Peripheral blood lymphocyte changes after stereotactic ablative body radiotherapy to lung or liver metastases in patients with oligometastatic cancers

Sergey Nikolaevich Novikov(Sergey Nikolaevich Novikov ),Irina Aleksandrovna Baldueva(Irina Aleksandrovna Baldueva ),Anton Yurievich Zozulya(Anton Yurievich Zozulya ),Natalya Viktorovna Emelyanova(Nata 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.1

Purpose: To perform the analysis of the peripheral blood lymphocyte changes after stereotactic ablative radiotherapy (SABR) in patients with oligometastatic cancers. Materials and Methods: The dynamics of the immune status in peripheral blood was prospectively evaluated in 46 patients with lung (17 cases) or liver (29 cases) metastases treated by SABR. Flow cytometry of peripheral blood lymphocyte subpopulations was performed before SABR, 3–4 weeks and 6–8 weeks after the end of SABR: 3 fractions of 15–20 Gy or 4 fractions of 13.5 Gy. The number of treated lesions varied from 1 (32 patients) to 2–3 (14 patients). Results: SABR induced a significant increase of T-lymphocytes (CD3+CD19–) (p = 0.001), T-helper (CD3+CD4+) (p = 0.004), activated cytotoxic T-lymphocytes (CD3+CD8+HLA-DR+) (p = 0.001), activated T-helpers (CD3+CD4+HLA-DR+) (p < 0.001). A significant decrease of T-regulated immune suppressive lymphocytes (CD4+CD25brightCD127low) (p = 0.002) and NKT-cells (CD3+CD16+CD56+) (p = 0.007) was recorded after the SABR. The comparative analysis demonstrated that lower doses of SABR (EQD2Gy(α/β=10) = 93.7–105.7 Gy) induced significant increase of T-lymphocytes, activated cytotoxic T-lymphocytes, and activated CD4+CD25+ T-helpers, while SABR with higher doses (EQD2Gy(α/β=10) = 150 Gy) was not associated with these effects. A more efficient activations of T-lymphocytes (p = 0.010), activated T-helpers (p < 0.001), and cytotoxic T-lymphocytes (p = 0.003) were associated with SABR to a single lesion. A significant increase of T-lymphocytes (p = 0.002), T-helpers (p = 0.003), and activated cytotoxic T-lymphocytes (p = 0.001) was observed after SABR for hepatic metastases in contrast to SABR for lung lesions. Conclusion: Changes in peripheral blood lymphocytes after SABR could be influenced by the location or the number of irradiated metastasis, and the dose of SABR.

Eurasia in Russian and Chinese Political Expertise: A Comparative Analysis

Novikov Dmitrii,Bocharova Alexandra 한양대학교 아태지역연구센터 2024 Journal of Eurasian Studies Vol.15 No.1

Since Russia and China are both leading states on the Eurasian continent, the dynamism of their relations to a large extent dominates the dynamics of geopolitical processes in the region. The growing and escalating stand-off with the West in both countries, notably due to the recent developments in Ukraine, appears likely to further the rapprochement between Moscow and Beijing on many issues of strategic interaction. The relevant question in that context is whether the Russian and Chinese perceptions of Eurasia, of Eurasian regionalism, are truly compatible. In the past few years, Russia has made considerable attempts to foster its vision of an external international order on the continent, including the popularisation and substantiation of Eurasia as a concept with regard to its geopolitical surroundings. One of the main consumers of these ideas was supposed to be China. Have Russian endeavours accomplished their goals? In seeking to provide an appropriate response to this question, the authors have focused on an analysis of both states’ expert and academic discourse on Eurasia and Eurasian regionalism. This article conceptualises Eurasia as a social construct, an element of foreign policy discourse that is intended to be mirrored in academic and expert discourse. A comparative analysis of Russian and Chinese discourses should ascertain – albeit at least in part – the extent to which Beijing has embraced Moscow’s ideas on the development of Eurasian regionalism and the proximity of Russian and Chinese approaches to the international order of the continent or a particular part of it.

