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Nalae Kang,Seok-Chun Ko,Hyun-Soo Kim,Hye-Won Yang,Ginnae Ahn,Seung-Cheol Lee,Tae-Gee Lee,Jung-Suck Lee,You-Jin Jeon 제주대학교 해양과학연구소 2020 해양과환경연구소 연구논문집 Vol.44 No.-
This study investigated the antihypertensive effects of an antioxidant peptide, Leu-Trp-His-Thr-His (LWHTH), purified from Styela clava peptic hydrolysate, to assess the bioactivity of the peptide and verify the value of S. clava as a health-promoting food. Also, the study presented structural evidence for the effects of LWHTH. The inhibitory effect of LWHTH on angiotensin I-converting enzyme (ACE) was assessed using enzyme reaction methods and the simulation methods in computational space. LWHTH inhibited ACE with an IC50 value of 16.42 – 0.45 lM. The LWHTH structure was stable, and its ACE inhibitory effect was retained under simulated gastrointestinal conditions. In silico simulations revealed that LWHTH binds the active site of ACE, with residues LW making the ACE–LWHTH complex stable and residues HTH making the complex strong. Furthermore, LWHTH significantly reduced blood pressure in spontaneously hypertensive rats. These results demonstrate that LWHTH has the potential to be a healthy functional food with antihypertensive effects. Therefore, S. clava consumption may be beneficial for human health.
A Study on Measuring and Defining Customer Equity of Complex Shopping Malls
Nalae Kim,Jina Park,Kyung Hoon Kim,Gaetano Aiello,Raffaele Donvito 한국마케팅과학회 2012 Journal of Global Fashion Marketing Vol.3 No.2
As leisure time is extended, the time that consumers spendat one shopping space increases, and complex shopping mallsare taking center stage as a new type of retail venue, channelingfamily-focused shopping culture by allowing, the wholefamily to enjoy themselves at the same time in a space withboth shopping space and entertainment facilities. With theirnew combination of traditional retail activities with entertainmentelements, these complex shopping malls satisfy a varietyof consumer’ needs, changing buying patterns, in the competitivedistribution market. Complex shopping malls are evolvinginto a living space that offers goods, service, entertainmentfacilities, and a variety of experiences. Companies have been increasingly employing SNS as a newmarketing communication tool. Companies can appeal to consumersand cut marketing costs through use of SNS. Companies use SNS as an important means of marketing toform, keep, and develop relations with consumers. These socialnetwork service marketing activities influence complex shoppingmalls and the malls form relationships with consumerswith Twitter, Facebook, and blogs. The final purpose of this study is to suggest a marketingstrategy for complex shopping malls by categorizing consumersaccording to customer equity and lifestyle and by discoveringtheir characteristics through mall image and awareness of usersof SNS of complex shopping malls. An online survey of followers of Twitter operated by MallA and Mall B. The questionnaire was conducted in October 2011 amongTwitter followers of Mall A, and the 220 questionnaires thatwere returned were used in statistical analysis. The 261 questionnairesreturned by Twitter followers of Mall B fromOctober 2011 to November 2011 were also used in the statisticalanalysis. The data of this study were analyzed using the Amos 18,SPSS 18.0 program. Confirmatory factor analysis was conducted to analyze thevalidity and reliance of the study parameters and reliance analysiswas conducted to confirm the consistency of the questionsin the criteria. The structured equation model was used for hypothesistesting and cluster analysis was conducted to analyzethe lifestyle of SNS users and to separate groups. Multiplegroup analysis was conducted to investigate the relationships ofeach parameter in each cluster. The outcomes of the study are summarized as follows:First, a survey of social network service users of complexshopping malls was performed to identify mall awareness andimage. Second, the effect of mall image on self-congruity wasconfirmed. Customers acknowledged the shopping mall as aself-extension or part of themselves when they feel thatself-image and mall image correspond. Third, mall awareness proved to have no effect on mallcommitment. A customer’s mere awareness of a shopping mallcan hardly be extended to commitment to that shopping mall. Fourth, self-congruity has a significant, positive effect onshopping mall commitment, because self-congruity makes customersmore dependent on the shopping mall, continuous commitmentresults, not to mention emotional commitment. Fifth, the hypothesis that the higher is the customer’s commitmentto the shopping mall, the higher is the loyalty, provedto be correct. Sixth, loyalty proved to have an effect on customer equity. Seventh, shopping mall awareness was found to have an effecton customer equity. Eighth, this study classified customer groups into the threecategories of fashion-oriented, sociability-oriented, and rationality-oriented, according to the lifestyles of users of multipurposeshopping malls’ SNS. Implications obtained from the study include the following: In a bid to provide assistance in developing marketing strategiesfor complex shopping malls using social network services,social network service users were categorized by characteristics,and the differences in the use and awareness of SNSwere identified. This study reviewed previous studies on SNS and lifestyleat home and abroad,...
Nalae Kang,Seyeon Oh,Hyun-Soo Kim,Hyosang Ahn,Junwon Choi,Soo-Jin Heo,Kyunghee Byun,You-Jin Jeon 제주대학교 해양과학연구소 2020 해양과환경연구소 연구논문집 Vol.44 No.-
Leptin, a well-known appetite hormone, plays a role in fat metabolism in peripheral tissues including the adipose, liver, and muscle tissues. In this study, we investigated the antiobesity and fat accumulation regulatory effects of Ishophloroglucin A, derived from the brown seaweed Ishige okamurae, which acts via the leptin signaling pathway in the peripheral tissues of a high-fat-diet-induced obese mouse model. Obesity in C57BL/6J mice was induced by feeding them with a high-fat diet for 10 weeks and Ishophloroglucin A (2.5 mg/kg) was orally treated for the last 4 weeks. Body weights were monitored once per week during the experimental period. After the experiment, several serum biochemical parameters were measured using commercial kits and the white adipose, liver, and muscle tissues were observed using immunohistochemistry methods. Ishophloroglucin A significantly reduced glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, and leptin level, which increase as a result of high-fat diet. Also, Ishophloroglucin A clearly activated the leptin signaling pathway in all examined peripheral tissues, reduced the adipose tissue size, and alleviated steatosis in the liver and muscle tissues. These results implied that Ishophloroglucin A treatment for 4 weeks positively induced molecular mechanisms and histologic changes related with leptin signaling. These findings suggested that constant Ishophloroglucin A treatment clearly regulates obesity and peripheral fat accumulation via the leptin signaling pathway in high-fat-diet-induced obese mice.