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Nishtha,Yaduvanshi Rajveer Singh,Varshney Gaurav 한국물리학회 2023 Current Applied Physics Vol.50 No.-
A technique is developed for enhancing the isolation between the ports of a terahertz (THz) dielectric resonator (DR) antenna (DRA) with two ports and single radiator. A two-port DRA provides the isolation of 6.88 dB which is further enhanced to 16.78 dB by inserting a circular slot in the ground plane of this antenna structure. The sidewalls of the DR at opposite to the source ends are then coated with the graphene material which enhances the value of isolation between the ports up to 25.05 dB. The coating of top surface of DR with graphene material enhances the isolation up to 35.10 dB. Coating of graphene material at all the open surfaces of the DR can enhance the isolation up to 63.06 dB. The frequency response of antenna can be tuned by applying the electrostatic field on the graphene coating at top surface of the DR. Moreover, the multi-input-multi-output performance parameters like envelope correlation coefficient and diversity gain remains less than 0.06 and 9.8 in the passband. The orthogonal feed arrangement used in the antenna structure can provide the polarization diversity.
Factors Contributing to an Emerging Russia-Pakistan Strategic Proximity: An Indian Perspective
Nishtha Kaushiki 서울대학교 국제학연구소 2019 Journal of International and Area Studies Vol.26 No.1
The primary objective of this paper is to examine the factors due to which both Pakistan and Russia have displayed an eagerness to normalise and deepen their strategic relations. Historically, Pakistan and former Soviet Union always saw each other either through the prism of the U.S. or India resulting in the absence of an independent foreign policy towards each other with little scope of strategic manoeuvring between the two. Today, the trajectories of their relations have undergone rapid changes in the backdrop of the new Cold War. Besides covering the historical background, the present study examines the predominant reasons reflecting the contemporary developments for their strategic bonhomie from an Indian perspective. The contemporary economic and strategic calculations have been highlighted in the present study. In the process it also examines how their strategic synergy may alter the existing balance of power in South Asia and international peace.
Nishtha Kaushiki,Hilal Ramzan 서울대학교 국제학연구소 2015 Journal of International and Area Studies Vol.22 No.2
The primary objective of this paper is to trace the shifting balance of power in favour of China in South Asia by examining the Sino-Russo entente. The trajectories of their strategic relations have gained momentum after the announcement of the ‘Asia Pivot’ and the unfolding of the Crimean crisis. As their synergy is currently changing the status quo of south Asian states, the paper has attempted to explore three main factors for the same. Moscow-Beijing-Tehran Axis; warming up of Russo-Pak ties and China’s revival of the old silk route have been analysed to examine their respective consequences in altering the balance of power. Also, India’s concerns have been addressed and some policy options have been discussed.
A Survey of Digital Image Tampering Techniques
Nishtha Parashar,Nirupama Tiwari,Deepika Dubey 보안공학연구지원센터 2016 International Journal of Signal Processing, Image Vol.9 No.2
Due to powerful computers and advanced photo-editing software tools the manipulation of images has become an easy task. Confirming the authenticity of images and detecting tampered regions in an image without any knowledge about the image content is an important part of the research field. An effort is made to survey the recent advancements being made in the field of digital image forgery detection and thus passive methods for forgery detection are being presented. Blind or passive methods do not require any explicit former information about the image. In the first part, various image forgery detection techniques are classified and then an overview of passive image authentication is presented and the existing blind forgery detection techniques are reviewed
The New Great Game and India's Connect Central Asia Policy: Strategic Perspectives and Challenges
Nishtha Kaushiki 서울대학교 국제학연구소 2013 Journal of International and Area Studies Vol.20 No.2
The article is a humble attempt to explore the various strategic and political challenges faced by India in its connect central Asia policy (CCAP) in the backdrop of the New Great Game that has overtime developed in the Central Asian Region (CAR). The article analyses the objectives of the major powers in the CAR while establishing linkages between the key developments in the Asian region such as emerging Sino-Russo strategic alliance, Obama's Asia Pivot, Dushanbe summit, etc. It discusses its implications in the form of challenges for India. Finally, it attempts to recommend a multifaceted approach for India to strengthen its position in the CAR.