Treatment of Cotton by β-Cyclodextrin/Triclosan Inclusion Complex and Factors Affecting Antimicrobial Properties

Mikhail Novikov,Kwai Lin Thong,Nur Izzurianna Mohd Zazali,Sharifah Bee Abd Hamid 한국섬유공학회 2018 Fibers and polymers Vol.19 No.3

The efficacy of antimicrobial treatment of cotton fabrics depends on various parameters of the coating process, such as the chemical nature and concentration of the antimicrobial agent, the composition of the crosslinking formulation, and the curing temperature. The inclusion complex of triclosan with β-cyclodextrin (βCD) was synthesized and characterized by FTIR, XRD, NMR, Raman, SEM, and TGA. The minimum inhibitory concentration and minimum bactericidal concentration of the complex against Klebsiella pneumoniae and Staphylococcus aureus were compared to those of its precursor. A multifactorial study included an evaluation of the effects of triclosan complexation with β-cyclodextrin, a comparison between the glyoxal and tetracarboxylic acid as crosslinkers, an investigation of the effect of crosslinker and catalyst concentrations, and a comparison of curing at 120 oC and 180 oC. The cotton was characterized by FTIR-ATR, the micrographs of treated samples were obtained by SEM and the weight add-on was calculated. The bactericidal properties were determined according to AATCC-147. The correlation between the coating process parameters and the antimicrobial efficacy was determined. The optimal combination leading to the highest weight add-on and the antimicrobial coating that was most durable to multiple detergent washes at an elevated temperature was the use of complexed triclosan grafted onto the cotton in the presence of tetracarboxylic acid, followed by curing at 180 oC. The curing temperatures were 120 oC (P=0.002) and 180 oC (P=0.008), catalysts were 1 % and 2 % aluminium sulfate and sodium hypophosphite (P<0.001), and the crosslinkers were 5 % and 10 % glyoxal and butanetetracarboxylic acid (P<0.001); these parameters significantly enhanced the antimicrobial properties of the treated fabrics. The study showed that βCD did not have antimicrobial activity, while the βCD/ triclosan-treated textile exhibited potential antimicrobial properties. Overall, the bactericidal activity of fabrics can be enhanced by using βCD/triclosan with 10 % butanetetracarboxylic acid as a cross-linker and 5 % sodium hypophosphite as a catalyst at a curing temperature of 180 oC.

A comparison between high dose rate brachytherapy and stereotactic body radiotherapy boost after elective pelvic irradiation for high and very high-risk prostate cancer

Sergey Novikov 대한방사선종양학회 2022 Radiation Oncology Journal Vol.40 No.3

Purpose: To compare biochemical recurrence-free survival (BRFS) and toxicity outcomes of high doserate brachytherapy (HDRB) and stereotactic body radiotherapy (SBRT) boost after elective nodal irra-diation for high/very high-risk prostate cancer. Materials and Methods: A retrospective analysis was performed in 149 male patients. In 98 patients,the boost to the prostate was delivered by HDRB as 2 fractions of 10 Gy (EQD2 for α/β = 1.5; 66 Gy)or 1 fraction of 15 Gy (EQD2 for α/β = 1.5; 71 Gy). In 51 male patients, SBRT was used for the boostdelivery (3 fractions of 7 Gy; EQD2 for α/β = 1.5; 51 Gy) because brachytherapy equipment was out oforder. Results: In 98 patients that received HDRB boost, 3- and 5-year BRFS were 74.6% and 66.8%. Lategrade-II genitourinary toxicity was detected in 27, grade-III in 1 case. Grade-II (maximum) rectal tox-icity was diagnosed in nine patients. For 51 male patients that received SBRT boost, 3- and 5-yearBRFS was 76.5% and 67.7%. Late grade-II (maximum) genitourinary toxicity was detected in fivecases, late grade-II rectal toxicity in four cases. Other three patients developed late grade-III–IV rectaltoxicity that required diverting colostomy. SBRT boost was associated with higher maximum dose to2 cm3 of anterior rectal wall (D2cm³rectum) compared to HDRB: 92% versus 55% of dose to prostate. Se-vere rectal toxicity was negligible at EQD2 D2cm³rectum <85 Gy and EQD2 D5cm³ rectum <75 Gy. Conclusion: Our results indicate similar 3- and 5-year BRFS in patients with high/very high-risk pros-tate cancer who received HDRB or SBRT

