Thermal study of a scanning beam in granular flow target

Lin Ping,Qin Yuanshuai,Hao Changwei,Tian Yuan,Wan Jiangfeng,Jia Huan,Yang Lei,Duan Wenshan,Cai Han-Jie,Zhang Sheng 한국원자력학회 2022 Nuclear Engineering and Technology Vol.54 No.11

The concept of dense granular-flow target (DGT) for the China Initiative Accelerator Driven Subcritical system (CiADS) is an attractive choice for high heat removal ability, low chemical toxicity, and radiotoxicity. A wobbling hollow beam is proposed to enhance the homogeneity of temperature rise of flowing particles in beam-target coupling zone. In this paper, the design procedure of target and beam parameters was discussed firstly. Then we simulated the heat deposition and transfer of the scanning beam in DGT to study the effect of beam parameters. The results show the flux density of proton beam plays a crucial role in the distribution of temperature rise while the contributions from scanning frequency heat transfer are also obvious. Moreover, heat transfer in transversal directions is insignificant, resulting in a low heat flux towards the sidewalls of DGT. This work not only contributes to the design of DGT, but also beneficial for understanding the beam-target coupling in porous materials

A Case Study of Physical Education Student Teacher’s Development in Practical Knowledge

Lin Ching-Ping,Lee Ya-Yen 한국스포츠교육학회 2011 한국스포츠교육학회 국제학술대회 자료집 Vol.2011 No.12

Scutellaria Extract Decreases the Proportion of Side Population Cells in a Myeloma Cell Line by Down-regulating the Expression of ABCG2 Protein

Lin, Mei-Gui,Liu, Li-Ping,Li, Chen-Yin,Zhang, Meng,Chen, Yuling,Qin, Jian,Gu, Yue-Yu,Li, Zhi,Wu, Xin-Lin,Mo, Sui-Lin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.12

Background and Aims: Scutellaria is one of the most popular traditional Chinese herbal remedies against various human diseases, including cancer. In this study, we examined the active effects of Scutellaria extract and its main flavonoid constituents on the proportion of side population cells within human multiple myeloma cell line RPMI8226 in vitro and explored the potential molecular mechanisms involved. Materials and Methods: The contents of flavonoids in ethanolic extract of Scutellaria baicalensis Georgi were determined using high performance liquid chromatography. The antiproliferative effect of the ethanolic extract on RPMI-8226 was determined by CCK assay. Apoptosis was measured by annexin combining with propidium iodide in a flow cytometer. Cell cycle analysis was performed by propidium iodide staining in combination with flow cytometry analysis. Hoechst 33342 exclusion assay was used for the identification of side population within RPMI8226 cells. The expression of ABCG2 protein was assessed by Western blotting assay. Results: The content of major flavonoids constitutents of Scutellaria extract was baicalin (10.2%), wogonoside (2.50%), baicalein (2.29%), and wogonin (0.99%), respectively. The crude Scutellaria extract did not show significant anti-proliferative effect, apoptosis induction and cell cycle arrest in RPMI-8226 within the concentrations of $1-75{\mu}g/mL$. However, the ethanolic extract, baicalein, wogonin and baicalin reduced the side population cells in RPMI-8226, and data showed that baicalein and wogonin had stronger inhibitory effects. Correspondingly, they also exhibited significant effects on decreasing the expression level of ABCG2 protein in RPMI-8226 in vitro. Conclusions: Our results for the first time demonstrated a novel mechanism of action for Scutellaria extract and its main active flavonoids, namely targeting SP cells by modulating the expression of ABCG2 protein. This study provides an insight for new therapeutic strategies targeting cancer stem cells of multiple myeloma.

A study of learning motivation and school adaptation for athletics classes of the elementary school students in Taipei City

