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Malik Abdul Rub,Naved Azum,Dileep Kumar,Farah Khan,Abdullah M. Asiri 한국공업화학회 2015 Journal of Industrial and Engineering Chemistry Vol.21 No.1
Various additives viz. hydrotropes, bile salts, fatty acid and cyclodextrin effect on the cloudpoint (CP) behavior of amphiphilic drug promazine hydrochloride (PMZ) in 1 mmol dm 3 14-4-14 + 10 mmol dm 3 sodium phosphate (SP) buffer solutions have been investigated in the present study. These various additives are usually used as pharmaceutical excipients. The additives like anionichydrotropes, bile salts and fatty acid salts increase the CP of PMZ, when added in low concentrations,whereas at high concentration, decrease it. Cationic and nonionic hydrotropes increase the CP of PMZsolutions at all concentration. Cyclodextrin behave like simple sugar is found to decrease the CP of thedrug solutions at all concentrations. Gemini surfactant (14-4-14) has been found a better surfactant thatcan prevent clouding under physiological condition. It can thus be used as a drug-carrier system thatincreases the storage stability. The thermodynamic parameters are also evaluated: where DGocis foundto be negative and DHoc and TDSocvalues are negative as well as positive depending upon type and natureof additive.
Malik Abdul Rub,Naved Azum,Farah Khan,Abdullah G. Al-Sehemi,Abdullah M. Asiri 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.10
We studied the influence of cationic hydrotrope aniline hydrochloride on the micellization behavior of cationic amphiphilic phenothiazine drug promazine hydrochloride in the presence and absence of 50mmol kg−1 NaCl. The experimental critical micelle concentration (CMC) values came out to be lower than ideal CMC (CMCid) values, signifying attractive interactions between the two components in mixed micelles. NaCl further decreases the CMC of pure PMZ and aniline hydrochloride as well as their mixture due to screening of the electrostatic repulsion among the polar head groups. The bulk properties of solution were examined by using different theoretical models for justification and comparison of results. The micellar mole fraction of aniline hydrochloride (X1 Rub, X1 M, X1 Rod and X1 id) was evaluated by different proposed models, showing greater contribution of hydrotrope in mixed micelle. The negative values of interaction parameter (β) indicate synergistic interactions and negative values of β further decrease by the addition of salt in mixed systems. From the CMC values as a function of temperature, various thermodynamic properties have been evaluated and discussed in detail.
Malik Abdul Rub,Abdullah M. Asiri,Naved Azum,Kabir-ud-Din 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
The purpose of the present study was to determine the influence of various anionic hydrotropes on the self-aggregation and phase behavior of amphiphilic drug promazine hydrochloride (PMZ) and to search for means which reduce/increase the values of critical micelle concentration (cmc) and boost/suppress the cloud point (CP), respectively, used in pharmaceutical formulations. By using regular solution theory (RST) and Rosen’s model various micellar and surface properties such as micellar composition, surface excess concentration (Gmax), interaction parameters (bm, bs) etc. have been determined. The solution micellar behaviors were also investigated using Motomura and Rodenas models for defense and comparison of results. Thermodynamic parameters were also evaluated and discussed.
Malik Abdul Rub,Abdullah M. Asiri,Naved Azum,Anish Khan,Aftab Aslam Parwaz Khan,Sher Bahadar Khan,Mohammed M. Rahman,Kabir-ud-Din 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.6
Herein we report the micellization and cloud point of an amitriptyline hydrochloride (AMT) under the influence of cationic, anionic and nonionic hydrotropes. Anionic hydrotropes were employed to know the micellar and surface behaviors, besides studying the clouding behavior of AMT drug with cationic,anionic and nonionic hydrotropes. Tensiometric study has been performed and the properties studied include the critical micelle concentration (cmc), maximum surface excess at the air/water interface (Gmax), the minimum area per of amphiphilic molecule at air/water interface (Amin), and the different thermodynamic parameters, besides clouding phenomenon. Interaction parameters of micelles (bm) and monolayer (bs) indicate that drug-hydrotrope systems show better interaction at the interface than in micelles.
