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Hari Madhav,Paramjit Singh,Neetika Singh,Gautam Jaiswar 한국고분자학회 2017 Macromolecular Research Vol.25 No.7
The main object of this study is to analyse the effects of different functional groups on the thermal and microbial properties of nanocomposites of poly(methyl methacrylate) (PMMA). For this, amino functionalized PMMA were synthesized by using post polymer functionalization method. In this method, PMMA was treated with four different amino compounds to obtain functionalized PMMA. To determine the structural features, functionalized PMMA was characterized with Fourier transform infrared (FTIR) spectroscopy. These functionalized PMMA were used to prepare functionalized polymer nanocomposites with addition of nanoclay and Ag nanoparticles into the polymer matrix. These nanocomposites were further studied against thermal and antibacterial properties. Sophisticated analytical techniques i.e., thermal gravimetric analysis (TGA), differential thermal analysis (DTA), and derivative thermogravimetric curve (DTG) were used to characterize the thermal properties of nanocomposites. Antibacterial study was performed by using disc diffusion method against bacteria E. coli. The thermal results showed that, the maximum degradation temperature (Td) increases up to 85.5oC in air atmosphere in case of sample HM2. Antibacterial study showed that, the bacteria have least effect on the silver containing functionalized polymer nanocomposites.
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Lu, De-Yi,Mao, Xu-Hua,Zhou, Ying-Hui,Yan, Xiao-Long,Wang, Wei-Ping,Zheng, Ya-Biao,Xiao, Juan-Juan,Zhang, Ping,Wang, Jian-Guo,Ashwani, Neetika,Ding, Wei-Liang,Jiang, Hua,Shang, Yan,Wang, Ming-Hua Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.13
Nogo protein, encoded by gene reticulon-4 (RTN4), includes three major isoforms by different splicing, named Nogo-A Nogo-B and Nogo-C. Nogo proteins play an important role in the apoptosis of cells, especially in tumor cells. RTN4 single nucleotide polymorphisms (SNPs) can influence the efficiency of transcription and translation thus being related with an individual's predisposition to cancer. The CAA insertion/deletion polymorphism (rs34917480) within RTN4 3'-UTR has been reported to be associated with many cancer types. In order to investigate the relationship between this polymorphism and susceptibility to non-small cell lung cancer (NSCLC) in the Chinese population, we conducted the present case-control study including 411 NSCLC patients and 471 unrelated healthy controls. The genotype distributions were significantly different between cases and controls (p=0.014). We found that the del allele could significantly increase NSCLC risk (ins/ins vs ins/del: p=0.007, OR 1.46, 95%CI=1.11-1.93; dominant model: p=0.004, OR 1.47, 95%CI=1.13-1.92 and allele model: p=0.008, OR 1.35, 95%CI=1.08-1.67). This association was stronger in participants over 60 years old, males and smokers. We therefore conclude that the CAA insertion/deletion polymorphism (rs34917480) contributes to non-small cell lung cancer risk in Chinese population. Age, sex and environmental exposure are also related to carcinogenic effects of rs34917480.
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