http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Qichi (검색결과 3 건)
- 무료
- 기관 내 무료
- 유료
-
Zhiwen Shao,Qichi Le,Zhiqiang Zhang,Jianzhong Cui 대한금속·재료학회 2012 METALS AND MATERIALS International Vol.18 No.2
Ultrasound with different powers was applied to treat AZ80 alloy melt to attain grain refinement or purifi-cation processing of the alloy. The influence of ultrasonic powers from 0 W to 1400 W on microstruc-tures of the AZ80 alloy with ultrasonic grain refinement treatment was investigated. The average grain size of the alloy could be decreased from 387 µm to 147 µm after the ultrasound with the optimal power 600 W was applied to treat the melt. The effect of ultrasonic powers from 0 W to 230 W on the inclusion distribution in the ingot that was treated by ultrasonic purification processing was also studied. The opti-mal ultrasonic power in the ultrasonic purification processing was 80 W. In order to gain insight into the mechanism by which ultrasonic power affected the microstructure of the alloy or inclusion distribution in the ingot, numerical simulations were carried out and the ultrasonic field propagation in the melt was characterized.
-
Qiyu Liao,Wenxin Hu,Qichi Le,Xingrui Chen,Yanchao Jiang 대한금속·재료학회 2022 METALS AND MATERIALS International Vol.28 No.5
In this paper, effects of the La-rich MM (Misch Metal) on the microstructure, texture and mechanical properties of extrudedAZ110 alloy during tension and compression deformation were investigated. High strength and low tension–compressionyield asymmetry of AZ110MM alloy (AZ110 alloy with La-rich MM addition) are developed by hot extrusion. The additionof La-rich MM brings Al-RE phases (Al2(La, Ce) and Al11(La, Ce)3) to the as-cast AZ110 alloy, which play an importantrole in the grain refinement and texture weakening during extrusion deformation. Such grain refinement and texture weakeningobviously inhibit the nucleation and growth of twins and make the deformation mechanism change from twinning tomultiple slip during cold compression deformation. Furthermore, the Al-RE phases also improve the tension–compressionyield asymmetry performance of the extruded AZ110 alloy via the combining effects of grain refinement, texture weakeningand the transformation from twinning to multiple slip. Moreover, the extruded AZ110MM alloy shows much higher strengthover AZ110 alloy, owning to texture effect, grain boundary strengthening and precipitation strengthening.
-
Yunfei Zhao,Jiao He,Ling Yang,Qichi Luo,Zhi Liu 한국유방암학회 2018 Journal of breast cancer Vol.21 No.2
Purpose: The incidence and mortality of breast cancer is increasing worldwide. There is a constant quest to understand the underlying molecular biology of breast cancer so as to plan better treatment options. The purpose of the current study was to characterize the expression of histone deacetylases-3 (HDAC3), a member of class I HDACs, and assess the clinical significance of HDAC3 in breast cancer. Methods: Quantitative real-time polymerase chain reaction, immunohistochemistry, and western blot analysis were used to examine messenger RNA and protein expression levels. The relationships between HDAC3 expression and clinicopathological variables were analyzed. MTT assays were used to detect cell proliferation. Glucose-uptake, lactate, adenosine triphosphate, and lactate dehydrogenase assays were employed to detect aerobic glycolysis. Chromatin immunoprecipitation was used to detect microRNA-31 (miR-31) promoter binding. Results: Our data revealed that HDAC3 was upregulated in breast cancer tissue compared with matched para-carcinoma tissues, and high levels of HDAC3 were positively correlated with advanced TNM stage and N stage of cancer. Furthermore, overexpression of HDAC3 promoted breast cancer cellproliferation and aerobic glycolysis. The functional involvement of HDAC3 was related in part to the repression of miR-31 transcription via decreased histone H3 acetylation at lysine K9 levels of the miR-31 promoter. Survival analysis revealed that the level of HDAC3 was an independent prognostic factor for breast cancer patients. Conclusion: Our findings revealed that HDAC3 served as an oncogene that could promote cell proliferation and aerobic glycolysis and was predictive of a poor prognosis in breast cancer. HDAC3 participated in the cell proliferation of breast cancer, which may prove to be a pivotal epigenetic target against this devastating disease.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
