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Role of carbonic anhydrases in skin wound healing
Harlan Barker,Marleena Aaltonen,Peiwen Pan,Maria Vähätupa,Pirkka Kaipiainen,Ulrike May,Stuart Prince,Hannele Uusitalo-Järvinen,Abdul Waheed,Silvia Pastoreková,William S Sly,Seppo Parkkila,Tero AH Järv 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Skin wound closure occurs when keratinocytes migrate from the edge of the wound and re-epithelialize the epidermis. Their migration takes place primarily before any vascularization is established, that is, under hypoxia, but relatively little is known regarding the factors that stimulate this migration. Hypoxia and an acidic environment are well-established stimuli for cancer cell migration. The carbonic anhydrases (CAs) contribute to tumor cell migration by generating an acidic environment through the conversion of carbon dioxide to bicarbonate and a proton. On this basis, we explored the possible role of CAs in tissue regeneration using mouse skin wound models. We show that the expression of mRNAs encoding CA isoforms IV and IX are increased (~25 × and 4 × , respectively) during the wound hypoxic period (days 2–5) and that cells expressing CAs form a bandlike structure beneath the migrating epidermis. RNA-Seq analysis suggested that the CA IV-specific signal in the wound is mainly derived from neutrophils. Due to the high level of induction of CA IV in the wound, we treated skin wounds locally with recombinant human CA IV enzyme. Recombinant CA IV significantly accelerated wound re-epithelialization. Thus, CA IV could contribute to wound healing by providing an acidic environment in which the migrating epidermis and neutrophils can survive and may offer novel opportunities to accelerate wound healing under compromised conditions.
Lingbo Wang,Xin Kang,Peiwen Jiang 대한토목학회 2016 KSCE JOURNAL OF CIVIL ENGINEERING Vol.20 No.1
A numerical analysis of the dynamic behavior of multi-span continuous bridges subject to traffic loadings and vehicle dynamic interactions is presented in this paper using the finite element program ANSYS. The proposed numerical model is capable of: (1) analyze “complex bridge systems”, “complex vehicle models”, and “complex traffic conditions”; (2) predict the vehicle-bridge coupled vibration response under various complex traffic loadings and vehicle dynamic conditions including the passage of multiple vehicles, vehicles changing lanes, vehicles subject to constant acceleration, and vehicles overtaking; and, (3) investigate the effect of girder stiffness decay on the coupled vibration of the vehicle-bridge system. Analytical and experimental results indicate that decay in the girder stiffness has a major effect on the coupled vibrations between the vehicles and bridge. The established method could be extended to analyze the vehicle-bridge coupled vibrations of many different types of bridges subject to complex vehicle loadings, which potentially could have a broad impact in the field of Bridge Engineering.
Zhang Zhaoqi,Guo Peiwen,Liang Liang,Jila Shiju,Ru Xufang,Zhang Qiang,Chen Jingyu,Chen Zhi,Feng Hua,Chen Yujie 생화학분자생물학회 2023 Experimental and molecular medicine Vol.55 No.-
Hydrocephalus is a severe complication that can result from intracerebral hemorrhage, especially if this hemorrhage extends into the ventricles. Our previous study indicated that the NLRP3 inflammasome mediates cerebrospinal fluid hypersecretion in the choroid plexus epithelium. However, the pathogenesis of posthemorrhagic hydrocephalus remains unclear, and therapeutic strategies for prevention and treatment are lacking. In this study, an Nlrp3−/− rat model of intracerebral hemorrhage with ventricular extension and primary choroid plexus epithelial cell culture were used to investigate the potential effects of NLRP3-dependent lipid droplet formation and its role in the pathogenesis of posthemorrhagic hydrocephalus. The data indicated that NLRP3-mediated dysfunction of the blood–cerebrospinal fluid barrier (B-CSFB) accelerated neurological deficits and hydrocephalus, at least in part, through the formation of lipid droplets in the choroid plexus; these lipid droplets interacted with mitochondria and increased the release of mitochondrial reactive oxygen species that destroyed tight junctions in the choroid plexus after intracerebral hemorrhage with ventricular extension. This study broadens the current understanding of the relationship among NLRP3, lipid droplets and the B-CSFB and provides a new therapeutic target for the treatment of posthemorrhagic hydrocephalus. Strategies to protect the B-CSFB may be effective therapeutic approaches for posthemorrhagic hydrocephalus.
