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Advanced Imaging in the Current Era of Acute Reperfusion Therapies
Klearchos Psychogios,Odysseas Kargiotis,Apostolos Safouris,Georgios Magoufis,Lina Palaiodimou,Mariana Papadopoulou,Stavros Spiliopoulos,Georgios Velonakis,Michail Mantatzis,Theodore Karapanayiotides,P 대한신경초음파학회 2023 대한신경초음파학회지 (JNN) Vol.15 No.1
Reperfusion of the ischemic brain parenchyma with intravenous thrombolysis and/or mechanical thrombectomy is the cornerstone of acute ischemic stroke treatment. A paradigm shift from “time is brain” to a more precision medicine approach now called “imaging is brain”, has taken place during the last decade. This transformation has been fueled by the progress in neuroimaging. Advanced Neuroimaging incorporates perfusion imaging in order to depict real-time cerebral perfusion disturbances and provide maps of the penumbra and ischemic core that will inform individualized clinical decisions. Advance neuroimaging has now a fundamental role in triaging patients that will receive reperfusion treatments beyond the conventional time windows of 4.5 hours for intravenous thrombolysis and 6 hours for mechanical thrombectomy. We provide a narrative review of all the pivotal observational studies and randomized-controlled clinical trials that supported the use of advance neuroimaging, as well as technical issues and pitfalls that may be useful for its implementation in routine clinical practice.
The Emerging Clinical Utility of Neurosonology During COVID-19 Pandemic
Eleni Bakola,Odysseas Kargiotis,Klearchos Psychogios,Apostolos Safouris,Lina Palaiodimou,Maria-Ioanna Stefanou,Maria Chondrogianni,Theodoros Karapanayiotides,Konstantinos Vadikolias,Christos Krogias,S 대한신경초음파학회 2021 대한신경초음파학회지 (JNN) Vol.13 No.2
Coronavirus disease 2019 (COVID-19) is caused by severe acute respiratory syndrome coronavirus 2 infection. Over the last 2 years the virus has spread worldwide with enormous implications on the healthcare systems. COVID-19 patients suffer from mild upper-airway manifestations to pneumonia and severe acute respiratory distress syndrome and their hospitalizations are often prolonged. Neurological manifestations of the disease are common. Neurosonology (transcranial Doppler & cervical duplex ultrasound) is an easily repeatable diagnostic imaging modality that can be simply applied at the bedside of COVID-19 patients with cerebrovascular diseases or in critically ill patients in the intensive care unit. Neurosonology may provide hemodynamic assessment of cerebral circulation, quantitative evaluation of increased intracranial pressure and detection of micro-embolic signals in real-time. Consequently, it may assist substantially in the diagnosis, risk stratification and therapeutic approach of COVID-19 patients with or without cerebrovascular complications. In the present narrative review, we discuss the emerging clinical utility of neurosonology during COVID-19 pandemic and highlight the upgraded role of neurosonology resulting from the combination of the established applications coupled with the reduced risk of virus spreading during ultrasound evaluation compared to other imaging modalities including computed tomography and magnetic resonance imaging.
L1448-MM OBSERVATIONS BY THE <i>HERSCHEL</i> KEY PROGRAM, “DUST, ICE, AND GAS IN TIME” (DIGIT)
Lee, Jinhee,Lee, Jeong-Eun,Lee, Seokho,Green, Joel. D.,Evans II, Neal J.,Choi, Minho,Kristensen, Lars,Dionatos, Odysseas,Jørgensen, Jes K. IOP Publishing 2013 The Astrophysical journal, Supplement series Vol.209 No.1
Maria Sfakianaki,Chara Papadaki,Maria Tzardi,Maria Trypaki,Sardar Alam,Eleni D. Lagoudaki,Ippokratis Messaritakis,Odysseas Zoras,Dimitris Mavroudis,Vassilis Georgoulias,John Souglakos 대한암학회 2019 Cancer Research and Treatment Vol.51 No.4
Purpose The purpose of this study was to investigate the prognostic significance of liver kinase b1 (LKB1) loss in patients with operable colon cancer (CC). Materials and Methods Two hundred sixty-two specimens from consecutive patients with stage III or high-risk stage II CC, who underwent surgical resection with curative intent and received adjuvant chemotherapy with fluoropyrimidine and oxaliplatin, were analyzed for LKB1 protein expression loss, by immunohistochemistry as well as for KRAS exon 2 and BRAFV600E mutations by Sanger sequencing and TS, ERCC1, MYC, and NEDD9 mRNA expression by real-time quantitative reverse transcription polymerase chain reaction. Results LKB1 expression loss was observed in 117 patients (44.7%) and correlated with right-sided located primaries (p=0.032), and pericolic lymph nodes involvement (p=0.003), BRAFV600E mutations (p=0.024), and TS mRNA expression (p=0.041). Patients with LKB1 expression loss experienced significantly lower disease-free survival (DFS) (hazard ratio [HR], 1.287; 95% confidence interval [CI], 1.093 to 1.654; p=0.021) and overall survival (OS) (HR, 1.541; 95% CI, 1.197 to 1.932; p=0.002), compared to patients with LKB1 expressing tumors. Multivariate analysis revealed LKB1 expression loss as independent prognostic factor for both decreased DFS (HR, 1.217; 95% CI, 1.074 to 1.812; p=0.034) and decreased OS (HR, 1.467; 95% CI, 1.226 to 2.122; p=0.019). Conclusion Loss of tumoral LKB1 protein expression, constitutes an adverse prognostic factor in patients with operable CC.
