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Chini Deep Sankar,Mondal Niladri,Kar Avijit,Bunholi Ingrid,Singh Sourav,Ghosh Pratik,Patra Prasanta,Patra Shampa,Patra Bidhan Chandra 한국해양과학기술원 2023 Ocean science journal Vol.58 No.2
Marine fishes are one of the important factors in stabilizing the local aquatic ecosystem and regulating the nutritional socioeconomy of local fisher folks. The recent increases in anthropogenic activity, pollution and overfishing have led to the decline of marine fish species richness and their local aquatic habitats. In this study we sought to determine the inter-relationship between water quality, anthropogenic activity, and fish landing stations through a 31 km stretch of the East Midnapore coast in West Bengal, India which is known for its tourist destinations. The study was conducted monthly on different trawler fish landing sites from Dec 2018 to Dec 2021. During this period, we took fish samples and identified them. We obtained water quality data regarding Sea Surface Temperature (SST), Concentration of Chlorophyll-a (Chl-a), Turbidity, and Dissolved Oxygen (DO) in order to identify further correlation between the water quality analysis and species diversity. 154 numbers of commercially important marine fish species were documented. As per the IUCN database, 13% of the total fish species fall under the red list category and 16% of the species reveal a decreasing population trend. The availability of those red-listed fish throughout the season has been shown in the matrix plot to detect their gradual decrease in sighting. After analyzing the water quality data, we found out that DO, SST, Turbidity, and Chl-a correlate with the species richness on some sites and the water parameters are also differs during the seasons. Both fish species richness and water quality have been affected on those fish landing sites which have been subject to heavy anthropogenic loads.
Patra, N.,De, U.,Kim, T.H.,Lee, Y.J.,Ahn, M.Y.,Kim, N.D.,Yoon, J.H.,Choi, W.S.,Moon, H.R.,Lee, B.M.,Kim, H.S. Masson Pub. USA, Inc 2013 Biomedicine & pharmacotherapy Vol.67 No.5
Histone deacetylase (HDAC) inhibitors are a new class of anticancer agents that act by inhibiting cancer cell proliferation and inducing apoptosis in various cancer cell lines. To investigate the anticancer effect of a novel histone deacetylase (HDAC) inhibitor MHY219, its efficacy was compared to that of suberoylanilide hydroxamic acid (SAHA) in human prostate cancer cells. The anticancer effects of MHY219 on cell viability, HDAC enzyme activity, cell cycle regulation, apoptosis and other biological assays were performed. MHY219 was shown to enhance the cytotoxicity on DU145 cells (IC<SUB>50</SUB>, 0.36μM) when compared with LNCaP (IC<SUB>50</SUB>, 0.97μM) and PC3 cells (IC<SUB>50</SUB>, 5.12μM). MHY219 showed a potent inhibition of total HDAC activity when compared with SAHA. MHY219 increased histone H3 hyperacetylation and reduced the expression of class I HDACs (1, 2 and 3) in prostate cancer cells. MHY219 effectively increased the sub-G1 fraction of cells through p21 and p27 dependent pathways in DU145 cells. MHY219 significantly induced a G2/M phase arrest in DU145 and PC3 cells and arrested the cell cycle at G0/G1 phase in LNCaP cells. Furthermore, MHY219 effectively increased apoptosis in DU145 and LNCaP cells, but not PC3 cells, according to Annexin V/PI staining and Western blot analysis. These results indicate that MHY219 is a potent HDAC inhibitor that targets regulating multiple aspects of cancer cell death and might have preclinical value in human prostate cancer chemotherapy, warranting further investigation.