Effect of Water Adsorbed by Nano-relief of Si (100) Surface

Sergey Novikov,Sergey Timoshenkov,Natalia Korobova 한국정보통신학회 2014 2016 INTERNATIONAL CONFERENCE Vol.6 No.1

Effect of water adsorbed by nano-relief solid surfaces on their emission properties has been investigated by the methods of tunneling microscopy and electron work function measurements. Using samples of oxidized aluminum-foil and doped single-crystal silicon Si (100) was shown that coherent metastable clusters of water adsorbed by nano-relief samples at the transition to the stable state of molecular water emitted energy in the form of dipole-dipole radiation (Dicke super radiation). Observed phenomena of photoluminescence (electron emission), bioluminescence (Biophotons radiation) are the bright manifestation of Dicke super radiation in various conditions.

Single photon emission computed tomography-computed tomography visualization of sentinel lymph nodes for lymph flow guided nodal irradiation in oral tongue cancer

Sergey Nikolaevich Novikov,Pavel Ivanovich Krzhivitskii,Zamira Achmedovna Radgabova,Maxim Andreevitch Kotov,Mikhail Markovich Girshovich,Anna Sergeevna Artemyeva,Yulia Sergeevna Melnik,Sergey Vasilevi 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.3

Purpose: To evaluate correlation of single photon emission computed tomography-computed tomography (SPECT-CT) data on lymph flow (LF) from oral tongue cancer (OC) and the topography of lymph nodes (LN) metastases; to determine the clinical value of lymph flow guided radiotherapy (LFGRT). Materials and Methods: SPECT-CT visualization of LF from the OC lesions was performed after peritumoral injection of 99mTc-phytate in 26 primary patients with clinical stage cT1-2N0M0 disease. We determined the individual drainage (unilateral/bilateral) from the tumor, and localization of sentinel LNs according to the neck levels. Metastases in LNs were verified with histology and a 2-year follow-up. Results: SPECT-CT detected bilateral LF in 10 (38.5%) of 26 patients; in 16 (61.5%) cases the drainage was unilateral. Histology revealed LNs metastases in three cases; regional recurrences were diagnosed in other four patients. In all seven observations metastases were located at the same site and level as the sentinel LNs. In eight (30.8%) of 26 patients sentinel LNs were visualized unilaterally at levels Ib-IIa; in five cases, unilaterally at levels I-IIa-III. In these patients, LFGRT demonstrated 59%-70% reduction of irradiated volume, and 26%-42% and 51%-70% decrease of the mean dose to the spinal cord and the contralateral parotid gland. In patients with a bilateral drainage the reduction of doses absorbed by the spinal cord and contralateral parotid gland was 19% and 6%, respectively. Conclusion: Localization of sentinel LNs determined by SPECT-CT corresponds to the localization of metastatic LNs in terms of side and levels.

Different approaches to target volume definition and boost delivery in surgery de-escalation clinical trial in breast cancer patients with pathological complete response

Sergey Nikolaevich Novikov,Petr Krivorotko,Zhanna Bryantseva,Irina Akulova,Alexander Emelyanov,Viktoria Mortada,Olga Ponomareva,Pavel Krzhivitskiy,Sergey Kanaev 대한방사선종양학회 2023 Radiation Oncology Journal Vol.41 No.4

Purpose: We evaluate various approaches to target volume definition and boost delivery in patients with complete response to neoadjuvant systemic therapy (NST) who were treated by radiotherapy without a surgery. Materials and Methods: A pathological complete response (pCR) was diagnosed in 21 of 27 patients included in “surgery de-escalation” prospective observation study. Clips were placed in the primary tumor volume (PrTV) before NST and during the vacuum aspiration biopsy. Twenty patients with pCR underwent the whole breast irradiation and a boost to the PrTV. High-dose rate brachytherapy (HDRB) was the basic technique for boost delivery. Finally, we identified the value of fused images (computed tomography [CT] before NST with simulation CT), clips and their combination for an accurate boost delivery. Results: A complete overlap between PrTV on pre-treatment CT with the localization of the clips on simulation CT was mentioned in 10, partial mismatch in three patients. In 12 of these 13 women, HDRB was successfully used for the boost delivery. In five cases we mentioned a marked discrepancy between the PrTV on fused images and the topography of the clips. In other two women we did not find clips on simulation CT. The fused images in five of these seven patients showed anatomical landmarks (scar, fibrosis) used for identification of the gross tumor volume. In all 20 women with pCR (average follow-up of 16.6 months), there were no locoregional recurrences. Conclusion: Combination of the clips with fusion of pre-NST and simulation CTs is important for an accurate boost delivery.

