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Qi Zhang,Li-qun Hu,Hong-qi Li,Jun Wu,Na-na-Bian,Guang Yan 대한약리학회 2019 The Korean Journal of Physiology & Pharmacology Vol.23 No.2
The study is to investigate effects of andrographolide on experimental autoimmune myocarditis (EAM). Lewis rats were immunized on day 0 with porcine cardiac myosin to establish EAM. The EAM rats were treated with either andrographolide (25, 50, 100 mg/kg/day) or vehicle for 21 days. An antigen-specific splenocytes proliferation assay was performed by using the cells from control rats immunized with cardiac myosin. Survival rates, myocardial pathology and myocardial functional parameters (left ventricle end-diastolic pressure, ± dP/dt and left ventricular internal dimension) of EAM rats received andrographolide were significantly improved. Andrographolide treatment caused an decrease in the infiltration of CD3+ and CD14+ positive cells in myocardial tissue. Moreover, andrographolide treatment caused a reduction in the plasma levels of tumor necrosis factor-alpha, interleukin-17 (IL-17) and myosin-antibody, and an increase in the level of IL-10 in EAM rats. Oral administration of andrographolide resulted in the decreased expression of p-PI3K, p-Akt without any change of PI3K and Akt. Further results indicate andrographolide significantly inhibited myosin-induced proliferation in splenocytes, and this effect was inhibited by co-treatment of SC79 (Akt activator). Our data indicate andrographolide inhibits development of EAM, and this beneficial effect may be due to powerful anti-inflammatory activity and inhibitory effect on PI3K/Akt pathway.
Copolymer-Nanoparticles Mixture in a Cylindrical Pore
Jun-Xing Pan,Yu-Qi Guo,Yu-Fang Han,Min-Na Sun,Jin-Jun Zhang 성균관대학교(자연과학캠퍼스) 성균나노과학기술원 2017 NANO Vol.12 No.4
Computer simulation is carried out for investigating the effect of nanoparticles on diblock copolymer morphology under cylindrical confinement. The phase diagrams of polymer nanocomposites with nanoparticle-block wetting strength and concentration of nanoparticles are obtained in different nanopores. In small diameter nanopore, there is almost no influence of nanoparticles on the diblock copolymer morphology because of the stronger confinement effect; in middle diameter nanopore, the system can self-assemble into various novel structures due to the interaction between confinement effect and nanoparticles effect; in large diameter nanopore, due to the stronger effect of nanoparticles, a disorder-order-disorder phase transition occurs with the wetting strength and concentration of nanoparticles increasing. This result can be useful in designing new nanocomposites with advanced electrical conductivity and/or mechanical strength.
Jun Qi,Lan Yi 보안공학연구지원센터 2016 International Journal of u- and e- Service, Scienc Vol.9 No.4
In allusion to such problems as the no use of the structural information of the dataset in the traditional clustering effectiveness evaluation function and the excessive noisy point deletion, the research method integrating theoretical analysis and empirical analysis is adopted to establish KPI management index system model for telecommunication enterprises. A new clustering effectiveness evaluation function is proposed in this article. Specifically, PCA (principal component analysis) method in multivariate statistics is applied in the performance evaluation systems of telecommunication enterprises, and meanwhile relevant instances are analyzed and evaluated. Therein, the evaluation index system has the features of simpleness, strong practicability, low operation cost and high accuracy, and the geometric structure features of dataset are added for the performance evaluation of telecommunication enterprises. Additionally, distance critical value L is added in the compact indexes and the constraint condition thereof is also given in order to construct a new clustering effectiveness evaluation index model which can more scientifically and rationally reflect the actual evaluation result.