Green Nanobiotechnology: Factors Affecting Synthesis and Characterization Techniques
Patra, Jayanta Kumar,Baek, Kwang-Hyun Hindawi Limited 2014 Journal of nanomaterials Vol.2014 No.-
<P>Nanobiotechnology is gaining tremendous impetus in this era owing to its ability to modulate metals into their nanosize, which efficiently changes their chemical, physical, and optical properties. Accordingly, considerable attention is being given to the development of novel strategies for the synthesis of different kinds of nanoparticles of specific composition and size using biological sources. However, most of the currently available techniques are expensive, environmentally harmful, and inefficient with respect to materials and energy use. Several factors such as the method used for synthesis, pH, temperature, pressure, time, particle size, pore size, environment, and proximity greatly influence the quality and quantity of the synthesized nanoparticles and their characterization and applications. Additionally, characterization of the synthesized nanoparticles is essential to their potential use in various drug delivery and biomedical applications. The present review highlights various parameters affecting the synthesis of nanoparticles by green nanobiotechnology and different techniques used for characterizing the nanoparticles for their potential use in biomedical and environmental applications.</P>
Patra, Nabanita,De, Umasankar,Kang, Jin-Ah,Kim, Ji Mim,Ahn, Mee Young,Lee, Jaewon,Jung, Jee H.,Chung, Hae Young,Moon, Hyung Ryong,Kim, Hyung Sik Elsevier 2011 european journal of pharmacology Vol.658 No.2
<P><B>Abstract</B></P><P>Here, we reported the synthesis of a novel topoisomerase II inhibitor, MHY336, which that has strong topoisomerase-mediated anticancer activity but fewer side effects than other topoisomerase II inhibitors. The catalytic activity of MHY336 on the topoisomerase II enzyme was the same as that of the etoposide. In a cell-free system, MHY336 exhibited a potent activity on scavenging of reactive oxygen species against 3-morpholinosydnonimine hydrochloride (SIN-1)-induced oxidative stress. An <I>in vitro</I> cell-based assay demonstrated that MHY336 significantly inhibited the proliferation of three prostate cancer cell lines, LNCaP, PC-3, and DU145 cells. Notably, the cytotoxicity of MHY336 was more potent in LNCaP cells (IC<SUB>50</SUB>=1.39μM) than in DU145 (IC<SUB>50</SUB>=2.94μM) and PC3 cells (IC<SUB>50</SUB>=3.72μM). Furthermore, MHY336 treatment induced similar levels of cytotoxicity compared to doxorubicin treatment (IC<SUB>50</SUB>=1.55μM) in LNCap cells. Also, MHY336 significantly down-regulated topoisomerase II alpha expression and up-regulated p53 expression in LNCaP cells (wild-type p53), whereas it up-regulated the topoisomerase II alpha protein in both DU145 and PC3 cells (p53 mutated or deleted). MHY336 induced G2/M or S phase arrest in LNCaP cells through a well-documented topoisomerase II-dependent mechanism. Further studies using Annexin V-FITC binding assay, DAPI staining, and Western blot analyses illustrated that MHY336 markedly induced apoptotic cell death via the mitochondria-mediated intrinsic pathway in LNCaP cells. These results suggest that MHY336 is an attractive chemotherapeutic agent because of its topoisomerase II-mediated anti-tumour activity in human prostate cancer.</P>
Patra, A.K.,Sharma, K.,Dutta, Narayan,Pattanaik, A.K. Asian Australasian Association of Animal Productio 2002 Animal Bioscience Vol.15 No.12
This study was conducted to examine the effect of Leucaena leucocephala-Morus alba-Azadirachta indica (2:1:1) based leaf meal mixture as nitrogen source to partially replace (50%) soybean meal in conventional supplements on the performance of goats. Twelve non-descript female goats were divided into two equal groups in a completely randomized design to receive either the leaf meal mixture based supplement (LMAM) or soybean meal incorporated concentrate (SBM) and wheat straw for ad libitum intake for a two month period. The goats given LMAM and SBM concentrate had similar dry matter intake ($50.2{\pm}1.67g/kg\;W^{0.75}$) and nutrient digestibility. Nitrogen intake and its faecal and urinary excretion were similar irrespective of diets. The balance of nitrogen was positive and comparable ($1.63{\pm}0.08g/d$) in both dietary treatments. The plane of nutrition on both diets was comparable and the digestible crude protein and total digestible nutrients values of the composite diets offered did not differ significantly between the dietary supplements. The serum concentration of enzymes alanine aminotransferase and aspartate aminotransferase were statistically similar in both the groups, while haemoglobin and serum urea levels were significantly (p<0.05) higher in LMAM and SBM treatments, respectively. It was concluded that the leaf meal mixture of Leucaena leucocephala-Morus alba-Azadirachta indica could be used as a vegetable protein supplement to wheat straw based diet of goats.
