Is It Under-or Over-reaction? An Empirical Investigation

Xiu Qing Ji 한국증권학회 2008 Asia-Pacific Journal of Financial Studies Vol.37 No.2

Improving Clinician-Patient Communication Alleviates Stigma in Patients With Functional Dyspepsia Receiving Antidepressant Treatment

( Xiu-juan Yan ),( Hong-yi Qiu ),( Qing-qing Luo ),( Bo Wang ),( Ping Xu ),( Chen-feng Ji ),( Sheng-liang Chen ) 대한소화기기능성질환·운동학회 2022 Journal of Neurogastroenterology and Motility (JNM Vol.28 No.1

Background/Aims Antidepressants are effective in patients with functional dyspepsia (FD). However, stigma associated with FD and antidepressants may affect treatment adherence. This study aims to explore possible communication strategies to alleviate stigma and improve adherence in patients with FD. Methods In this randomized, single-center, and single-blind trial, 160 patients with FD initiating antidepressant treatment were recruited. Different communication strategies were performed when prescribing antidepressants. Participants in Group 1 were told that brain is the “headquarters” of gut, and that antidepressants could act as neuromodulators to relieve symptoms of FD through regulating the functions of gut and brain. Participants in Group 2 were told that antidepressants were empirically effective for FD. Stigma scores, medication-related stigma, treatment compliance, and efficacy were analyzed. Results After 8-week antidepressant treatment, the proportion of patients with FD with decreased stigma scores in Group 1 was significantly higher than in Group 2 (internalized stigma: 64.10% vs 12.00%; perceived stigma: 55.13% vs 13.33%; P < 0.01). Medication-related stigma was lower in Group 1 than in Group 2 (P < 0.05 for 3 of 4 questions). Concurrently, patients in Group 1 had better treatment compliance (0.71 ± 0.25 vs 0.60 ± 0.25, P < 0.01) and efficacy. In Group 1, participants with decreased post-treatment stigma scores showed better treatment compliance and efficacy than those with non-decreased scores. Decrease in stigma scores positively correlated with treatment compliance. Conclusion Improving knowledge of patients with FD of the disease and antidepressants via proper communication may be an effective way to alleviate stigma and promote adherence. (J Neurogastroenterol Motil 2022;28:95-103)

Is It Under-or Over-reaction? An Empirical Investigation

Xiu Qing Ji 한국증권학회 2008 한국증권학회지 Vol.37 No.2

XIST Induced by JPX Suppresses Hepatocellular Carcinoma by Sponging miR-155-5p

Xiu-qing Lin,Zhi-ming Huang,Xin Chen,Fang Wu,Wei Wu 연세대학교의과대학 2018 Yonsei medical journal Vol.59 No.7

Purpose: The influence of X-inactive specific transcript (XIST) and X-chromosome inactivation associated long non-coding RNAs (lncRNAs) just proximal to XIST (JPX) on hepatocellular carcinoma (HCC) remains controversial in light of previous reports, which the present study aimed to verify. Materials and Methods: The DIANA lncRNA-microRNA (miRNA) interaction database was used to explore miRNA interactions with JPX or XIST. JPX, XIST, and miR-155-5p expression levels in paired HCC specimens and adjacent normal tissue were analyzedby RT-qPCR. Interaction between XIST and miR-155-5p was verified by dual luciferase reporter assay. Expression levels of miR-155-5p and its known target genes, SOX6 and PTEN, were verified by RT-qPCR and Western blot in HepG2 cells with or withoutXIST knock-in. The potential suppressive role of XIST and JPX on HCC was verified by cell functional assays and tumor formationassay using a xenograft model. Results: JPX and XIST expression was significantly decreased in HCC pathologic specimens, compared to adjacent tissue, which correlated with HCC progression and increased miR-155-5p expression. Dual luciferase reporter assay revealed XIST as a direct target of miR-155-5p. XIST knock-in significantly reduced miR-155-5p expression level and increased that of SOX6 and PTEN, while significantly inhibiting HepG2 cell growth in vitro, which was partially reversed by miR-155-5p mimic transfection. JPX knock-in significantly increased XIST expression and inhibited HepG2 cell growth in vitro or tumor formation in vivo in a XIST dependent manner. Conclusion: JPX and XIST play a suppressive role in HCC. JPX increases expression levels of XIST in HCC cells, which suppresses HCC development by sponging the cancer promoting miR-155-5p.