Aftab Aslam Parwaz Khan,Abdullah M. Asiri,Anish Khan,Naved Azum,Malik Abdul Rub,Mohammed M. Rahman,Sher Bahadar Khan,K. S. Siddiqi,Khalid A. Alamry 한국공업화학회 2013 Journal of Industrial and Engineering Chemistry Vol.19 No.2
The reactions of Cefuroxime (CFA) by hexacyanoferrate (III) (HCF(III)) in alkaline medium at a constant ionic strength has been studied spectrophotometrically. It is a first order reaction, but fractional order in both CFA and alkali. Decrease in dielectric constant of the medium decreases the rate of reaction. The effect of added products and ionic strength has also been investigated. A mechanism involving free radicals is proposed. In a composite equilibrium step, CFA binds to HCF(III) to form a complex that subsequently decomposes to the products. The main two products were separated and identified by column chromatography, TLC and FT-IR. There is good agreement between the observed and calculated rate constants under different experimental conditions. The reaction was studied at different temperatures and activation parameters were computed with respect to the slow step of the proposed mechanism.
Automation Monitoring With Sensors For Detecting Covid Using Backpropagation Algorithm
( Pravin R. Kshirsagar ),( Hariprasath Manoharan ),( Vineet Tirth ),( Mohd Naved ),( Ahmad Tasnim Siddiqui ),( Arvind K. Sharma ) 한국인터넷정보학회 2021 KSII Transactions on Internet and Information Syst Vol.15 No.7
This article focuses on providing remedial solutions for COVID disease through the data collection process. Recently, In India, sudden human losses are happening due to the spread of infectious viruses. All people are not able to differentiate the number of affected people and their locations. Therefore, the proposed method integrates robotic technology for monitoring the health condition of different people. If any individual is affected by infectious disease, then data will be collected and within a short span of time, it will be reported to the control center. Once, the information is collected, then all individuals can access the same using an application platform. The application platform will be developed based on certain parametric values, where the location of each individual will be retained. For precise application development, the parametric values related to the identification process such as sub-interval points and intensity of detection should be established. Therefore, to check the effectiveness of the proposed robotic technology, an online monitoring system is employed where the output is realized using MATLAB. From simulated values, it is observed that the proposed method outperforms the existing method in terms of data quality with an observed percentage of 82.
Effect of low levels of hydrotropes on micellization of phenothiazine drug
Sulaiman Y. M. Alfaifi,Dileep Kumar,Malik Abdul Rub,Farah Khan,Naved Azum,Anish Khan,Abdullah M. Asiri,Hurija Džudžević-Čančar 한국화학공학회 2021 Korean Journal of Chemical Engineering Vol.38 No.2
Interactions within mixtures of the phenothiazine drug promethazine hydrochloride (PMH) and cationic hydrotropes ortho-toluidine hydrochloride (o-TDH) and para-toluidine hydrochloride (p-TDH) were investigated at different ratios and temperatures via conductometry to understand various physicochemical properties. Critical micelle concentration (cmc) was less than values of cmcid (cmc in ideal mixed system), indicating significant interaction among the studied constituents in solution mixtures. The cmc of pure PMH was also determined by measuring the surface tension for comparison. A variety of micellization thermodynamic parameters (Gibbs free energy [Gm 0 ], change in standard enthalpy [Hm 0 ], and change in entropy [Sm 0 ]) were computed using conductometry. The micellar mole fraction (X1 Rb, X1 Rod, and X1 id) of hydrotropes estimated by various theoretical models (Rubingh, Rodenas, and Motomura) was assessed, and the results showed a greater contribution of hydrotropes in mixed micelles along with their values increasing via an increase in mole fraction (1) of hydrotropes (o-TDH/p-TDH). Negative values suggest extremely favorable attractive interaction/synergism, as declines occurred in the whole quantity of amphiphile used for the desired purpose, leading to a drop of expenditure along with ecological concern. Obtained activity coefficients (f1 and f2) were always beneath unity, meaning nonideality was found between PMH and o-TDH/p-TDH. Like the conductivity method, the UV-visible and FT-IR techniques also demonstrate the interaction between the PMH and o-TDH/p-TDH.
