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Concurrent Relations of Commodity Futures
Namkoong,Hongseok,Kim, Woochang 대한산업공학회 2011 대한산업공학회 추계학술대회논문집 Vol.2011 No.11
Literatures have focused on the relationship between basis, cost of storage and convenience yield, as given by the Theory of Storage. However, the relations among futures contracts should be considered as a whole, upon discussion of futures-spot relationships: futures curve reflects inventory level and the risk premium and thus the dynamics of future spot price. Here the predictive ability of the futures curve over future spot price dynamics is empirically proven. When the futures curve is highly volatile, market participants’ expectation on inventory and risk premium vary. As this discrepancy widen, spot inventory is deemed unstable. Thus, spot price rises for a short time. But then, as inventory restores itself, spot mean reverts, making a sharp market correction. An investment strategy that predicts spot price crashes using the futures curve is devised. Equal weight portfolio of 26 commodities is used. Results corroborate the conjecture; it predicts major market crashes. Result indicates that contemporary relations among futures contracts are crucial in futures-spot relationships. This result expands the view offered by the Theory of Storage by highlighting the importance of relationship among futures contracts.
김유철,남궁재관 한국산업안전학회 1994 한국안전학회지 Vol.9 No.1
Ultrasonic for MoSi₂/Y. C. Kim, C. K. Namkoong/MoSi₂ in the silicides has excellence in the oxidation and corrosion resistence. When the solid state bonding sintered-MoSi₂/metal or the thermal sprayed coating by powder-MoSi₂ on the metal are carried out, the defects may be occured at the bonded surface. So, the method for evaluating the existence of the defects by non-destructive inspection is strongly desired. Here, the characteristics of ultrasonic for sintered-MoSi₂ are elucidated and the possibility of the detection of defects using by ultrasonic is investigated.
Effect of anti-muscarinic autoantibodies on leukocyte function in Sjögren’s syndrome
Namkoong, Eun,Lee, Sang-woo,Kim, Nahyun,Choi, Youngnim,Park, Kyungpyo 3M Company 2017 Molecular immunology Vol.90 No.-
<P>Our results suggest that anti-M3R autoantibodies in primary Sjogren's syndrome induce downregulation of plasma membrane-resident M3R and MHC class I molecules in leukocytes followed by NK cell-mediated cell death. This mechanism may explain the frequency of leukopenia occurrence in patients with primary Sjogren's syndrome.</P>
Namkoong, Sim,Kim, Tack-Joong,Jang, Ik-Soon,Kang, Keon-Wook,Oh, Won-Keun,Park, Junsoo Pharmaceutical Society of Japan 2011 BIOLOGICAL & PHARMACEUTICAL BULLETIN Vol.34 No.2
<P>The extracellular signal-regulated kinases/mitogen activated protein kinase (ERK/MAPK) and nuclear factor-κB (NF-κB) pathways are critical for cell survival and proliferation. Alpinumisoflavone (AIF), isolated from the African medicinal plant <I>Erythrina lysistemon</I>, is a member of the isoflavone group. In this report, we demonstrated that AIF treatment induces cell death of human lung tumor cells. Incubation of lung tumor cells with AIF increased the sub-G1 population and caspase 3/7 activity, suggesting that the cell death is caused by apoptosis. To identify the signaling pathway involved in the tumor cell death, we examined the modulation of transcriptional activity using various reporter constructs and found that AIF significantly deregulated both the ERK/MAPK and NF-κB pathways. Western blot analysis with antibodies to MAP/ERK kinase (MEK) and ERK showed that AIF dephosphorylates both MEK and ERK. Alpinumisoflavone also repressed lipopolysaccharide (LPS)-induced nitric oxide (NO) production in RAW264.7 cells by inhibiting NF-κB-dependent transcription. Therefore, the cell death induced by AIF may be <I>via</I> repressing both the ERK/MAPK and NF-κB pathways.</P>
Effect of Probenecid on the Biliary Excretion of Belotecan
NamKoong, Eun-Mi,Kim, In-Wha,Kim, Dae-Duk,Chung, Suk-Jae,Shim, Chang-Koo 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.11
The purpose of this study was to investigate the effect of probenecid, an inhibitor of the MRP2/ABCC transporter, on the pharmacokinetics and transport of belotecan (7-[2-(N-isopropy-lamino)ethyl]-(20S)-camptothecin). The effect of probenecid on the pharmacokinetics of belotecan was studied in rats. When belotecan was injected as a bolus dose of 5 mg/kg after probenecid was infused at a rate of 42.8 mg/2 mL/h/kg, the cumulative biliary excretion amounts and biliary clearance $(CL_b)$ of belotecan decreased ($28.29{\pm}2.83$ versus $19.96{\pm}1.45%$ of dose and $161.01{\pm}26.95$ versus $92.66{\pm}1.45$ mL/min/kg), whereas the systemic pharmacokinetics did not change. This indicates that the MRP2 transporter is involved in the biliary excretion of belotecan. The involvement of MRP2 in the secretory transport was further characterized using Caco-2 cell monolayers expressing MRP2. The apparent permeability across Caco-2 cell monolayers from basolateral to apical was 2.3 times greater than that from the apical to the basolateral side at the $50{\mu}M$ belotecan. In addition, probenecid significantly decreased the basolateral-to-apical transport of belotecan (52.9%). These results indicate that MRP2 is involved in the secretory transport of belotecan in biliary excretion.
