The 8th Biennial Meeting of the Asian Society of Gynecologic Oncology, December 1st to 3rd, 2023

Heng-Cheng Hsu,김재원,박정열,서동훈,김세익,Jen-Ruei Chen,Peng-Hui Wang 대한부인종양학회 2024 Journal of Gynecologic Oncology Vol.35 No.2

As per the 2018 GLOBOCAN database, Asia accounted for 48.7% (637,761) of new gynecologiccancer cases and 50.1% (305,000) of gynecologic cancer deaths [1]. Recognizing the distinctdifferences in genetic background, cancer epidemiology, disease characteristics, and socio-cultural environment between Asian and non-Asian women, it is noteworthy that much ofthe experimental evidence guiding clinical gynecologic oncology practices has historicallybeen drawn from studies in Western populations. Established in 2008, the Asian Society ofGynecologic Oncology (ASGO) ser ves as a key organization in Asia, dedicated to advancingthe study, prevention, and treatment of gynecological cancer through scientific exchange,regional/international collaboration, educational initiatives, and fostering camaraderieamong its members [2]. Presently, ASGO boasts members from over 10 countries in Asia. Building on the success of the previous meetings held in Tokyo (2009) [3], Seoul (2011)[4], Kyoto (2013) [5], Seoul (2015) [6], Tokyo (2017) [7], Incheon (2019) [8], and Bangkok(2021) [9], the eighth Biennial Meeting of ASGO took place at the state-of-the-art HNBKInternational Convention Center in Taipei, Taiwan, from December 01 to 03, 2023. Theoverarching theme for this event was “Reunion to Overcome Gynecologic Cancer in Asia.”Notably, due to the impact of the coronavirus disease 2019 pandemic in 2021, the meetingwas transformed into a hybrid format. This gathering marked a significant milestone as thefirst in-person Pan-Asia meeting focused on gynecological cancer following the pandemic. Additionally, it is worth highlighting that this was the inaugural ASGO meeting held outsideof Korea and Japan, underscoring the broadening geographical scope and global impactof the conference. Professor Peng-Hui Wang and Jae-Weon Jim chaired the organizingcommittee. ASGO 2023 witnessed the participation of 633 attendees from 17 countries,featuring 152 honored speakers and chairs from 12 countries. The event included 44 oral/surgical video presentations and 187 poster presentations, covering a diverse range ofscientific topics, from fundamental principles of gynecological cancer care to advanced, high-technology practices rooted in cutting-edge research (Table 1). Photos from the meetingare accessible on the official meeting website (http://tinyurl.com/26xtts2f ).

ANODIC OXIDES FORMED ON SPUTTERED AL THIN FILMS FOR THIN FILM TRANSISTOR LIQUID CRYSTAL DISPLAY APPLICATIONS

Chang, Chang, Peng-Heng,Chiu, Chiu, Re-Long 한국재료학회 1995 Fabrication and Characterization of Advanced Mater Vol.2 No.e3

Anodic $Al_2O_3$ capping layer has been reported to be albe to prohibit hillocks formation in Al thin film, a problem which has prevented the use of Al metallization to thin film transistor(TFT) liquid crystal display(LCD) until recently. This paper reports the characteristics of $Al_2O_3$grown by anodizing Al films sputtered on borophosphosilicate glass$(BPSG)/SiO_2/Si$ substrates. In particular, the effects of impurity doping, pre-treatment, and anodizing temperature on the structure and properties of the dielectric films are studied in detail

Production of Anti-Helicobacter pylori Metabolite by the Lichen-Forming Fungus Nephromopsis pallescens

Heng Luo,Yoshikazu Yamamoto,Hae-Sook Jeon,Yan Peng Liu,Jae Sung Jung,Young Jin Koh,허재선 한국미생물학회 2011 The journal of microbiology Vol.49 No.1

The present study was conducted to evaluate the antibacterial activity of lichen-forming fungi (LFF) against Helicobacter pylori, and to optimize the culture conditions of LFF for maximum production of natural antibiotics against H. pylori. To accomplish this, a screening assay was first conducted among 19 species of LFF. The extract of Nephromopsis pallescens (KOLRI-040516) exhibited the strongest anti-H. pylori activity. Bioautograghic TLC and HPLC analysis identified usnic acid as the main antibacterial substance produced by N. pallescens. The growth of N. pallescens and production of antibacterial substances produced by the fungus were then investigated under several culture conditions including the culture media, initial medium pHs, incubation temperatures, and the degree of aeration. The results indicated that culture in MY medium with an initial pH of 6.0, a temperature of 15°C and a low degree of aeration supported the largest usnic acid production of the fungus (16.4 μg usnic acid/g dry biomass). Especially, aeration was found to be an important factor that affect both growth and usnic acid production of N. pallescens.