Biomedical features and therapeutic potential of rosmarinic acid
Saba Noor,Taj Mohammad,Malik Abdul Rub,Ali Raza,Naved Azum,Dharmendra Kumar Yadav,Md Imtaiyaz Hassan,Abdullah M. Asiri 대한약학회 2022 Archives of Pharmacal Research Vol.45 No.4
For decades, the use of secondary metabolitesof various herbs has been an attractive strategy in combatinghuman diseases. Rosmarinic acid (RA) is a bioactivephenolic compound commonly found in plants of Lamiaceaeand Boraginaceae families. RA is biosynthesizedusing amino acids tyrosine and phenylalanine via enzymecatalyzedreactions. However, the chemical synthesis of RAinvolves an esterifi cation reaction between caff eic acid and3,4-dihydroxy phenyl lactic acid contributing two phenolicrings to the structure of RA. Several studies have ascertainedmultiple therapeutic benefi ts of RA in various diseases,including cancer, diabetes, infl ammatory disorders, neurodegenerativedisorders, and liver diseases. Many previousscientifi c papers indicate that RA can be used as an antiplasmodic,anti-viral and anti-bacterial drug. In addition,due to its high anti-oxidant capacity, this natural polyphenolhas recently gained attention for its possible applicationas a nutraceutical compound in the food industry. Here we provide state-of-the-art, fl exible therapeutic potential andbiomedical features of RA, its implications and multipleuses. Along with various valuable applications in safeguardinghuman health, this review further summarizes thetherapeutic advantages of RA in various human diseases,including cancer, diabetes, neurodegenerative diseases. Furthermore,the challenges associated with the clinical applicabilityof RA have also been discussed.
Anish Khan,Aftab Aslam Parwaz Khan,Abdullah M. Asiri,Malik Abdul Rub,Naved Azum,Sher Bahadar Khan,Hadi M. Marwani 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
A new class hybrid poly(2-methoxy aniline) Sn(II)silicate carbon nanotubes composite was synthesized by sol–gel method. The physico-chemical characterization was carried out by Scanning Electron micrograph, X-ray Diffraction, Fourier Transform Infrared, Ultraviolet–Visible Spectroscopy and simultaneous Thermo Gravimetric Analysis. The ion-exchange studies were also carried out to understand the ion-exchange capabilities. The dc electrical conductivity studies reviles its highly conducting nature in the range of 2–3-2 S cm-1. On the basis of distribution studies it was found highly selective for Hg2+. Due to selectivity of the composite, ion selective membrane was prepared and employed it as an indicator electrode in potentiometric titrations.
Mohammed M. Rahman,Sher Bahadar Khan,Hadi M. Marwani,Abdullah M. Asiri,Khalid A. Alamry,Malik Abdul Rub,Anish Khan,Aftab Aslam Parwaz Khan,Naved Azum 한국공업화학회 2014 Journal of Industrial and Engineering Chemistry Vol.20 No.4
In this report, the doped ZnO-CdO nanoblocks (NBs) have been synthesized by facile wet-chemical technique at low-temperature and characterized by UV–vis, FT-IR, XRD, FESEM, XPS, XEDS, etc. The NBs were applied for the selective detection of Fe(III) ions and photo-catalytic degradation using Brilliant cresol blue (BCB). The analytical efficiency of NBs phase was also investigated for a selective detection of Fe(III) by ICP-OES. NBs were found to be the most selective toward Fe(III), where adsorption process was mainly monolayer on a homogeneous adsorbent surface. In photo-catalysis, almost 52.3% degradation with BCB dye was observed under solar sources with NBs.