Epigenetic Regulation of Human Riboflavin Transporter 2(hRFT2) in Cervical Cancers from Uighur Women
Ma, Jun-Qi,Kurban, Shajidai,Zhao, Jun-Da,Li, Qiao-Zhi,Hasimu, Ayshamgul Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.6
In the present study, we studied the hypermethylation of the human riboflavin transporter 2 (hRFT2) gene and regulation of protein expression in biopsies from resected tissues from Uighur cervical squamous cell carcinoma (CSCC) patients and their neighboring normal tissues. hRFT2 gene promoter region methylation sequences were mapped in cervical cancer cell line SiHa by bisulfite-sequencing PCR and quantitative detection of methylated DNA from 30 pairs of Uighur's CSCCs and adjacent normal tissues by MassARRAY (Sequenom, San Diego, CA, USA) and hRFT2 protein expression was analyzed by immunohistochemistry. In SiHa, we identified 2 CG sites methylated from all of 12CpG sites of the hRFT2 gene. Analysis of the data from quantitative analysis of single CpG site methylation by Sequenom MassARRAY platform showed that the methylation level between two CpG sites (CpG 2 and CpG 3) from CpG 1~12 showed significant differences between CSCC and neighboring normal tissues. However, the methylation level of whole target CpG fragments demonstrated no significant variation between CSCC ($0.476{\pm}0.020$) and neighboring normal tissues ($0.401{\pm}0.019$, p>0.05). There was a tendency for translocation the hRFT2 proteins from cytoplasm/membrane to nucleus in CSCC with increase in methylation of CpG 2 and CpG 3 in hRFT2gene promoter regions, which may relate to the genesis of CSCC. Our results suggested that epigenetic modifications are responsible for aberrant expression of the hRFT2 gene, and may help to understand mechanisms of cervical carcinogenesis.
Tang, Qi-Ling,Guo, Ji-Quan,Wang, Qi-You,Lin, Hai-Shu,Yang, Zhou-Ping,Peng, Tong,Pan, Xue-Diao,Liu, Bing,Wang, Su-Jun,Zang, Lin-Quan Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.6
Curcumol is a sesquiterpene originally isolated from curcuma rhizomes, a component of herbal remedies commonly used in oriental medicine. Its beneficial pharmacological activities have attract significant interest recently. In this study, anti-cancer activity of curcumol was examined with both in vitro and in vivo models. It was found that curcumol exhibited time- and concentration-dependent anti-proliferative effects in SPC-A-1 human lung adenocarcinoma cells with cell cycle arrest in the G0/G1 phase while apoptosis-induction was also confirmed with flow cytometry and morphological analyses. Interestingly, curcumol did not display growth inhibition in MRC-5 human embryonic lung fibroblasts, suggesting the anti-proliferative effects of curcumol were specific to cancer cells. Anti-neoplastic effects of curcumol were also confirmed in tumor bearing mice. Curcumol (60 mg/ kg daily) significantly reduced tumor size without causing notable toxicity. In conclusion, curcumol appears a favorable anti-cancer candidate for further development.
미생물전기화학적 혐기성소화조에서 벌크와 전극에서의 메탄발생량 정량분석
박준규 ( Jun-gyu Park ),사위기 ( Wei-qi Shi ),전항배 ( Hang-bae Jun ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 한국폐기물자원순환학회 심포지움 Vol.2019 No.1
본 연구에서는 BAD반응조에서 음식물류폐기물로부터 메탄발생량을 분석하고, BEAD 반응조에서 bulk sludge와 bio-film이 미치는 영향을 정량적으로 분석하였다. 그 결과, BEAD 반응조에서 벌크 슬러지, 바이오 필름 및 전극의 전기화학적 반응의 메탄 생성에 대한 기여도는 각각 70.2, 29.8 및 0%였으며, 주요 메탄 생성반응은 bulk sludge내의 H2-dependent methylotrophic과 hydrogenotrophic methanogens에 의해 일어났으며 Hydrogenotrophic methanogenesis는 주요 메탄생성 반응으로써 bio-electrode에 부착 된 biofilm에서의 반응이다. 생물막의 메탄 생산량(29.8%)을 정량적으로 분석한 결과, H2 및 전기 화학적 메탄 생성을 통한 bioelectrochemical 메탄 생산의 기여도는 각각 8.2%와 0.5%로 나타났다. 흥미로운 점은 biocilm에서 생물학적 메탄생성이 biofilm 전체메탄생성 중 가장 큰 기여를 했다는 것이다(21.1%). 또한 bulk suldge는 biofilm보다 메탄 생성에 더 많은 기여를 하였다, 그러나 전극상의 volatile solid 단위 질량 당 메탄 생산량은 벌크 슬러지의 메탄 생산량보다 약 1.6 배 더 높았으며, biofilm이 없는 전극에서 전압을 걸어주었을 때 메탄은 생성되지 않았다. 따라서, biofilm의 형성과 유지는 BEAD 반응기에서 메탄 생산을 향상시키기 위해 필수적이라고 판단된다. 사사: 이 논문은 2019년도 폐자원 에너지화 특성화대학원 사업의 지원을 받아 수행된 기초연구 사업임.