Green, Joel D.,Evans II, Neal J.,Jørgensen, Jes K.,Herczeg, Gregory J.,Kristensen, Lars E.,Lee, Jeong-Eun,Dionatos, Odysseas,Yildiz, Umut A.,Salyk, Colette,Meeus, Gwendolyn,Bouwman, Jeroen,Visser, Ruu IOP Publishing 2013 The Astrophysical journal Vol.770 No.2
<P>We present 50-210 mu m spectral scans of 30 Class 0/I protostellar sources, obtained with Herschel-PACS, and 0.5-1000 mu m spectral energy distributions, as part of the Dust, Ice, and Gas in Time Key Program. Some sources exhibit up to 75 H2O lines ranging in excitation energy from 100 to 2000 K, 12 transitions of OH, and CO rotational lines ranging from J = 14 -> 13 up to J = 40 -> 39. [O I] is detected in all but one source in the entire sample; among the sources with detectable [O I] are two very low luminosity objects. The mean 63/145 mu m [O I] flux ratio is 17.2 +/- 9.2. The [O I] 63 mu m line correlates with L-bol, but not with the time-averaged outflow rate derived from low-J CO maps. [C II] emission is in general not local to the source. The sample L-bol increased by 1.25 (1.06) and T-bol decreased to 0.96 (0.96) of mean (median) values with the inclusion of the Herschel data. Most CO rotational diagrams are characterized by two optically thin components (< N > = ( 0.70 +/- 1.12) x 10(49) total particles). N-CO correlates strongly with L-bol, but neither T-rot nor N-CO(warm)/N-CO(hot) correlates with L-bol, suggesting that the total excited gas is related to the current source luminosity, but that the excitation is primarily determined by the physics of the interaction (e.g., UV-heating/shocks). Rotational temperatures for H2O (< T-rot > = 194 +/- 85 K) and OH (< T-rot > = 183 +/- 117 K) are generally lower than for CO, and much of the scatter in the observations about the best fit is attributed to differences in excitation conditions and optical depths among the detected lines.</P>
CO in Protostars (COPS): <i>Herschel</i>-SPIRE Spectroscopy of Embedded Protostars
Yang, Yao-Lun,Green, Joel D.,Evans II, Neal J.,Lee, Jeong-Eun,Jørgensen, Jes K.,Kristensen, Lars E.,Mottram, Joseph C.,Herczeg, Gregory,Karska, Agata,Dionatos, Odysseas,Bergin, Edwin A.,Bouwman, Jeroe American Astronomical Society 2018 The Astrophysical journal Vol.860 No.2
<P>We present full spectral scans from 200 to 670. mu m of 26 Class 0+I protostellar sources obtained with Herschel-SPIRE as part of the 'COPS-SPIRE' Open Time program, complementary to the DIGIT and WISH Key Programs. Based on our nearly continuous, line-free spectra from 200 to 670. mu m, the calculated bolometric luminosities (L-bol) increase by 50%. on average, and the bolometric temperatures (T-bol) decrease by 10%. on average, in comparison with the measurements without Herschel. Fifteen protostars have the same class using Tbol and L-bol/L-smm. We identify rotational transitions of CO lines from J = 4 -> 3to J = 13 -> 12, along with emission lines of (CO)-C-13, HCO+, H2O, and [C I]. The ratios of (CO)-C-12 to (CO)-C-13 indicate that (CO)-C-12 emission remains optically thick for J(up) < 13. We fit up to four components of temperature from the rotational diagram with flexible break points to separate the components. The distribution of rotational temperatures shows a primary population around 100 K with a secondary population at similar to 350 K. We quantify the correlations of each line pair found in our data set and find that the strength of the correlation of CO lines decreases as the difference between J levels between two CO lines increases. The multiple origins of CO emission previously revealed by velocity-resolved profiles are consistent with this smooth distribution if each physical component contributes to a wide range of CO lines with significant overlap in the CO ladder. We investigate the spatial extent of CO emission and find that the morphology is more centrally peaked and less bipolar at high-J lines. We find the CO emission observed with SPIRE related to outflows, which consists of two components, the entrained gas and shocked gas, as revealed by our rotational diagram analysis, as well as the studies with velocity-resolved CO emission.</P>