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클링커를 골재로 활용한 콘크리트의 특성에 관한 문헌연구
배준걸 ( Pei Jun Jie ),장정국 ( Jang Jeong Gook ) 한국구조물진단유지관리공학회 2020 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.24 No.2
클링커는 소성로에서 석회석과 점토 등이 소성, 화합되어 나오는 직경 3~26mm 정도 크기의 잔자갈 모양의 덩어리이다. 콘크리트 제조에 사용되는 천연 골재의 부족 문제를 해결하기 위하여 다양한 재료가 검토되고 있으며, 클링커는 후보 물질 중 하나로서 다수의 연구가 진행되고 있다. 문헌 조사 연구 결과에 의하면 천연 골재의 대체재로 클링커를 사용하면 클링커의 표면에서 일어나는 수화반응으로 인해 콘크리트의 압축강도가 향상될 수 있는 반면 굳지않은 콘크리트의 물성에는 부정적인 영향을 미칠 수도 있음을 알 수 있다. 본 연구에서는 클링커 골재를 활용한 기존의 연구들을 고찰하여 향후 클링커 골재 대체 기술의 전망을 제시하였다.
중국의 CSA 시멘트 제조기술 및 구조분야 활용에 관한 문헌 연구
배준걸 ( Pei Jun Jie ),장정국 ( Jang Jeong Gook ) 한국구조물진단유지관리공학회 2020 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.24 No.1
중국에서 처음 제안된 CSA(Calcium Sulfoaluminate) 시멘트는 속경성, 조강성, 고강도성, 침투저항성, 동결융해저항성, 방식성 및 저알칼리성 등의 특징을 가지고 있다. 뿐만 아니라 제조과정에서 요구되는 소성온도가 일반 포틀랜드 시멘트보다 낮아 소비되는 에너지를 절약할 수 있어 최근 전 세계적으로 친환경 시멘트로 주목받고 있다. 본 문헌 연구에서는 중국 내에서 산업 고체 폐기물을 원료로 사용한 칼슘설포알루미네이트 시멘트 제조기술을 주제로 수행되었던 기존의 연구들을 고찰하여 분석하였으며, 이를 바탕으로 향후 CSA 시멘트 기술의 전망을 제시하였다.
Shu-Tsen Liu(Shu-Tsen Liu),Sheng-Che Lin(Sheng-Che Lin),Jane Pei-Chen Chang(Jane Pei-Chen Chang),Kai-Jie Yang(Kai-Jie Yang),Che-Sheng Chu(Che-Sheng Chu),Chia-Chun Yang(Chia-Chun Yang),Chih-Sung Liang( 대한정신약물학회 2023 CLINICAL PSYCHOPHARMACOLOGY AND NEUROSCIENCE Vol.21 No.1
There is growing evidence that the coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is associated with increased risks of psychiatric sequelae. Depression, anxiety, cognitive impairments, sleep disturbance, and fatigue during and after the acute phase of COVID-19 are prevalent, long-lasting, and exerting negative consequences on well-being and imposing a huge burden on healthcare systems and society. This current review presented timely updates of clinical research findings, particularly focusing on the pathogenetic mechanisms underlying the neuropsychiatric sequelae, and identified potential key targets for developing effective treatment strategies for long COVID. In addition, we introduced the Formosa Long COVID Multicenter Study (FOCuS), which aims to apply the inflammation theory to the pathogenesis and the psychosocial and nutrition treatments of post-COVID depression and anxiety.
Pei-Ying Huang,Xin Yin,Yue-Ting Huang,Qi-Qing Ye,Si-Qing Chen,Xun-Jie Cao,Tian-Ao Xie,Xu-Guang Guo 연세대학교의과대학 2022 Yonsei medical journal Vol.63 No.5
Purpose: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the pathogen of coronavirus disease 2019. Diagnosticmethods based on the clustered regularly interspaced short palindromic repeats (CRISPR) have been developed to detect SARSCoV-2 rapidly. Therefore, a systematic review and meta-analysis were performed to assess the diagnostic accuracy of CRISPR fordetecting SARS-CoV-2 infection. Materials and Methods: Studies published before August 2021 were retrieved from four databases, using the keywords “SARS-CoV-2”and “CRISPR.” Data were collected from these publications, and the sensitivity, specificity, negative likelihood ratio (NLR), positivelikelihood ratio (PLR), and diagnostic odds ratio (DOR) were calculated. The summary receiver operating characteristic curve wasplotted for analysis with MetaDiSc 1.4. The Stata 15.0 software was used to draw Deeks’ funnel plots to evaluate publication bias. Results: We performed a pooled analysis of 38 independent studies shown in 30 publications. The reference standard was reversetranscription-quantitative PCR. The results indicated that the sensitivity of CRISPR-based methods for diagnosis was 0.94 (95% CI0.93–0.95), the specificity was 0.98 (95% CI 0.97–0.99), the PLR was 34.03 (95% CI 20.81–55.66), the NLR was 0.08 (95% CI 0.06–0.10), and the DOR was 575.74 (95% CI 382.36–866.95). The area under the curve was 0.9894. Conclusion: Studies indicate that a diagnostic method based on CRISPR has high sensitivity and specificity. Therefore, this wouldbe a potential diagnostic tool to improve the accuracy of SARS-CoV-2 detection.
