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Pengming Sun,Yiyi Song,Guanyu Ruan,Xiaodan Mao,Yafang Kang,Binhua Dong,Fen Lin 대한부인종양학회 2017 Journal of Gynecologic Oncology Vol.28 No.5
Objective: To determine the clinical significance of the polymerase chain reaction (PCR)-reverse dot blot (RDB) human papillomavirus (HPV) genotyping assay in cervical cancerscreening. Methods: A total of 10,442 women attending the Fujian Provincial Maternity and Children'sHealth Hospital were evaluated using the liquid-based cytology (thinprep cytologic test[TCT]) and the PCR-RDB HPV test. Women with HPV infection and/or abnormal cytologywere referred for colposcopy and biopsy. For HPV DNA sequencing, 120 specimens wererandomly selected. Pathological diagnosis was used as the gold standard. Results: Using the PCR-RDB HPV test, overall HPV prevalence was 20.57% (2,148/10,442)and that of high-risk (HR)-HPV infection was 18.68% (1,951/10,442). There was 99.2%concordance between HPV PCR-RDB testing and sequencing. In this studied population,the most common HR-HPV types were HPV-16, -52, -58, -18, -53, -33, and -51, rank fromhigh to low. HPV-16, -18, -58, -59, and -33 were the top 5 prevalent genotypes in cervicalcancer but HPV-16, -18, -59, -45, and -33 were the top 5 highest risk factors for cancer (oddsratio [OR]=34.964, 7.278, 6.728, 6.101, and 3.658; all p<0.05, respectively). Among 10,442cases, 1,278 had abnormal cytology results, of which, the HR-HPV positivity rate was 83.02%(1,061/1,278). To screen for cervical cancer by PCR-RDB HPV testing, when using CIN2+,CIN3+, and cancer as observed endpoints, the sensitivity was 90.43%, 92.61%, and 94.78%and the negative predictive value (NPV) was 99.06%, 99.42%, and 99.78%, respectively. PCRRDBHPV and TCT co-testing achieved the highest sensitivity and NPV. Conclusion: For cervical cancer screening, the PCR-RDB HPV test can provide a reliable andsensitive clinical reference.
Yafang Kang,Pengming Sun,Xiaodan Mao,Binhua Dong,Guanyu Ruan,Lihua Chen 대한부인종양학회 2019 Journal of Gynecologic Oncology Vol.30 No.3
Objective: To evaluate the polymerase chain reaction (PCR)-reverse-dot-blot (RDB) human papillomavirus (HPV) genotyping test as a feasible assay for the cervical cancer primary screening. Methods: In a hospital-based cohort, a total of 21,568 women were voluntarily enrolled from March 2009 to November 2016 for evaluating the 3 current cervical cancer screening strategies: co-test, cytology primary and high-risk HPV (HR-HPV) primary by using PCRRDB HPV genotyping and liquid-based cytology (thinprep cytologic test [TCT]). Women with HR-HPV infection and/or abnormal cytology were referred for colposcopy, and the biopsy or conization was performed according to the American Society for Colposcopy and Cervical Pathology (ASCCP) guidelines. Results: Overall, 18.20% (3,935/21,568) of the women were detected as HR-HPVpositive, 5.04% (1,088/21,568) were diagnosed with cervical intraepithelial neoplasia 2 or higher (CIN2+), and 3.43% (739/21,568) with CIN3+. The cumulative incidence rates for CIN2+/CIN3+ in patients with HPV-16/18-positive were 48.28%/37.20%, while they were 0.86%/0.38%, 0.30%/0.15% and 0.18%/0.09% in cytology-negative, HR-HPV-negative and co-test-negative population, respectively. Using CIN2+ and CIN3+ as the observed endpoints, the sensitivity and negative predictive value (NPV) of HR-HPV genotyping as a primary screening tool were 90.99%/99.49% and 91.57%/99.80%. Moreover, using HR-HPV genotyping primary screening could detect the same more CIN2+/CIN3+ cases in baselinedetection as co-testing (990/700 vs. 991/701) and far more than cytology primary screening (903/656, p<0.05). It also achieved the lowest misdiagnosis rate (8.01%/5.02%). Although HPV genotyping primary screening required an increased number of colposcopies (2.75/3.89 per CIN2+/CIN3+ case), it yielded an acceptable rate. Conclusions: The PCR-RDB HPV genotyping test is a cost-effective and beneficial cervical cancer primary screening for hospital-based opportunistic screening.