Patra, Dhananjaya,Lee, Jaehyuk,Lee, Jongbok,Sredojevic, Dusan N.,White, Andrew J. P.,Bazzi, Hassan S.,Brothers, Edward N.,Heeney, Martin,Fang, Lei,Yoon, Myung-Han,Al-Hashimi, Mohammed The Royal Society of Chemistry 2017 Journal of materials chemistry. C, Materials for o Vol.5 No.9
<P>New low band gap copolymers P1-P4, based on thienylenevinylene (TV) and pyrrolo[3,2-d:4,5-d']bisthiazole (PBTz) units composed of different alkyl side chains, such as 2-octyldodecyl (OD), n-hexadecyl (HD), 2-ethylhexyl (EH), and 9-heptadecyl (HD) groups, respectively, have been synthesized and characterized. Electrochemical and optical studies of the copolymers indicated low energy band gaps in the range of 1.40-1.47 eV. Moreover, theoretical calculation with density functional theory (DFT) and time-dependent DFT calculations demonstrated that the energy band gaps, HOMO energy levels and maximum absorption values in the copolymers were in good agreement with the experimental results. The decomposition temperature of all copolymers was measured to be above 340 degrees C by thermogravimetric analysis (TGA), which indicates high thermal stability. Thermally annealed OTFT devices based on P1-P4 thin films demonstrated a range of hole mobilities; thus, the P2 based OTFT device exhibited the highest hole mobility of 0.062 cm(2) V-1 s(-1).</P>
Patra, J.K.,Baek, K.H. Elsevier Sequoia 2017 Journal of photochemistry and photobiology. B, Bio Vol.173 No.-
In this study, a simple, rapid, and eco-friendly green method was introduced to synthesize magnetite iron oxide nanoparticles (Fe<SUB>3</SUB>O<SUB>4</SUB> NPs) using the aqueous extracts of two food processing wastes, namely silky hairs of corn (Zea mays L.) and outer leaves of Chinese cabbage (Brassica rapa L. subsp. pekinensis). The boiled solutions of silky hairs (MH) and outer leaves of Chinese cabbage (CCP) were used to synthesize Fe<SUB>3</SUB>O<SUB>4</SUB> NPs under photo exposed condition. The MH-FeNPs and CCP-FeNPs synthesized via green route were characterized by UV-Vis spectroscopy, field emission scanning electron microscopy (FE-SEM), energy-dispersive X-ray spectroscopy (EDX), Fourier-transform infrared spectroscopy (FT-IR), X-ray diffraction (XRD), differential thermogravimetric (TG/DTG) analysis, and vibrating sample magnetometer (VSM) analysis. The UV-Visible spectra displayed two absorption bands at 325nm and 375mm for the MH-FeNPs, and 325mm and 365mm for the CCP-FeNPs, respectively. The estimated absolute crystallite sizes of the MH-FeNPs and CCP-FeNPs were calculated to be 84.81 and 48.91nm, respectively. VSM analysis revealed that both FeNPs were superparamagnetic in nature. Both FeNPs mixed with kanamycin and rifampicin displayed positive synergistic antibacterial activity against pathogenic foodborne bacteria (9.36-24.42mm inhibition zones), and those mixed with amphotericin b also exerted synergistic anticandidal activity against five different pathogenic Candida species (9.81-17.68mm inhibition zones). Both FeNPs exhibited strong antioxidant activities; therefore, all the properties of the green synthesized MH-FeNPs and CCP-FeNPs using food processing wastes could be beneficial for their potential applications in various fields such as drug delivery, antibacterial and anticandidal drugs, and biomedical fields.