Atlas of sentinel lymph nodes in early breast cancer using single-photon emission computed tomography: implication for lymphatic contouring

Sergey Nikolaevich Novikov,Pavel Ivanovich Krzhivitskii,Yulia Sergeevna Melnik,Alina Albertovna Valitova,Zhanna Viktorovna Bryantseva,Irina Alexandrovna Akulova,Sergey Vasilevich Kanaev 대한방사선종양학회 2021 Radiation Oncology Journal Vol.39 No.1

Purpose: To determine the localization of sentinel lymph nodes (SLNs) in a large cohort of patients with breast cancer and validate the European Society for Therapeutic Radiology and Oncology (ESTRO), Radiation Therapy Oncology Group (RTOG), and Radiotherapy Comparative Effectiveness (RADCOMP) guidelines on regional lymph node clinical target volume (CTV-LN) delineation. Materials and Methods: A total of 254 women with cT1-3N0-1M0 breast cancer underwent single-photon emission computed tomography (SPECT-CT) visualization of SLNs after intra- and peritumoral injection of 99mTc-radiocolloids. All SPECT-CT images were fused with reference simulation computed tomography. A 3D atlas of SLNs was created and used for evaluation of CTV-LN defined by contouring guidelines. Results: SPECT-CT visualized 532 SLNs that were localized in axillary level I in 67.5%, level II in 15.4%, level III in 7.3%, internal mammary in 8.5%, and supraclavicular in 1.3% cases. The majority of level II–IV and internal mammary SLNs were inside the recommended CTV-LN. Axillary level I SLNs were covered by ESTRO and RTOG contours in 85% and 85% cases, respectively. “Out of contours” SLNs were mostly detected in lateral subgroup of level I LN (18.5%), while 98%–99% of anterior pectoral and central axillary SLNs were covered by CTV-LN. Internal mammary SLNs were visualized in 33 cases and were outside ESTRO and RTOG contours in 3 and 6 observations, respectively. Conclusion: SPECT-CT atlas of SLNs demonstrated that in most cases ESTRO and RTOG guidelines correctly represented CTV-LNs with the exception of lateral subgroup of SLNs.

ВЛИЯНИЕ УКРЕПЛЕНИЯ НАЦИОНАЛЬНОЙ ВАЛЮТЫ НА ЭКОНОМИКУ РОССИИ И РЕСПУБЛИКИ КОРЕЯ

И.А. Новиков(A. Novikov) 한국로고스경영학회 2007 한국로고스경영학회 학술발표대회논문집 Vol.2007 No.7월_2

Sino-Russian rapprochement and Greater Eurasia: From geopolitical pole to international society?

Alexander Lukin,Dmitry Novikov 한양대학교 아태지역연구센터 2021 Journal of Eurasian Studies Vol.12 No.1

Can international anarchy be stabilized, if not globally, then at least regionally? Those scholars who give a positive answer usually refer to the North Atlantic community which can be categorized as an international society from the viewpoint of the English school. The emergence of such a community outside the West is traditionally considered hardly possible. However, this article argues that it may already be emerging in Eurasia, with Russia and China being the key drivers of this trend. In the past few years, these two powers have put forward a number of major initiatives aimed at developing transport networks and logistics, and deepening economic and institutional ties between different parts of the continent. These include but are not limited to Eurasian Economic Union, supported by Russia, and China’s Belt and Road Initiative. Together, Moscow and Beijing began to form a new platform for security and economic cooperation “from Kaliningrad to Shanghai”—the community of Greater Eurasia. Based on the analysis of the geopolitical logic of these initiatives, this article suggests that a new, non-Western international society may be forming in Eurasia among the states with different political systems and cultures, but common geopolitical aims and fears.