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Column Generation Algorithm-Based DTN Routing Strategy in Complex Data Transmission Scenario
Qun Wang,Huanyan Qian,Chenchen Ni,Qianmu Li 보안공학연구지원센터 2015 International Journal of Future Generation Communi Vol.8 No.6
An ideal routing strategy shall be able to help the delay tolerant network (DTN) achieve an optimal transmission performance under the premise of lower energy consumption. However, due to the diverse of the application scenarios, it is hard to use one or more types of routing strategies as a universal optimum solution. There is a need to establish a routing strategy model of the corresponding DTN network for different application scenarios, analyze and evaluate the strategy model in combination of the knowledge of the operational research and statistics. For a complex data transmission DTN network scenario, with the introducing of a line programming method, the big-data and multi-node network transmission problem can be abstracted to a large-scale line programming problem. In this paper, the feasibility of solving the large-scale line programming problem by the column generation algorithm has been analyzed, and a column generation algorithm-based DTN routing strategy under the complex data transmission scenario has been designed. This routing strategy can realize the quantization of the routing strategy performance by the column generation algorithm. Also, by the simulation experiments, the performance of complex data transmission DTN routing strategy under different factors has been analyzed, and the performance of the column generation algorithm-based DTN routing strategy has been compared with the performance of the traditional jet waiting routing strategy
Insulin-positive ductal cells do not migrate into preexisting islets during pregnancy
Liu Qun,Jiang Yinan,Zhu Lingyan,Qian Jieqi,Wang Chaoban,Yang Tianlun,Prasadan Krishna,Gittes George K.,Xiao Xiangwei 생화학분자생물학회 2021 Experimental and molecular medicine Vol.53 No.-
The adult pancreatic ductal system was suggested to harbor facultative beta-cell progenitors similar to the embryonic pancreas, and the appearance of insulin-positive duct cells has been used as evidence for natural duct-to-beta-cell reprogramming. Nevertheless, the phenotype and fate of these insulin-positive cells in ducts have not been determined. Here, we used a cell-tagging dye, CFDA-SE, to permanently label pancreatic duct cells through an intraductal infusion technique. Representing a time when significant increases in beta-cell mass occur, pregnancy was later induced in these CFDA-SE-treated mice to assess the phenotype and fate of the insulin-positive cells in ducts. We found that a small portion of CFDA-SE-labeled duct cells became insulin-positive, but they were not fully functional beta-cells based on the in vitro glucose response and the expression levels of key beta-cell genes. Moreover, these insulin-positive cells in ducts expressed significantly lower levels of genes associated with extracellular matrix degradation and cell migration, which may thus prevent their budding and migration into preexisting islets. A similar conclusion was reached through analysis of the Gene Expression Omnibus database for both mice and humans. Together, our data suggest that the contribution of duct cells to normal beta-cells in adult islets is minimal at best.
The 2518 A/G Polymorphism in the MCP-1 Gene and Cancer Risk: A Meta-analysis
Jia, Liu-Qun,Shen, Yong-Chun,Guo, Shu-Jin,Hu, Qian-Jing,Pang, Cai-Shuang,Wang, Tao,Chen, Lei,Wen, Fu-Qiang Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Background: The 2518 A/G polymorphism in the MCP-1 gene has been extensively studied for association swith cancer; however, results from replication studies have been inconsistent. The aim of this investigation was to determine links with risk of cancer by meta-analysis. Methods: We searched Pubmed, Embase, CNKI, Weipu and Wanfang databases, covering all case-control studies until March, 2013. Statistical analyses were performed using the Revman 5.0 software. Results: A total of 11 case-control studies met our inclusion criteria, including 1,422 cases and 2,237 controls. The results indicated that the MCP-1 2518 gene polymorphism had no association with cancer risk overall (GG vs.GA+ AA: OR = 0.89, 95%CI = 0.61-1.28, P = 0.52). However, in the subgroup analysis by ethnicity, a decrease of cancer risk was found in Asian populations (GG vs.GA+ AA: OR = 0.79, 95%CI = 0.63-0.99, P = 0.04). Conclusion: This meta-analysis suggested that the 2518A/G polymorphism of MCP-1 gene is associated with risk of cancer among Asian, but not in Caucasian populations.
Liang, Jun,Qian, Ying,Xu, Dan,Yin, Qun,Pan, Hui-Juan Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6
Objective: To explore changes in the serum tumor makers, hypoxia-inducible factor-$1{\alpha}$ (HIF-$1{\alpha}$) and vascular endothelial growth factor (VEGF) level and their relations in patients with non-small cell lung cancer (NSCLC) before and after intervention. Materials and Methods: Forty patients with NSCLC and 40 healthy individuals undergoing physical examination in our hospital provided the observation and control groups. HIF-$1{\alpha}$ and VEGF levels in serum were detected by enzyme-linked immuno-sorbent assay (ELISA) in the observation group before and after intervention and in control group on the day of physical examination, along with serum carcino-embryonic antigen (CEA), neuron-speci ic enolase (NSE) and squamous cell carcinoma antigen (SCC) levels in the observation group with a fully automatic biochemical analyzer. Clinical effects and improvement of life quality in the observation group were also evaluated. Results: The total effective rate and improvement of life quality after treatment in observation group were 30.0% and 32.5%, respectively. Serum HIF-$1{\alpha}$ and VEGF levels in the control group were lower than that in observation group (p<0.01), but remarkably elevatedafter intervention (p<0.01). In addition, serum CEA, NSE and SCC levels were apparently lowered by treatment (p<0.01). Serum HIF-$1{\alpha}$ demonstrated a positive relation with VEGF level (p<0.01) and was inversely related with CEA, NSE and SCC levels (p<0.01). Conclusions: Significant correlations exist between marked increase of serum HIF-$1{\alpha}$ and VEGF levels and decrease of indexes related to hematological tumor markers in NSCLC patients after intervention.