Yang, Chengbin,Panwar, Nishtha,Wang, Yucheng,Zhang, Butian,Liu, Maixian,Toh, Huiting,Yoon, Ho Sup,Tjin, Swee Chuan,Chong, Peter Han Joo,Law, Wing-Cheung,Chen, Chih-Kuang,Yong, Ken-Tye The Royal Society of Chemistry 2016 Nanoscale Vol.8 No.17
<P>First-line therapy of chronic myelogenous leukemia (CML) has always involved the use of BCR-ABL tyrosine-kinase inhibitors which is associated with an abnormal chromosome called Philadelphia chromosome. Although the overall survival rate has been improved by the current therapeutic regime, the presence of resistance has resulted in limited efficacy. In this study, an RNA interference (RNAi)-based therapeutic regime is proposed with the aim to knockdown the BCR-ABL hybrid oncogene using small interfering RNA (siRNA). The siRNA transfection rates have usually been limited due to the declining contact probability among polyplexes and the non-adherent nature of leukemic cells. Our work aims at addressing this limitation by using a biodegradable charged polyester-based vector (BCPV) as a nano-carrier for the delivery of BCR-ABL-specific siRNA to the suspension culture of a K562 CML cell line. BCR-ABL siRNAs were encapsulated in the BCPVs by electrostatic force. Cell internalization was facilitated by the BCPV and assessed by confocal microscopy and flow cytometry. The regulation of the BCR-ABL level in K562 cells as a result of RNAi was analyzed by real-time polymerase chain reaction (RT-PCR). We observed that BCPV was able to form stable nanoplexes with siRNA molecules, even in the presence of fetal bovine serum (FBS), and successfully assisted in vitro siRNA transfection in the non-adherent K562 cells. As a consequence of downregulation of BCR-ABL, BCPV-siRNA nanoplexes inhibited cell proliferation and promoted cell apoptosis. All results were compared with a commercial transfection reagent, Lipofectamine2000 (TM), which served as a positive control. More importantly, this class of non-viral vector exhibits biodegradable features and negligible cytotoxicity, thus providing a versatile platform to deliver siRNA to non-adherent leukemia cells with high transfection efficiency by effectively overcoming extra-and intra-cellular barriers. Due to the excellent in vitro transfection results from BCPV-siRNA, a newly developed biodegradable transfection agent, BCPV, is being probed for transfection performance in an animal model.</P>
Tandon, Sarthak,Gairola, Munish,Ahlawat, Parveen,Sharma, Kanika,Barik, Soumitra,Sachdeva, Nishtha,Pasricha, Sunil,Shenoy, Apeksha The Korean Society for Radiation Oncology 2018 Radiation Oncology Journal Vol.36 No.4
Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.
Kanika Sharma,Parveen Ahlawat,Munish Gairola,Sarthak Tandon,Nishtha Sachdeva,Muhammed Ismail Sharief 대한방사선종양학회 2019 Radiation Oncology Journal Vol.37 No.2
Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent upfront primary surgical resection followed by adjuvant radiotherapy with or without concurrent chemotherapy if indicated. Results: The median follow-up was 35.2 months (range, 1.2 to 99.9 months). The median duration of locoregional control (LRC) was 84.9 months (95% confidence interval, 67.3–102.4). The 3- and 5-year LRC rate was 68.5% and 58.3%, respectively. Multivariate analysis showed that increasing pT stage, increasing pN stage, and the presence of extracapsular extension (ECE) were significantly associated with poorer LRC. The median duration of overall survival (OS) was not reached at the time of analysis. The 3- and 5-year OS rate was 70.5% and 66.6%, respectively. Multivariate analysis showed that increasing pT stage and the presence of ECE were significantly associated with a poorer OS. Conclusion: Locoregional failure remains the main cause of treatment failure in resectable OTSCC. There is scope to further improve prognosis considering modest LRC and OS. Pathological T-stage, N-stage, and ECE are strong prognostic factors. Further research is required to confirm whether adjuvant therapy adds to treatment outcomes in cases with lymphovascular invasion, perineural invasion, and depth of invasion, and help clinicians tailoring adjuvant therapy.
Sharma, Kanika,Ahlawat, Parveen,Gairola, Munish,Tandon, Sarthak,Sachdeva, Nishtha,Sharief, Muhammed Ismail The Korean Society for Radiation Oncology 2019 Radiation Oncology Journal Vol.37 No.2
Purpose: There is sparse literature on treatment outcomes research on resectable oral tongue squamous cell carcinoma (OTSCC). The aim of this study was to measure the treatment outcomes, explore the failure patterns, and identify the potential clinicopathological prognostic factors affecting treatment outcomes for resectable OTSCC. Materials and Methods: It is a retrospective analysis of 202 patients with resectable OTSCC who underwent upfront primary surgical resection followed by adjuvant radiotherapy with or without concurrent chemotherapy if indicated. Results: The median follow-up was 35.2 months (range, 1.2 to 99.9 months). The median duration of locoregional control (LRC) was 84.9 months (95% confidence interval, 67.3-102.4). The 3- and 5-year LRC rate was 68.5% and 58.3%, respectively. Multivariate analysis showed that increasing pT stage, increasing pN stage, and the presence of extracapsular extension (ECE) were significantly associated with poorer LRC. The median duration of overall survival (OS) was not reached at the time of analysis. The 3- and 5-year OS rate was 70.5% and 66.6%, respectively. Multivariate analysis showed that increasing pT stage and the presence of ECE were significantly associated with a poorer OS. Conclusion: Locoregional failure remains the main cause of treatment failure in resectable OTSCC. There is scope to further improve prognosis considering modest LRC and OS. Pathological T-stage, N-stage, and ECE are strong prognostic factors. Further research is required to confirm whether adjuvant therapy adds to treatment outcomes in cases with lymphovascular invasion, perineural invasion, and depth of invasion, and help clinicians tailoring adjuvant therapy.
Sarthak Tandon,Munish Gairola,Parveen Ahlawat,Kanika Sharma,Soumitra Barik,Nishtha Sachdeva,Sunil Pasricha,Apeksha Shenoy 대한방사선종양학회 2018 Radiation Oncology Journal Vol.36 No.4
Surgical excision along with use of postoperative radiotherapy forms an integral management of sinonasal teratocarcinosarcoma (SNTCS). However, given the rarity of the tumor, no standardised guidelines, dose, technique and target delineation exist especially in the era of modern radiation delivery techniques. This is a case of 55-year-old male diagnosed as SNTCS treated with radical ethmoidectomy followed by volumetric modulated radiotherapy, showing good local control and acceptable toxicity profile.