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Xiao Nianjun,Zhang Tongzhen,Zhang Jing,Zhang Jinlong,Li Hao,Ning Shoubin 거트앤리버 소화기연관학회협의회 2023 Gut and Liver Vol.17 No.2
Background/Aims: Enteroenteric intussusception in Peutz-Jeghers syndrome (EI-PJS) is traditionally treated by surgery. However, enteroscopic treatment is a minimally invasive approach worth attempting. We aimed to develop a risk scoring system to facilitate decision-making in the treatment of EI-PJS. Methods: This was a single-center case-control study, including 80 patients diagnosed with PJS and coexisting intussusception between January 2015 and January 2021 in Air Force Medical Center. We performed logistic regression analysis to identify independent risk factors and allocated different points to each subcategory of risk factors; the total score of individuals ranged from 0 to 9 points. Then, we constructed a risk stratification system based on the possibility of requiring surgery: 0–3 points for “low-risk,” 4–6 points for “moderate-risk,” and 7–9 points for “high-risk.” Results: Sixty-one patients (76.25%) were successfully treated with enteroscopy. Sixteen patients (20.0%) failed enteroscopic treatment and subsequently underwent surgery, and three patients (3.75%) received surgery directly. Abdominal pain, the diameter of the responsible polyp, and the length of intussusception were independent risk factors for predicting the possibility of requiring surgery. According to the risk scoring system, the incidence rates of surgery were 4.44% in the low-risk tier, 30.43% in the moderate-risk tier, and 83.33% in the high-risk tier. From low- to high-risk tiers, the trend of increasing risk was significant (p<0.001). Conclusions: We developed a risk scoring system based on abdominal pain, diameter of the responsible polyps, and length of intussusception. It can preoperatively stratify patients according to the risk of requiring surgery for EI-PJS to facilitate treatment decision-making.
Evaluating optimum tilt angle for PV modules using solar radiation models in Wuhan, China
Fen. Li,Nianjun. Ma,Jinbin. Zhao,Keqing. Qu,Xingwu. Yang,Zhenghong. Chen 전력전자학회 2015 ICPE(ISPE)논문집 Vol.2015 No.6
Four models are used to estimate the hourly solar radiation on 15 pieces of different tilted photovoltaic (PV) modules in Wuhan, China based on power and solar radiation data during a whole year. The optimum tilt angle (OTA) in Wuhan for yearly and semi-yearly adjustment was determined. Then it was determined that the best mode is the tilt angle of PV module adjusted every half a year. In semi-yearly adjustment, OTA in semi-year of winter and summer is found as 45°, 15°, respectively. Experimental results verify the theoretical calculated values of the OTA with high precision. Energy radio (ER) reveals PV modules with adjustment of tilt angle twice a year has a capability to improve nearly 7% in comparison with fixed type. The best model was chosen based on test results from statistical indicators. The statistical results demonstrate that among the studied models, Liu&Jordan model is the most accurate.
Warfarin pharmacogenetics: a single VKORC1 polymorphism is predictive of dose across 3 racial groups
Limdi, Nita A.,Wadelius, Mia,Cavallari, Larisa,Eriksson, Niclas,Crawford, Dana C.,Lee, Ming-Ta M.,Chen, Chien-Hsiun,Motsinger-Reif, Alison,Sagreiya, Hersh,Liu, Nianjun,Wu, Alan H. B.,Gage, Brian F.,Jo American Society of Hematology 2010 Blood Vol.115 No.18
<B>Abstract</B><P>Warfarin-dosing algorithms incorporating CYP2C9 and VKORC1 −1639G>A improve dose prediction compared with algorithms based solely on clinical and demographic factors. However, these algorithms better capture dose variability among whites than Asians or blacks. Herein, we evaluate whether other VKORC1 polymorphisms and haplotypes explain additional variation in warfarin dose beyond that explained by VKORC1 −1639G>A among Asians (n = 1103), blacks (n = 670), and whites (n = 3113). Participants were recruited from 11 countries as part of the International Warfarin Pharmacogenetics Consortium effort. Evaluation of the effects of individual VKORC1 single nucleotide polymorphisms (SNPs) and haplotypes on warfarin dose used both univariate and multi variable linear regression. VKORC1 −1639G>A and 1173C>T individually explained the greatest variance in dose in all 3 racial groups. Incorporation of additional VKORC1 SNPs or haplotypes did not further improve dose prediction. VKORC1 explained greater variability in dose among whites than blacks and Asians. Differences in the percentage of variance in dose explained by VKORC1 across race were largely accounted for by the frequency of the −1639A (or 1173T) allele. Thus, clinicians should recognize that, although at a population level, the contribution of VKORC1 toward dose requirements is higher in whites than in nonwhites; genotype predicts similar dose requirements across racial groups.</P>