High early pregnancy serum 25-hydroxy vitamin D level, within a sub-optimal range, is associated with gestational diabetes mellitus: a prospective cohort study

Heng Yaw Yong,Zalilah Mohd Shariff,Lalitha Palaniveloo,Su Peng Loh,Barakatun Nisak Mohd Yusof,Zulida Rejali,Jacques Bindels,Yvonne Yee Siang Tee,Eline M. van der Beek 한국영양학회 2022 Nutrition Research and Practice Vol.16 No.1

GATA2-Mediated Transcriptional Activation of Notch3 Promotes Pancreatic Cancer Liver Metastasis

Heng Lin,Peng Hu,Hongyu Zhang,Yong Deng,Zhiqing Yang,Leida Zhang 한국분자세포생물학회 2022 Molecules and cells Vol.45 No.5

The liver is the predominant metastatic site for pancreatic cancer. However, the factors that determine the liver metastasis and the specific molecular mechanisms are still unclear. In this study, we used human pancreatic cancer cell line Hs766T to establish Hs766T-L3, a subline of Hs766T with stable liver metastatic ability. We performed RNA sequencing of Hs766T-L3 and its parental cell line Hs766T, and revealed huge differences in gene expression patterns and pathway activation between these two cell lines. We correlated the difference in pathway activation with the expression of the four core transcriptional factors including STAT1, NR2F2, GATA2, and SMAD4. Using the TCGA database, we examined the relative expression of these transcription factors (TFs) in pan-cancer and their relationship with the prognosis of the pancreatic cancer. Among these TFs, we considered GATA2 is closely involved in tumor metastasis and may serve as a potential metastatic driver. Further in vitro and in vivo experiments confirmed that GATA2-mediated transcriptional activation of Notch3 promotes the liver metastasis of Hs766T-L3, and knockdown of either GATA2 or Notch3 reduces the metastatic ability of Hs766T-L3. Therefore, we claim that GATA2 may serve as a metastatic driver of pancreatic cancer and a potential therapeutic target to treat liver metastasis of pancreatic cancer.

H_3PW_12_O40/SiO_2 for sorbitol dehydration to isosorbide: High efficient and reusable solid acid catalyst

Peng Sun,He Huang,Ding Hua Yu,Yi Hu,Zhen Chen Tang,Jiao Jiao Xia,Heng Li 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.1

Tungstophosphoric acids (PW) supported on various metal oxides (SiO_2, γ_Al_2O_3, TiO_2, ZrO_2 and CeO_2)were synthesized and used as catalysts for sorbitol dehydration to isosorbide for the first time. 30% PW/SiO_2 exhibited the best catalytic performance for sorbitol dehydration, over which 56% isosorbide selectivity could be gained at a 95% sorbitol conversion at 250℃. The catalytic performance of regenerated 30% PW/SiO_2 catalysts by dichloromethane elution showed no loss after recycling five runs. Characterizations with UV-Vis, XRD, NH3-TPD and thermal analysis techniques revealed that PW had a good dispersion, and the primary Keggin structure was preserved after supporting PW on different supports. The interaction between PW and oxides resulted in different acidity of catalysts,which affected conversion of sorbitol and selectivity for isosorbide. The final acidity order of supported PW catalysts was the following: SiO_2>γ_Al_2O_3>TiO_2 ≈ZrO_2>CeO_2.

The In Vitro Antioxidant Properties of Chinese Highland Lichens

( Heng Luo ),( Yoshikazu Yamamoto ),( Yan Peng Liu ),( Jae Sung Jung ),( Hyung Yeel Kahng ),( Young Jin Koh ),( Jae Seoun Hur ) 한국미생물 · 생명공학회 2010 Journal of microbiology and biotechnology Vol.20 No.11

The antioxidant properties of 46 lichen species, collected from the highly UV-exposed alpine areas of southwestern China, were evaluated for their potential therapeutic utilization. The anti-linoleic acid peroxidation activity, 1,1- diphenyl-2-picryl-hydrazyl (DPPH) scavenging activity, reducing power, and total phenolic contents were all assessed in vitro in the methanol extract of the lichens. A potent reducing power was detected in a number of the lichen extracts, when compared with butylated hydroxyanisole (BHA). In general, it was found that many of the lichens, with antioxidant properties, contained large quantities of phenolic content. Extracts of Peltigera praetextata and Sticta nylanderiana were found to exhibit the most potent activity in all of the antioxidant tests. In particular, extracts of S. nylanderiana displayed a 1.37 times greater anti-linoleic acid peroxidation activity, when compared with the ascorbic acid used as the positive control. S. nylanderiana also possessed the strongest free radical scavenging activity amongst all the tested species, with an inhibition rate of 90.4% at concentration of 330 ?g/ml. Activity-guided bioautographic TLC and HPLC analyses were used to establish which compounds were responsible for the potent antioxidant activities of the S. nylanderiana extract. These analyses revealed lecanoric acid to be primarily responsible for the effective antioxidant properties of S. nylanderiana. Overall, these results have indicated that several highland lichens have the potential of being utilized as novel bioresources for naturally occurring antioxidant therapies.