Yanjie Ji,Pengming Fu,P.T. Blythe,W. Guo,Wei Wang 대한토목학회 2015 KSCE JOURNAL OF CIVIL ENGINEERING Vol.19 No.7
Parking Guidance and Information (PGI) System becomes highly favorable for reducing circulating traffic and making efficient use of existing parking facilities. This paper is to examine the factors influence drivers’ willingness to use PGI. Factor analysis and the Structure Equation Model (SEM) were used to identify the latent attitudinal factors and the sensitivity of the factors was judged by Bayesian network. The heterogeneity of the factors was explored based on driver’s gender, age, driving years, education and travel frequency. The results show that drivers’ willingness to use PGI is significantly correlated to five attitudinal factors: perception of existing PGIs, difficulty in parking, confidence in the accuracy of the information, easy acquisition of information and information attributes. Male drivers, younger drivers, novice drivers and drivers who travel less frequently have lower level of willingness to use PGI.
The Research on Prediction Models for Urban Family Member Trip Generation
Shuo Yang,Wei Deng,Qionghua Deng,Pengming Fu 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.7
This paper validates the hypothesis that head of household’s attributes and travel behavior having effects on other family members’ trip frequency in the same household. With using Multinomial Logit Model (MNL) and data source obtained from Resident Trip Survey in Nanjing, 2010, it shows that other family members’ trip frequency are much more relative to head of household’s. Therefore, we propose an idea that investigates the potential possibility of using Multinomial Logit model (MNL) and Support Vector Machine (SVM) to predict other family members’ trip frequency with household’s information. By comparing the prediction accuracy, it is found that the SVM only slightly performs better on overall average accuracy. Then a modified SVM model with significant variables estimated by MNL model is given. The results report that, modified SVM model not only performs better on overall average accuracy than general SVM model and MNL model, but significantly improves partial average accuracy compared with general SVM model. However, the modified SVM still expectedly has a poor performance on predicting for small proportion samples. In the end, some possible improvements are discussed as well as expectation for further studies.
Cho, Y. M.,Oh, Seung Hun,Zhang, Pengming World Scientific Publishing Company 2018 International Journal of Modern Physics A Vol.33 No.7
<P>After Dirac introduced the monopole, topological objects have played increasingly important roles in physics. In this review we discuss the role of the knot, the most sophisticated topological object in physics, and related topological objects in various areas in physics. In particular, we discuss how the knots appear in Maxwell’s theory, Skyrme theory, and multicomponent condensed matter physics.</P>
New topological structures of Skyrme theory: baryon number and monopole number
Cho, Y. M.,Kimm, Kyoungtae,Yoon, J. H.,Zhang, Pengming Springer 2017 European Physical Journal C Vol.77 No.2
<P>Based on the observation that the skyrmion in Skyrme theory can be viewed as a dressed monopole, we show that the skyrmions have two independent topology, the baryon topology pi(3)(S-3) and the monopole topology pi(2)(S-2). With this we propose to classify the skyrmions by two topological numbers (m, n), the monopole number m and the shell (radial) number n. In this scheme the popular (non spherically symmetric) skyrmions are classified as the (m, 1) skyrmions but the spherically symmetric skyrmions are classified as the (1, n) skyrmions, and the baryon number B is given by B = mn. Moreover, we show that the vacuum of the Skyrme theory has the structure of the vacuum of the Sine-Gordon theory and QCD combined together, which can also be classified by two topological numbers (p, q). This puts the Skyrme theory in a totally new perspective.</P>
Is the exotic 0−− glueball a pure gluon state?
Pimikov, Alexandr,Lee, Hee-Jung,Kochelev, Nikolai,Zhang, Pengming American Physical Society 2017 Physical Review D Vol.95 No.7
<P>We present a new calculation of the mass and width of the exotic 0(--) glueball in the framework of the QCD sum rules. We next construct a new current which couples to a pure 0(--) gluon state and derive consistent and stable sum rules. A previously used current in this approach was shown to be inconsistent. We obtain for this state a mass MG = 6.3(-1.1)(+0.8) GeV and an upper limit for the total width Gamma(G) <= 235 MeV. These values can be used as an important guide for the experimental search of this exotic state. We argue that the mixing of this glueball state with the 0(--) tetraquark is very small. Therefore, the exotic 0(--) glueball can be considered as a pure gluon state.</P>