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Chun-Yu Liu,Tzu-Ting Huang,Pei-Yi Chu,Chun-Teng Huang,Chia-Han Lee,Wan-Lun Wang,Ka-Yi Lau,Wen-Chun Tsai,Tzu-I Chao,Jung-Chen Su,Ming-Huang Chen,Chung-Wai Shiau,Ling-Ming Tseng,Kuen-Feng Chen 생화학분자생물학회 2017 Experimental and molecular medicine Vol.49 No.-
Triple-negative breast cancer (TNBC) remains difficult to treat and urgently needs new therapeutic options. Nintedanib, a multikinase inhibitor, has exhibited efficacy in early clinical trials for HER2-negative breast cancer. In this study, we examined a new molecular mechanism of nintedanib in TNBC. The results demonstrated that nintedanib enhanced TNBC cell apoptosis, which was accompanied by a reduction of p-STAT3 and its downstream proteins. STAT3 overexpression suppressed nintedanib-mediated apoptosis and further increased the activity of purified SHP-1 protein. Moreover, treatment with either a specific inhibitor of SHP-1 or SHP-1-targeted siRNA reduced the apoptotic effects of nintedanib, which validates the role of SHP-1 in nintedanib-mediated apoptosis. Furthermore, nintedanib-induced apoptosis was attenuated in TNBC cells expressing SHP-1 mutants with constantly open conformations, suggesting that the autoinhibitory mechanism of SHP-1 attenuated the effects of nintedanib. Importantly, nintedanib significantly inhibited tumor growth via the SHP-1/p-STAT3 pathway. Clinically, SHP-1 levels were downregulated, whereas p-STAT3 was upregulated in tumor tissues, and SHP-1 transcripts were associated with improved disease-free survival in TNBC patients. Our findings revealed that nintedanib induces TNBC apoptosis by acting as a SHP-1 agonist, suggesting that targeting STAT3 by enhancing SHP-1 expression could be a viable therapeutic strategy against TNBC.
보리 가공에 의한 Deoxynivalenol의 감소 효과
Pei, Shi-Chun,Lee, Won-Jong,Ryu, Gi-Hyung,Chung, Duck-Hwa 한국식품위생안전성학회 2004 한국식품위생안전성학회지 Vol.19 No.3
Deoxynivalenol (DON)에 오염된 보리의 가공과정에서 도정, 단순가열, 제빵 및 압출성형 등 공정에 의한 DON의 감소 및 파괴에 미치는 영향을 시험하였다 실험에 사용된 보리의 DON오염도는 2.08 ppm이었으며 보리로부터 분리한 DON 생성균은 Fusarium graminearum으로 생성능은 Czapek-Dox Broth 액체배지에서 평균 6.33 ppm이었다. 도정에 의한 DON의 제거 정도는 56.5%였으며 단순가열에 의한 감소는 3.8-32.7%로 나타났다. Extrusion에 의한 제거 정도는 53-59%였으며 제빵과정에서 최종 10.4%의 DON이 제거 된 것으로 나타나 가공 후 상당한 DON이 잔류되어있어 DON의 완전제거 할 수 있는 방법을 새로 개발할 필요가 있다고 사료된다. This study examined the effects of pearling, simple heating, baking and extrusion in processing of barley contaminated with deoxynivalenol (DON) on the reduction or destruction of DON. The DON contamination level of barley used in the experiment was 2.08 ppm. The DON-forming strain isolated from the barley was Fusarium graminearum, and the DON formation potential of which was 6.3 ppm on the average in Czapek-Dox broth medium. The DON removal efficiency of pearling was 56.5%, simple heating 3.8-32.7%, extrusion 53-59%, and baking 10.4%. As a large quantity of DON still remains after processing, it is necessary to develop a new method of removing DON completely.