동북아 우정정책과 개방 환경 속의 한국행정 탐색 : 국제회의 ; 심화체제 개혁 추동 우정업 건강발전

진경수 ( Qing Xiu Chen ) 한국행정학회 2004 한국행정학회 학술발표논문집 Vol.2004 No.-

Nrf2 Overexpression Predicts Prognosis and 5-FU Resistance in Gastric Cancer

Hu, Xiu-Feng,Yao, Jun,Gao, She-Gan,Wang, Xin-Shuai,Peng, Xiu-Qing,Yang, Yan-Tong,Feng, Xiao-Shan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Objective: NF-E2-related factor 2 (Nrf2) is activated in several human malignancies. However, the role of Nrf2 in gastric cancer (GC) remains incompletely understood. In this study, we therefore analyzed associations of Nrf2 expression status with clinical features and chemotherapeutic resistance in GC. Materials and Methods: A total of 186 samples from GC patients who underwent gastrectomy were used for prognostic assessment. A further 142 samples from GC cases who received first-line combination chemotherapy were applied for investigation of chemoresistance. The Nrf2 expression was evaluated by immunohistochemistry in GC samples, and its relationship with clinicopathological parameters and chemotherapy sensitivity was analyzed. The effect of Nrf2 gene silencing on chemotherapy resistance was also examined by cell viability assay in vivo. Results: Of the 186 patients with GC, 104/186 (55.9%) showed high expression for Nrf2. The overexpression of Nrf2 was an independent predictor of overall survival [OS, hazard ratio (HR) 3.9; P=0.011] and disease-free survival (DFS, HR 4.3; P=0.002). The gene silencing of Nrf2 reduced resistance to cell death induced by 5-FU in GC cell lines. Conclusion: Our data show that Nrf2 is an independent prognostic factor in GC. Furthermore, Nrf2 confers resistance to chemotherapeutic drug 5-FU in GC cells. Taken together, Nrf2 is a potential prognostic marker and predictive for 5-FU resistance in GC.

A proteomic approach reveals the differential protein expression in Drosophila melanogaster treated with red ginseng extract (Panax ginseng)

Liu, Qing-Xiu,Zhang, Wei,Wang, Jia,Hou, Wei,Wang, Ying-Ping The Korean Society of Ginseng 2018 Journal of Ginseng Research Vol.42 No.3

Background: Red ginseng is a popularly used traditional medicine with antiaging effects in Asian countries. The present study aimed to explore the changes in protein expression underlying the mechanisms of life span extension and antiaging caused by red ginseng extract (RGE) in Drosophila melanogaster. Methods: A proteomic approach of two-dimensional polyacrylamide gel electrophoresis (2-DE) was used to identify the differential abundance of possible target proteins of RGE in D. melanogaster. The reliability of the 2-DE results was confirmed via Western blotting to measure the expression levels of selected proteins. Proteins altered at the expression level after RGE treatment (1 mg/mL) were identified by matrix-assisted laser desorption/ionization-time of flight tandem mass spectrometry and by searching against the National Center for Biotechnology nonredundant and Uniprot protein databases. The differentially expressed proteins were analyzed using bioinformatics methods. Results: The average survival life span of D. melanogaster was significantly extended by 12.60% with RGE treatment (1 mg/mL) compared to untreated flies. This followed increased superoxide dismutase level and decreased methane dicarboxylic aldehyde content. Based on the searching strategy, 23 differentially expressed proteins were identified (16 up-regulated and 7 down-regulated) in the RGE-treated D. melanogaster. Transduction pathways were identified using the Kyoto Encyclopedia of Genes and Genomes database, and included the hippo and oxidative phosphorylation pathways that play important roles in life span extension and antiaging process of D. melanogaster. Conclusion: Treatment with RGE in D. melanogaster demonstrated that mechanisms of life span extension and antiaging are regulated by multiple factors and complicated signal pathways.

