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Neha,Hare Krishna 대한해부학회 2018 Anatomy & Cell Biology Vol.51 No.1
A 68-year-old male cadaver showed bilateral variation in the sensory innervation of the dorsum of hand. On the dorsum of right hand, first digit and lateral half of second digit were supplied by lateral antebrachial cutaneous nerve (LABCN); medial side of second digit and lateral side of third digit were supplied by superficial branch of radial nerve (SBRN) and medial side of third digit, the fourth and fifth digits were supplied by dorsal cutaneous branch of ulnar nerve (DBUN). On the dorsum of the left hand, lateral side of first digit was supplied by LABCN, medial side of first digit, the second and third digits as well as the lateral side of fourth digit were supplied by SBRN; medial side of fourth digit and fifth digit were supplied by DBUN. These variations would be helpful in understanding peripheral neuropathy, in interpretation of conduction velocity studies and in reconstructive surgery of hand.
Neha,MA Khan,U Farooq 보안공학연구지원센터 2016 International Journal of Bio-Science and Bio-Techn Vol.8 No.3
Typhoid is a major public health problem in tropical and subtropical countries including India. Salmonella typhi, the causative agent of typhoid fever, is a gram-negative, motile, rod shaped, facultative anaerobe. It is solely a human pathogen and there is no animal reservoir. Antibiotic therapy is the mainstay for the treatment of typhoid fever and the complications associated with it. Nowadays, emerging multidrug resistance among Salmonella typhi strains has become a major public health problem. Present research work was carried out for the identification and molecular characterization of Trimethoprim resistant Salmonella enterica serovar typhi strains from individuals suffering with typhoid fever by means of various techniques i.e.; biochemicals, phenotypical and drug resistant gene specific polymerase chain reaction (PCR). A total of 14 blood specimen of infected patients were collected from Solan district of Himachal Pradesh with varying age groups and were processed via broth enrichment methods for primary isolation and identification of typhoid bacilli. Microbiological and biochemical investigations revealed the presence of S. typhi in all 14 specimens. The antibiotic susceptibility assay was carried out for 11 antimicrobial to study the MDR pattern of the identified bacilli. It was observed that 14/14 S. typhi strains were 100% resistance to Trimethoprim, Co-trimoxazole, Sulfanilamide, Penicillin, Ampicillin, Oxacillin, Tetracycline and Erythromycin, and 70-100% susceptible to Levofloxacin, Amikacin and Amoxicillin. The PCR analysis of these MDR strains showed the presence of dhfr a7 (365 bp) gene in only 10/14 isolates. This study confirmed that Trimethoprim resistance in these strains were due to the presence of dhfr a7 gene and also that PCR based diagnosis could be very useful for the rapid detection of drug resistant S. typhi strains. Present study emphasize that Trimethoprim drug is no longer useful for the treatment of typhoid fever as its MIC optimization was very high (750μg/ml). This study may further help the researchers in selecting the appropriate therapeutic approaches targeting Trimethoprim resistant Salmonella typhi strains.
Neha Jain,Jaya Dwivedi,Veena S. Kasture,Swapnil Sharma 경희대학교 융합한의과학연구소 2017 Oriental Pharmacy and Experimental Medicine Vol.17 No.4
Peritonitis is an inflammatory condition of peritoneal cavity. Escherichia coli is one of the causative microorganism reported to be involved in the several etiologies associated with peritoneal infection. Many antimicrobial agents are available; however, increased incidence of microbial resistance is an important concern for medical practitioner. Medicinal plants were used since ancient time for treatment of many infectious diseases, but still the potential of these plant resources is not well explored. Present study was designed to investigate protective potential of Coriandrum sativum seed extract on E. coli induced peritonitis and bacteraemia, when used alone or in combination with Levofloxacin. Different extracts were prepared by successive solvent extraction utilizing solvents of variable polarity viz. petroleum ether, ethyl acetate, chloroform and methanol (70%). These extracts were assessed for antimicrobial potential utilizing in-vitro well diffusion assay and MIC determination with E. coli, Staphylococcus aureus, Pseudomonas aeruginosa and Bacillus cereus. Being most potent among other extracts in in-vitro assays, methanolic extract was tested in an invivo model of E. coli induced peritonitis with immune-compromised mice at the dose of 400 mg/kg/day alone and in combination with Levofloxacin (20 mg/kg). Methanolic extract of Coriandrum sativum seeds exhibited potent protective potential against E. coli induced peritonitis and bacteraemia.