탄화수소 온도가열곡선에 따른 고강도 콘크리트의 내화특성
( Pei Chang-chun ),노상균 ( Noh Sang-kyun ),송용원 ( Song Yong-won ),이백수 ( Lee Bai-shou ),한천구 ( Han Cheon-goo ) 한국구조물진단유지관리공학회 2007 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.11 No.2
This study investigates the fire resistance of the high strength concrete to enforce a fire test according to the hydrocarbon(HC) temperature heating curve. The results are summarized as following. For the properties of the fresh concrete, all slump flow and air content corresponding to the variation of the fiber contents are satisfied with their target. For the properties of the hardened concrete, the compressive strengths of all specimens are about 70 MPa, and it is slightly decreased according to the fiber content. For the spalling occurrence after the fire test, the explosive spalling occurs below 0.01% of the fiber content, but there is no spalling on the 0,05% of the fiber content. The residual compressive strength corresponding to the fiber content is about 10%, and weight loss ratio is also about 10%, but they are comparatively favorable.
Interactive Motion Planning for Autonomous Robotic Photo Taking
Pei-Chun Lu,Kai-Tai Song 제어로봇시스템학회 2021 제어로봇시스템학회 국제학술대회 논문집 Vol.2021 No.10
In this paper, a motion planning method is proposed for an autonomous photo-taking robot. The developed human-robot interactive motion planning and control system is based on face recognition and facial pose estimation of a target person. The target person’s location is estimated after combined with robot self-localization result. Then the goal position and orientation of the robot are determined for autonomous photo-taking of the specific person. An APP for mobile phones has been integrated to select the target person and transmit the command to the robot for photo taking. After receiving the command, the robot autonomously navigates to the goal location and shoots pictures of the target person. Experimental results show that the experimental mobile robot can recognize the specific person, regardless the person is stand alone or in a crowd. The robot completed two types of picture-taking tasks by using the proposed method.
Pei-Chun Chao,Chuan-Chia Chang,Hsin-An Chang 대한신경정신의학회 2018 PSYCHIATRY INVESTIGATION Vol.15 No.9
Transcranial direct current stimulation (tDCS), a non-invasive neuromodulation technique, has been increasingly used to treat bipolar depression. Researchers recently noticed the risk of tDCS-emergent mania/hypomania in depressed patients and started to evaluate this risk by launching a meta-analysis. Here we present a female with bipolar II depression who rapidly developed hypomanic switching during bifrontal tDCS.
The Presence of Borrelia valaisiana-Related Genospecies in Ticks and a Rodent in Taiwan
Chun-Man Huang,Hsi-Chieh Wang,Ying-Chun Lin,Shih-Hui Chiu,Ying-Shun Kao,Pei-Lung Lee,Hsiu-I Wang,Ruei-Chen Hung,Huang-I Chan,Ho-Sheng Wu,Chuen-Sheue Chiang,Jung-Jung Mu 한국미생물학회 2010 The journal of microbiology Vol.48 No.6
A field survey was conducted to investigate the presence of Borrelia burgdorferi sensu lato (s.l.) in six counties of Taiwan. Spirochetes were successfully isolated from one rodent ear sample out of 485 rodent ears and 53live, fed tick (Ixodes granulatus) samples. The spirochetes were confirmed to be B. burgdorferi s.l. by real-time PCR. In addition, 23 of 113 tick samples were tested positive for Borrelia DNA according to real-time PCR. The Borrelia isolate from the rodent and the 23 Borrelia DNA samples from the ticks were identified as B. valaisiana-related genospecies by phylogenetic analysis based on flagellin gene sequences. These findings suggest that the Borrelia valaisiana-related strains are maintained in a zoonotic cycle between tick vectors and reservoir hosts in Taiwan.
고강도 콘크리트의 폴리머수지 혼입율 변화에 따른 내화특성 검토
( Pei Chang-chun ),허영선 ( Heo Young-sun ),이보형 ( Lee Bo-hyeong ),한창평 ( Hann Chang-pyung ),양성환 ( Yang Seong-hwan ),한천구 ( Han Cheon-goo ) 한국구조물진단유지관리공학회 2007 한국구조물진단유지관리공학회 학술발표대회 논문집 Vol.11 No.1
This study investigates spalling appearance and residual compressive strength after examination of fundamental properties on the concrete and fire test to prevent spalling of the concrete. Test results showed that fluidity, air content, and compressive strength are excellent in the case that polyethylene Polyvinyl Acetate and polyvinyl alcohol fiber was mixed. After fire test, it is analyzed that using polyvinyl alcohol fiber is effective considering spalling property.