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A simple time-to-event model with NONMEM featuring right-censoring
Quyen Thi Tran,Jung-woo Chae,Kyun-Seop Bae,Hwi-yeol Yun 대한임상약리학회 2022 Translational and Clinical Pharmacology Vol.30 No.2
In healthcare situations, time-to-event (TTE) data are common outcomes. A parametricapproach is ofen employed to handle TTE data because it is possible to easily visualizediferent scenarios via simulation. Not all pharmacometricians are familiar with the use ofnon-linear mixed efects models (NONMEMs) to deal with TTE data. Therefore, this tutorial simply explains how to analyze TTE data using NONMEM. We show how to write the codeand evaluate the model. We also provide an example of a hands-on model for training.
The Role of Semantic Features on the L2 Acquisition of English Articles
Quyen Nguyen 한국중원언어학회 2017 언어학연구 Vol.0 No.45
This study examines the role of semantic features associated with the English article system, namely presuppositionality and specificity, in the acquisition of English articles by Vietnamese L2 learners. Specifically, the study aims to determine whether the Vietnamese L2 learners of English overuse the with specific indefinites and presuppositional indefinites and how the overuse changes depending on contexts and the learners’ proficiency level. Using a forced choice elicitation task, the study has yielded two significant contributions. Firstly, it was found that the learners were affected by both semantic factors as manifested in the overusing of the with specific and presuppositional indefinites. Secondly, the effects of two factors were not equal, with presuppositionality having a stronger and more persistent effect than specificity in triggering article misuses. From the findings, it was suggested that instead of associating the with definiteness, L2 learners often mistakenly associate the with specificity and presuppositionality. Such findings put forward some important pedagogical implications for L2 learners and instructors as well.
Production of transgenic soybean plants carrying modified cry1Ac gene
Quyen Nguyen Thi,Jung Hun Pak,Mi-Jin Kim,Hye Jeong Kim,Ha Neui Hong,Yeon Ho Je,Young Soo Chung 한국육종학회 2012 한국육종학회 심포지엄 Vol.2012 No.07
Cry1Ac protein is known as one of toxin crystal proteins synthesized from Bacillus thuringenesis that plays a critical role for the insect resistance. Recently, cry1Ac genes have introduced into many plants in general and soybean as well. However, the gene expression of cry1Ac genes in transgenic plants remains low that need to be improved. Several mutations we reintroduced into the cry1Ac genes in order to enhance the insecticidal effect. In this study, the cry1Ac with mutant #2, #11 and #16 were transformed into Kwangan, a Korean soybean variety by using the “half-seed” method. The plant lets carrying modified cry1Ac genes were primarily selected on media containing Phosphinothricine (PPT), a bar selective agent and Basta leaf painting. Then, the presence of introduced genes in T0 plants and the gene expression were investigated by PCR, RT-PCR and Real-time PCR. PCR and RT-PCR analysis showed expression of bar and cry1Ac genes from tested transgenic soybean plants. The number of copy of bar gene ranged from 1 to 3 by Real-time PCR analysis. These results provided a fundamental back ground for our further experiments: Confirmation of the gene expression by Southern blot and identification of the function of modified cry1Ac by insect bioessays.
Quyen Van Nguyen,Hang Thi Khuat,Yen‑Ngoc Thi Nguyen,Dung Thi Vu,Thu‑Ha Bui,부경환 한국식물생명공학회 2020 Plant biotechnology reports Vol.14 No.5
Drynaria bonii H. Christ is a medicinal plant that has traditionally been used for the treatment of chronic diseases and tuberculosis. However, D. bonii has not yet been cultivated or propagated. In this study, we optimized the conditions for the spore culture of D. bonii to produce sporophytes. First, we evaluated the efects of various factors, such as temperature, light intensity, potting material, and pH, on spore germination and early gametophyte development. Under optimal culture conditions, 95–99% of the spores germinated within 2 weeks of culture. Next, based on these results, we established a culture system for gametophyte development and sporophyte production. Mature gametophytes frst appeared 5 months post-germination (mpg), and at 12 mpg, the rate of production of heart-shaped gametophytes reached 56.6%. Sporophytes at the early frst-leaf stage frst appeared at 6 mpg, and at 12 mpg, the rate of formation of sporophytes reached 15.4%. Interestingly, 6.3% of all gametophytes produced multiple sporophytes. Additionally, 42–62% of the gametophytes also produced multiple secondary gametophytes, indicating a high potential of D. bonii gametophytes to generate new gametophytes and, subsequently, sporophytes. When transferred to new trays or pots, sporophytes grew well and showed 100% survival. Overall, we conclude that this spore culture system can be successfully used for the propagation of D. bonii sporophytes.
Quyen Le Hoang Thuy To NGUYEN,Du Van NGUYEN,Ngoc Nguyen Mong CHU,Van Hong TRAN 한국유통과학회 2020 The Journal of Asian Finance, Economics and Busine Vol.7 No.11
The shift from elite education to mass education in Vietnam has met the demand for education for everybody as well as for quality human resource talent for an emerging nation. Under the resource constraint, understanding the quality dimensions of education and its priority level is important for effective and efficient policies. This study was carried out using both qualitative and quantitative methodologies to develop quality criteria and a ranking model. Two rounds of in-depth interviews were conducted with fifteen experts in the field, who were rectors, employers, and recruitment specialists to develop the quality framework applied in Vietnamese universities under total quality management (TQM), starting from the input of the senior secondary school leavers, through a teaching process to the output. The first round of interviews were unstructured questionnaires designed to explore the main factors in quality assessment model. The second round affirmed the experts’ agreement on the assessment model. Then, fuzzy logic was applied to rank eight criteria in the quality assessment model into priority order: cost, teaching and administrative staff, leadership, curriculum, student-related factors, internationalization, admissions, and campus. The results are critical for identifying the necessary actions to enhance the education quality and to further research on the optimal quality model.
Multi-Carrier Differential Chaos-Shift Keying with Repeated Spreading Sequence
Quyen, Nguyen Xuan The Korean Institute of Communications and Informa 2018 Journal of communications and networks Vol.20 No.3
This paper proposes a multi-carrier differential chaos-shift keying (MC-DCSK) system using repeated spreading sequence (RSS), namely RSS-MC-DCSK, for chaos-based wireless communications. In the proposed system, instead of transmitting the chaotic spreading sequence on a predefined subcarrier as in conventional MC-DCSK, a DCSK-modulated signal, of which each two-bit duration consisting of reference and data-bearing sequences is sent via this subcarrier. Meanwhile, a repeated spreading sequence is produced by copying the reference sequence of the DCSK-modulated signal to the same and next bit periods. The parallel bit streams are multiplied with this RSS and the resulting signals are then conveyed by corresponding subcarriers. In the receiver, the signal retrieved from the predefined subcarrier is DCSK-demodulated and simultaneously used to recover the repeated spreading sequence. The correlative demodulation is performed for all the signals retrieved from the remaining subcarriers to decode the data. The structure and operation of the proposed system are described. Bit error rate (BER) performance under a multipath Rayleigh fading channel is theoretically analyzed and then verified by numerical simulations. In addition, the BER performance, energy and spectral efficiencies of RSS-MC-DCSK are evaluated in comparison to those of MC-DCSK.