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Aceng Ruyani,Deni Parlindungan,Eda Kartika,Reza Julian Putra,Agus Sundaryono,Agus Susanta 한국독성학회 2020 Toxicological Research Vol.36 No.2
This study aimed to investigate the effectiveness of leaf ethanolic extract of Etlingera hemisphaerica (LE3H) against the teratogenic effects of mercuric chloride ( HgCl2) in mice (Mus musculus). Pregnant M. musculus were divided into four groups, each consisting of 10 dams, and received drink and food ad libitum. The first, second, and third, and fourth (control) groups were administered with LE3H, HgCl2, HgCl2 + LE3H, and double-distilled water alone, respectively. HgCl2 (5 mg/kg bw) was administered by injection on gestation day (GD) 9, and LE3H (0.39 mg/g bw) was administered by gavage on GD 10. Treated and control animals were killed by cervical dislocation on GD 18, dissected, and the fetuses were collected for evaluation of maternal, embryonic, and fetal toxicity. Eight parameters were measured: (a) embryo resorption or resorbed embryo, (b) dead fetus, (c) living fetus, (d) morphologically normal living fetus, (e) malformed living fetus, (f) number of MLF, (g) length of MNLF, and (h) weight of MNLF. LE3H caused 4 (50.00%), whereas HgCl2 resulted in 7 (87.50%) parameters that were significantly different from those of the control, indicating that the teratogenicity of HgCl2 was significantly higher than that of LE3H. HgCl2 + LE3H showed two effects of LE3H on the teratogenicity of HgCl2: increased 2 (25.00%), and decreased 6 (75.00%). Thus, LE3H decreased the teratogenic effects of HgCl2 in M. musculus.
Dispersion stability and its effect on tape casting of solvent-based SiC slurries
이종현,Weon-Ju Kim,Ji-Yeon Park,Parlindungan Yonathan,윤당혁 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.3
Slurries containing well-dispersed ceramic particles are essential for further processing, such as tape casting and infiltration to a woven fabric, to produce high quality products. In this study, various types of suspensions were prepared with 4 different types of commercial dispersants to examine the dispersion mechanism and determine the optimum conditions for the microsized α- and 50 nm-sized β-SiC systems in a toluene/ethanol mixed solvent. According to the sedimentation and rheological results, 3 and 20 wt.% of a polyester/polyamine co-polymeric dispersant were found to be the most effective dispersant for α- and β-SiC suspensions, respectively. An electrostatic mechanism did not play a major role in the mixed solvent system when a dispersant was added. The optimum amount of dispersant for the slurry was less than that for the suspension due to the dispersing effect of the polyvinyl butyral (PVB) binder. Due to the high specific surface area of the nano-sized β-SiC powder, 40 wt.% binder resin was needed to achieve a tape with desirable properties, while 15 wt.% of binder was adequate for the slurry with α-SiC with a lower surface area. Overall, the tape properties, such as green morphology and density, were strongly related to the dispersion state of the slurry. Slurries containing well-dispersed ceramic particles are essential for further processing, such as tape casting and infiltration to a woven fabric, to produce high quality products. In this study, various types of suspensions were prepared with 4 different types of commercial dispersants to examine the dispersion mechanism and determine the optimum conditions for the microsized α- and 50 nm-sized β-SiC systems in a toluene/ethanol mixed solvent. According to the sedimentation and rheological results, 3 and 20 wt.% of a polyester/polyamine co-polymeric dispersant were found to be the most effective dispersant for α- and β-SiC suspensions, respectively. An electrostatic mechanism did not play a major role in the mixed solvent system when a dispersant was added. The optimum amount of dispersant for the slurry was less than that for the suspension due to the dispersing effect of the polyvinyl butyral (PVB) binder. Due to the high specific surface area of the nano-sized β-SiC powder, 40 wt.% binder resin was needed to achieve a tape with desirable properties, while 15 wt.% of binder was adequate for the slurry with α-SiC with a lower surface area. Overall, the tape properties, such as green morphology and density, were strongly related to the dispersion state of the slurry.