Rui Liu,Qian-Qun Gu,Wei-Ming Zhu,Cheng-Bin Cui,Guo-Tao Fan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.9
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.
Performance and applications of flow-guided sieve trays for distillation of highly viscous mixtures
Hui Liu,Qun Shen Li,Chun Ying Song,Hai Long Wu,Yi Qiu Qian 한국화학공학회 2008 Korean Journal of Chemical Engineering Vol.25 No.6
With a particular focus on the distillation of highly viscous or self-polymerized mixtures, this study reports the hydrodynamic and mass transfer performance of two flow-guided sieve trays, including their pressure drop, entrainment, weeping and tray efficiency, obtained experimentally with an air-water/oxygen system in a Φ600 mm plexiglass column. The results show that the 8 mm hole flow-guided sieve tray tested shows better characteristics than the 7 mm flow-guided hole tray in terms of pressure drop and mass transfer. Then we present practical industrial examples of applications of the flow guided trays for distillation of viscous mixtures, i.e., the separation of vinyl acetate (VAC) from a polyvinyl acetate (PVAC) polymer solution with dynamic viscosity μ=50,000 mPas, the separation of highly unsaturated C5 mixtures by extractive distillation, and the distillation of thick, condensed and highly viscous fermentation mixtures made from fermented mash. It is demonstrated that flow-guided sieve trays with relatively large holes are an excellent candidate for distillation of mixtures with suspended solids, or concentrated/self-polymerized polymer solutions.
( Xiao Lan Liu ),( Xi Qun Zheng ),( Peng Zhi Qian ),( Narasimha Kumar Kopparapu ),( Yong Ping Deng ),( Masanori Nonaka ),( Naoki Harada ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.2
A fibrinolytic enzyme was produced by an edible mushroom of Pleurotus ostreatus using submerged culture fermentation. The enzyme was purified from the culture supernatant by applying a combination of freeze-thaw treatment, ammonium sulfate precipitation, hydrophobic interaction, and gel filtration chromatographies. The enzyme was purified by a 147-fold, with a yield of 7.54%. The molecular masses of the enzyme an determined by gel filtration and SDSPAGE were 13.6 and 18.2 kDa, respectively. The isoelectric point of the enzyme was 8.52. It hydrolyzed fibrinogen by cleaving the α and β chains of fibrinogen followed by the γ chains, and also activated plasminogen into plasmin. The enzyme was optimally active at 45°C and pH 7.4. The enzyme activity was completely inhibited by EDTA, whereas protease inhibitors of TPCK, SBTI, PMSF, aprotinin and pepstatin showed no inhibition on its activity. The partial amino acid sequences of the enzyme as determined by Q-TOF2 were ATFVGCSATR, GGTLIHESSHFTR, and YTTWFGTFVTSR. These sequences showed a high degree of homology with those of metallo-endopeptidases from P. ostreatus and Armillaria mellea. The purified enzyme can also be applied as a natural agent for oral fibrinolytic therapy or prevention of thrombosis.
Aiqun Lin,Guangwei Wu,Qian Qun Gu,Tian-Jiao Zhu,De-Hai Li 대한약학회 2014 Archives of Pharmacal Research Vol.37 No.7
Chemical investigation of an Antarctic deepseaderived fungus Penicillium sp. PR19 N-1 yielded fivenew eremophilane-type sesquiterpenes 1–5 and a new rarelactam-type eremophilane 6, together with three knowncompounds 7–9. The structures of these diverse sesquiterpeneswere determined by extensive NMR and massspectroscopic analyses. Compounds 1, 2, 4–6, 8 and 9 wereevaluated for their cytotoxities against HL-60 and A-549human cancer cell lines, and 5 was the most active one withIC50 value of 5.2 lM against the A-549 cells.
Xueqian He,Zhenzhen Zhang,Qian Che,Tianjiao Zhu,Qian-Qun Gu,Dehai Li 대한약학회 2018 Archives of Pharmacal Research Vol.41 No.1
Seven polyketides, including four new onesnamed as varilactones A–B (1–2) and wortmannilactonesM–N (3–4), as well as three biogenetically related knownwortmannilactones E, F and H (5–7), were isolated fromthe fungus Penicillium variabile HXQ-H-1, cultivated inpotato-based medium with the histone deacetylase inhibitorsuberoylanilide hydroxamic acid (SAHA). Their structures(1–7) were established by analysis of NMR and MS data,and the absolute configuration of oxabicyclo[2.2.1]heptaneunit was deduced from 1H-NMR analyses on MPA estersafter chemical reduction reaction. Among them, varilactonesA and B (1 and 2), features a novel skeleton with atriene unit linking an oxabicyclo[2.2.1]heptane and anoxabicyclo[3.3.0]octane rings.
Liu Rui,Gu Qian-Qun,Zhu Wei-Ming,Cui Cheng-Bin,Fan Guo-Tao The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.9
Two known modified dipeptides, trichodermamide A (1) and aspergillazine A (2), were isolated from an ethyl acetate extract of the metabolite of a marine-derived fungus Spicaria elegans, and were found to have a weak cytotoxic effect on three cancer cell lines P388, A-549, and HL-60 agreed. To our knowledge, this is the first report on the isolation of compounds 1 and 2 from the fungus Spicaria elegans and their cytotoxic effect.