NamKoong, Seung,Kang, Se-Chan,Do, Hang,Jang, Ki-Hyo,Jang, Seon-A,Choung, Myoung-Gun,Sohn, Eun-Hwa The Plant Resources Society of Korea 2011 한국자원식물학회지 Vol.24 No.3
A large number of edible seaweeds are consumed by the coastal peoples of Asia. Some of them are used in traditional remedies in many parts of the world. In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis (EBE) on rat macrophage to evaluate the possibilities as immune-modulators. Twelve male SD rats were divided into two groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) intake and distilled water ; B, oral supplemented with EBE 200 mg/kg. After 5 weeks of supplementation, rats were sacrificed to assess the effect on peritoneal macrophage functions. We showed no increasing effects on tumoricidal activity, phagocytic activity and NO production in macrophages in EBE supplementation group. However, EBE supplementation suppressed NO-iNOS production and p65 translocation into the nucleus in LPS-stimulated macrophages. Overall, these results suggest that the supplementation of EBE might have an anti-inflammatory effects on NO-iNOS production in macrophages throughout the inhibition of NF-${\kappa}B$ activation.
Namkoong, S.,Lee, E.J.,Jang, I.S.,Park, J. North-Holland Pub ; Elsevier Science Ltd 2012 FEBS letters Vol.586 No.20
Replication protein A (RPA) is a eukaryotic single-stranded DNA binding protein that is essential for DNA replication, repair, and recombination, and human RPA interacting protein α (hRIPα) is the nuclear transporter of RPA. Here, we report the regulatory role of hRIPα protein in cell proliferation. Western blot analysis revealed that the level of hRIPα was frequently elevated in cervical tumors tissues and hRIPα knockdown by siRNA inhibited cellular proliferation through deregulation of the cell cycle. In addition, overexpression of hRIPα resulted in increased clonogenicity. These results indicate that hRIPα is involved in cell proliferation through regulation of RPA transport.
NamKoong, Seung,Cheoung, Eui-Su,Joo, Hae-Mi,Jang, Seon-A,Yang, Yoon-Jung,Kang, Se-Chan,Jang, Ki-Hyo,Sohn, Eun-Hwa The Plant Resources Society of Korea 2011 한국자원식물학회지 Vol.24 No.3
In this study we investigated effects of supplementation with ethyl acetate extracts of the brown alga Eisenia bicyclis on innate immune cells to evaluate the possibilities as an immunomoulator in exercise stress. Twenty male SD rats were divided into four groups and the treatments were as follows: A, no Eisenia bicyclis extract (EBE) (200 mg/kg) intake and maintained at rest ; B, no EBE intake and undergoing exercise ; C, EBE intake and undergoing exercise ; D, EBE intake and maintained at rest. After 5 weeks of oral supplementation, rats were undergoing intensive swimming exercises for 2 h and sacrificed to assess the effects on peritoneal macrophages, spleen cells and natural killer (NK) cells. We showed increasing effects on nitric oxide-inducible nitric oxide synthase (NO-iNOS) production by macrophages and no effects of NK tumoricidal activity and suppressive effects on spleen cell proliferation in exercise group. However, EBE supplementation suppressed NO-iNOS production by macrophages and increased NK tumoricidal activity and spleen cell proliferative response to mitogen in exercise group. Overall, these results that EBE supplementation has differential effects on innate immune response and could be useful as sports nutrition.
Central administration of GLP-1 and GIP decreases feeding in mice
NamKoong, C.,Kim, M.S.,Jang, B.T.,Lee, Y.H.,Cho, Y.M.,Choi, H.J. Academic Press 2017 Biochemical and biophysical research communication Vol. No.
Glucagon-like peptide-1 amide (GLP-1) and gastric inhibitory polypeptide (GIP) are incretin hormones regulating energy metabolism. GLP-1 and GIP combination is suggested as a promising therapeutic strategy for treatment of obesity and diabetes. However, the neuronal mechanisms are not yet investigated. In the present study, we investigated the role of central GLP-1 and GIP in regulation of body weight homeostasis. The effect of GLP-1 with GIP on food intake, body weight, locomotor activity were determined following intracerebroventricular (ICV) administration of GLP-1 and/or GIP in mice. ICV administration of low dose GLP-1 (0.3 nmol) and GIP (1 and 3 nmol) did not change food intake. However, ICV administration of higher doses GLP-1 (1 and 3 nmol) and GIP (6 nmol) significantly decreased food intake and body weight. To investigate the synergic effect of ICV GLP-1 and GIP, subeffective dose GLP-1 (0.3 nmol) and subeffective dose GIP (1 nmol) were chosen for further co-administration study. ICV co-administration of GLP-1 and GIP significantly decreased food intake, body weight and drinking. ICV co-administration of GLP-1 and GIP significantly increased neuronal activation and pro-opiomelanocortin (POMC) expression in hypothalamic arcuate nucleus. The neuronal activation and POMC expression were observed in two distinct neuronal populations. These results provide neuronal mechanisms supporting the development of GLP-1 and GIP combination therapeutics for treatment of obesity and diabetes.