammaticalization except for “mán” in the intermediate stage. Their dominant sentence structure is the same basic simple one as conventional degree adverbs instead of more complicated compound structures. Furthermore it is claimed that their preferences for parts of phrases as a kind of function words rather than their uses as a single word also indicate the low stages of grammaticalization for the four adverbs. In addition, their uses as degree adverbs depend on the genres and are more preferable in online language and media platforms. Hence it is concluded that the grammaticalization of all four words is still at a relatively low level and depends on various factors. We hope that this study will make modest contributions for those who want to look into the development and functions of the Chinese degree adverbs.

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