Proinflammatory Properties of Peroxidized Fat May Contribute to the Etiology of Crohn's Disease
Neha Bhaskar,Chandrakala Aluganti Narasimhulu,Esraa Keewan,Michael Rohr,Sampath Parthasarathy 한국식품영양과학회 2019 Journal of medicinal food Vol.22 No.2
Crohn's disease (CD) is a well-known subset of inflammatory bowel disease (IBD) that results in patchy inflammation through the entire thickness of the bowel wall, with the ability to target virtually any part of the gastrointestinal tract, but most commonly affecting the area between the ileum and the cecum. While a bacterial origin of Crohn's is well speculated, it is difficult to pinpoint what drives inflammation in these subjects, particularly the flare-ups or the sudden symptomatic intensification or recurrence. This review aims at tracing the etiology of CD back to diet, particularly fried foods, a known aggravator of symptoms. Based on the reactions that frying entails, the chemical composition of the food is altered in ways that can lead to maldigestion and inflammation. Current evidence suggests a direct dietary role in the inflammation underlying CD or the flare-ups. The presented review focuses on an underresearched, yet, very applicable topic. We suggest that emphasis should be put on dietary alteration as a means of treatment for patients with CD to supplement current therapy for optimal results. With the widespread popularity of fried foods, it is important to raise awareness about the potential negative outcomes that are prevalent worldwide.
Beyond probiotics: a narrative review on an era of revolution
Neha Sharma,강대경,백현동,박영서 한국식품과학회 2023 Food Science and Biotechnology Vol.32 No.4
Whether knowingly or unknowingly, humans have been consuming probiotic microorganisms through traditionally fermented foods for generations. Bacteria, like lactic acid bacteria, are generally thought to be harmless and produce many metabolites that are beneficial for human health. Probiotics offer a wide range of health benefits; however, their therapeutic usage is limited because they are living organisms. As a result, the focus on the health advantages of microbes has recently shifted from viable live probiotics to non-viable microbes made from probiotics. These newly emerging non-viable microbes include paraprobiotics, postbiotics, psychobiotics, nutribiotics, and gerobiotics. Their metabolites can boost physiological health and reveal the therapeutic effects of probiotics. This new terminology in microbes, their traits, and their applications are summarized in the present review.
Neha G. Wasnik,Mahalakshmi. Muthusamy,Savitha Chellappan,Veena Vaidhyanathan,Ramakrishna Pulla,Kalaiselvi Senthil,양덕춘 한국자원식물학회 2009 한국자원식물학회지 Vol.22 No.6
Adventitious root culture was established in the Jawahar variety of Withania somnifera using MS basal medium supplemented with 0.5 (mg/l) IAA and 2.0 (mg/l) IBA. Root tips from germinated seedlings, MS0 maintained plants and adventitious roots were maintained in suspension medium (1/2 MS basal medium supplemented with 3% sucrose) for a period of 1 to 6 months. The weight gain in roots was noted and the withanolides were extracted from the dry roots using solvents petroleum ether, 50% ethanol and chloroform. The withanolides in the chloroform fractions of all root samples analyzed were compared using thin layer chromatographic analysis. Withanolide content in adventitious root sample was found to be superior compared to other roots at any given point of time during the 6month growth period.HPLC analysis of in vitro adventitious roots showed the presence of a new compound.