Involvement of MicroRNA-198 Overexpression in the Poor Prognosis of Esophageal Cancer

Qi, Bo,Yao, Wen-Jian,Zhao, Bao-Sheng,Qin, Xiu-Guang,Wang, Yi,Wang, Wen-Ju,Wang, Tian-Yun,Liu, Shang-Guo,Li, Han-Chen Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.9

Objective: This study aimed to investigate whether the miR-198 expression level is related to clinicopathological factors and prognosis of esophageal cancer. Methods: MicroRNA was extracted from esophageal cancer patients who underwent surgery for assessment using the Taqman@ MicroRNA assay. The correlation between miR-198 expression and clinicopathological features was analyzed, and the significance of miR-198 as a prognostic factor and its relationship with survival was determined. Results: MicroRNA-198 (miR-198) expression was higher in patients with poor prognosis than those with good prognosis (P<0.05). Kaplan-Meier analysis results showed that the miR-198 expression level had a significant correlation with survival time (P=0.030) and that patients with a higher expression of miR-198 had a shorter survival time. Cox multi-factor model analysis showed that patient prognosis (P=0.014), tumor length (P=0.040) and expression (P=0.012), and survival time had a significant correlation; the corresponding risks were 7.268, 1.246, and 3.524, respectively. Conclusion: miR-198 overexpression is involved in the poor prognosis of esophageal cancer and can be used as a biomarker for selection of cases requiring especial attention.

AMDM for free vibration analysis of rotating tapered beams

Qibo Mao 국제구조공학회 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.3

The free vibration of rotating Euler-Bernoulli beams with the thickness and/or width of the cross-section vary linearly along the length is investigated by using the Adomian modified decomposition method (AMDM). Based on the AMDM, the governing differential equation for the rotating tapered beam becomes a recursive algebraic equation. By using the boundary condition equations, the dimensionless natural frequencies and the closed form series solution of the corresponding mode shapes can be easily obtained simultaneously. The computed results for different taper ratios as well as different offset length and rotational speeds are presented in several tables and figures. The accuracy is assured from the convergence and comparison with the previous published results. It is shown that the AMDM provides an accurate and straightforward method of free vibration analysis of rotating tapered beams.

Four Degree-of-Freedom Geometric Error Measurement System with Common-Path Compensation for Laser Beam Drift

Qibo, Feng,Bin, Zhang,Cuifang, Kuang Korean Society for Precision Engineering 2008 International Journal of Precision Engineering and Vol.9 No.4

A precision four-degree-of-freedom measurement system has been developed for simultaneous measurement of four motion errors of a linear stage, which include straightness and angular errors, The system employs a retro-reflector to detect the straightness errors and a plane mirror to detect the angular errors. A common-path compensation method for laser beam drift is put forward, and the experimental results show that the influences of beam drift on four motion errors can be reduced simultaneously. In comparison with the API 5D laser measuring system, the accuracy for straightness measurement is about ${\pm}1.5{\mu}m$ within the measuring range of ${\pm}650{\mu}m$, and the accuracy for pitch and yaw measurements is about ${\pm}1.5$ arc-seconds within the range of ${\pm}600$ arc-seconds.

Four Degree-of-Freedom Geometric Error Measurement System with Common-Path Compensation for Laser Beam Drift

Feng Qibo,Zhang Bin,Kuang Cuifang 한국정밀공학회 2008 International Journal of Precision Engineering and Vol.9 No.4

A precision four-degree-of-freedom measurement system has been developed for simultaneous measurement of four motion errors of a linear stage, which include straightness and angular errors. The system employs a retro-reflector to detect the straightness errors and a plane mirror to detect the angular errors. A common-path compensation method for laser beam drift is put forward, and the experimental results show that the influences of beam drift on four motion errors can be reduced simultaneously. In comparison with the API 5D laser measuring system, the accuracy for straightness measurement is about ±1.5㎛ within the measuring range of ±650㎛, and the accuracy for pitch and yaw measurements is about ± 1.5arc-seconds within the range of ±600arc-seconds.