Effects of Propranolol on the Left Ventricular Volume of Normal Subjects During CT Coronary Angiography

Yuan Heng Mo,Fu Shan Jaw,Yung Cheng Wang,Chin Ming Jeng,Shinn Forng Peng 대한영상의학회 2011 Korean Journal of Radiology Vol.12 No.3

Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed. Objective: The purpose of this study is to determine the effects of propranolol on the left ventricular (LV) volume during CT coronary angiography. Materials and Methods: The LV volume of 252 normal Chinese subjects (126 subjects with propranolol medication and 126 age- and gender-matched Chinese subjects without medication) was estimated using 64 slices multi-detector CT (MDCT). The heart rate difference was analyzed by the logistic linear regression model with variables that included gender, age, body height, body weight, systolic blood pressure (SBP), diastolic blood pressure (DBP) and the dosage of propranolol. The following global LV functional parameters were calculated: the real-end diastolic volume (EDV), the real-end systolic volume (ESV) and the real-ejection fraction (EF). Results: The female subjects had a greater decrease of heart rate after taking propranolol. The difference of heart rate was negatively correlated with the dosage of propranolol. The real-EDV, the real-ESV and the real-EF ranged from 48.1 to 109 mL/m2, 6.1 to 57.1 mL/m2 and 41% to 88%, respectively. There was no significant difference in the SBP and DBP between the groups without and with propranolol medication (123 ± 17 and 80 ± 10 mmHg; 120 ± 14 and 80 ± 11 mmHg, respectively). The real-EDV showed no significant difference between these two groups, but the real-ESV and real-EF showed significant differences between these two groups (69.4 ± 9.3 and 70.6 ± 8.9 mL/m2; 23.5 ± 5.7 and 25.6 ± 3.7 mL/m2, 66.5 ± 5.1% and 63.5 ± 4.6%, respectively). Conclusion: The difference of heart rate is significantly influenced by gender and the dosage of propranolol. Propranolol will also increase the ESV, which contributes to a decreased EF, while the SBP, DBP and EDV are not statistically changed.

Biruloquinone, an Acetylcholinesterase Inhibitor Produced by Lichen-Forming Fungus Cladonia macilenta

( Luo Heng ),( Chang Tian Li ),( Jin Cheol Kim ),( Yan Peng Liu ),( Jae Sung Jung ),( Young Jin Koh ),( Jae Seoun Hur ) 한국미생물 · 생명공학회 2013 Journal of microbiology and biotechnology Vol.23 No.2

At present, acetylcholinesterase (AChE) inhibitors are the first group of drugs to treat mild to moderate Alzheimer`s disease (AD). Although beneficial in improving cognitive and behavioral symptoms, the effectiveness of AChE inhibitors has been questioned since they do not delay or prevent neurodegeneration in AD patients. Therefore, in the present study, in order to develop new and effective anti-AD agents from lichen products, both the AChE inhibitory and the neuroprotective effects were evaluated. The AChE inhibitory assay was performed based on Ellman`s reaction, and the neuroprotective effect was evaluated by using the MTT method on injured PC12 cells. One AChE inhibitor (IC50 = 27.1 μg/ml) was isolated by means of bioactivity-guided isolation from the extract of lichen-forming fungus Cladonia macilenta, which showed the most potent AChE inhibitory activity in previous screening experiment. It was then identified as biruloquinone by MS, and 1H- and 13C-NMR analyses. The inhibitory kinetic assay suggested that biruloquinone is a mixed-II inhibitor on AChE. Meanwhile, biruloquinone improved the viability of the H2O2- and β-amyloid-injured PC12 cells at 1 to 25 μg/ml. The protective effects are proposed to be related to the potent antioxidant activities of biruloquinone. These results imply that biruloquinone has the potential to be developed as a multifunctional anti- AD agent.

Fuzzy Resilient Energy-to-Peak Filtering for Continuous-Time Nonlinear Systems

Chang, Xiao-Heng,Park, Ju H.,Shi, Peng Institute of Electrical and Electronics Engineers, 2017 IEEE Transactions on Fuzzy Systems Vol. No.

<P>The problem of resilient energy-to-peak filtering for a class of uncertain continuous-time nonlinear systems is investigated in this paper. A Takagi–Sugeno fuzzy model with norm-bounded uncertainties is used to represent the nonlinear plant. Attention is focused on the design of an energy-to-peak filter such that the filtering error system is asymptotically stable and the prescribed energy-to-peak filtering performance is guaranteed, where the designed filter is assumed to have additive gain variations. The proposed design is aimed at all filter matrices with gain variations, which improves the existing results on resilient energy-to-peak filtering for continuous-time systems. A simulation example is provided to show the effectiveness of the proposed methods.</P>