Jie-Hao Chen,Chih-Chun Hsieh,Pei-Shing Hua,Chia-Ming Chang,Chi-Ming Lin,Paxon Ti-Yuan Wu,Weite Wu 대한금속·재료학회 2013 METALS AND MATERIALS International Vol.19 No.1
A series of Fe-Cr-C hardfacing alloys is deposited by gas tungsten arc welding and subjected to abrasive wear testing. Pure Fe with various amounts of CrC (Cr:C=4:1) powders are mixed as the fillers and used to deposit hardfacing alloys on low carbon steel. Depending on the various CrC additions to the alloy fillers,the claddings mainly contain hypoeutectic, near eutectic, or hypereutectic microstructures of austenite γ-Fe phase and (Cr,Fe)7C3 carbides on hardfacing alloys, respectively. When 30% CrC is added to the filler, the finest microstructure is achieved, which corresponds to the γ-Fe+(Cr,Fe)7C3 eutectic structure. With the addition of 35% and 40% CrC to the fillers, the results show that the cladding consists of the massive primary (Cr,Fe)7C3 as the reinforcing phase and interdendritic Fe+(Cr,Fe)7C3 eutectics as the matrix. The (Cr,Fe)7C3 carbide-reinforced claddings have high hardness and excellent wear resistance under abrasive wear test conditions. Concerning the abrasive wear feature observable on the worn surface, the formation and fraction of massive primary (Cr,Fe)7C3 carbides predominates the wear resistance of hardfacing alloys. Abrasive particles result in continuous plastic grooves when the cladding has primary γ-Fe phase in a hypoeutectic structure.
Novel Phage Display-Derived H5N1-Specific scFvs with Potential Use in Rapid Avian Flu Diagnosis
( Jie Wu ),( Xian Qiao Zeng ),( Hong Bin Zhang ),( Han Zhong Ni ),( Lei Pei ),( Li Rong Zou ),( Li Jun Liang ),( Xin Zhang ),( Jin Yan Lin ),( Chang Wen Ke ) 한국미생물 · 생명공학회 2014 Journal of microbiology and biotechnology Vol.24 No.5
The highly pathogenic avian influenza A (HPAI) viruses of the H5N1 subtype infect poultry and have also been spreading to humans. Although new antiviral drugs and vaccinations can be effective, rapid detection would be more efficient to control the outbreak of infections. In this study, a phage-display library was applied to select antibody fragments for HPAI strain A/Hubei/1/2010. As a result, three clones were selected and sequenced. A hemagglutinin inhibition assay of the three scFvs revealed that none exhibited hemagglutination inhibition activity towards the H5N1 virus, yet they showed a higher binding affinity for several HPAI H5N1 strains compared with other influenza viruses. An ELISA confirmed that the HA protein was the target of the scFvs, and the results of a protein structure simulation showed that all the selected scFvs bound to the HA2 subunit of the HA protein. In conclusion, the three selected scFVs could be useful for developing a specific detection tool for the surveillance of HPAI epidemic strains.
Detection of Thiocholine Ions with Cobalt Phthalocyanine Mediated Screen Printed Electrode
Jie-Kai Er,윤용진,Sum Huan Ng,King Ho Holden Li,신충수,Pei-Chen Su,Nam Beng Tay,Wei Wang 한국정밀공학회 2014 International Journal of Precision Engineering and Vol. No.