AMDM for free vibration analysis of rotating tapered beams

Mao, Qibo Techno-Press 2015 Structural Engineering and Mechanics, An Int'l Jou Vol.54 No.3

The free vibration of rotating Euler-Bernoulli beams with the thickness and/or width of the cross-section vary linearly along the length is investigated by using the Adomian modified decomposition method (AMDM). Based on the AMDM, the governing differential equation for the rotating tapered beam becomes a recursive algebraic equation. By using the boundary condition equations, the dimensionless natural frequencies and the closed form series solution of the corresponding mode shapes can be easily obtained simultaneously. The computed results for different taper ratios as well as different offset length and rotational speeds are presented in several tables and figures. The accuracy is assured from the convergence and comparison with the previous published results. It is shown that the AMDM provides an accurate and straightforward method of free vibration analysis of rotating tapered beams.

Methods and Systems for High-temperature Strain Measurement of the Main Steam Pipe of a Boiler of a Power Plant While in Service

Chen Guang,Feng Qibo,Ding Keqin 한국광학회 2016 Current Optics and Photonics Vol.20 No.6

It has been a challenge for researchers to accurately measure high temperature creep strain online withoutdamaging the mechanical properties of the pipe surface. To this end, a noncontact method for measuringhigh temperature strain of a main steam pipe based on digital image correlation was proposed, and a systemfor monitoring of high temperature strain was designed and developed. Wavelet thresholding was usedfor denoising measurement data. The sub-pixel displacement search algorithm with curved surface fittingwas improved to increase measurement accuracy. A field test was carried out to investigate the designedmonitoring system of high temperature strain. The measuring error was less than 0.4 ppm/ºC, which meetsactual measurement requirements for engineering. Our findings provide a new way to monitor creep damageof the main steam pipe of a boiler of an ultra-supercritical power plant in service.

Plant‐expressed Fc‐fusion protein tetravalent dengue vaccine with inherent adjuvant properties

Kim, Mi Young,Copland, Alastair,Nayak, Kaustuv,Chandele, Anmol,Ahmed, Muhammad S.,Zhang, Qibo,Diogo, Gil R.,Paul, Matthew J.,Hofmann, Sven,Yang, Moon‐,Sik,Jang, Yong‐,Suk,Ma, Julian K BLACKWELL 2018 PLANT BIOTECHNOLOGY JOURNAL Vol.16 No.7

<P><B>Summary</B></P><P>Dengue is a major global disease requiring improved treatment and prevention strategies. The recently licensed Sanofi Pasteur Dengvaxia vaccine does not protect children under the age of nine, and additional vaccine strategies are thus needed to halt this expanding global epidemic. Here, we employed a molecular engineering approach and plant expression to produce a humanized and highly immunogenic poly‐immunoglobulin G scaffold (PIGS) fused to the consensus dengue envelope protein III domain (cEDIII). The immunogenicity of this IgG Fc receptor‐targeted vaccine candidate was demonstrated in transgenic mice expressing human FcγRI/CD64, by induction of neutralizing antibodies and evidence of cell‐mediated immunity. Furthermore, these molecules were able to prime immune cells from human adenoid/tonsillar tissue <I>ex vivo</I> as evidenced by antigen‐specific CD4<SUP>+</SUP> and CD8<SUP>+</SUP> T‐cell proliferation, IFN‐γ and antibody production. The purified polymeric fraction of dengue PIGS (D‐PIGS) induced stronger immune activation than the monomeric form, suggesting a more efficient interaction with the low‐affinity Fcγ receptors on antigen‐presenting cells. These results show that the plant‐expressed D‐PIGS have the potential for translation towards a safe and easily scalable single antigen‐based tetravalent dengue vaccine.</P>