A Role of YlBud8 in the Regulation of Cell Separation in the Yeast Yarrowia lipolytica

( Yun-qing Li ),( Qing-jie Xue ),( Yuan-yuan Yang ),( Hui Wang ),( Xiu-zhen Li ) 한국미생물 · 생명공학회 2019 Journal of microbiology and biotechnology Vol.29 No.1

The spatial landmark protein Bud8 plays a crucial role in bipolar budding in the budding yeast Saccharomyces cerevisiae. The unconventional yeast Yarrowia lipolytica can also bud in a bipolar pattern, but is evolutionarily distant from S. cerevisiae. It encodes the protein YALI0F12738p, which shares the highest amino acid sequence homology with S. cerevisiae Bud8, sharing a conserved transmembrane domain at the C-terminus. Therefore, we named it YlBud8. Deletion of YlBud8 in Y. lipolytica causes cellular separation defects, resulting in budded cells remaining linked with one another as cell chains or multiple buds from a single cell, which suggests that YlBud8 may play an important role in cell separation, which is distinct from the function of Bud8 in S. cerevisiae. We also show that the YlBud8-GFP fusion protein is located at the cell membrane and enriched in the bud cortex, which would be consistent with a role in the regulation of cell separation. The coiled-coil domain at the Nterminus of YlBud8 is important to the correct localization and function of YlBud8, as truncated proteins that do not contain the coiled-coil domain cannot rescue the defects observed in Ylbud8Δ. This finding suggests that a new signaling pathway controlled by YlBud8 via regulation of cell separation may exist in Y. lipolytica.

Effects of Ozone on the Cytomembrane and Ultrastructure of Pseudomonas aeruginosa

Yong-qing Zhang,Qing-ping Wu,Ju-mei Zhang,Xiu-hua Yang 한국식품과학회 2015 Food Science and Biotechnology Vol.24 No.3

The ozone impact on Pseudomonas aeruginosa ATCC27853 cells was studied. Ozone-induced loss of K+, Mg2+, and ATP was measured using inductively coupled plasma/mass spectrometry and a bioluminescence assay. Maximum releases of K+ and Mg2+ were achieved at 0.37 mg/L of ozone after 2 min with a killing rate of culturable bacteria greater than 93%. Maximum release of ATP was attained at 0.42 mg/L of ozone after 3 min. Transmission electron microscopy showed that shapes of treated cells were integrated, but cytoplasmic agglutinations and vacuoles appeared. Ozone treatment caused lysis of P. aeruginosa cells to be sensitive to sodium dodecyl sulfate, insensitive to NaOH, and subject to inactivation by proteinase K. A combined action of cytoplasm agglutination, protein denaturation, and membrane permeabilization, rather than cell lysis, leads to non-culturability of P. aeruginosa cells.

Functional Features and Significance of the Times of Neo-Romantic Music in the 1970s

Fang, Xiu Qing 한국문화산업학회 2017 문화산업연구 Vol.17 No.2

Due to the influence of postmodernism in the 1960s, a trend was observed that avant-garde composers returned to tonality in the pre-twentieth century. Thus, the composers no longer pursued only serialism, but combined avant-garde music with composition music instead. The resulting work of this combination was called Neo-Romantic Music. This study analyzes functional features of Neo-Romantic Music in 1970s and sheds light on its significance of the times. This study further proposes a direction at which pure musical composers of our time should aim. Due to the influence of postmodernism in the 1960s, a trend was observed that avant-garde composers returned to tonality in the pre-twentieth century. Thus, the composers no longer pursued only serialism, but combined avant-garde music with composition music instead. The resulting work of this combination was called Neo-Romantic Music. This study analyzes functional features of Neo-Romantic Music in 1970s and sheds light on its significance of the times. This study further proposes a direction at which pure musical composers of our time should aim.