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Olmos-Serrano, J.,Kang, H.,Tyler, William A.,Silbereis, John C.,Cheng, F.,Zhu, Y.,Pletikos, M.,Jankovic-Rapan, L.,Cramer, Nathan P.,Galdzicki, Z.,Goodliffe, J.,Peters, A.,Sethares, C.,Delalle, I.,Gold Cell Press 2016 Neuron Vol.89 No.6
Trisomy 21, or Down syndrome (DS), is the most common genetic cause of developmental delay and intellectual disability. To gain insight into the underlying molecular and cellular pathogenesis, we conducted a multi-region transcriptome analysis of DS and euploid control brains spanning from mid-fetal development to adulthood. We found genome-wide alterations in the expression of a large number of genes, many of which exhibited temporal and spatial specificity and were associated with distinct biological processes. In particular, we uncovered co-dysregulation of genes associated with oligodendrocyte differentiation and myelination that were validated via cross-species comparison to Ts65Dn trisomy mice. Furthermore, we show that hypomyelination present in Ts65Dn mice is in part due to cell-autonomous effects of trisomy on oligodendrocyte differentiation and results in slower neocortical action potential transmission. Together, these results identify defects in white matter development and function in DS, and they provide a transcriptional framework for further investigating DS neuropathogenesis.
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Olmos Buitrago, J.,Perez, R.A.,El-Fiqi, A.,Singh, R.K.,Kim, J.H.,Kim, H.W. Elsevier BV 2015 ACTA BIOMATERIALIA Vol.28 No.-
Moldable hydrogels that incorporate stem cells hold great promise for tissue engineering. They secure the encapsulated cells for required periods while allowing a permeable exchange of nutrients and gas with the surroundings. Core-shell fibrous structured hydrogel system represents these properties relevant to stem cell delivery and defect-adjustable tissue engineering. A designed dual concentric nozzle is used to simultaneously deposit collagen and alginate with a core-shell structured continuous fiber form in the ionic calcium bath. We aimed to impart extrinsic osteogenic cues in the nanoparticulate form, i.e., bioactive glass nanoparticles (BGn), inside the alginate shell, while encapsulating rat mesenchymal stem cells in the collagen core. Ionic measurement in aqueous solution indicated a continuous release of calcium ions from the BGn-added and -free scaffolds, whereas silicon was only released from the BGn-containing scaffolds. The presence of BGn allowed higher number of cells to migrate into the scaffolds when implanted in subcutaneous tissues of rat. Cell viability was preserved in the presence of the BGn, with no significant differences noticed from the control. The presence of BGn enhanced the osteogenic differentiation of the encapsulated rat mesenchymal stem cells, presenting higher levels of alkaline phosphatase activity as well as bone related genes, including collagen type I, bone sialoprotein and osteocalcin. Taken together, the incorporated BGn potentiated the capacity of the core-shell fibrous hydrogel system to deliver stem cells targeting bone tissue engineering.
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Recent Developments in the EU Investment Policy : Towards an Investment World Court?
Belen Olmos Giupponi 한국중재학회 2016 중재연구 Vol.26 No.3
The controversies that have surrounded the negotiation of both the Comprehensive Economic and Trade Agreement (CETA) and the Transatlantic Trade and Investment Partnership (TTIP) have underlined the difficulties arising out from the adoption of a truly common EU investment policy. Non‐governmental organizations have called into question transparency and legitimacy of international investment arbitration during the negotiations. The article presents a reflection about current developments of the EU investment policy addressing, in particular, the criticisms towards the whole investor‐to‐State system and the EU’s efforts in developing a “tailor‐made” investment agreement and Investor‐to‐State Dispute resolution system. Along these lines, the article critically assesses the recently announced proposal for the establishment of an ‘Investment Court System’ put forward by the EU during the TTIP negotiations.