Lin Ching-Ping,Hsieh Yu-Chen 한국스포츠교육학회 2011 한국스포츠교육학회 국제학술대회 자료집 Vol.2011 No.12

“把”와 “把”자구

林毓萍(Lin, Yu - Ping) 동덕여자대학교 인문과학연구소 2001 人文科學硏究 Vol.7 No.-

Ba is among the most commonly used word in Mandarin Chinese, and it helps to form rather unique construction which have beeb topics of numerous research by modern scholars of Chinese linguistics. Lots of research have been conducted on syntactic structure and historical development of the Ba-Construction. Ba was used as a complete verb in the archaic chinese. After the period, its syntactical and morpho-logical features as a verb became gradually weakened. Although grammarians insisted that Ba- construction was used in Taug Dynasty, jiang, and ba characters began to be weakened during Han Dynasty. It is at the age of the Six Dynasties that Yi- Construction was substituted by Ba-construction ; from Tang Dynasty to the present, Ba-construction generally has become used. Linguistic systems are arbitary and subjective products of the human mind when it tries to represent the external world. Speakers of different languages use different systems for their representation of outside world, and their systems all have their own intrinsic logic and can thus be specified or formulated. The basic structure of Ba-construction can be abstracted into the following formulas : NP1 + (X1) +把+ NP2 + (X2) + V + X3. In these formulas, the most prominent semantic feature is perhaps the restriction that the part " V + X3".

Prognostic value of right pulmonary artery distensibility in dogs with pulmonary hypertension

I-Ping Chan,Min-Chieh Weng,Tung Hsueh,Yun-Chang Lin,Shiun-Long Lin 대한수의학회 2019 Journal of Veterinary Science Vol.20 No.4

The right pulmonary artery distensibility (RPAD) index has been used in dogs with pulmonary hypertension (PH) caused by heartworm infection, myxomatous mitral valve disease, or patent ductus arteriosus. We hypothesized that this index correlates with the tricuspid regurgitation pressure gradient (TRPG) assessed by echocardiography and could predict survival in dogs with PH secondary to various causes. To assess this hypothesis, the medical records of 200 client-owned dogs at a referral institution were retrospectively reviewed. The RPAD index and the ratios of acceleration time to peak pulmonary artery flow (AT) and to the ejection time of pulmonary artery flow (ET) were recorded for each dog. The owners were contacted for follow-up assessments. The findings indicated that the RPAD index was correlated with the TRPG (R2 = 0. 362, p < 0.001). The survival time was significantly shorter in dogs with an RPAD index ≤ 21% that were followed up for 3 months and in dogs with an RPAD index ≤ 24% that were followed up for 1 year. Thus, the RPAD index was correlated with the TRPG and could predict the clinical outcome in dogs with PH caused by various diseases. This index could be used to evaluate the severity of PH in dogs without tricuspid regurgitation.

Efficient hole injection in blue organic light-emitting devices by using a double hole injection layer to improve chromaticity and electrical characteristics

Hua-Ping Lin,Fan Zhou,Xiao-Wen Zhang,Dong-Bin Yu,Jun Li,Liang Zhang,Xue-Yin Jiang,Zhi-Lin Zhang 한국물리학회 2011 Current Applied Physics Vol.11 No.3

A double hole injection layer consisting of Ag_2O//MoO_x was applied to a 4,40-bis (2,2-diphenylvinyl)-1,10-biphenyl-based blue organic light-emitting device (OLED). The hole current injection of the devicewas improved and the performance of the blue OLED was enhanced. We have observed that the insertion of such double layer leads to a striking improvement in chromaticity and electrical characteristics. This device showed much better chromaticity and less current-induced color shift as compared to the corresponding single hole injection layer counterparts. Using this strategy, a striking improvement in the electrical properties with lower driving voltage, higher power efficiency and a weak current-induced fluorescence quenching was achieved. This could be explained by the fact that an interlayer of Ag_2O//MoO_x provided a stepped energy level which greatly facilitated hole injection and hence enhanced injection current. The result is verified by using the J―V curves of ‘only’ devices and further explained with the help of Fowler-Nordheim (F-N) tunneling theory.

Add-on Tiotropium in Chinese Patients With Moderate Asthma: A Pooled Subgroup Analysis of MezzoTinA-Asthma 1 and 2

Jiangtao Lin,Huanying Wan,Jian Kang,Qianli Ma,Ping Chen,Meiling Jin,Haoyan Wang,Shuang Liu,Qinglin Hao,Yong Lin,Lin Su,Na Hu 대한천식알레르기학회 2019 Allergy, Asthma & Immunology Research Vol.11 No.4

