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( Pritam Thapa ),( Radha Karki ),( Min Ho Yun ),( Tara Man Kadayat ),( Eun Young Lee ),( Han Byeol Kwon ),( Young Hwa Na ),( Won Jea Cho ),( Nam Doo Kim ),( Byeong Seon Jeong ),( Young Joo Kwon ),( Eu 영남대학교 약품개발연구소 2012 영남대학교 약품개발연구소 연구업적집 Vol.22 No.0
We have designed and synthesized a series of 2,4,6-triaryl pyridine derivatives containing chlorophenyl and phenolic moeity at 2- and 4- position of the central pyridine, respectively, resulting in a total of 42 compounds. They were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Most compounds showed better topoisomerase II inhibitory activity compared to topoisomerase I inhibitory activity. Compounds 19, 20, 26-28, and 47-50 especially showed stronger topo II inhibitory activity than etoposide. ⓒ 2012 Elsevier Masson SAS. All rights reserve
Pritam Mandal,Amitava Choudhury,Amitava Basu Mallick,Manojit Ghosh 대한금속·재료학회 2023 METALS AND MATERIALS International Vol.29 No.1
The purpose of this investigation is to predict the different phases present in various high entropy alloys and subsequentlyclassify their crystal structure by various machine learning algorithms using five thermodynamic, configurational andelectronic parameters, which are considered to be essential for the formation of high entropy alloy phases. Proper predictionof phases and crystal structures can eventually trace the properties of high entropy alloy, which is crucial for selectingthe suitable elements for designing. The model has been developed by various machine learning (ML) algorithms using anexperimental dataset consisting of 322 different HEAs, including 258 solid solution (SS), 31 intermetallic (IM), and 33 amorphous(AM) phases. The ML algorithms include (1) K-nearest neighbours (KNN), (2) support vector machines (SVM), and(3) logistic regression (LR), (4) decision tree (DT), (5) random Forest (RF), and (6) gaussian naive bayes classifier. Amongthem, both DT and SVM algorithms exhibited the highest accuracy of 93.84% for phase prediction. Crystal structure classificationof SS phases was also done using a dataset consisting of 194 different HEAs data, including 76 body centered cubic(BCC), 61 face centered cubic (FCC) and 57 mixed body-centered and face-centered cubic (BCC + FCC) crystal structuresand found that the SVM algorithm shows the highest accuracy of 84.32%. The effect of the parameters on determining theaccuracy of the model was calculated and tracking the role of individual parameters in phase construction was also attempted.
( Pritam Thapa ),( Yurngdong Jahng ),( Pil Hoon Park ),( Jun Goo Jee ),( Youngjoo Kwon ),( Eung Seok Lee ) 영남대학교 약품개발연구소 2014 영남대학교 약품개발연구소 연구업적집 Vol.24 No.0
Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3- furyl, 2- or 3-thienyl, and 2-pyridyl were substituted at 2- or 4- position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2- or 4- position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 μM.
Flavonoid-induced apoptotic cell death in human cancer cells and itsmechanisms
Pritam Bhagwan Bhosale,하상은,Preethi Vetrivel,김훈환,김진아,박광일,김성민,김곤섭 충북대학교 동물의학연구소 2020 Journal of Biomedical and Translational Research Vol.21 No.2
Cancer is the second leading cause of death worldwide and currently there are many approaches developing towards cancer treatment. Cancer treatments like chemotherapy and radiation therapy are often painful and have adverse effects. The mechanism of apoptosis is a complex process and it involves different pathways in its mechanism of action. Apoptosis can be caused by signals within the cell such as stress, or by extrinsic signals such as ligands binding to cell surface death receptors. The programmed cell death plays a important role in the several physiological and pathological processes. It plays important role in homeostasis. Flavonoids have gained importance as anticancer agents promoting cytotoxicity and apoptosis in cancer cells. Flavonoids are present in many medicinal plants which are a kind of ubiquitous natural products and essential active ingredients. They have strong biological activities with high efficiency and low toxicity, possessing good preventive and cure effects on different tumor forms. Flavonoids such as Scutellarein, Pectolinarigenin and Naringin have reported to possess significant anti-cancer effects on different cancer cell lines till date. In this review, we provide a summary about the anti-cancer effect of the three flavonoids and its mechanisms of action that can be used in future for understanding their potent anti-tumor properties.
Pritam THAPA,장영동,박필훈,지준구,권영주,이응석 대한화학회 2013 Bulletin of the Korean Chemical Society Vol.34 No.10
Designed and synthesized twenty-four 2,4-diaryl benzofuro[3,2-b]pyridine derivatives were evaluated for topoisomerase I and II inhibitory activities as well as cytotoxicities against several human cancer cell lines. Various aryl groups such as phenyl, 2- or 3- furyl, 2- or 3-thienyl, and 2-pyridyl were substituted at 2- or 4- position of central pyridine. Compounds 8, 12, 13, and 14, with 2-furyl either at 2- or 4- position of central pyridine showed the significant topoisomerase II inhibitory activity at 100 μM.
A 23.52μW / 0.7V Multi-stage Flip-flop Architecture Steered by a LECTOR-based Gated Clock
Pritam Bhattacharjee,Alak Majumder,Bipasha Nath 대한전자공학회 2017 IEIE Transactions on Smart Processing & Computing Vol.6 No.3
Technology development is leading to the invention of more sophisticated electronics appliances that require long battery life. Therefore, saving power is a major concern in current-day scenarios. A notable source of power dissipation in sequential structures of integrated circuits is due to the continuous switching of high-frequency clock signals, which do not carry any information, and hence, their switching is eliminated by a method called clock gating. In this paper, we have incorporated a recent clock-gating style named Leakage Control Transistor (LECTOR)-based clock gating to drive a multi-stage sequential architectures, and we focus on its performance under three different process corners (fast-fast, slow-slow, typical-typical) through Monte Carlo simulation at 18 ㎓ clock with 90 ㎚ technology. This gating is found to be one of the best gated approaches for multi-stage architectures in terms of total power consumption.