Bo Yang,Yuesong Shen,Yun Su,Peiwen Li,Yan-Wei Zeng,Shubao Shen,Shemin Zhu 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.50 No.-
A novel Mn-Ce-Nb-Ox/P84 catalyticfilter for synergetic removal of particulates and NO was designed andprepared by a new method using functional foaming coating. Removal characteristics of nitrogen oxides(including catalyst loading amount, O2 concentration, NH3/NO molar ratio, H2O and SO2) andparticulates, were systematically studied. Results showed that the NO removal efficiency of catalyticfilter reached 95.3% at 200 C, as the catalyst loading amount,filtration velocity and mole ratio of NH3/NOwere set to be 450 g/m2, 1 m/min and 1, respectively. The removal characteristic of particulates of Mn-Ce-Nb-Ox/P84 catalyticfilter belonged surfacefiltration and the PM2.5 removal efficiency reached 99.98%.
Zhongwei Zhai,Haibo Wang,Benmei Wei,Peiwen Yu,Chengzhi Xu,Lang He,Juntao Zhang,Yuling Xu 한국고분자학회 2018 Macromolecular Research Vol.26 No.7
Self-assembled environment of collagen is one of the important factors for improving and regulating the properties of collagen-based biomaterials. This study aimed to investigate the effect of ionic liquids (ILs) on the fibril-formation and gel properties of grass carp (Ctenopharyngodon idellus) skin collagen. Fibrillogenic kinetics analysis showed that the collagen self-assembly can be suppressed by the introduction of ILs, and the inhibitory effect is influenced by concentration and types of ILs. Scanning electron microscopy test indicated that the assembled collagen fibrils in the presence of ILs had bigger diameters than that in the conventional buffer. Differential scanning calorimetry analysis revealed that the thermal stability of collagen fibrils can be significantly increased when self-assembly is performed in the presence of ILs. Moreover, the introduction of ILs enhanced the mechanical strength of collagen gels. Finding from this work provides a new idea for improving the performance of fish-sourced collagen biomaterials.
Diphoton signal of the light Higgs boson in natural NMSSM
Cao, Junjie,Guo, Xiaofei,He, Yangle,Wu, Peiwen,Zhang, Yang American Physical Society 2017 Physical review. D Vol.95 No.11
<P>The natural Next-to-Minimal Supersymmetric Standard Model (nNMSSM) is featured by predicting one CP-even Higgs boson satisfying m(h1) less than or similar to 120 GeV and Higgsinos lighter than about 300 GeV, and consequently, the cross section for dark matter (DM)-nucleon scattering in this scenario is usually quite large. We study the diphoton signal of the light Higgs boson in nNMSSM by considering the tight constraints from the latest LUX and PandaX-II experiments, and we conclude that the optimal value of the signal rate at 8 TeV LHC is greatly reduced in comparison with earlier predictions. For example, previous studies indicated that the rate may exceed 120 fb for m(h1) similar or equal to 80 GeV, while it is at most 25 fb if the lightest neutralino in the scenario is fully responsible for the measured DM relic density. We also investigate the case of m(h1) similar or equal to 98 GeV, which is hinted by the excesses of the large electron proton collider analysis on Z (b) over bar b signal and the compact muon solenoid analysis on the diphoton signal. We conclude that nNMSSM can simultaneously explain the excesses at the 1 sigma level without violating any known constraints.</P>