Acetylcholine (ACh) is a neurotransmitter that is responsible for many of our bodily functions while acetylcholineesterase (AChE) isits enzyme. Certain nerve agents inhibit AChE to cause malfunctions of our body system. To detect those agents, the concentrationof AChE by-product, choline, is used as a detection marker. Using a screen printed electrode and acetylthiocholine (ATCh) as areplacement for ACh, amperometry is employed to detect the concentration of the AChE-ATCh reaction by-product, thiocholine. Results showed that 0.1 V is the optimum potential for thiocholine detection. Voltages of 0.2 V and 0.3 V also produced similar currentmagnitudes. From 0.225 mM to 0.9 mM of thiocholine, the amperometry current exhibits a linear relation with concentration. Thesensitivity electrode is around 2.53 μA/mM. A flow rate of 100 μL/min is chosen as it is close to the saturation oxidation rate of theelectrode and is useful in practical situations. Taking into account the errors met at 0.1 V, the sensitivity of the system is calculatedto a minimum of 0.04 mM.
Hui Jie Wong,Sakinah Harith,Pei Lin Lua,Khairul Azmi Ibrahim 대한노인병학회 2022 Annals of geriatric medicine and research Vol.26 No.2
Background: Screening for sarcopenia in the stroke population is an emerging concept in research and clinical practice. Therefore, this cross-sectional study aimed to assess the prevalence of possible sarcopenia and its associated factors among older stroke survivors who visited the neurology and rehabilitation departments of three public hospitals in Malaysia. Methods: We acquired data on sociodemographic characteristics, clinical profiles, malnutrition risk, dietary intake, physical activity level, and health-related quality of life. Possible sarcopenia was diagnosed in individuals with decreased calf circumference and low handgrip strength, as proposed by the Asia Working Group for Sarcopenia (2019). Finally, we performed descriptive analysis and binary logistic regression. Results: Among 196 older adults with stroke (mean± standard deviation of age: 67.60 ± 5.70 years), 42.3% had possible sarcopenia, with a higher prevalence in the more advanced age group (≥70 years). In univariable analysis, possible sarcopenia was significantly associated with anthropometric indices, malnutrition risk, nutrient intake, physical activity level, and health-related quality of life. In multivariable analysis, body mass index (adjusted odds ratio [AOR]=0.57; 95% confidence interval [CI], 0.43–0.75) was the only factor associated with possible sarcopenia among individuals aged ≥70 years. Recurrent stroke (AOR=3.48; 95% CI, 1.02–11.92), body mass index (AOR=0.64; 95% CI, 0.54–0.76), and EQ-5D index (AOR=0.15; 95% CI, 0.03–0.78) were significantly associated with possible sarcopenia in the 60–69-year age group. Conclusion: The prevalence of possible sarcopenia among community-dwelling older stroke survivors was high. Therefore, we recommend routine screening for possible sarcopenia to ensure early nutritional and exercise intervention.
Jyun-Pei Jhou,Se-Jie Chen,Ho-Yin Huang,Wan-Wan Lin,Duen-Yi Huang,Shiang-Jong Tzeng 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Resveratrol, an anti-inflammatory agent, can inhibit pro-inflammatory mediators by activating Sirt1, which is a class III histone deacetylase. However, whether resveratrol can regulate inhibitory or anti-inflammatory molecules has been less studied. FcγRIIB, a receptor for IgG, is an essential inhibitory receptor of B cells for blocking B-cell receptor-mediated activation and for directly inducing apoptosis of B cells. Because mice deficient in either Sirt1 or FcγRIIB develop lupus-like diseases, we investigated whether resveratrol can alleviate lupus through FcγRIIB. We found that resveratrol enhanced the expression of FcγRIIB in B cells, resulting in a marked depletion of plasma cells in the spleen and notably in the bone marrow, thereby decreasing serum autoantibody titers in MRL/lpr mice. The upregulation of FcγRIIB by resveratrol involved an increase of Sirt1 protein and deacetylation of p65 NF-κB (K310). Moreover, increased binding of phosphor-p65 NF-κB (S536) but decreased association of acetylated p65 NF-κB (K310) and phosphor-p65 NF-κB (S468) to the − 480 promoter region of Fcgr2b gene was responsible for the resveratrol-mediated enhancement of FcγRIIB gene transcription. Consequently, B cells, especially plasma cells, were considerably reduced in MRL/lpr mice, leading to improvement of nephritis and prolonged survival. Taken together, we provide evidence that pharmacological upregulation of FcγRIIB expression in B cells via resveratrol can selectively reduce B cells, decrease serum autoantibodies and ameliorate lupus nephritis. Our findings lead us to propose FcγRIIB as a new target for therapeutic exploitation, particularly for lupus patients whose FcγRIIB expression levels in B cells are downregulated.