Purpose: Asthma affects approximately 30 million patients in China; however, tiotropium data for Chinese patients is limited. This study aimed to assess the efficacy and safety of tiotropium in Chinese patients with moderate symptomatic asthma. Methods: A post hoc subgroup analysis was conducted on 430 Chinese patients pooled from two 24-week, replicate phase 3 trials (NCT01172808 and NCT01172821), in which they received once-daily tiotropium 2.5 μg (Tio R2.5) or 5 μg (Tio R5) (n = 106 or 109, respectively), twice-daily salmeterol 50 μg (Sal 50) (n = 110), or placebo (n = 105), while maintaining inhaled corticosteroids (ICS). The co-primary endpoints assessed in week 24 were forced expiratory volume in 1 second (FEV1) peak0–3h response, trough FEV1 response, and responder rate as assessed using the Asthma Control Questionnaire (ACQ). Results: For both FEV1 peak0–3h responses and trough FEV1 responses, the mean treatment differences were greater for Tio R2.5, Tio R5, and Sal 50 compared with placebo at 0.249 L, 0.234 L, and 0.284 L, and 0.172 L, 0.180 L, and 0.164 L, respectively (P< 0.001). The ACQ responder rate in placebo, Tio R2.5, Tio R5, and Sal 50 was 58.7%, 62.3%, 59.3%, and 69.1%, respectively. Furthermore, 11 (2.6%) of 430 patients had serious adverse events (Tio R5, n = 4; Tio R2.5, n = 1; Sal 50, n = 1; and placebo, n = 5). Conclusions: Once-daily tiotropium, as add-on to medium-dose ICS, was effective and well tolerated for Chinese patients with moderate symptomatic asthma, consistent with the main analysis.

Protein Cyclization Enhanced Thermostability and Exopeptidase-Resistance of Green Fluorescent Protein

( Zhong Lin Zhao ),( Xin Ma ),( Liang Li ),( Wei Zhang ),( Shu Zhen Ping ),( Ming Qun Xu ),( Min Lin ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.3

QTL Analysis of Floral Traits of Rice (Oryza Sativa L.) under Well-Watered and Drought Stress Conditions

Song Ping Hu,Ying Zhou,Lin Zhang,Xu Dong Zhu,Zheng Gong Wang,Lin Li,Li Jun Luo,Qing Ming Zhou 한국유전학회 2009 Genes & Genomics Vol.31 No.2

Three floral traits, spikelet number per panicle (SNP), percentage of single exserted stigma (PSES) and dual exserted stigma (PDES) of a RI population with 185 lines under water stress and non-stress conditions for two years were investigated in a drought tolerance screening facility. ANOVA results showed high significance between years, lines, and water stress treatments, together with interactions among them in pairs. High phenotypic correlation was found between PSES and PDES (r=0.5424***). Based on a linkage map of 203 SSR markers, when under well-watered condition, six QTLs (qSNP-3b, qSNP-4, qSNP-11 qSNP-2, qSNP-5 and qSNP-9) were detected for SNP. Half of them had significant Q×E interactions. Three QTLs (qPSES-1, qPSES-2, qPSES-5) were found to influence PSES, including one locus (qPSES-2) having Q×E interaction. And three QTLs (qPDES-2, qPDES-5 and qPDES-8) were also detected to influence PDES. qPDES-5 was found to have Q×E interaction. The contribution rate of a single QTL varied from 0.80% to 8.83% for additive effect, and 1.86% to 15.25% for Q×E interactions. Under drought stress, six QTLs (qSNP-3a, qSNP-4, qSNP-7a, qSNP-7b, qSNP-8 and qSNP-9) were associated with SNP, including qSNP-3a and qSNP-4 with Q×E interaction. Three QTLs (qPSES-1, qPSES-10 and qPSES-12) were located on rice chromosome 1, 10 and 12 for PSES. Four QTLs (qPDES-1a, qPDES-1b, qPDES-4 and qPDES-9) were detected for PDES, including qPDES-9 with Q×E interaction. The additive effect of single QTL can only explain 1.16% to 5.84% of total variance while Q×E interaction of four loci can explain 4.25% to 11.54% of total variance for each locus. There were one to nine pairs of epistatic QTLs influencing SNP and stigma exsertion. The contribution rates of additive and epistatic effects seemed to be in a low magnitude for most cases (0.76%~9.92%) while a few QTLs or QTL pairs explained more than 10% of total variance. Some main effect QTL and epistasis were commonly detected among PSES and PDES, explaining the high positive correlation between them. Few QTLs were detected under both water stress and non-stress conditions, indicating that drought had severe impact on the genetic behaviors of both spikelet number and stigma exsertion.