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Analysis of Compression and Permeability Behavior of Porous Ti6Al4V by Computed Microtomography
Luis Olmos,Didier Bouvard,Jose Luis Cabezas‑Villa,Jose Lemus‑Ruiz,Omar Jiménez,Dante Arteaga 대한금속·재료학회 2019 METALS AND MATERIALS International Vol.25 No.3
Porous materials were developed as a good alternative to replace different bones in the human body as they improve osseointegration,tissue ingrowth and simulate the mechanical properties of human bones. Such characteristics highly depend on thepore features and volume fraction. Samples with a pore volume fraction between 16 and 60% and a pore size distribution of100–500 μm were analyzed by computed microtomography. 3D images acquisition was performed at 10 μm pixel resolution,which permitted to observe the complete sample. Features like size, shape, orientation, connectivity and pore coordinationwere determined from the 3D image analysis. Compression behavior was evaluated by interrupted compression testing and,after that, new 3D images were acquired. In order to evaluate permeability, numerical simulations of flow throughout the3D images were carried out by using Avizo® software. It was found that shape and pore size distribution was similar in allsamples, showing good distribution of the pore formers inside the matrix. Full connectivity of pores was obtained with 32%volume fraction and above, and the coordination number follows the Artz model. The pores showed a radial orientation,which induces anisotropy in the flow properties. The compression showed two different behaviors, pore closing and porecoalescence. Values of permeability match with those reported for bones as well as the anisotropy in the radial and verticaldirections. It is concluded that the sample with 60 vol% of pores could be consider to be used for bone implants.
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Recent Developments in the EU Investment Policy : Towards an Investment World Court?
Giupponi, Belen Olmos The Korean Association of Arbitration Studies 2016 중재연구 Vol.26 No.3
The controversies that have surrounded the negotiation of both the Comprehensive Economic and Trade Agreement (CETA) and the Transatlantic Trade and Investment Partnership (TTIP) have underlined the difficulties arising out from the adoption of a truly common EU investment policy. Non-governmental organizations have called into question transparency and legitimacy of international investment arbitration during the negotiations. The article presents a reflection about current developments of the EU investment policy addressing, in particular, the criticisms towards the whole investor-to-State system and the EU's efforts in developing a "tailor-made" investment agreement and Investor-to-State Dispute resolution system. Along these lines, the article critically assesses the recently announced proposal for the establishment of an 'Investment Court System' put forward by the EU during the TTIP negotiations.
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Discrete Element Simulation of the Sintering of Composite Powders
Martina C. L.,Olmos L.,Schneiderb L. C. R.,Bouvardc D. 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1
The free sintering of metallic powders blended with non sintering inclusions is investigated by the Discrete Element Method (DEM). Each particle, whatever its nature (metallic or inclusion) is modeled as a sphere that interacts with its neighbors. We investigate the retarding effect of the inclusions on the sintering kinetics. Also, we present a simple coarsening model for the metallic particles, which allows large particles to grow at the expense of the smallest.
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End-of-Life Jeepneys in the Philippines
( Noemi Torre ),( Edwin Olmos ),( Theta Ponce ),( Solito Nudo ) 한국폐기물자원순환학회(구 한국폐기물학회) 2019 ISSE 초록집 Vol.2019 No.-
Each year, millions of motor vehicles reach their end-of-life. The Philippines with the initiative of the current administration, launched the PUV Modernization Program which aims to i) modernize the current PUV fleet, ii) reform and consolidate the industry, iii) move towards low emission PUVs iv)improve welfare of commuters and encourage modal shift and v) improve standards of living of drivers, operators, and their families. There are around 200,000 jeepneys in the Philippines and 90% of which are 15 years old and above. Most are unsafe and environmentally harmful. Some car manufacturers have started to be mindful of their vehicles recyclability index. Besides being considered as the “king of the road” in the Philippines, the jeepney has its share of cultural contribution to the country. Add to this that all of this jeepneys are locally made. And so the handling of the end-of-life jeepneys is very crucial not only to the manufacturers, but also to the riding public and drivers of the jeepneys. With the volume of jeepneys facing end-of-life, the Philippines cannot afford to just throw the dismantled parts in the filled-up landfills. Besides, most of the jeepneys composition is metal which will definitely have many uses afterwards. The motivation of the research is to maximize the reuse of the jeepneys parts while minimizing the parts that will be dumped in the landfill.
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( Viviana P. Rubio ),( Alejandra Bravo ),( Jorge Olmos ) 한국미생물 · 생명공학회 2017 Journal of microbiology and biotechnology Vol.27 No.1
In this work, we isolated a surface layer protein (SLP) from a Bacillus thuringiensis (Bt) strain to evaluate it cytotoxic effects against MDA-MB-231 human breast cancer cells. AP11 was selected from a g roup o f B t s trains u sing SLP o lig onucleotides developed f rom Bacillus conserved regions. The AP11 strain was grown in Luria Bertani medium until the late exponential phase; an 86 kDa protein was extracted using 5 M LiCl and identified by liquid chromatography- tandem mass spectrometry. It corresponded to a multispecies SLP highly similar to previously described SLPs in Bt. The MDA-MB-231 breast cancer cells LC50 was obtained using 0.25 μg/ml of the isolated SLP. HaCat non-cancerous cells presented 90% survival using the same protein concentration. Our data suggest that SLP cytotoxicity against MDA-MB-231 could be induced by an interaction with the CDH11 cell membrane receptor.
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Cruz R. Santa,Barbieri I. De,Olmos V. Morales,Montossi F.,Viñoles C. 아세아·태평양축산학회 2022 Animal Bioscience Vol.35 No.10
Objective: The objective was to test if creep feeding (CF) improves the average daily gain (ADG) and weaning weight of calves submitted to temporary weaning (TW) and if the combination of CF and TW improves conception and pregnancy rates of cows. Methods: Primiparous (n = 74) and primiparous and multiparous (n = 104) cows grazing native grasslands were used in experiment 1 and 2; respectively. The experimental design was in plots divided into complete random blocks with two replications. The CF was the big plot and TW the small plot, thus four experimental groups were formed: i) –CF–TW (n = 21 and 27); ii) –CF+TW (n = 16 and 24); iii) +CF–TW (n = 20 and 26); iv) +CF+TW (n = 17 and 27) with cow-calf pairs for experiments 1 and 2; respectively. Nose plate application for TW had a duration of 14 and 15 days for experiment 1 and 2: respectively. In experiment 1, calves were fed at 1% of live weight for 112 days using a commercial supplement with 18.4% crude protein. In experiment 2, the supplementation lasted 98 days, and was carried out with corn dried distillers grains with soluble (DDGS) at 40% of the potential intake on a daily basis. Results: The TW reduced ADG during the TW period and the following 14 days, but the negative effect of TW was maintained until the final weaning only in experiment 2. The CF increased ADG during TW period in both experiments. The TW promoted an earlier conception of the dams (12 days in –CF treatment and 19 days in +CF treatment, p<0.01) and CF increased pregnancy rate in experiment 1, being the effects not consistent between experiments. Conclusion: The CF consistently promoted an increase in ADG during the period of TW and increased final weaning weight of calves, therefore it is economically viable. Objective: The objective was to test if creep feeding (CF) improves the average daily gain (ADG) and weaning weight of calves submitted to temporary weaning (TW) and if the combination of CF and TW improves conception and pregnancy rates of cows.Methods: Primiparous (n = 74) and primiparous and multiparous (n = 104) cows grazing native grasslands were used in experiment 1 and 2; respectively. The experimental design was in plots divided into complete random blocks with two replications. The CF was the big plot and TW the small plot, thus four experimental groups were formed: i) –CF–TW (n = 21 and 27); ii) –CF+TW (n = 16 and 24); iii) +CF–TW (n = 20 and 26); iv) +CF+TW (n = 17 and 27) with cow-calf pairs for experiments 1 and 2; respectively. Nose plate application for TW had a duration of 14 and 15 days for experiment 1 and 2: respectively. In experiment 1, calves were fed at 1% of live weight for 112 days using a commercial supplement with 18.4% crude protein. In experiment 2, the supplementation lasted 98 days, and was carried out with corn dried distillers grains with soluble (DDGS) at 40% of the potential intake on a daily basis.Results: The TW reduced ADG during the TW period and the following 14 days, but the negative effect of TW was maintained until the final weaning only in experiment 2. The CF increased ADG during TW period in both experiments. The TW promoted an earlier conception of the dams (12 days in –CF treatment and 19 days in +CF treatment, p<0.01) and CF increased pregnancy rate in experiment 1, being the effects not consistent between experiments.Conclusion: The CF consistently promoted an increase in ADG during the period of TW and increased final weaning weight of calves, therefore it is economically viable.
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